Supercritical Drug Impregnation onto Intraocular Lenses Abir BOULEDJOUIDJA a, Yasmine MASMOUDI a, *, Baoguang JIANG b,c,wei HE b,c, Elisabeth BADENS a
|
|
- Felix Summers
- 6 years ago
- Views:
Transcription
1 Supercritical Drug Impregnation onto Intraocular Lenses Abir BOULEDJOUIDJA a, Yasmine MASMOUDI a, *, Baoguang JIANG b,c,wei HE b,c, Elisabeth BADENS a a Aix Marseille université, CNRS, Centrale Marseille, M2P2 UMR 7340, 13451, Marseille, France b Shenyang Bio Medical Device Co., Ltd., Shenyang , Liaoning Province, China c Shenyang He Eye Hospital, Shenyang , Liaoning Province, China * Yasmine.masmoudi@univ-amu.fr Abstract Supercritical impregnation is an attractive clean alternative to conventional soaking into liquid process, using generally organic solvents. Impregnation process can be used for the development of controlled delivery systems that can be applied in pharmaceutical and medical fields. This work focuses on the preparation of controlled drug delivery systems for ophthalmic applications through supercritical impregnation. More particularly, commercial intraocular lenses (IOLs) used in cataract surgery are loaded with ciprofloxacin (an antibiotic) and dexamethasone 21-phosphate disodium salt (an anti-inflammatory drug) in order to prevent short- and long-term postoperative complications. Foldable hydrophilic and rigid hydrophobic acrylate IOLS, made respectively from derivative of poly (2-hydroxyethyl methacrylate) (P-HEMA) and Poly (methyl methacrylate) PMMA were studied. Supercritical impregnations were carried out in a batch mode and impregnation yields were determined through drug release kinetic studies in a solution simulating the aqueous humor. The influence of operating conditions on impregnation was studied by performing preliminary impregnation experiments followed by experimental designs. Transparent IOLs presenting an effective impregnation were obtained. The highest impregnation yields for DXP and CIP in PMMA IOLs were 18.3 and 2.8 µg drug /mg IOL respectively and the highest impregnation yields for DXP and CIP in P-HEMA IOLs were 14.5 and 4.1 µg drug /mg IOL respectively. Those results indicate higher affinity of DXP for PMMA and P-HEMA IOLs than CIP, which was confirmed by partition coefficient values. Despite the low solubility of each drug in the fluid phase, homogeneous and in-depth impregnations were successfully obtained. A prolonged drug delivery during 40 days was obtained for most impregnation experiments (for both kinds of IOLs). Optical characterizations of IOLs were carried out by evaluating the diopter power as well as the imaging quality through the determination of the Modulating Transfer Function at a specified spatial frequency according to European Standard (ISO :2014). Results show that optical properties were conserved after supercritical impregnation. I. Introduction Among other diseases, cataract is the most common cause of blindness and severe visual impairment worldwide. The number of patients with cataract is continuously increasing [1]. It is conventionally treated through a surgery consisting in replacing the opacified natural crystalline lens with a synthetic intraocular lens (IOL). It is generally safe but the risk of postoperative endophthalmitis has to be considered and an IOL implantation is always a concern even with topical drug coverage [1]. A relevant solution to overcome those drawbacks could be the use of controlled drug delivery systems (DDS) placed inside the eye. These DDS can allow a slow release of drug over time in the potential infection area [2]. If the DDS is the impregnated IOL, this solution does not require an additional act on the surgeon. As an alternative to conventional impregnation techniques, supercritical fluid impregnation, especially using supercritical carbon dioxide (scco 2 ) can reduce or even eliminate the use of organic solvents [3]. Furthermore, when applied to polymers, scco 2 can act as a swelling and/or plasticizing agent promoting therefore the impregnation process. 1
2 The aim of the present work was to study the supercritical impregnation of commercially available intraocular lenses (IOLs), used for cataract surgery with an anti-inflammatory drug (dexamethasone 21-phosphate disodium salt, namely DXP) and an antibiotic (ciprofloxacin, designed CIP). Two polymeric IOLs were particularly tested: rigid IOLs (PMMA) and foldable IOLs (hydrated in their original form) (P-HEMA). A number of parameters such as pressure, impregnation duration and the presence/quantity of co-solvent were investigated to achieve optimized drug loading, homogeneous distribution of drugs in IOLs and a controlled drug release. II. Materials Supercritical impregnation was performed on two types of commercially available IOLs supplied by the Fred Hollows Intraocular Lens (Nepal): Rigid hydrophobic IOLs made from derivative of Poly (methyl methacrylate) (PMMA): IOLs with a diopter of D were used, Foldable IOLs made from derivative of Poly (2-hydroxyethyl methacrylate) (P-HEMA): IOLs are initially conditioned in a soaking physiological solution. IOLs with three different diopters were used (+5.0D, +21.0D and 32.0D). Ciprofloxacin (CIP, C 17 H 18 FN 3 O 3, 516 g.mol -1 ) and dexamethasone 21-phosphate disodium salt (DXP, C 22 H 28 FNa 2 O 8 P, 331 g.mol -1 ) are commonly used ophthalmic drugs in postoperative cataract treatment. Both drugs were supplied by Sigma-Aldrich (France). The solvents employed in this work were carbon dioxide (99.7 % purity) from Air Liquide (France) and ethanol ( 99.8 % purity) supplied by Groupe MERIDIS (France). III. Methods III. 1. Experimental design and response surface methodology In RSM, an empirical mathematical model (Eq. 1) is postulated and a suitable experimental design is performed to estimate required coefficients. This model, once validated can be used to predict the response in the whole experimental domain with good precision [4]. k k y = b 0 + b i x i + b ii x i 2 + b ij x i x j i=1 j=1 i<j Eq. 1 In a first step, a series of preliminary supercritical impregnation was carried out in order to delimit the experimental operating domain by varying different parameters. Based on the obtained results, two different experimental designs were elaborated for each type of IOLs, considering two factors in a central composite design with 9 individual design points in a spherical domain. III. 2. Supercritical impregnation set-up A detailed description of the batch impregnation process is presented elsewhere [5]. 2
