Novel Applications of Nano-Technology

Transcription

1 Novel Applications of Nano-Technology January 2004 by David Soane Chairman and CEO Soane Labs, LLC 5764 Shellmound St. Emeryville, CA Tel:

2 Common Theme Applying nanotechnology to solve problems for mature industries with mass markets. Combination of High Tech and Rust Belt Nanotechnology Polymer Chemistry Precision Engineering

3 Nano-Technology and Everyday Life Apparel Buildings Medicine Bio-Protection Cosmetics Food and Beverage

4 Soane Labs, LLC ZMS, LLC. Contact lens and precision optics Alnis BioSciences, Inc. Engineered therapeutics and diagnostics NanoTex, LLC. Nano-fabrics for easy care and daily wear ICBM, LLC. Innovative Construction and Building Materials Cosmetica, Inc. Personal care products DuraFizz, LLC. Powdered beverages

5 Alnis BioSciences,Inc. Engineered Therapeutics

6 Alnis BioSciences, Inc. Alnis BioSciences Multifunctional Nanoparticle Therapeutics Platform Alnis Confidential

7 Poly-Functional Nanoparticles Alnis BioSciences Targeting Elements Nanoparticle Vehicle Payload Alnis Confidential

8 Alnis BioSciences Cancer Cell Uptake of Dox-Loaded Hydrogel NPs Dox Dox-Dextran Dox-Hydrogel NPs C-32 Skin Melanoma Dox at same concentration in all examples Alnis Confidential

9 RGD-Dox NP Efficacy Alnis BioSciences No necrosis in Control, Doxil, and untargeted Dox- NP groups Massive central necrosis in RGD-Dox NP groups, especially those with large tumors Alnis Confidential

10

11 Nano-Whiskers Whiskers Spine Hooks Cotton or Wool Fiber

12 Nano-Whiskers Water Droplet nm 100nm Fiber 10-50µm

13 Water Repellency - 100% Cotton Untreated New 20 Washings 50 Washings

14 Branding Today

15 ICBM Innovative Construction and Building Materials

16 Comparison of Structural Bone Materials Gypsum High Strength Low Weight Low Strength High Weight Calcium Hydroxyapatite Collagen Fibril Inorganic/Organic Composite ICBM Proprietary

17 Brittle Inorganic Material Chalk ICBM Proprietary

18 Organic Reinforced Brittle Inorganic Material Chalk in Plastic Wrap ICBM Proprietary

19 Mold Resistance US Gypsum: 7 days Gen Gen 4 Mold 4, Newspaper: Resistant: Starch, National US Gypsum: no paper: 7 days 24 7 days 42 days Starch, no paper: 24 days National Gypsum: 7 days Gen 4 Mold Resistant: 42 days ICBM Proprietary

20 ICBM Novel Air Filters with Protective Capabilities against a Broad Spectrum of Pathogens and Toxic VOCs

21 Spectrum of Pathogens Mold spore ( microns) Influenza virus (0.1 microns) Anthrax spore ( microns) Cyanide gas ( microns) Smallpox Polio virus (0.2 microns) (0.03 microns) ICBM Proprietary

22 Cosmetica Inc. personal care products

23 Commercial Hair Dyes Consumer Perceptions Extensive hair damage; drying; weakening; split ends Foul odor; chemical treatment; burning; irritation; gloves Time consuming; tedious; expensive Permanent and irreversible; cannot change color Reluctant necessity Q: Why use these products? A: There are no viable alternatives Cosmetica, Inc. **confidential**

24 Permanent Hair Dyes: Chemistry Hair Formation of Dyes via Oxidative Coupling Bleaching Primary pretreatment Many Couplers Intermediates reaction products (3-5 used) (2-3 used) Coupling inside the cortex NH 2 NH 2 (ship in a bottle) CH 3 Oxidizing agent H 2 O 2 NH 3 H 2 O 2 NH 3 NH NH H 2 O 2 2 NH NH N(CH 2 CH 2 ) 2 2 NH 2 NH 3 NH 2 H 2 O 2 Cl H 3 C H 3 C H Severe structural 2 N damage NH primary intermediates Destruction couplers of melanin NH CH each 2 CH 2 commercial dye Melanin a (natural vast pigment) in the cortex Complicated array of new chemicals are formed only and toxic chemistry is performed on the head Some potential toxins/carcinogens; long-term effects largely unknown H 2 N NH 2 NH 2 NH NH 2 NH 3 H 2 O 2 NH N 2 Cl Cosmetica, Inc. **confidential** O CH 3 NH 3 H 2 O 2 CH 3 Amine (alkaline/ - ) NH 3 or NH 3 /alkanolamine

25 Cosmetica Hair Dyes All chemistry is performed off-line Completely Nothing removed Safe and Water, easy soap, to use Proprietary remover shampoo, conditioner, etc. no hair damage no exposure to toxic chemicals environmentally friendly Original Different Hair Untreated Original coated hair colors hair restored with hair are (melanin nanoparticles restored easily (no damage) intact) applied after multiple treatments Completely reversible color can be changed at will Conditioning and strengthening colored and colorless Scented, fixative, etc. (if desired) Nanoparticle solution or suspension Cosmetica, Inc. **confidential**

26 Nano-Technology and Everyday Life Apparel Buildings Medicine Bio-Protection Cosmetics Food and Beverage???