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1 MarketsandMarkets Publisher Sample Phone: (US) or or (Int'l) Hours: Monday - Thursday: 5:30am - 6:30pm EST Fridays: 5:30am - 5:30pm EST customerservice@marketresearch.com MarketResearch.com

2 FLOW CHEMISTRY MARKET BY REACTOR TYPE (CSTR, Plug Flow Reactor, Microreactor, Microwave System), APPLICATION & GEOGRAPHY Trends & Forecasts to MarketsandMarkets

3 MarketsandMarkets is a global market research and consulting company based in the U.S. We publish strategically analyzed market research reports and serve as a business intelligence partner to Fortune 500 companies across the world. MarketsandMarkets also provides multi-client reports, company profiles, databases, and custom research services. MarketsandMarkets covers fourteen industry verticals, including aerospace & defence, advanced materials, automotives and transportation, banking and financial services, biotechnology, chemicals, consumer goods, energy and power, food and beverages, industrial automation, medical devices, pharmaceuticals, semiconductor and electronics, and telecommunications and IT. Copyright 2013 MarketsandMarkets All Rights Reserved. This document contains highly confidential information and is the sole property of MarketsandMarkets. No part of it may be circulated, copied, quoted, or otherwise reproduced without the approval of MarketsandMarkets. MarketsandMarkets Sample Pages 2

4 1 INTRODUCTION 1.1 REPORT DESCRIPTION Continuous flow reactors are the devices used for continuous production, i.e. the reaction takes place in a continuous flowing stream instead of the batch production. Various advantages such as flexibility of operation, safety, and energy saving potentials are seen with the use of these devices. The report discusses four major types of reactors that are Continuous Stirred Tank Reactors (CSTR), Plug Flow Reactors (PFR), Micro Reactor Systems (MRT), and Microwave systems. Market revenues have been estimated till 2018 for all types of reactors, along with the regional analysis and trends. For each reactor, applications have been identified and market numbers have been provided for them. Further, the MRT system is classified as platebased, tube/capillary-based and milli-structured/microstructured devices. MarketsandMarkets Sample Pages 3

5 2 EXECUTIVE SUMMARY The continuous flow reactor market is witnessing a significant growth globally, due to various unique advantages when compared to the traditional batch reactors. The types of continuous flow reactors discussed in the report are Micro Reactor systems (MRT), Continuous Stirred Tank Reactors (CSTR), Plug Flow Reactors (PFR), and Microwave systems. A wide range of applications that cater to various industries such as Chemicals, Pharmaceuticals, Petro Chemicals, Bio fuels, Perfume and Fragrance Industries, Academia research and laboratories, etc. have also been studied in the report. Under the MRT system segment, chip, capillary, and microstructured-based systems have been taken into consideration. Due to the evolution of energy savings regulations, cgmp (current good manufacturing practices), environmental and safety laws, etc. companies are adopting sustainable production techniques. Also, the chemicals and pharmaceuticals industries, which are end-users of flow reactors, are growing at a significant pace globally, owing to the rising per capita income of medical products, the ever growing population, rising per capita income, etc. MarketsandMarkets Sample Pages 4

6 FIGURE 1 MRT MARKET VALUE, BY TYPE, APPLICATION & GEOGRAPHY, 2012 ($MILLION) Revenue, 2012 ($Million) By Type By Application By Region Plate Based Capillary Based Milli/ micro structured Pharmaceuticals Academic Research Fine Chemicals Petrochemcials Others North America Europe APAC ROW Source: Expert Interviews, Green Chemistry Council, CEFIC, Company Presentations, and MarketsandMarkets Analysis For MRT systems, four chief applications have been considered-pharmaceutical, academic research, fine chemicals, petro chemicals, and others. The others includes bio fuels, perfume and fragrance manufacturing, nano particles production, etc. which are discussed in depth in MarketsandMarkets Sample Pages 5

7 the report. The major regions considered are North America, Europe, ASIA-PACIFIC, and ROW. The top countries from all regions have also been discussed in the report. The total MRT systems market was $ million in 2012 and is expected to grow at a CAGR of % till 2018, to reach $ million. The plate or chip-based MRT systems had a share of % in MRT systems, with capillary and micro structured that garnered shares of % and % respectively in TABLE 1 CONTINUOUS FLOW REACTORS: MARKET VALUE, BY TYPE, ($MILLION) Type CAGR% ( ) CSTR PFR MRT systems Microwave systems Others Total Source: Expert Interviews, Company Annual Reports, and MarketsandMarkets Analysis The continuous flow reactors market was $ million in 2012 and is expected to reach $ million by 2018, growing at a CAGR of %. The MRT systems market is the fastest growing market due to their continuous production advantage. The MRT systems market is estimated to grow at the highest CAGR i.e. % till The CSTR and PFR market are upcoming markets, but the growth rate is less compared to MRT systems due to lesser efficiency and manufacturing issues. The Microwave systems, a type of continuous flow reactor, are estimated to grow at a CAGR %, since they can only be used for laboratory applications. Europe and Asia-Pacific are the largest markets for continuous flow reactors due to heavy rates of industrialization that take place in these regions and in the recovering economy. MarketsandMarkets Sample Pages 6