3 IV. Characterizations IV. 1. Drug release kinetics studies In-vitro drug release kinetics studies were conducted by immersing impregnated IOLs in 5 ml of simulated aqueous humor (ph of 7.2) under stirring in a closed vessel at 310 K. An aliquot of 0.4 ml was collected every day for 60 days and drug (CIP or DXP) release was quantified through spectrophotometer analyses (Jenway 6715 UV/Vis spectrophotometer). Aliquots were then returned to the release vessel to maintain the initial volume. IV. 2. Impregnation yields The impregnated amounts were determined through release studies and defined as cumulative mass of the released drug after reaching a constant value. The impregnation yield was calculated according to the following equation (Eq. 2) where, m imp is the mass of impregnated API (corresponding to m during release) and m 0 IOL is the initial mass of dry IOL. Y imp = m imp m 0 IOL Eq. 2 IV. 3. Partition coefficients The affinity between the drug and the polymer can be determined through the partition coefficient (K), corresponding to the mass ratio of the drug in the impregnation matrix to that in scco 2 phase. It is calculated with equation 3, where y drug-polymer and y drug-co2 are the mass fractions of the drug in the impregnation matrix and in the fluid phase respectively. K = y drug polymer y drug CO2 Eq. 3 IV. 4. Optical properties The diopter power and the modulating transfer function (MTF) at a specified spatial frequency of IOLs were characterized according to the European Standard methods (ISO :2014). V. Results and discussions In this work, we are interested in the impregnation of drugs into PMMA and P-HEMA IOLs. For each kind of IOL, the results were discussed first for DXP and then for CIP. Solubility measurements of both drugs (DXP and CIP) in scco 2 (without using a co-solvent) were carried out at 308 K [6]. Experimental conditions and drug solubilities are summarized in the Table 1. Solubilities of both DXP and CIP in scco 2 are low, with higher values obtained for CIP. An increase in pressure (from 8 to 20 MPa) enhances drug solubility in scco 2 ( to for DXP and to for CIP in molar fraction). To our knowledge experimental data of DXP and CIP in scco 2 is presented for the first time in this work. Table 1. Solubilities of DXP and CIP (y drug in molar fraction) in scco 2 at 308 K [6]. P (MPa) CO 2 density (kg.m -3 ) y drug DXP CIP
4 V. 1. PMMA IOLs V Dexamethasone 21-phosphate disodium salt impregnation a. Preliminary impregnation In a first part of this study, supercritical impregnations were performed with pure scco 2 or using a co-solvent (ethanol, 5 %mol) at 8 and 20 MPa on IOLs with a diopter of D (Table 2). Temperature was kept constant at 308 K, impregnation duration at 2 hours and depressurization rate at 0.2 MPa.min -1. Experiment repeatability was verified by reproducing impregnations three or four times. Table 2. Influence of pressure and the use of a co-solvent (ethanol 5 %mol) on supercritical impregnation of PMMA IOLs with DXP (at 308 K and for 2 hours). N m 0IOL (*) Y Pressure imp t release m DXP imp (**) (mg) (MPa) ( g) ( g drug /mg IOL) days Without co-solvent DXP_ DXP_ With co-solvent (5 %mol) DXP_ DXP_ (*) Initial mass of the dry IOL before impregnation; (**) Release duration In the absence of co-solvent, pressure increase from 8 to 20 MPa had no significant effect on impregnation yields. Addition of ethanol at low pressure (8 MPa) resulted in an increase in impregnated DXP amount. It is well known that a co-solvent such as ethanol promotes the solubility of polar drugs as well as CO 2 sorption in polymers and swelling/plasticizing effect. However, a lower impregnation yield was obtained at 20 MPa which can be explained by a drug partition becoming more favorable towards the fluid phase. Interestingly, impregnation yields were improved at low pressure in presence of co-solvent. Hence, all DXP loadings later in this work were performed at 8 MPa and in the presence of co-solvent. b. Experimental design According to these first results, a response surface methodology based on experimental designs was used to study the influence of the amount of the co-solvent (1 to 10 %mol) as well as the impregnation duration (30 to 240 min). The pressure was kept at 8 MPa, the temperature at 308 K and the depressurization rate at 0.2 MPa.min -1. Figure 1 shows impregnated amounts and impregnation yields evolution respectively predicted by the RSM model in terms of amount of co-solvent and impregnation duration defined as the two input variables of the experimental design. The amount of impregnated drug varies between 118 and 398 g corresponding to impregnation yields between 5.6 to 18.3 g drug /mg IOL, which suggests that the studied factors influence the surface response. According to the response surface presented in Figure 1, the predominant effect is the impregnation duration. Indeed, response variations are significant in the defined experimental domain, particularly for low quantities of co-solvents (lower than 5.5 %mol). The most 4
5 advantageous conditions of impregnation are short duration (30 min) with low amount of cosolvent (5.5 %mol). µg 320 m imp Figure 1. Two-dimensional contour plot of impregnation yields and three-dimensional response surface of impregnated mass for supercritical impregnation of PMMA IOLs with DXP. V Ciprofloxacin impregnation Supercritical impregnation of CIP in PMMA IOLs was carried out at various conditions, the influence of pressure (8 and 20 MPa) and use of a co-solvent (5 %mol ethanol) on drug impregnation was studied for diopter D. Other parameters i.e. temperature (308 K), impregnation duration (2 hours), depressurization rates (0.2 MPa.min -1 ) were kept constant for all experiments. The obtained results were presented in the table 3. In the absence of co-solvent, increase in pressure from 8 to 20 MPa improved significantly the impregnation yields (from 0.8 to 2.4 g drug /mg IOL ). This could be attributed to the concurrent increase in CIP solubility in scco 2 (from to respectively), CO 2 sorption in the polymeric IOLs and their resulting swelling. Addition of ethanol as co-solvent in the procedure resulted in a further increase in drug impregnation yield (from 0.8 to 2.8 g drug /mg IOL at 8 MPa). However, in presence of ethanol, increase in pressure (from 8 to 20 MPa) did not affect the drug loading. This could be either due to the saturation of IOLs with drug or no further improvement in polymer/drug interactions at higher pressures. Table 3. Influence of pressure and the use of a co-solvent (ethanol 5 %mol) on supercritical impregnation of PMMA IOLs with CIP (at 308 K and for 2 hours). N m 0IOL Pressure m CIP imp Y imp t release (mg) (MPa) ( g) ( g drug /mg IOL) (days) Without co-solvent CIP_ CIP_ With co-solvent CIP_ CIP_ In-vitro kinetic studies of drug release from impregnated IOLs with each drug, were conducted for 60 days on all impregnated IOLs. Drug release for all the studied conditions x 2 x 1 : Amount of co-solvent x 2 : Impregnation duration t imp 5
