Biology 210- Introduction to Cellular and Molecular Biology

Transcription

1 1 Biology 210- Introduction to Cellular and Molecular Biology Spring Semester 2006 Instructor: Dr. Matt Escobar Office: Science Hall II Rm. 123 Phone: Office Hours: M 4-5, W 11-1 (or by appointment) Teaching Assistant: Walter Tamulis Office: TBA wtamulis@csusm.edu Office Hours: TBA Supplemental Instructor (SI): Daniel Francis SI Hours, location: TBA Lectures: MWF 10:00-10:50 PM, Academic Hall Rm. 205 Laboratories: M/T 1:00-3:45 PM, Science Hall II Rm. 145 Course Objectives: 1. To introduce the atomic, molecular, and cellular processes which underlie biology 2. In combination with the companion course BIOL 211 (Introduction to Organismal and Population Biology), to help students to develop an integrated view of how molecular biology affects the biosphere, and vice versa 3. To provide students with theoretical background and practical experience in the current techniques utilized in molecular and cellular biology research 4. To explore the interface between science and society through review of specific, detailed case studies designed to reinforce scientifically-informed decision making

2 2 5. To assist students in building a solid factual and conceptual base in molecular/cellular biology, which will be the basis for further learning in upper division biology courses and future careers 6. To promote the development of critical thinking, problem solving, and higher order thinking skills Required Texts: Biology, 7 th ed. E. Solomon, L. Berg, and D.W. Martin. BIOL 210 Laboratory Manual, Spring 2006 ed. T.M. Wahlund, M. Escobar, R. Mustard Course Website: All lecture materials, handouts, supplemental readings, etc. will be posted on the class WebCT site. The site can be accessed through the online courses index ( by selecting BIOL 210 and entering your CSUSM username and password (same as university ). If you are unfamiliar with WebCT, refer to the IITS information page at: Exams and Grading: As an introductory course, BIOL 210 is designed to help you to understand and retain the critical terminology, facts, and concepts of cellular and molecular biology. Just as important, this course will require you to develop and improve your critical thinking and problem solving skills. Both the factual knowledge and the higher order thinking skills which you develop will be essential for success in your upper division coursework and in a career in scientific research, medicine, scientific education, etc. Lecture: Two midterm exams (100 pts. each) will be given during the semester (see lecture schedule), along with a comprehensive final exam (200 pts.). The final can count as much as two-thirds, or as little as one third of your final lecture exam grade. This is because your score on the final will be divided by two to generate two 100 pt. exam equivalents. Along with the two midterm grades, this

3 3 will give you a total of four 100 pt. exam equivalents. The top three of these four scores will be summed to yield your total (maximum 300 pts.). Because this effectively allows you to drop one 100 pt. exam, there will be no makeup exams. In the weeks prior to each exam, a short quiz (3 total, 10 pts. each) will be given. These quizzes will accustom you with the testing format and will provide you with feedback on your progress in the course. There will be no makeup quizzes. Please note that material from both lecture and laboratory will be covered on exams and quizzes. Laboratory: Laboratory evaluation will consist of three quizzes (15 pts. each) and two laboratory notebook evaluations (75 pts. each). Late submission of laboratory notebooks will result in the loss of 10 pts. per late day. Laboratory attendance is mandatory and you will not be able to receive credit for a laboratory investigation that you do not attend. Grading Summary: 3 lecture exams: 300 pts. 3 lecture quizzes: 30 pts. 2 laboratory notebook evaluations: 150 pts. 3 laboratory quizzes: 45 pts. Total: 525 pts. Grades will be assigned on a straight percentage: % = A, 93-90% = A % = B+, 86-84% = B, 83-80% = B % = C+, 76-74% = C, 73-70% = C % = D+, 66-64% = D, 63-60% = D- < 60% = F