8 3 PREMIUM INSIGHTS 3.1 INTRODUCTION CHINA IS-THE LARGEST BUYER OF CONTINUOUS FLOW REACTORS FIGURE 2 CHINA: CONTINUOUS FLOW REACTORS MARKET VALUE, BY TYPE, ($MILLION) MRT Systems CSTR Revenue, 2012 ($Million) Revenue, 2012 ($Million) (E) (E) PFR Microwave Systems Revenue, 2012 ($ Million) Revenue, 2012 ($Million) (E) (E) Source: Expert Interviews, AICM, CPCIA, and MarketsandMarkets Analysis MarketsandMarkets Sample Pages 7

9 4 MARKET OVERVIEW 4.1 INTRODUCTION MATERIAL SELECTION, BY APPLICATION Various Materials Used for Micro Reactors The type of materials used to manufacture MRT systems changes according to the application and pressure to be handled. Glass: Glass is the most common material used to manufacture the body of a micro reactor due to its optical transparency. Various aggressive chemicals can be manufactured as well as complex reactions can be performed due to its chemically inert property and fine heat resistivity. Borofloat, Pyrex, and Foturan are a few examples of brands of glasses that are widely used in the industry. Syrris, Mikroglas, ThalesNano Inc, Chemtrix are leading players in the suppliers of micro reactor systems made of glass for laboratory purpose. Silicon: Silicon micro reactors are suitable for lab on chip systems that can find applications in bio catalytics. Silicone is inert, synthetic compound and is heat resistant in nature thus making it suitable for micro reactor application. Little Things Factory (Germany) is a pioneer in manufacturing of silicon micro reactors. Polymer: Polymer micro reactors are used extensively in medical and bio technological applications. The various types of polymers used are PET, PTFE, PFA, PDMS, PMMA, PEEK. The advantages of polymer micro reactors are excellent strength, stiffness and dimensional stability in high temperatures and harsh environment, easy to process and light weight as compared to steel and aluminum. Stainless Steel: Stainless steel is the most common material for micro reactor after glass because of its robustness and good thermal conductivity. Also stainless steel does not corrode, stain or rust. MarketsandMarkets Sample Pages 8

10 Silicon Carbide (Ceramic): Ceramic are extremely hard and resistant to high temperature, abrasion and corrosion. They have high thermal and variable electrical conductivity. Ceramic micro reactors can be used for industrial production. ESK Advanced technical ceramics (Germany) have developed a ceramic flow reactor which has thermal conductivity five times more than stainless steel. Hastelloy: Hastelloy is a super alloy made from nickel and various percentages of other materials. The alloy is designed to withstand high temperature and high stress. This alloy is used by Lonza (Switzerland) for manufacturing industrial micro reactors with high production capacity VALUE CHAIN ANALYSIS FIGURE 3 VALUE CHAIN ANALYSIS OF MRT SYSTEMS Collaborated Engineering companies Micro reactor systems and modules manufacturers Global distributors Customers Source: MarketsandMarkets Analysis MarketsandMarkets Sample Pages 9

11 5 CONTINUOUS FLOW REACTORS MARKET, BY TYPE 5.1 CONTINUOUS FLOW REACTOR MARKET, BY TYPE This report estimates the market of continuous flow reactors in terms of revenue. Currently, the market is still undersized, but it is expected to reach a significant value in future, as a majority of the companies find these new devices efficient and help companies achieve sustainable production methods. The major devices taken into account are Combined Stirred Tank Reactor (CSTR), Plug Flow Reactor (PFR), Micro reactors (MRT), Micro wave Chemistry, and others. The Plug flow reactors market is inclusive of its various types such as Pipe reactors, Packed Bed reactors, Trickle Bed reactors, Bubble Column reactors, and Ebulating bed reactors. Presently, the market of continuous flow reactors is dominated by CSTR and PFR devices as they are heavily commercialized. Micro wave chemistry devices are also one of the important applications of continuous flow reactors and have a healthy growth rate. FIGURE 4 CONTINUOUS FLOW REACTORS MARKET VALUE SHARE, BY TYPE, 2012 % % % % P C M M O % Source: MarketsandMarkets Analysis MarketsandMarkets Sample Pages 10

12 In 2012, the market share of CSTR was % and for PFR was %. MRT systems captured a share of %, but it is expected to gain the fastest growth rate, to reach a CAGR of %. The output of these systems can be increased with an addition of extra chips in processing substances, without increasing the size of the system. Microwave reactors are often used for small scale batch reactions. However, due to the extreme temperatures and pressures generated in the microwave, it often becomes difficult to transfer these reactions to conventional non-microwave apparatus for subsequent development that leads to difficulties with scaling studies. A flow reactor with suitable high temperature ability and pressure control can directly and accurately mimic the conditions created in a microwave reactor. This eases the synthesis of larger quantities by extending the reaction time. Microwave systems are majorly used in analytical chemistry and in chemicals synthesis. Over the years, with the advancement in technology, these systems also find applications in perfume manufacturing, the food industry, biological industry, etc. In the tubular reactor, the reactants are continually consumed as they flow down the length of the reactor. In modelling or designing the tubular reactor, designers assume that concentration varies continuously in the axial direction through the reactor. Consequently, the reaction rate, which is a function of concentration for all but zero-order reactions, will also vary axially. The tube reactors or PFR find huge applications in the petro chemicals industry, pharmaceuticals, as well as in the generation of alternative energy. MarketsandMarkets Sample Pages 11

13 TABLE 2 CONTINUOUS FLOW REACTORS MARKET VALUE, BY TYPE, ($MILLION) Type CAGR% ( ) MRT CSTR PFR Microwave systems Others Total Source: Company Presentations, Annual Reports, ICIS, Expert Interviews, and MarketsandMarkets Analysis MarketsandMarkets Sample Pages 12

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