Biomaterial -Interaktion mellan levande vävnad och syntetiska material
|
|
- April Summers
- 6 years ago
- Views:
Transcription
1 Biomaterial -Interaktion mellan levande vävnad och syntetiska material LTH EXTG005 HT2014 Lars Magnus Bjursten Cecilia Eriksson Linsmeier Kursmaterial finns att hämta här:
2 Kursmål Understand the special requirements imposed on biomaterials Interaction with biological environment Lack of serviceability Special requirements in various applications (vascular, orthopaedic, ophtalmic) The development path for a new medical device/ biomaterial/
3 Kurslitteratur Kompletterande läsning Buddy-Ratner/isbn /
4 Kurslitteratur Kompletterande läsning Buddy-Ratner/isbn /
5 Biomaterial A biomaterial is any matter, surface, or construct that interacts with biological systems. Material intended to interface with biological systems to evaluate, treat, augment or replace any tissue, organ or function of the body (ESB Consensus Conference II)
6 Biocompatibility 1. "The ability of a material to perform with an appropriate host response in a specific application", (this definition deals with materials and not with devices ESB Consensus Conference I). 2. "The quality of not having toxic or injurious effects on biological systems" 3. "Comparison of the tissue response produced through the close association of the implanted candidate material to its implant site within the host animal to that tissue response recognised and established as suitable with control materials" - ASTM 4. "Refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimising the clinically relevant performance of that therapy" 5. "Biocompatibility is the capability of a prosthesis implanted in the body to exist in harmony with tissue without causing deleterious changes".
7 Medical device Europalagstiftning Medical device' means any instrument, apparatus, appliance, material or other article, whether used alone or in combination, including the software necessary for its proper application intended by the manufacturer to be used for human beings for the purpose of: - diagnosis, prevention, monitoring, treatment or alleviation of disease, - diagnosis, monitoring, treatment, alleviation of or compensation for an injury or handicap, - investigation, replacement or modification of the anatomy or of a physiological process, - control of conception,
8 Medical device US legislation Medical machine, contrivance, implant, in vitro reagent, or other similar or related article, including a component part, or accessory that is: Recognized in the official National Formulary, or the United States Pharmacopoeia, or any supplement to them Intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment or prevention of disease, in man or other animals Intended to affect the structure or any function of the body of man or other animals, and does not achieve any of its primary intended purposes through chemical action within or on the body of man or other animals and does not depend on metabolic action to achieve its primary intended purposes.
9 Use of Biomaterials Substitute for organ function To promote tissue regeneration Access devices Drug delivery Diagnostic procedures Biotechnology
10 Substitute for organ function Organs where the function is primarily related to cell function Liver, Muscle, Intestine, Nerve, Brain Organs where the function is related to the Extra Cellular Matrix (ECM) and the cells are primarily supporting the ECM Skeleton, ligament, tendon, tooth, intraocular lens Other functions Access device, drug delivery, diagnostics,some barriers, component in tissue engineering
11 Historisk utveckling av höftproteser Wear and poor anchorage 1920 Glass as sliding surface Fatigue and corrosion problems 1953 Acrylic used as bone cement 1956 Metal to metal 1958 Metal to Teflon, Metal to HMWPE 1970 Ceramic to HMWPE 2010 World market $4.7 billion
12 Historisk utveckling av Intraocular lenses Accidentally implanted fragments of canopy WWII (ICI Perspex PMMA) First implant Industry, Soft lenses million lenses
13 Development and testing of Medical Devices Idea Proof of principle Physiological principle Materials evaluation In vitro tests In vivo test Adaptation to a clinical device Human anatomy and physiology Clinical evaluation Risk/benefit Cut off point
14 Ethics How to develop Biomaterials? Use of animals? Clinical evaluation? Commercial aspects vs patient needs? How to regulate devices? Different devices for young and old? Exposure to litigation
15 Wound healing
16
17
18
19
20
21
22 Cells in the Immune system Lymphocytes T-cell (helper, supressor...) B-cell (incl. plasma cell) Macrophages (Monocytes, dendritic cells) Basophils Eosinophils