4 4 Tentative Lecture Schedule Date Topic Readings 1/18 (W) 1/20 (F) 1/23 (M) 1/25 (W) 1/27 (F) 1/30 (M) 2/1 (W) 2/3 (F) 2/6 (M) 2/8 (W) 2/10 (F) 2/13 (M) 2/15 (W) 2/17 (F) 2/20 (M) 2/22 (W) 2/24 (F) 2/27 (M) 3/1 (W) 3/3 (F) 3/6 (M) 3/8 (W) 3/10 (F) 3/13 (M) 3/15 (W) 3/17 (F) 3/20 (M) Introductions, course overview The chemistry of life: Introduction The chemistry of life: Functional groups The chemistry of life: Carbohydrates and lipids The chemistry of life: Nucleic acids The chemistry of life: Proteins Thermodynamics and chemical energy Enzyme activity and control mechanisms A tour of the cell: I A tour of the cell: II Biological Membranes and Cell Signaling: I Biological Membranes and Cell Signaling: II The cell cycle: an overview (Quiz #1) DNA replication: I DNA replication: II Midterm exam I Aerobic cellular respiration Anaerobic respiration and fermentation Photosynthesis: The light reactions Phototsynthesis: CO 2 fixation pathways Overview of primary metabolism The central dogma of molecular biology Eukaryotic genome organization and structure Sequencing the human genome: A case study The central dogma: transcription (Quiz #2) The regulation of transcription: I The regulation of transcription: II Ch. 1 Ch. 2 Ch. 2 Ch. 3 Ch. 3 Ch. 3 Ch. 6 Ch. 6 Ch. 4 Ch. 4 Ch. 5 Ch. 47 ( ) Ch. 9 ( ) Ch. 11, Ch. 12 ( ) Ch. 11, Ch. 12 ( ) Ch. 7 ( ) Ch. 7 ( ) Ch. 8 ( ) Ch. 8 ( ) Ch. 7-8 Ch. 12 ( ) Ch. 9 ( ) and supplemental material Ch. 15 ( ) and supplemental material

5 5 3/22 (W) 3/24 (F) 4/3 (M) 4/5 (W) 4/7 (F) 4/10 (M) 4/12 (W) 4/14 (F) 4/17 (M) 4/19 (W) 4/21 (F) 4/24 (M) 4/26 (W) 4/28 (F) 5/1 (M) 5/3 (W) 5/10 (W) The central dogma: translation Midterm exam II SPRING BREAK The regulation of translation and mrna stability Post-translational regulation Recombinant DNA technology and cloning Practical Applications of DNA technologies Genetically modified crops: A case study Genes and Development: I Genes and Development: II Human stem cells: A case study Meiosis An introduction to transmission genetics: I (Quiz #3) An introduction to transmission genetics: II Genetics of Human Disease Course Summary and Review Final exam review Final Examination 9:15-11:15 Ch. 14 ( ) Ch. 14 ( ), Ch. 15 ( ) Supplemental material Ch. 16 Ch. 16 Supplemental material Ch. 9 ( ) Ch. 10 Ch. 10 Ch. 14 ( ) Academic Honesty and Integrity: Students are responsible for honest completion and representation of their work. Your course catalog (pg ) details the ethical standards and penalties for infractions. The instructor reserves the right to discipline any student for academic dishonesty, in accordance with the general rules and regulations of the university. Disciplinary action may include the lowering of grades and/or the assignment of a failing grade for an exam, assignment, or the class as a whole. Disabled Student Services: Students with disabilities who require reasonable accommodations must be approved for services by providing appropriate and recent documentations to the Office

6 6 of Disabled Student Services (DSS). This office is located in Craven Hall 5205, and can be contacted by phone at (760) , or TTY (760) Students authorized by DSS to receive reasonable accommodations should meet with me during my office hours in order to ensure confidentiality. Study Tips for BIOL 210: Your success in this class will depend to a large extent on your commitment to reading the assigned material as well as your attendance, and attention, during class meetings. In addition, there is no substitute for starting your studying early and keeping up on a day-to-day basis. A good rule of thumb is to review your notes for approximately one hour the evening after a lecture, highlighting any important points and filling in any gaps. This will provide you with immediate reinforcement on that day s material and will make studying for the exams substantially simpler. Finally, if some concepts are unclear or if you have any questions, please make use of my office hours (or make an appointment).