6 exhibited a sustained release profile (about 40 days) without an initial burst release which suggests deep impregnation of the drug in IOLs. NMR analyses were carried out on impregnated IOLs in the presence of co-solvent without and with carrying out a CO 2 washing step phase (1 hour) before depressurization. Ethanol peaks (non shown in this article) disappear when the washing phase is carried out indicating an efficient removal of ethanol (residual ethanol lower than 0.01 wt %) which is suitable for the intended application. V. 2. Comparison between PMMA and P-HEMA IOLs impregnation Supercritical impregnation study of P-HEMA IOLs with both drugs (DXP and CIP) is described elsewhere [5]. In order to compare impregnation of both IOLs referring to partition coefficients, results obtained with both drugs in similar experimental conditions in the absence of co-solvent are presented in table 4. Table 4. Comparison of PMMA and PHEMA IOLs impregnation with CIP and DXP in absence of a co-solvent. Pressure Y imp ( g drug /mg K Y imp ( g drug /mg IOL) K (MPa) IOL) PMMA P-HEMA DXP CIP Despite low solubilities of DXP and CIP (slightly higher for CIP) in scco 2, partition coefficients were higher for DXP indicating a better affinity than CIP with both polymeric matrixes. Regarding DXP impregnation, the partition coefficient (K) decreases with pressure increase from 8 to 20 MPa for both types of IOLs indicating a partition of the drug becoming more favorable towards the fluid phase. This phenomenon can be explained by two factors. First, an increase in CO 2 density with pressure results in increased solvent power of CO 2, enhancing thus DXP solubility in the fluid phase ( to in molar fraction). At the same time, increasing CO 2 density promotes PMMA swelling favoring DXP dragging in the fluid phase during depressurisation. The partition coefficients of DXP were quite similar for both IOLs, which could be explained by quite similar affinities between DXP and both IOLs (PMMA and P-HEMA) in these conditions. Regarding CIP impregnation, in absence of co-solvent, the partition coefficient (K) increases with pressure increase (8 to 20 MPa) in similar way for both types of IOLs. These results could be explained by an increase in CIP solubility in the fluid phase ( to ) and a weak affinity between CIP and both kinds of IOLs. In absence of co-solvent, the partition coefficients of CIP were quite comparable for both types IOLs indicating by quite similar affinities between CIP and both types of IOLs. 6
7 V. 3. Optical properties In order to study the influence of supercritical impregnation on the optical properties of IOLs, optical characterization were performed. IOLs (P-HEMA and PMMA blends) commercialized by Shenyang Bio Medical Device were used for this part of study since they present well defined initial optical properties. Diopter power and modulating transfer function (MTF) at a specified spatial frequency of this type of IOLs were determined before and after supercritical treatment or impregnation with different diopters according to the European Standard methods and conditions (ISO :2014). IOLs optical properties respect the European standard conditions if the MTF values are higher or equal to 0.43 in both directions (sagittal and meridional) and the tolerance limits on spherical diopter power are respectively of ( 0.4) and ( 0.5) for the IOLs with diopters between (15 and 25) and (25 and 30). The experimental conditions and corresponding optical properties of IOLs treated with scco 2 and impregnated with DXP and CIP are presented respectively in table 5 and 6. Optical properties were conserved either after supercritical treatment and/or supercritical impregnation. Indeed, the values of diopter and MTF respect the standard conditions which is suitable for the intended application. Table 5. Influence of the supercritical treatment on the optical properties of IOLs. Before treatment After treatment Pressure Ethanol (MPa) (%mol) Diopter MTF MTF MTF MTF Diopter (sagittal) (meridional) (sagittal) (meridional) Table 6. Influence of the supercritical impregnation on the optical properties of IOLs. Before impregnation After impregnation Drug Pressure Ethanol MTF MTF MTF MTF Diopter Diopter (MPa) (%mol) (sagital) (meridional) (sagital) (meridional) 1 CIP CIP DXP DXP DXP DXP VI. Conclusion This work aimed to load rigid and foldable intraocular lenses (PMMA and P-HEMA) with ophthalmic drugs in order to combine cataract surgery and postoperative treatment in a single procedure. Two commonly used drugs to prevent cataract postoperative complications, ciprofloxacin and dexamethasone 21-phosphate disodium salt, were studied in this work. Supercritical impregnation was carried out in a batch mode and impregnation yields were determined through drug release studies for both types of IOLs. Despite the low solubility of drugs (DXP and CIP) in the fluid phase, homogeneous / in depth impregnated IOLs and presenting a prolonged drug delivery during 40 days were successfully obtained for most impregnation experiments (both kinds of IOLs). 7