23 Professional Phagocytes Main location Blood Bone marrow Bone tissue Gut and intestinal Peyer's patches Connective tissue Liver Lung Lymphoid tissue Variety of phenotypes neutrophils, monocytes macrophages, monocytes, sinusoidal cells, lining cells osteoclasts macrophages histiocytes, macrophages, monocytes, dendritic cells Kupffer cells, monocytes self-replicating macrophages, monocytes, mast cells, dendritic cells free and fixed macrophages and monocytes, dendritic cells Nervous tissue microglial cells (CD4 + ) Spleen Thymus Skin free and fixed macrophages, monocytes, sinusoidal cells free and fixed macrophages and monocytes resident Langerhans cells, other dendritic cells, conventional macrophages, mast cells
24 S. Gordon: Nat Rev Immunol. 3, Jan 2003, p23
25 The Macrophage Foreign Compound soluble particle surface Phagocytosis Immune response Cytokines Antigen processing Reactive Oxygen Intermediates (ROI) Metalloproteases Local Environment: Cells & Matrix Proteolytic enzymes Cell surface receptor activation
26
27
28
29 Wound healing
30 Foreign body reaction
31 Foreign body reaction Tissue is organized parallel to the surface! Macrophages (Mø) are usually closest to the materials interface
32
33
34
35 What can a cell detect? Surface chemistry! Non specific! Receptor specific! Surface structures! Particles! Shear stress
36
37
38 Gold with covalently bound self assembling monolayers (Whiteside) -OH functionality -CH3 functionality gluthation
39 Foreign body capsule formation by modified surfaces Capsule thickness 30 days µm Gold OH- CH3- Gluthation
40 Surface ligands e.g. RGD e.g. Bone Sialoprotein
41 Bone sialo protein adsorbed on polystyrene Control: albumin
42 Ligand binding Cell binding e.g. RGD Matrix binding: e.g. Bone sialoprotein
43
44 Surface geometry Polyethylene film Coarse side: 100 grit sandblasted glass imprint smoth side: air interface or smooth glass imprint
45
46 If surface contact or substance release triggers adverse host response, then a smooth surface should induce least reaction
47
48 Polymer degradation Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: In vivo degradation behaviour. Löfgren et al J.Biomater.Sci. Polymer Edn. 6, 411(1994)
49 In-vitro results rarely translate to in-vivo
50 ?
51 Cell death at the interface shown by i.v. injection of propidium iodide Rosengren et al: JBMR, , p. 918
52 The Macrophage Mr Hyde: Induction of Tissue Injury Dr Jekyll: Extracellular Matrix Remodelling and Resolution of Inflammation
53 Macrophage activation from Duffield JS: Clin Sci (Lond). 2003;104(1):27-38
54 Proposed negative feedback for inflammatory Mø populations entering the inflamed site Monocytes entering the inflamed tissue become classically activated and induce apoptotic death of other cells in the tissue. These newly apoptotic cells are phagocytosed by the killer Møs and this process brings about a switch in Mø function to a cell sharing many features with the alternatively activated Mø. from Duffield JS: Clin Sci (Lond). 2003;104(1):27-38
55 S. Gordon: Nat Rev Immunol. 3, Jan 2003, p23
56 S. Gordon: Nat Rev Immunol. 3, Jan 2003, p23
57 S. Gordon: Nat Rev Immunol. 3, Jan 2003, p23
58 S. Gordon: Nat Rev Immunol. 3, Jan 2003, p23
59 Cell death at the interface shown by i.v. injection of propidium iodide Rosengren et al: JBMR, , p. 918
60
61 The Young Modulus is the gradient of the stress-strain graph for the region that obeys Hooke s Law Young modulus = tensile stress tensile strain = Fl Ae
62 Typical Young s moduli Aluminium oxide ceramics Stainless steel, CoCr alloys Titanium alloy PMMA Polyethylene Silicone elastomere Bone (cortical) Soft tissue muscle, tendons Cells 350 GPa 200 GPa 100 GPa 3 GPa 1 GPa 2 MPa 20 GPa 40 KPa KPa
63 Stress on tissue?
64 Klein-Nulend et.al: FASEB (1995) 9, 441
65 Shear at the interface Cell death Intracellular sensor/effector Alternate Mø activation circuits in macrophages? ECM remodelling/foreign body formation
66 Macrophage Activation by Biomaterials Soluble products from material Immunogenic materials ((Materials that become immunogenic by protein interaction)) Surface activation of cascade systems Mechanical shear at the interface!?
67 By applying magnets in a rotating magnetic field controlled oscillating shear can be applied
68 Exposure to (increased) controlled shear 5 x 10-6 Nm 1 w 2 hours daily 1 Hz Exposure with magnet Exposure without magnet
69 The thickness of the fibrotic capsule at implanted polyethylene spheres, different only in their size. Mathematical modeling suggests that mechanical factors are most important for the observed differences and release of substances from the different sized materials cannot explain the differences
