Regional or Global Molybdenum-99 Supply Indian Perspective

Transcription

1 Regional or Global Molybdenum- Supply Indian Perspective Dr. Anupam Mathur Board of Radiation and Isotope Technology (BRIT) Department of Atomic Energy (DAE) Navi Mumbai, India

2 Board of Radiation and Isotope Technology- Radioisotopes for societal benefits Production and Supply 45% 5% 50% Radiopharmaceuticals/ RIA kits Industrial products and services Research Radiopharmaceuticals/ RIA kits Industrial Services RIA kits/ Cold kits Sealed/ Open sources Medical products sterilization facility Mo- m Tc generator Radiographic camera Spice/ agricultural products irradiation facility Diagnostic (PET/SPECT) Radiopharmaceuticals Gamma chamber Radiotracer analyses Therapeutic Radiopharmaceuticals Blood Irradiators Theoretical dose calculations

3 Radiopharmaceutical products CLEAN ROOM FOR m Tc-COLD KITS Mo- m Tc GENERATOR FACILITY SHIELDED FACILITY FOR RADIOPHARMACEUTICALs 3 H and 14 C-LABELED COMPOUNDS LABORATORY Industrial products/services RADIOGRAPHIC CAMERA GAMMA CHAMBER MEDICAL PRODUCTS STERILIZATION FACILITY

4 Available Mo m Tc Generator systems Alumina column based Mo m Tc generator 11.1 GBq (300 mci) 18.5 GBq (500 mci) 22.2 GBq (600 mci) 37 GBq (1Ci) Frequency of Supply : Weekly Fission Mo is imported for its produce Sodium molybdate- Mo in Sodium Hydroxide Solvent Extraction Generator Frequency of Supply : Weekly Zirconium molybdate- based Mo- m Tc Gel generator 5.55 GBq (150 mci) 9.25 GBq (250 mci) 15 GBq (400 mci) Frequency of Supply: In absence of alumina column generator

5 BRIT s Mo/ m Tc market Nuclear Medicine Centres Regular Mo or Mo/mTc generator buyers BRIT supply ~80% of market potential is still untapped due to non-availability of fission produced Mo (High specific activity > 370 GBq/mg) within the country

6 Mo radioisotope sources Low specific activity Mo ( GBq/g) produced by neutron activation route in Dhruva research reactor, Bhabha Atomic Research Centre (BARC), India High specific activity Mo production (>370 GBq/mg) from LEU target under developmental stage NEW Scope of work Executing authority Average thermal n flux : n/cm 2 /sec Radiochemical processing Building BARC India LEU Target Processing equipments, technology and chemistry on Turnkey basis BARC India INVAP Argentina

7 Radiochemical Processing Facility for Fission produced Mo NEW FMP Building Total activity Production frequency Seismic resistant building constructed Area: 850 sq m Radioactive processing area: ~50% Side view 11.1 TBq (300 Ci) calibrated after six days/ batch Weekly Regulatory Board (AERB India) approvals Site clearance Construction clearance Fire safety analysis report submitted

8 NEW Hot cell area (Inside view) Lab area Potentially radioactive waste storage tanks (hand-wash)

9 LEU Target NEW Building for LEU target production constructed 650 targets /year Design - Completed by BARC Targets using Natural Uranium prepared and send for testing to INVAP Single Irradiation Target plates : 12 numbers Irradiation period : 5 days Cooling Period : 10 hours Target Meat Target Plate

10 M/s INVAP Argentina Execution Time-line Design Documentation Complete Critical Design Review Complete NEW Manufacture & procurement Shipment & delivery Oct 2017 Dec 2017 Mo production and supply launch Installation & startup Jun 2018 Jan 2019 Hot Commissioning & acceptance test Aug 2018 Final Safety Analysis Documentation Oct 2018

11 Other technical challenges INVAP: 5 days irradiation BARC: 14 days irradiation in Dhruva reactor? Influence Mo production Fortnightly from Dhruva reactor Fortnightly from Apsara reactor once it becomes operational (Expected Start: Dec 2018) Apsara reactor Mo production (< 11.1 TBq) due to low neutron flux ( n/cm 2 /sec) Other regulatory approvals Final PSAR submission Hot commissioning Regular production approvals Awaited FSAR submission for regular production and supply

12 Approaches for bringing Mo to market Nearly 100 generators (37 GBq 6 day pre-calibrated activity) per week are planned for supply Current Mo- m Tc alumina column generator facility can handle upto ~ 1TBq (six-day precalibrated) of Mo/ batch New Mo- m Tc alumina column generator facility coming up ~ 1TBq (six-day pre-calibrated) of Mo/ batch Production frequency of both facilities : 4 batches/week Rest will be available for private producers of Mo- m Tc generators in India and abroad Mo- m Tc generator facility

13 Conclusions Future market for fission produced Mo Fortnightly 11.1 TBq (300 Ci) six day pre-calibrated activity 7.4 TBq (200 Ci) for Indian market 3.7 TBq (100 Ci) open for supply to International market Mo- m Tc generator / Mo as Sodium Molybdate LOGISTICAL CHALLENGES Take time to completely indigenize the Mo need of the country ECONOMIC CHALLENGES No major economic challenge LEU Targets will be indigenously produced and fuel will be reprocessed which will not affect the cost of generator

14 ACKNOWLEDGEMENTS Dr. Rania Kosti and National Academies of Sciences, Engineering, and Medicine IAEA Mr. G. Ganesh, Chief Executive BRIT Fission Molybdenum- team Mr. S.S. Sachdev Mr. A. C. Dey Mr. Prabhakar Naskar Mr. Abhishek Sharma Mr. Sudip Bhunia Mr. Soumen Das

15 Board of Radiation and Isotope Technology, Navi Mumbai, India