8 Higher impregnation yields were obtained for both IOLs (PMMA and P-HEMA) with DXP than with CIP indicating better affinity of DXP with both IOLs than CIP and this result was confirmed by the values of partition coefficient. NMR analyses were performed on impregnated lenses (PMMA and P-HEMA) with both drugs in the presence of a co-solvent and did not show presence of residual ethanol. These results showed that impregnated IOLs are suitable for ophthalmic application. An important result of this work is that optical properties of IOLs were maintained after supercritical treatment and impregnation. Such results have never been reported until now. References [1] EPERON, S., RODRIGUEZ-ALLER, S., BALASKAS, K., GURNY, R., and GUEX- CROSIER, Y., International Journal of Pharmaceutics, vol. 443, 2013, p [2] SAURINA, J., DOMINGO, C., KAZARIAN, S. G., ANDANSON, J. M., GARCÍA- GONZÁLEZ, C. A., LÓPEZ-PERIAGO, A., FERNÁNDEZ, V., and ARGEMÍ, A., Journal of Supercritical Fluids, vol. 48, 2009, p. 56. [3] BADENS, E., Techniques de l ingénieur, 2012, vol. 33. [4] BAŞ, D and BOYAC İ. H., Journal of Food Engineering, vol. 78, 2007, p [5] BOULEDJOUIDJA, A., MASMOUDI, Y., SERGENT, M., TRIVEDI, V., MENIAI, A., and BADENS, E., International Journal of Pharmaceutics, vol. 500, 2016, p. 85. [6] CHEN, Y-P., Personal communication, National Taiwan University,
SUPERCRITICAL DEVELOPMENT OF SUSTAINED DRUG DELIVERY INTRAOCULAR LENSES
SUPERCRITICAL DEVELOPMENT OF SUSTAINED DRUG DELIVERY INTRAOCULAR LENSES Y. MASMOUDI 1*, S. ABDELLI 1, O. FORZANO 2, J-M. ANDRE 2, E. BADENS 1 1 Laboratoire de Mécanique, Modélisation & Procédés Propres
More informationDissolution Enhancement of Active Pharmaceutical Ingredients in Eudragit E100 by Melt Extrusion Coupled with Supercritical Carbon Dioxide
Dissolution Enhancement of Active Pharmaceutical Ingredients in Eudragit E100 by Melt Extrusion Coupled with Supercritical Carbon Dioxide Martial SAUCEAU 1, Tamás VIGH 2, Elisabeth RODIER 1, Zsombor NAGY
More informationPOWER DISSIPATED IN AN IMPINGING JET DEVICE IN SAS PROCESS. Stéphanie Caréno, Olivier Boutin, Elisabeth Badens
POWER DISSIPATED IN AN IMPINGING JET DEVICE IN SAS PROCESS Stéphanie Caréno, Olivier Boutin, Elisabeth Badens Laboratoire de Modélisation Mécanique et Procédés Propres (MP), UMR CNRS 68, Université Paul
More informationSUPERCRITICAL FLUID IMPREGNATION FOR THE ELABORATION OF SUSTAINED RELEASE DRUG DELIVERY
SUPERCRITICAL FLUID IMPREGNATION FOR THE ELABORATION OF SUSTAINED RELEASE DRUG DELIVERY Abir Bouledjouidja To cite this version: Abir Bouledjouidja. SUPERCRITICAL FLUID IMPREGNATION FOR THE ELABORATION
More informationIMPREGNATION SUPERCRITIQUE POUR L'ELABORATION DE SYSTEMES A LIBERATION PROLONGEE
AIX-MARSEILLE UNIVERSITE TITRE: IMPREGNATION SUPERCRITIQUE POUR L'ELABORATION DE SYSTEMES A LIBERATION PROLONGEE SUPERCRITICAL FLUID IMPREGNATION FOR THE ELABORATION OF SUSTAINED RELEASE DRUG DELIVERY
More informationCHAPTER 7. VISCOSITY AND DENSITY OF POLY (ε-caprolactone) IN ACETONE + CARBON DIOXIDE MIXTURES
CHAPTER 7 VISCOSITY AND DENSITY OF POLY (ε-caprolactone) IN ACETONE + CARBON DIOXIDE MIXTURES For processing of polymer solutions at high pressure in dense or supercritical fluids there is a continuing
More informationDissolution enhancement of active pharmaceutical ingredients in Eudragit E100 by melt extrusion coupled with supercritical carbon dioxide
Dissolution enhancement of active pharmaceutical ingredients in Eudragit E100 by melt extrusion coupled with supercritical carbon dioxide Martial Sauceau, Tamas Vigh, Elisabeth Rodier, Zsombor Kristof
More informationIT S A GLOBAL LEADER. IT S PROVEN.
isert Preloaded IOL System IT S A GLOBAL LEADER. IT S PROVEN. IT S isert. isert delivers the combination of simple operation, outstanding visual quality, and procedural efficiency. LEADERSHIP, WITH VISION
More informationSUPERCRITICAL IMPREGNATION OF ANTICANCER DRUG INTO BIODEGRADABLE POLYMER. Introduction
SUPERCRITICAL IMPREGNATION OF ANTICANCER DRUG INTO BIODEGRADABLE POLYMER Keisuke Sato, Satoshi Yoda 2, Hideko T. Oyama, Department of Science, Rikkyo Univ., Tokyo, Japan, 2 National Institute of Advanced
More informationIntroducing the envista IOL. Dr Kerrie Meades PersonalEYES Pty Ltd
Introducing the envista IOL Dr Kerrie Meades PersonalEYES Pty Ltd envista IOL Basic Features Hydrophobic acrylic IOL, single piece 6.0mm aspheric neutral optic, modified C haptic 12.5mm overall length
More informationMATERIAL & DESIGN MAKE THE DIFFERENCE
First-in-class material & unique patented design make the difference 01 Easy and reproducible injection 02 2.4 mm incision 03 100% glistening free 04 Long-term axial, radial and torsional stability 05
More informationImprovement Of Mechanical Properties Of Polymers With A Supercritical CO 2 Based Process
Improvement Of Mechanical Properties Of Polymers With A Supercritical CO 2 Based Process G. Del Re *, P. P. Ponti, G. Di Giacomo, F. Bettinardi Universita di L Aquila, Dipartimento di Chimica, Ingegneria
More informationBellaterra, Spain. Piazz.le Tecchio 80, Naples, Italy. Naples, Italy
Design and fabrication of micro and nano-structured scaffolding biomaterials for tissue engineering applications via low temperature supercritical CO 2 processes A. Salerno 1,2,3,*, P.A. Netti 3, C.A.
More informationImproving the Efficiency of the Supercritical Impregnation of Poly(D,L-lactide-co-glycolide) with Indomethacin
Improving the Efficiency of the Supercritical Impregnation of Poly(D,L-lactide-co-glycolide) with Indomethacin Cabezas, L. I., Fernández, V., Gracia, I., de Lucas, A., Rodríguez, J. F.* Department of Chemical
More informationPreparation and Tribological Investigations of PVA-H/HA Composites
16 International Conference on Material Science and Civil Engineering (MSCE 16) ISBN: 978-1-6595-378-6 Preparation and Tribological Investigations of PVA-H/HA Composites Gang WU a,1, Yin-yu LI b and Hong-ling
More informationCrystallization Of Amorphous Peek: A Comparison Among Thermal Treatment, Sinc Process And Supercritical Carbon Dioxide Treatment
Crystallization Of Amorphous Peek: A Comparison Among Thermal Treatment, Sinc Process And Supercritical Carbon Dioxide Treatment Del Re G., Bologna S., Spagnoli G. Università di L Aquila Dipartimento di
More informationModeling and simulation of drug release through polymer hydrogels. Shantanu Maheshwari, Sivakumar Cherlo, Rama Subba Thavva and Venkataramana Runkana
Modeling and simulation of drug release through polymer hydrogels Shantanu Maheshwari, Sivakumar Cherlo, Rama Subba Thavva and Venkataramana Runkana 1 Drug delivery: Key challenges Oral delivery Currently,
More informationMimetic Blue Affinity Adsorbents Mimetic Blue 1 P6XL, Mimetic Blue SA P6XL Mimetic Blue SA HL P6XL, Mimetic Blue ELISA Kit
Mimetic Blue Affinity Adsorbents Mimetic Blue 1 P6XL, Mimetic Blue SA P6XL Mimetic Blue SA HL P6XL, Mimetic Blue ELISA Kit WWW.PROMETICBIOSCIENCES.COM/PRODUCT DATASHEET Mimetic Blue affinity chromatography
More informationPart 7: Clinical investigations