70 Interfacial shear seems to be the single most important factor for host tissue response (?)
71 Implant 50 µm
72 Fluorescein (green) released from implant, cell nuclei (blue) Capillaries (red; CD31)
73 Meghdi Babakhanlou James Ko
74 Any substance or cytokine released at the interface will only have a limited reach before it is distributed systemically
Immunology 101: Implications for Medical Device Failure. Joshua B. Slee, PhD Assistant Professor of Biology
Immunology 101: Implications for Medical Device Failure Joshua B. Slee, PhD Assistant Professor of Biology Learning Goals Understand innate and adaptive immunity Explain how innate and adaptive immunity
More informationCHAPTER 1. Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm
CHAPTER 1 Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm 1.1 Introduction 1.2 Genotype/Phenotype (Fig. 1.1) 1.3 The Working Paradigm: The Unit Cell Process/The Control Volume
More informationGrowth factor delivery
Growth factor delivery S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Joint Initiative of IITs
More informationStrategies for Assessment of Immunotoxicology in Preclinical Drug Development
Strategies for Assessment of Immunotoxicology in Preclinical Drug Development Rebecca Brunette, PhD Scientist, Analytical Biology SNBL USA Preclinical Immunotoxicology The study of evaluating adverse effects
More informationBEH.462/3.962J Molecular Principles of Biomaterials Spring 2003
Lecture 17: Drug targeting Last time: Today: Intracellular drug delivery Drug targeting Reading: T.J. Wickham, Ligand-directed targeting of genes to the site of disease, Nat. Med. 9(1) 135-139 (2003) Drug
More informationChapter 3 The Immune System
Chapter 3 The Immune System Why is the Immune System Important? Why is the Immune System Relevant to HIV? T Lymphocyte Infected by HIV Brief History of Immunology Immunity- Observation reported in 430
More informationInterplay of Cells involved in Therapeutic Agent Immunogenicity. Robert G. Hamilton, Ph.D., D.ABMLI Professor of Medicine and Pathology
Interplay of Cells involved in Therapeutic Agent Immunogenicity Robert G. Hamilton, Ph.D., D.ABMLI Professor of Medicine and Pathology Disclosure The author works with Amicus on an immunogenicity project
More informationBlood is 55% Plasma (Liquid)
Blood is 55% Plasma (Liquid) The plasma portion of blood is: 91% Water Maintains blood volume Transports molecules 7% Proteins (ie: clotting proteins, albumin, immunoglobulins ) 2 % Salts, gases (O 2,
More informationBIOLOGICAL PERFORMANCE of MATERIALS
FOURTH EDITION BIOLOGICAL PERFORMANCE of MATERIALS Fundamentals of Biocompatibility Jonathan Black QfP) Taylor &. Francis >^ J Taylor & Francis Group Boca Raton London New York A CRC title, part of the
More informationBNG 331 Cell-Tissue Material Interactions. Wound Healing I
BNG 331 Cell-Tissue Material Interactions Wound Healing I Course update LBL 4 Friday; paper posted Need a volunteer to switch groups! Much better job on LBL 3 figure summaries BNG spring seminar 3 this
More informationBlood. Intermediate 2 Biology Unit 3 : Animal Physiology
Blood Intermediate 2 Biology Unit 3 : Animal Physiology Composition of Blood Blood contains Red blood cells White blood cells platelets plasma Plasma Watery, yellowish fluid Suspended in plasma Proteins
More informationANTIBODIES. Agents of Immunity
ANTIBODIES Agents of Immunity - Antibodies are: The Organization What are they? Protective agents of the immune system Neutralize foreign agents called antigens Essential part of the Adaptive Immune System
More informationSelection criteria for Biomaterials
Selection criteria for Biomaterials Biomaterials and biomedical devices are used throughout the human body. 2 important aspects: Functional performance Biocompatibility Hip joint prosthesis 1 Functional
More informationCardiovascular (connective tissue)
Cardiovascular (connective tissue) Blood Connective tissue Blood Proteins 7% Plasma 55% Other solutes 2% Water 91% Erythrocytes ~5.2 million per cubic mm Formed elements 45% Leukocytes ~7 thousand per
More informationBiocompatibility and War and Peace
Professor David Williams, D.Sc.,F.R.Eng., Professor and Director of International Affairs, Wake Forest Institute of Regenerative Medicine, North Carolina, USA Editor-in-Chief, Biomaterials President-elect,
More informationA review of Dr. Dinakar Golla s clinical research with AdMatrix surgical grafts for soft tissue repair
TEAMeffort: Using aggressive surgical techniques in combination with AdMatrix (Lattice Biologics acellular dermal scaffold product) to heal difficult and persistent wounds A review of Dr. Dinakar Golla
More informationUNIT CELL PROCESSES UNDERLYING TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Massachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2.79J/3.96J/20.441/HST522J UNIT CELL PROCESSES UNDERLYING TISSUE ENGINEERING AND REGENERATIVE
More informationCeramics, Glasses, and Glass-Ceramics
Ceramics, Glasses, and Glass-Ceramics Ceramics, Glasses, and Glass-Ceramics include a broad range of inorganic/nonmetallic compositions. Eyeglasses Diagnostic instruments Thermometers Tissue culture flasks
More informationNanosystems in regenerative medicine. Jöns Hilborn Materials Chemistry The Ångström Laboratory Uppsala University Sweden
Nanosystems in regenerative medicine Jöns Hilborn Materials Chemistry The Ångström Laboratory Uppsala University Sweden Outline Motivation for tissue regeneration Cell based approaches Material based
More informationIntroduction [1] Introduction to the course; CEO and CLO
MME 297: Lecture 01 Introduction [1] Introduction to the course; CEO and CLO Dr. A. K. M. Bazlur Rashid Professor, Department of MME BUET, Dhaka Topics to discuss today. What are Biomaterials? Classes
More informationChE 125. Principles of Bioengineering
ChE 125 Principles of Bioengineering ChE 125 Instructor: Prof. Samir Mitragotri Room 3349, Engineering II Email: samir@engineering.ucsb.edu Office Hours: Tuesday 1-2 pm Teaching Assistant: Aaron Anselmo
More informationThe University of North Texas Department of Materials Science & Engineering
The University of North Texas Department of Materials Science & Engineering 2017 Spring Semester Course Title: MTSE 4020, Materials in Medicine Instructor: Narendra B. Dahotre, Office DP C136E, Phone:
More informationBiomaterials in Medical device design
Biomaterials in Medical device design 1 Dr Joseph Buhagiar B. E n g ( H o n s. ) P h D ( B h a m ) D e p a r t m e n t o f M e t a l l u r g y a n d M a t e r i a l s E n g i n e e r i n g U n i v e r
More informationCourse Syllabus. BMEN 4360: Biomaterials and Medical Devices Fall Course Information
Course Syllabus Course Information Course Number/Section: BMEN 4360.001 Biomaterials and Medical Devices Term: Spring 2017 Days &Times: Class meets in ECSS 2.305 on Mondays and Wednesdays, 8:30 AM 9:45
More informationThe Cardiovascular System: Blood
The Cardiovascular System: Blood The Functions of Blood General Overview Provides a system for rapid transport within the body Nutrients Hormones Waste products Respiratory gases Cells & Blood Components
More informationDisclaimer: this is a very big topic and coverage will be only superficial.
Vascular Biology 4 Blood and its components: 1 Disclaimer: this is a very big topic and coverage will be only superficial. 1. Erythrocytes: eat your spinach (or steak). ~8 um diameter, 2 um thickness no
More informationUNIVERSITY OF ROME LA SAPIENZA NANOTECHNOLOGIES ENGINEERING NANOPARTICLES IN BIOMEDICINE
UNIVERSITY OF ROME LA SAPIENZA NANOTECHNOLOGIES ENGINEERING NANOPARTICLES IN BIOMEDICINE Challenges The challenges are: in-situ analysis and in vivo at micro level recognize biomolecules functionality
More informationThe Effects of Scaffold Rigidity on Retinal Pigment Epithelial Cells. Corina White Symposium on Biomaterials Science 24 October 2016
The Effects of Scaffold Rigidity on Retinal Pigment Epithelial Cells Corina White Symposium on Biomaterials Science 24 October 2016 Background Physiology The retina is the light-responsive tissue layer
More informationVeins Valves prevent engorgement and backflow. Baroreceptor reflex. Veins returning blood
Veins have large radii and low resistance. Walls are thin, not elastic Most blood volume is in veins Veins returning blood Veins Valves prevent engorgement and backflow Sympathetic NS constricts veins
More informationPreclinical development for SSc indications NO COPY. a preclinical portfolio in a perfect world. Jörg Distler
Preclinical development for SSc indications a preclinical portfolio in a perfect world Jörg Distler Department of Internal Medicine 3 and Institute for Clinical Immunology University of Erlangen-Nuremberg
More informationGUIDANCE NOTE FOR MANUFACTURERS OF CUSTOM-MADE MEDICAL DEVICES
GUIDANCE NOTE FOR MANUFACTURERS OF CUSTOM-MADE MEDICAL DEVICES Foreword This guidance document is informative and advisory and has no legal authority. Individual national enforcement authorities are bound
More informationTissue Engineering: The art of growing body parts. Robby Bowles, Ph.D Cornell University
Tissue Engineering: The art of growing body parts Robby Bowles, Ph.D Cornell University What is Tissue Engineering? What is Tissue Engineering? TE is an interdisciplinary field that applies the principles
More informationKeynote&Address&Abstracts&
Keynote&Address&Abstracts& Keynote&Address&1:& &Entrepreneurship&in&Biomaterials & Speaker:JamieGrooms,ChairmanandDirectorofAxoGenInc. Abstract Thetermsentrepreneurshipandengineerseamlesslyfittogether.However,asengineers,