Provläsningsexemplar / Preview INTERNATIONAL STANDARD ISO 11979-7 Third edition 2014-09-01 Ophthalmic implants Intraocular lenses Part 7: Clinical investigations Implants ophtalmiques Lentilles intraoculaires
More informationSupplementary Figure S1. Swelling and mechanical properties as a function of the PS-b- PAA block copolymer composition. a, Swelling kinetics of PAA
Supplementary Figure S1. Swelling and mechanical properties as a function of the PS-b- PAA block copolymer composition. a, Swelling kinetics of PAA homopolymer and PS-b-PAAs (4 mm disc with 1 mm thickness)
More informationControlled Drug Delivery. Martin s Ch 23; - pages Saltzman Ch 9;
Controlled Drug Delivery Martin s Ch 23; - pages 623 631 Saltzman Ch 9; -235-280 Controlled-delivery systems Are used for: - Alternative approach to regulate both the duration and spatial localization
More informationWater soluble drug releasing soft contact lens in response to ph of tears
IOP Conference Series: Earth and Environmental Science PAPER OPEN ACCESS Water soluble drug releasing soft contact lens in response to ph of tears To cite this article: G Kim and H Noh 2016 IOP Conf. Ser.:
More informationOPHTHALMIC DRUG DELIVERY BY SOFT CONTACT LENSES
OPHTHALMIC DRUG DELIVERY BY SOFT CONTACT LENSES By JINAH KIM A DISSERTATION PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR
More informationStart with ME. LEAVE A LEGACY OF EXCELLENT OUTCOMES WITH PEACE OF MIND. TECNIS MONOFOCAL IOL WITH TECNIS itec PRELOADED DELIVERY SYSTEM
LEAVE A LEGACY OF EXCELLENT OUTCOMES WITH PEACE OF MIND. Start with ME. TECNIS itec PRELOADED DELIVERY SYSTEM INDICATIONS: AMO TECNIS 1-Piece Lenses are indicated for the visual correction of aphakia in
More informationSupplementary Information. Facile fabrication of microsphere-polymer brush hierarchically. three-dimensional (3D) substrates for immunoassays
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Supplementary Information Facile fabrication of microsphere-polymer brush hierarchically three-dimensional
More informationTEPZZ _Z57 A_T EP A1 (19) (11) EP A1 (12) EUROPEAN PATENT APPLICATION. (51) Int Cl.: A61F 2/16 ( )
(19) TEPZZ _Z7 A_T (11) EP 3 2 72 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication:.08.17 Bulletin 17/3 (1) Int Cl.: A61F 2/16 (06.01) (21) Application number: 1617906. (22) Date of filing:
More informationEffect of Timolol Maleate Concentration on Uptake and Release from Hydrogel Contact Lenses using Soaking Method
Research Article Effect of Timolol Maleate Concentration on Uptake and Release from Hydrogel Contact Lenses using Soaking Method FURQAN A. MAULVI 1, TEJAL G. SONI 2, DINESH O. SHAH 3 & 4 1 Maliba Pharmacy
More informationCo-precipitation of Mefenamic Acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process
440 Chiang Mai J. Sci. 2013; 40(3) Chiang Mai J. Sci. 2013; 40(3) : 440446 http://it.science.cmu.ac.th/ejournal/ Contributed Paper Coprecipitation of Mefenamic Acid and Polyethylene Glycol 4000 Using the
More informationPHASE TRANSITIONS OF BINARY AND TERNARY SYSTEMS WITH CARBON DIOXIDE, TRIGLYCERIDES AND ETHANOL
PHASE TRANSITIONS OF BINARY AND TERNARY SYSTEMS WITH CARBON DIOXIDE, TRIGLYCERIDES AND ETHANOL P. M. Ndiaye 1,2, W.L. Priamo 1, E. Franceschi 1, C. Dariva 1, D. Oliveira 1, F.W. Tavares 2 and J. Vladimir
More informationStart with ME. TECNIS MONOFOCAL IOL WITH TECNIS itec PRELOADED DELIVERY SYSTEM LEAVE YOUR LEGACY OF EXCELLENT OUTCOMES WITH PEACE OF MIND.
LEAVE YOUR LEGACY OF EXCELLENT OUTCOMES WITH PEACE OF MIND. Start with ME. WITH INDICATIONS: AMO 1-Piece Lenses are indicated for the visual correction of aphakia in adult patients in whom a cataractous
More informationBLOCK COPOLYMERS ORGANIZATION AT INTERFACE
THE 19 TH INTERNATIONAL CONFERENCE ON COMPOSITE MATERIALS BLOCK COPOLYMERS ORGANIZATION AT INTERFACE D.Fischer, S. Bistac *, M. Brogly, Université de Haute Alsace, LPIM, Mulhouse France * Corresponding
More information10. Validated Normal Phase HPLC Method for the Determination. Fulvestrant is primarily used in the treatment of hormone receptor
229 10. Validated Normal Phase HPLC Method for the Determination of Fulvestrant in Pharmaceutical Dosage Forms 10.1 Introduction Fulvestrant is primarily used in the treatment of hormone receptor positive
More informationChapter 1. Introduction
Chapter 1 Introduction Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional
More informationAmerican Journal of Advanced Drug Delivery.
American Journal of Advanced Drug Delivery www.ajadd.co.uk Original Article Development and Study of an Erodible Matrix Drug Delivery Platform for Sustained Release of Non-Steroidal Anti-Inflammatory Drugs
More informationInternational Journal of Drug Research and Technology
Int. J. Drug Res. Tech. 2012, Vol. 2 (5), 393-398 ISSN 2277-1506 International Journal of Drug Research and Technology Available online at http://www.ijdrt.com Original Research Paper DESIGN AND EVALUATION
More informationThe research work highlights the development and evaluation of. bioavailability of drugs. The buccal route can bypass the first-pass
212 9. Summary, conclusion and recommendation 9.1 Summary and conclusion The research work highlights the development and evaluation of novel transbuccal drug antagonist of Famotidine. route have a rapid
More information4. PREPARATION OF GELATIN MICROSPHERES. Intra-articular delivery of drug loaded microspheres has been developed by
64 4. PREPARATION OF GELATIN MICROSPHERES Intra-articular delivery of drug loaded microspheres has been developed by many authors (Ratcliffe et al., 1987; Pavanetto et al., 1994; Tuncay et al., 2000a;
More informationApplications in Cardiology Hollow Fiber Membranes and Applications
Applications in Cardiology Want is meant by the term silicones?; Describe in general terms a typical synthetic scheme for a silicone consisting of half PDMS and half polysiloxane; Describe three cross-linking
More informationPassive Dosing of hydrophobic organic chemicals (HOCs) to in vitro assays controlling, defining and linking exposure
Passive Dosing of hydrophobic organic chemicals (HOCs) to in vitro assays controlling, defining and linking exposure Philipp Mayer Contributions from Dorothea Gilbert, Stine Schmidt, Kilian Smith and more
More informationFighting Hospital Acquired Infection
Fighting Hospital Acquired Infection Exploring methods of combining silicone tubing with APIs Introduction Healthcare-Associated Infections (HAI) are a major, yet often preventable threat to patient safety.