More informationStem cells and tissue engineering
Stem cells and tissue engineering S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Joint Initiative
More informationVeins Valves prevent engorgement and backflow. Baroreceptor reflex. Veins returning blood
Veins have large radii and low resistance. Walls are thin, not elastic Most blood volume is in veins Veins returning blood Veins Valves prevent engorgement and backflow Sympathetic NS constricts veins
More informationMechanical Characterization and Stimulation Solutions for Biomaterials
Mechanical Characterization and Stimulation Solutions for Biomaterials BioDynamic Instruments Biomaterials and Tissue Characterization Application Examples Bone Bending Creep Test Clinical Need: Understand
More informationBiomaterials. Third Edition
Biomaterials Third Edition Joon Park R.S. Lakes Biomaterials An Introduction Third Edition Joon Park Biomedical and Mechanical Engineering University of Iowa Iowa City, IA 52242-1414 USA joon-park@uiowa.edu
More informationThere are 100 possible points on this exam. THIS EXAM IS CLOSED BOOK. 1. (6 points) Distinguish between the innate and adaptive immune responses:
BENG 100b: Frontiers in Biomedical Engineering Midterm Examination 28 February 2006 There are 100 possible points on this exam. THIS EXAM IS CLOSED BOOK. SHORT ANSWER (Total=70 points) Read the questions
More informationFrom Bench to Bedside: Role of Informatics. Nagasuma Chandra Indian Institute of Science Bangalore
From Bench to Bedside: Role of Informatics Nagasuma Chandra Indian Institute of Science Bangalore Electrocardiogram Apparent disconnect among DATA pieces STUDYING THE SAME SYSTEM Echocardiogram Chest sounds
More informationApplied Human Anatomy and Biomechanics
Applied Human Anatomy and Biomechanics Course Content I. Introduction to the Course II. Biomechanical Concepts Related to Human Movement III. Anatomical Concepts & Principles Related to the Analysis of
More informationFINAL DOCUMENT. Global Harmonization Task Force (revision of GHTF/SG1/N29:2005)
GHTF/SG1/N071:2012 FINAL DOCUMENT Global Harmonization Task Force (revision of GHTF/SG1/N29:2005) Title: Definition of the Terms Medical Device and In Vitro Diagnostic (IVD) Medical Device Authoring Group:
More informationThe Road to Functional Bioanalysis: Development and Validation of a Cell-Based Assay for Neutralizing Anti-Drug Antibody Analysis
The Road to Functional Bioanalysis: Development and Validation of a Cell-Based Assay for Neutralizing Anti-Drug Antibody Analysis Christelle Pythoud, PhD 2 nd EBF YSS, Barcelona Spain Celerion Switzerland
More informationLecture Outline. History. Purpose? Func:on of Bioscaffolds. Extracellular Matrix (ECM) 12/08/15
Associate Professor Rod Dilley Dr Rob Marano Ear Sciences Centre School of Surgery Harry Perkins Research Building 4 th Floor Lecture Outline History Purpose Functions Properties Approaches to bioscaffold
More informationLecture #8: ECM Natural Scaffold Materials
Lecture #8: ECM Natural Scaffold Materials Extracellular Matrix (ECM) ECM is a complex structural network surrounding and supporting cells Most natural polymers used as biomaterials are constituents of
More informationCourse Handbook MSc in Bioengineering Tissue Engineering Specialisation
Course Handbook 2013-2014 MSc in Bioengineering Tissue Engineering Specialisation 1 Course Objectives & Learning Outcomes This programme aims to give a sound and broad basis in tissue engineering. In particular,
More informationTEAK Traveling Engineering Activity Kits
TEAK Bioengineering Laparoscopic Lesson Plan Page 1 TEAK Traveling Engineering Activity Kits Biomedical Engineering Kit: Laparoscopic Surgery Laparoscopic Surgery Activity TEAK Bioengineering Laparoscopic
More informationFirst Global Forum on Medical Devices Bangkok-Thailand, September Regulatory Control of Medical Devices in Tanzania
First Global Forum on Medical Devices Bangkok-Thailand, September 9-11 2010 Regulatory Control of Medical Devices in Tanzania Mr. Hiiti Sillo Ag. Director General Tanzania Food and Drugs Authority hiiti@yahoo.com/hiiti.sillo@tfda.or.tz
More informationInternational Foundations of Medicine Basic Science Exam Blueprint
International Foundations of Medicine Basic Science Exam Blueprint General Principles 28% 30% Biochemistry and molecular biology gene expression: DNA structure, replication, and exchange gene expression:
More informationMaterials consiting of 2 or more chemically distinct constituens at the macro-size range.
Composites Materials consiting of 2 or more chemically distinct constituens at the macro-size range. One or more discontinous phases are embedded within a continous phase: Discontinous phase: is usually
More informationRESEARCH REPOSITORY.
RESEARCH REPOSITORY This is the author s final version of the work, as accepted for publication following peer review but without the publisher s layout or pagination. The definitive version is available
More informationTERMS AND DEFINITIONS
TERMS AND DEFINITIONS Advisory notice A notice issued by the organization, subsequent to delivery of the medical device, to provide supplementary information and/or to advise what action should be taken
More informationThe Biomechanics of ProLayer Acellular Dermal Matrix: suture retention strength
The Biomechanics of ProLayer Acellular Dermal Matrix: suture retention strength Reginald Stilwell, B.S., C.T.B.S., Ryan Delaney, M.S. ProLayer, Centennial, CO Basic science volume 2 ProLayer Acellular
More informationApplications in Cardiology Hollow Fiber Membranes and Applications
Applications in Cardiology Want is meant by the term silicones?; Describe in general terms a typical synthetic scheme for a silicone consisting of half PDMS and half polysiloxane; Describe three cross-linking
More informationNegatively charged microspheres provide an additional surface for cell attachment leading to proliferation, tissue regeneration and wound healing
Negatively charged microspheres provide an additional surface for cell attachment leading to proliferation, tissue regeneration and wound healing Authors: Correa LG, Peter R, Clerici G, Ritter V. 2017
More informationISO INTERNATIONAL STANDARD. Biological evaluation of medical devices Part 1: Evaluation and testing within a risk management process
INTERNATIONAL STANDARD ISO 10993-1 Fourth edition 2009-10-15 Biological evaluation of medical devices Part 1: Evaluation and testing within a risk management process Évaluation biologique des dispositifs
More informationIntroduction to Biomaterials
Introduction to Biomaterials Objective To introduce the different biomaterials used in Biomedical Engineering To provide some fundamentals properties of these materials, And to indicate how they are used.
More informationName:
Course No: DNTS2311 Course Title: General Histology I Date: 23/11/4104 No. of Questions: Time: 0hours Using Calculator (No) University of Palestine Midterm Exam 2014/2015 Total Grade: Instructor Name:
More informationSurface Characterization of Biomaterials
Surface Characterization of Biomaterials Biomaterials are determined The desire for well-being and long life expectancy goes hand in-hand with the use of non-viable materials to conserve health. 2000 years
More informationIntroduction to Material Science
Introduction to Material Science Materials are very important in the development of human civilization. Historians have identified civilization by the name of most used material. Thus, we have: Stone Age,
More informationMagnesium alloys for biodegradable implants
Magnesium alloys for biodegradable implants Laboratory for Metal Physics and Technology Department of Materials, ETH Zürich Victor Wessels Anja Hänzi, Bruno Zberg, Jörg Löffler, Peter J. Uggowitzer Mg
More informationBiocompatible materials
Biocompatible materials 07.11.2011 Reactions of the human body on materials and components Effects of some metal ions Determination of biocompatibility by using in vitro and in vivo methods Non-metallic
More informationFreshman/Sophomore Junior Senior
Freshman/Sophomore Junior Senior Course Recommendations Mathematics (6 courses) MA 1021 MA 1024 (Calculus I) (Calculus IV) MA 1022 MA 2051 (Calculus II) (Differential Equations) MA 1023 MA 2611 (Calculus
More informationCourse Syllabus. BMEN 4360: Biomaterials and Medical Devices Fall Course Information
Course Syllabus Course Information Course Number/Section: BMEN 4360.001 Biomaterials and Medical Devices Term: Fall 2016 Days &Times: Class meets in JSOM 2.902 on Mondays and Wednesdays, 8:30 AM 9:45 AM
More informationAlternative MicroFabrication and Applications in Medicine and Biology
Alternative MicroFabrication and Applications in Medicine and Biology Massachusetts Institute of Technology 6.152 - Lecture 15 Fall 2003 These slides prepared by Dr. Hang Lu Outline of Today s Materials
More informationIntroduction to Materials Science & Engineering
Introduction to Materials Science & Engineering Course Objective... Introduce fundamental concepts in Materials Science You will learn about: material structure how structure dictates properties how processing
More informationAt the conclusion of this lesson you should be able to:
Learning Objectives At the conclusion of this lesson you should be able to: Understand the key terms and definitions regarding stem cells Differentiate between the adult and embryonic stem cells Differentiate
More informationLecture 8: Cell-Surface Interactions: Host Responses to Biomaterials (Part II) Implantation of a biomaterial initiates the inflammatory response:
1 Lecture 8: Cell-Surface Interactions: Host Responses to Biomaterials (Part II) Implantation of a biomaterial initiates the inflammatory response: - response of vascularized tissue to local injury - severity
More informationISO INTERNATIONAL STANDARD. Biological evaluation of medical devices Part 1: Evaluation and testing within a risk management process
INTERNATIONAL STANDARD ISO 10993-1 Fourth edition 2009-10-15 Biological evaluation of medical devices Part 1: Evaluation and testing within a risk management process Évaluation biologique des dispositifs
More informationDrug /Device Combinations: The Convergence of Pharmaceutical and Biomaterial Science
Drug /Device Combinations: The Convergence of Pharmaceutical and Biomaterial Science Are We Just Raising the Stakes for Industry, Regulators, and Decision Makers? David Ames Director, Health Economics
More informationMedical Device Regulatory Framework 9 SEPTEMBER 2015 FUNDISA CONFERENCE JANE ROGERS
Medical Device Regulatory Framework 9 SEPTEMBER 2015 FUNDISA CONFERENCE JANE ROGERS Key Topics Definitions Essential Principles Classification Conformity Assessment Framework License to Manufacture, Import,
More informationNEXT GENERATION ECM-BASED ALLOGRAFT TECHNOLOGY:
NEXT GENERATION ECM-BASED ALLOGRAFT TECHNOLOGY: Potent biological scaffolds strategically control stem cell fate and function, allowing our allografts to harness the regenerative potential of patient s
More informationD.K.M. COLLEGE FOR WOMEN (AUTONOMOUS), VELLORE-1 DEPARTMENT OF ZOOLOGY IMMUNOLOGY (15CZO6B)
D.K.M. COLLEGE FOR WOMEN (AUTONOMOUS), VELLORE-1 DEPARTMENT OF ZOOLOGY IMMUNOLOGY (15CZO6B) SECTION-A (UNIT-I) 1. Lysozyme. 2. SALT(skin associated lymphoid tissues). 3. Innate immunity. 4. Sources of
More informationChapter 2 The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials
Chapter 2 The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials Tony Yu, Valerie J. Tutwiler and Kara Spiller 2.1 Introduction Biomaterials are part of the solution to many unmet
More informationBiocompatibility, FDA and ISO 10993
Introduction to BioMEMS & Medical Microdevices Biocompatibility, FDA and ISO 10993 Companion lecture to the textbook: Fundamentals of BioMEMS and Medical Microdevices, by, http://saliterman.umn.edu/ ISO
More informationEvaluation of RNA interference (RNAi) in Skin
Evaluation of RNA interference (RNAi) in Skin Next Generation in RNAi Pamela A. Pavco VP Pharmaceutical Development 3rd International SCAR Club Meeting March 26, 2010 www.rxipharma.com Massachusetts, USA
More informationPre-Clinical Testing for Devices and Diagnostics
Pre-Clinical Testing for Devices and Diagnostics Larry O. Blankenship Evergreen Research, Inc. April, 2016 1 Many Levels, Many Approaches The requirements differ dramatically by class and category and
More informationPIB for Fun and Profit
Polymers for Biology and Medicine Session: Biomaterials Entrepreneurship Santa Rosa CA, Oct. 9-12, 2013 PIB for Fun and Profit Entrepreneurship with Polyisobutylene Joseph P. Kennedy with many coworkers
More informationBASIC MEDICAL SCIENCES MODULE 2016/17
BASIC MEDICAL SCIENCES MODULE 2016/17 STUDENT INFORMATION MODULE CO-ORDINATOR: Email: edged@tcd.ie DEPARTMENT OF PHYSIOLOGY, BIOMEDICAL SCIENCES INSTITUTE, TRINITY COLLEGE, PEARSE STREET, DUBLIN 2. 1 LEVEL:
More informationThirupathi Kumara Raja. S, 1 Thiruselvi. T, 1 Asit Baran Mandal, 1 Gnanamani. A, 1* Adyar, Chennai Tamil Nadu, India
Supplementary File ph and redox sensitive albumin hydrogel : A self-derived biomaterial Thirupathi Kumara Raja. S, 1 Thiruselvi. T, 1 Asit Baran Mandal, 1 Gnanamani. A, 1* 1 CSIR-CLRI Adyar, Chennai Tamil
More informationImmunogenicity: Assessing the Clinical Relevance and Risk Minimization of Antibodies to Biopharmaceuticals
Immunogenicity: Assessing the Clinical Relevance and Risk Minimization of Antibodies to Biopharmaceuticals Daniel Kramer/Kathleen Beach Need for public-private collaboration 1 All biopharmaceuticals are
More informationISO Definition of a Medical Device
Introduction to BioMEMS & Medical Microdevices Biocompatibility, FDA and ISO 10993 Prof., http://saliterman.umn.edu/ ISO Definition of a Medical Device Any instrument, apparatus, appliance, material or