More informationCARBONATION OF WOLLASTONITE USING SUPERCRITICAL CARBON DIOXIDE
CARBONATION OF WOLLASTONITE USING SUPERCRITICAL CARBON DIOXIDE Clifford Y. Tai*, W.-R. Chen and Shin-Min Shih Department of Chemical Engineering National Taiwan University Email: cytai@ntu.edu.tw The feasibility
More informationSwelling Behavior of Acrylamide-2-Hydroxyethyl Methacrylate Hydrogels
Turk J Chem 24 (2000), 147 156. c TÜBİTAK Swelling Behavior of Acrylamide-2-Hydroxyethyl Methacrylate Hydrogels Belma IŞIK Hacettepe University, Chemistry Department, 06532, Beytepe, Ankara-TURKEY Received
More information(Refer Slide Time: 00:16)
(Refer Slide Time: 00:16) Proteins and Gel-Based Proteomics Professor Sanjeeva Srivastava Department of Biosciences and Bioengineering Indian Institute of Technology, Bombay Mod 02 Lecture Number 5 Welcome
More informationThe Role of Polymer Excipients in Hot Melt Extrusion A Continuous Manufacturing Process
The Role of Polymer Excipients in Hot Melt Extrusion A Continuous Manufacturing Process Nigel Langley ExcipientFest May 1, 2018 Hot-Melt Extrusion A Continuous Manufacturing Process Principle of HME 2
More informationBIODEGRADABLE INJECTABLE IMPLANT SYSTEMS FOR SUSTAINED DELIVERY USING POLY (LACTIDE-CO-GLYCOLIDE) COPOLYMERS
International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009 Research Article BIODEGRADABLE INJECTABLE IMPLANT SYSTEMS FOR SUSTAINED DELIVERY USING POLY (LACTIDE-CO-GLYCOLIDE)
More informationBLOCK COPOLYMER PHOTONIC GEL FOR DETECTING INTERFACIAL SEPARATION
BLOCK COPOLYMER PHOTONIC GEL FOR DETECTING INTERFACIAL SEPARATION Edwin P. Chan, Materials Research Engineer, National Institute of Standards and Technology, Gaithersburg, MD Introduction Mechanochromism,
More informationiserf Tore Introducing with 100% Hydrophobic Acrylic I0L with PMMA Haptic Tips
Introducing iserf Tore with 100% Hydrophobic Acrylic I0L with PMMA Haptic Tips More than just a new I0L a complete solution for enhancing toric IOL performance and results Available from T3 to T9 A, SURGICAL
More informationHydrogel Contact Lense for Extended Delivery of an Anti-Biotic in Combination with Anti-Inflammatory Drug for Ophthalmic Application
Hydrogel Contact Lense for Extended Delivery of an Anti-Biotic in Combination with Anti-Inflammatory Drug for Ophthalmic Application Chethana SR and Mohammed Gulzar Ahmed* Department of Pharmaceutics,
More informationLASER-INDUCED REFRACTIVE INDEX MODIFICATION OF INTRAOCULAR LENSES
Abstract LASER-INDUCED REFRACTIVE INDEX MODIFICATION OF INTRAOCULAR LENSES C. Bacharis 1, G. Tsilikas 1, I. Sianoudis 2, M. Makropoulou 1, G. Zoulinakis 1 and A.A. Serafetinides 1 1. National Technical
More informationPREPARATION OF VISIBLE-LIGHT-DRIVEN TIO 2 PHOTOCATALYST DOPED WITH IRON IN SUPERCRITICAL CARBON DIOXIDE
PREPARATION OF VISIBLE-LIGHT-DRIVEN TIO 2 PHOTOCATALYST DOPED WITH IRON IN SUPERCRITICAL CARBON DIOXIDE Esther Alonso *, Héctor Fernández-Rodríguez and M.J. Cocero Department of Chemical Engineering &
More information5. Discussion of the results for magnesium sulfate
Induction times as a function of temperature are depicted in Figure 4.2-11. Experiments have been carried out in the temperature range between 30 and 46 C. Temperatures below 30 C could not be reached,
More informationUSP s Perspective on Drug Product Performance Test
USP s Perspective on Drug Product Performance Test Course Overview 1. The concept of in vitro dissolution Definition and application 2. Compendial dissolution/ drug release testing 3. Method development
More informationThe use of surrogates for dissolution testing for Immediate Release (IR) formulations, when is it feasible?
The use of surrogates for dissolution testing for Immediate Release (IR) formulations, when is it feasible? Limin Zhang (Bristol-Myers Squibb Company) Andre Hermans (Merck & Co., Inc.) 2017 M-CERSI Workshop
More informationINVESTIGATION OF THE INTERACTION BETWEEN NAPROXEN AND HUMAN SERUM ALBUMIN
INVESTIGATION OF THE INTERACTION BETWEEN NAPROXEN AND HUMAN SERUM ALBUMIN A. PÎRNĂU, M. BOGDAN National R&D Institute for Isotopic and Molecular Technologies, 71 103 Donath str., 400293Cluj-Napoca, Romania
More informationInvestigation of a Venlafaxine HCl (37.5 mg) Extended Release Formulation Using Hypromellose (HPMC) Matrices
METHOCEL Application Data Partially Pregelatinized Maize Starch Investigation of a Venlafaxine HCl (37.5 mg) Extended Release Formulation Using Hypromellose (HPMC) Matrices ABSTRACT SUMMARY The aim of
More information5. PREPARATION OF GELATIN MAGNETIC MICROSPHERES. Targeting the drug with magnetic microspheres was first described by Widder et
5. PREPARATION OF GELATIN MAGNETIC MICROSPHERES 79 Targeting the drug with magnetic microspheres was first described by Widder et al. (1979a), who used magnetically responsive biodegradable drug carrier
More informationPRODUCT DATA SHEET. Carboxylated Gold Nanoparticles. Description. Features. Storage. Applications. Handling. Characteristics
PRODUCT DATA SHEET Carboxylated Gold Nanoparticles Description Cytodiagnostics carboxylated gold nanoparticles are available with two different lengths of PEG surface spacers, i.e. 3000Da and 5000Da offering
More informationSoluplus. Technical Information. October _090801e-01/Page 1 of 8. = Registered trademark of BASF group. Pharma Ingredients & Services
Technical Information Soluplus October 2009 03_090801e-01/Page 1 of 8 = Registered trademark of BASF group Pharma Ingredients & Services 03_090801e-01 October 2009 Page 2 of 8 Soluplus 1. Introduction
More informationStreamlined Manufacture of Modified Release Matrix Tablets via Direct Compression. Katie Hewlett, Dow Gus LaBella, Colorcon
Streamlined Manufacture of Modified Release Matrix Tablets via Direct Compression Katie Hewlett, Dow Gus LaBella, Colorcon Controlled Release Alliance Unique Together Leading polymer expertise Quality