More informationTissue- Biomaterial Interactions
An Introduction To Tissue- Biomaterial Interactions Kay C Dee, Ph.D Tulane University Department of Biomedical Engineering New Orleans, Louisiana David A. Puleo, Ph.D University of Kentucky Center for
More informationAdaptive Immunity: Specific Defenses of the Host
PowerPoint Lecture Presentations prepared by Bradley W. Christian, McLennan Community College C H A P T E R 17 Adaptive Immunity: Specific Defenses of the Host The Adaptive Immune System Adaptive immunity:
More informationISO Definition of a Medical Device
Introductory Medical Device Prototyping Biocompatibility, http://saliterman.umn.edu/ Department of Biomedical Engineering, University of Minnesota ISO Definition of a Medical Device Any instrument, apparatus,
More informationBiocompatibility: a risk based approach
Biocompatibility: a risk based approach Legal framework The regulatory requirements include: Demonstration of safety Demonstration of efficacy Positive balance of risk and benefit The regulatory requirements
More informationTISSUE ENGINEERING AND REGENERATION: TECHNOLOGIES AND GLOBAL MARKETS
TISSUE ENGINEERING AND REGENERATION: TECHNOLOGIES AND GLOBAL MARKETS HLC101B August 2014 Yojana Jeevane Project Analyst ISBN: 1-56965-894-3 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA
More informationHumoral Immune Response. Dr. Iman Hussein Shehata Professor of Medical Microbiology and Immunology
Humoral Immune Response Dr. Iman Hussein Shehata Professor of Medical Microbiology and Immunology Intended Learning Outcomes By the end of this lesson the student is expected to: 1-Decribe the sequence
More informationGUIDANCE NOTES FOR MANUFACTURERS OF CLASS I MEDICAL DEVICES
MDEG - 2007-12 - II-3.3 MSOGClassIGuidance_Final GUIDANCE NOTES FOR MANUFACTURERS OF CLASS I MEDICAL DEVICES Foreword These guidance notes do not aim to be a definite interpretation of National Laws and/or
More informationBASIC MEDICAL SCIENCES MODULE 2018/19
BASIC MEDICAL SCIENCES MODULE 2018/19 STUDENT INFORMATION ME7B04 MODULE CO-ORDINATOR: Email: tsanovm@tcd.ie DEPARTMENT OF PHYSIOLOGY, TRINITY BIOMEDICAL SCIENCES INSTITUTE, TRINITY COLLEGE, PEARSE STREET,
More informationPhylogenetic Assessment of Innate Immunity s Complement Component C3 and Factor B (Bf)
Phylogenetic Assessment of Innate Immunity s Complement Component C3 and Factor B (Bf) In Cnidarians 3D! Sarah McAnulty Innate Immunity Organism is born with its innate immune system No development over
More informationAdditive manufacturing for long term implants. Presentation Content
Additive manufacturing for long term implants Jac Koenen DSM Amsterdam February 4, 2015 Presentation Content DSM and DSM 3D printing of medical devices/implants Advantages Unique DSM materials Some Relevant
More informationCOATING SYSTEMS BIOLINE COATING
COATING SYSTEMS BIOLINE COATING BIOLINE COATING MIMICKING HUMAN TISSUE MAQUET THE GOLD STANDARD MAQUET is an international synonym for innovative and technological advances in operating rooms and intensive
More informationPoint-of-Care Cell Processing Devices A Manufacturer s Perspective Clinical trials, regulatory compliance, and commercialization.
Philadelphia, 2013 Point-of-Care Cell Processing Devices A Manufacturer s Perspective Clinical trials, regulatory compliance, and commercialization. Brian Barnes, Ph.D. VP, Clinical and Regulatory Affairs
More informationDevelopment of new polymeric biomaterials for in vitro and in vivo liver reconstruction
SIXTH FRAMEWORK PROGRAMME PRIORITY 3 NMP- Nanotechnology and nano sciences, knowledge-based multifunctional materials and new production processes and devices Development of new polymeric biomaterials
More informationREIMAGINING DRUG DEVELOPMENT:
Biology Reconstructed REIMAGINING DRUG DEVELOPMENT: Accurate Disease Modeling To Drive Successful Therapies Julia Kirshner, CEO julia@zpredicta.com 1 SUCCESS RATES OF DRUG DEVELOPMENT ARE LOW, " PARTICULARLY
More information3.4 DNA sequencing: the Sanger method
3.4 DNA sequencing: the Sanger method Four separate polymerization reactions are performed 1 3.4 DNA sequencing: the Sanger (dideoxy) method 2 3.4 The polymerase chain reaction 3 3.5 Centrifugation can
More informationAntibody-Mediated Immunity
Color code: Important in red Extra in blue Antibody-Mediated Immunity For team error adjustments, click here Objectives To describe B-cells as the mediators of humoral immunity, (antibody-mediated immunity)
More information