More informationOxidation of Hazardous Wastes by Supercritical Water Oxidation(SCWO)
Oxidation of Hazardous Wastes by Supercritical Water Oxidation(SCWO) SuperCritical Water Oxidation (SCWO) is an end of pipe technology applicable to industrial waste effluents or sludges breaking down
More informationPRODUCTION OF FUSED SILICA CORES USING POWDER INJECTION MOULDING TECHNIQUES
Pakistan Engineering Congress, 69th Annual Session Proceedings 101 PRODUCTION OF FUSED SILICA CORES USING POWDER INJECTION MOULDING TECHNIQUES Dr. M. Yousaf Anwar* ABSTRACT A core is a separable part of
More informationStudy on the Cure Kinetics of Epoxy Resin Prepreg in Fiber Metal Laminates
Study on the Cure Kinetics of Epoxy Resin Prepreg in Fiber Metal Laminates Xintong Wu 1, Lihua Zhan 1,a, Shujian Li 2 and Wenke Li 2 1 College of Mechanical and Electrical Engineering, Central South University,
More informationInvestigation of the Mechanical Properties of Bagasse Fiber-Reinforced Epoxy Composite using Taguchi and Response Surface Methodology
Investigation of the Mechanical Properties of Bagasse Fiber-Reinforced Epoxy Composite using Taguchi and Response Surface Methodology Kanthavel Karuppusamy, a, * Palanisamy Ramanaicker, b and Vivek Somasundaram
More informationContinuous Crystallization of Pharmaceuticals. Allan S. Myerson
Continuous Crystallization of Pharmaceuticals Allan S. Myerson Dept. of Chemical Engineering Novartis-MIT Center for Continuous Manufacturing Massachusetts Institute of Technology Crystallization Process
More informationFoaming of Cyclic Olefin Copolymer (COC) and Nanocomposites by Carbon Dioxide
Foaming of Cyclic Olefin Copolymer (COC) and Nanocomposites by Carbon Dioxide Yan Li & Changchun Zeng Department of Industrial & Manufacturing Engineering High-Performance Materials Institute Florida State
More informationA REVIEW OF WATER RESISTANCE TEST METHODS FOR PRESSURE SENSITIVE ADHESIVES
A REVIEW OF WATER RESISTANCE TEST METHODS FOR PRESSURE SENSITIVE ADHESIVES Laura J Donkus, Technical Service Scientist, The Dow Chemical Company, Collegeville, PA William B Griffith, PhD, Principal Scientist,
More informationCapto * Blue and Capto Blue (high sub)
GE Healthcare Life Sciences Data file 28-9369-6 AC Affinity chromatography Capto * Blue and (high sub) and (high sub) are affinity chromatography media (resins) for the capture of human serum albumin,
More informationA new bleeding process of additives in a polypropylene film under atmospheric pressure
1 A new bleeding process of additives in a polypropylene film under atmospheric pressure M. Wakabayashi (a,c), T. Kohno (b), Y. Tanaka (b), T. Kanai (a,c) (a) Idemitsu Kosan Co., Ltd., Japan (b) Prime
More informationControlled Release Drug Delivery from Hydrogels
Controlled Release Drug Delivery from Hydrogels Teacher s Guide Keith Neeves CSIP Graduate Fellow Cornell University 1 Overview The objective of this project is to introduce students to the concepts of
More informationMethyl Cellulose and Hydroxypropyl Methyl Cellulose
Ronas Chemicals Ind.Co.,Ltd. Tel/Fax:86-28-8608-2869 Email:d.chen@ronasgroup.com www.ronasgroup.com Methyl Cellulose and Hydroxypropyl Methyl Cellulose Brief Introduction: Name: Methyl Cellulose Abbreviation:
More informationSYNTHESIS OF CORE-SHELL POLYURETHANE- POLYDIMETHYLSILOXANE PARTICLES IN SUPERCRITICAL CARBON DIOXIDE
SYNTHESIS F CRE-SHELL PLYURETHANE- PLYDIMETHYLSILXANE PARTICLES IN SUPERCRITICAL CARBN DIXIDE Eric Cloutet, Pierre Chambon, Henri Cramail* Laboratoire de Chimie des Polymères rganiques (LCP), UMR 5629,
More informationEffect of the Process Mode on the Properties of the Drug- Polymer Composite Particles Prepared by SAS Process
Effect of the Process Mode on the Properties of the Drug- Polymer Composite Particles Prepared by SAS Process I. N. Uzun 1*, P. Alessi 2, I. Kikic 2, N. De Zordi 3, M. Moneghini 3, D. Solinas 2, S. Dinçer
More informationSoft Fabrication and Polymers
Introduction to BioMEMS & Medical Microdevices Soft Fabrication and Polymers Companion lecture to the textbook: Fundamentals of BioMEMS and Medical Microdevices, by Prof., http://saliterman.umn.edu/ R012408
More informationAPPLICATIONS OF HIGH SENSITIVITY DSC
APPLICATIONS OF HIGH SENSITIVITY DSC The Seiko DSC6100 offers proven high sensitivity performance which is ten to thirty times greater than most DSC instruments on the market. The high sensitivity DSC
More information3.051J/20.340J Problem Set 1 Solutions
1 1. (12 pts) Bone tissue engineering generally involves the implantation of a synthetic or biologically derived material that upon implantation allows for bone in-growth and eventual replacement. In a
More informationInspection. Implementation of ICH Q8, Q9, Q10
Implementation of ICH Q8, Q9, Q10 International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Outline Aim of - as a key part of the regulatory
More informationSupporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Supporting Information A Green Route to Fabricate MoS 2 Nanosheets in Water/ethanol/CO 2 Yuhang
More informationAnalysis of Solute Distribution in Ice Formed in Progressive Freeze-concentration
Food Sci. Technol. Res., 19 (3), 369 374, 2013 Analysis of Solute Distribution in Ice Formed in Progressive Freeze-concentration Mihiri Gunathilake, Kiyomi Shimmura and Osato Miyawaki * Department of Food
More informationIntraocular Lens (IOL): Market Shares, Strategies, and Forecasts, Worldwide, Nanotechnology, 2013 to 2018
Published on Market Research Reports Inc. (https://www.marketresearchreports.com) Home > Intraocular Lens (IOL): Market Shares, Strategies, and Forecasts, Worldwide, Nanotechnology, 2013 to 2018 Intraocular
More informationGB/T Translated English of Chinese Standard: GB/T NATIONAL STANDARD
Translated English of Chinese Standard: GB/T1690-2010 www.chinesestandard.net Sales@ChineseStandard.net GB NATIONAL STANDARD OF THE PEOPLE S REPUBLIC OF CHINA ICS 83.060 G 40 GB/T 1690-2010 Replacing GB/T
More informationModule 16: Gel filtration: Principle, Methodology & applications. Dr. Savita Yadav Professor Department of Biophysics AIIMS, New Delhi
PAPER 9: TECHNIQUES USED IN MOLECULAR BIOPHYSICS I Module 16: Gel filtration: Principle, Methodology & applications Dr. Savita Yadav Professor Department of Biophysics AIIMS, New Delhi Module 16 Gel filtration:
More informationPolymer-based Microfabrication
Polymer-based Microfabrication PDMS SU-8 PMMA Hydrogel 1 Soft Lithography Developed by Whitesides, et. al A set of techniques for microfabrication based on the use of lithography, soft substrate materials
More informationRegenerez Degradation and Release Kinetics White Paper
R Regenerez Degradation and Release Kinetics White Paper A White Paper by Carissa Smoot, Scientist, Secant Group, Jeremy Harris, Ph.D, Secant Group and Stephanie Reed, Ph.D, Secant Group Introduction Implantable
More informationIntroduction. Controlled Release Drug Delivery Systems
Introduction Engineering Drug Delivery By: Aron Deen, Michael Matlock, Brian Copeland, Brett Covey, Jenny Oberlag Capstone Design Project- University of Oklahoma - Spring 2003 Based on extensive research
More informationSample Prep - Solid Phase Extraction
Atoll TM - Polymer based Atoll TM is a comprehensive product range based upon porous polymers consisting of ultra pure spherical particles with strictly controlled particle & pore size distribution. Atoll
More informationModel-based Technology Selection for Bioavailability Enhancement CPHI DAVID K. LYON, PH.D. OCTOBER 25, 2017
Model-based Technology Selection for Bioavailability Enhancement CPHI DAVID K. LYON, PH.D. OCTOBER 25, 2017 Biopharmaceutical Classification System Approximately 80% of drugs in the pharmaceutical compounds
More informationON-LINE CONTROL OF A RED AZO DISPERSE DYE : VIS ABSORPTION SPECTROPHOTOMETRY WITH SUPERCRITICAL CARBON DIOXIDE
ON-LINE CONTROL OF A RED AZO DISPERSE DYE : VIS ABSORPTION SPECTROPHOTOMETRY WITH SUPERCRITICAL CARBON DIOXIDE Dalila KERDOUD, Danielle BARTH * Laboratoire de Thermodynamique des Milieux Polyphasés Ecole
More informationPolymeric hydrogels are of special importance in polymeric biomaterials because of
POLYMERIC HYDROGELS Polymeric hydrogels are of special importance in polymeric biomaterials because of their favorable biocompatibility. Hydrogels are cross-linked macromolecular networks formed by hydrophilic
More informationLaboratory experiments on core-scale behavior of CO 2 exolved from CO 2 - saturated brine
Available online at www.sciencedirect.com Energy Energy Procedia Procedia 4 (2011) 00 (2010) 3210 3215 000 000 www.elsevier.com/locate/procedia www.elsevier.com/locate/xxx GHGT-10 Laboratory experiments
More informationExcipient Development at NCL
New Reverse Enteric Polymer for Oral Dosage Forms Excipient Development at omplete Solution for Taste Masking Moisture Barrier Sustained Release Immediate Release Polymorphism Inhibition National hemical
More informationAcrylic Block Copolymer for Adhesive Application
Acrylic Block Copolymer for Adhesive Application Shinya Oshita, Advanced Adhesives Engineer, KURARITY Business Promotion Department, Kuraray Co., Ltd., JAPAN Ken Tomono, Sales Manager, SEPTON Business
More informationCapto Blue and Capto Blue (high sub)
Data file 28-9369-6 AD Affinity chromatography Capto Blue and (high sub) and (high sub) are affinity chromatography media (resins) for the capture of human serum albumin (HSA), as well as purification
More informationOil Extraction from Enriched Spirulina Microalgae
Oil Extraction from Enriched Spirulina Microalgae Christelle Crampon 1 *, Mohamed Zaier 1, Olivier Lépine 2, Elisabeth Badens 1 Université Paul Cézanne Aix-Marseille III, 1 Laboratoire M2P2 (Mécanique,
More informationIssues Related to the Formulation and Delivery of Pharmaceutical Proteins
Issues Related to the Formulation and Delivery of Pharmaceutical Proteins Pretoria16 August Prof. dr. Daan J.A. Crommelin Dept. Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, UIPS Scientific
More informationDetection of Ocular & Systemic Disease
Disclosures: Lyndon Jones Biosensing & Drug Delivery Lyndon Jones PhD FCOptom FAAO FCAHS Professor & University Research Chair School of Optometry & Vision Science Director, Centre for Ocular Research
More informationSupporting Information. Toward Understanding Drug Incorporation and. Delivery from Biocompatible Metal-Organic
Supporting Information Toward Understanding Drug Incorporation and Delivery from Biocompatible Metal-Organic Frameworks in View of Cutaneous Administration Sara Rojas, Isabel Colinet, Denise Cunha, Tania
More informationHomogenization Model for 7xxx Aluminum Alloys
Proceedings of the th International onference on Aluminium Alloys, September -9,, Yokohama, Japan The Japan Institute of Light Metals pp. 64-69 64 Homogenization Model for 7xxx Aluminum Alloys Wei Wang
More informationOctanol Water Partition
Another phase change H 3 C H 2 H 2 H 2 C C C OH C C C H2 H2 H2 A ater A octanol K o [ Aoctanol ] [ A ] ater C H2 octanol aqueous solution Why octanol? drug uptake animal testing mortality related to K
More informationTuning Organic Carbon Dioxide Absorbents for Carbonation and Decarbonation
Tuning Organic Carbon Dioxide Absorbents for Carbonation and Decarbonation Ramachandran Rajamanickam, Hyungsoo Kim, Ji-Woong Park* School of Materials Science and Engineering, Gwangju Institute of Science
More informationSupplementary Information. for
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supplementary Information for Nanoslitting Phase-separated Block Copolymers by Solvent Swelling
More information