Single Cell Genomics (SCG): Market Size, Segmentation, Growth, Competition and Trends (2013-2021) May, 2017 3 rd Edition Information contained in this market report is believed to be reliable at the time of publication. DeciBio Consulting, LLC is not soliciting any action based on the information contained in this report. See appendix section for complete disclosures. DeciBio Consulting, LLC 725 Arizona Ave. Suite 202 Santa Monica, CA 90401 Phone: 310-451-4510 Email: info@decibio.com www.decibio.com 1
Report Author Biographies Lead Author: Miguel Edwards, PhD (edwards@decibio.com) Miguel Edwards is a senior associate at DeciBio with over a decade of combined experience in life science business consulting and academic research. Miguel s research and professional experience spans a variety of industries with a focus on disruptive technologies within life science research tools and diagnostics. Miguel earned his Ph.D. in Molecular Biology at UCLA where he identified key signatures of stem cells and the impact of these on differentiation mechanisms. Miguel has extensive experience in genome engineering, and next generation sequencing across the entire workflow from library generation through computational analysis. Supporting Author: Jessica Lee, MS (Jessica.lee@decibio.com) Jessica Lee is a market research associate at DeciBio with extensive experience in academic and clinical research and strategic consulting in the life sciences industry. Jessica has engaged in numerous projects to assess the market potential of novel technologies in the diagnostics and medical device industries. Prior to joining the firm, Jessica earned her Master s of Business Science degree from Keck Graduate Institute and her BA from Cornell University. Jessica has expertise in next generation sequencing, which she utilized in depth to develop HIV incidence assays in her research. Supporting Author: Stephane Budel, PhD (budel@decibio.com) Stephane Budel is a partner at DeciBio with over 17 years of combined experience in life science business consulting, entrepreneurship, and academic research. Stephane specializes in the analysis of private to mid-cap companies with established to emerging technologies in the life science research tools and molecular diagnostics spaces Stephane has expertise in the cutting edge of these markets, with a deep understanding of the technical and business potential of innovative technologies such as qpcr, and NGS. Prior to DeciBio, Stephane earned his Ph.D. from Yale University for his research on the molecular mechanisms of spinal cord injury and schizophrenia. 2
DeciBio forecasts the WW SCG market to grow at 25% p.a., reaching ~$800M in 2021 Abstract Single cell genomics (SCG) is a fast growing, emerging approach in which genomic technologies (i.e., that assess nucleic acids such as DNA or RNA) are applied at the level of single cells, rather than at the level of an entire cell population. The third edition of this report reviews the market size, segmentation, growth and trends of the SCG market. We assess the SCG market across 7 segments and 33 subsegments: customer (e.g., academia, biopharma, applied markets, clinical), workflow step (e.g., cell isolation, sample preparation, genomic analysis), analytical technology (e.g., PCR, qpcr, microarray, next-generation-sequencing, other), field-of-study (e.g., oncology, basic cell biology, stem cell biology, microbiology, neurology, immunology, other), application (e.g., genomic variation, subpopulation characterization, circulating tumor cells, cell differentiation / reprograming, method, other), product type (e.g., instruments, reagents) and geography (e.g., U.S., Europe, Japan, China, Asia-Pacific, ROW). For each of these segments, we provide an estimated market size and growth from 2013 to 2021, as well as key growth drivers and moderators. In addition, we review key factors driving future growth including 1) increasing competition, putting pressure on the market to innovate, 2) availability of new platforms that streamline the historically laborious and low throughput workflow, 3) growth in the number of SCG centers, core facilities, and service providers expanding the geographical footprint of SCG, 4) development of new protocols and reagents optimized to improve the single-cell DNA/RNA amplification and 5) adoption of SCG by new customers segments. On the other hand, we discuss several key factors moderating growth including 1) remaining workflow challenges, including isolating cells from tissue and recovering DNA / RNA at a high yield, amplifying DNA / RNA with limited bias and downstream computational analysis, and 2) lack of short-term clinical applications. Special analysis conducted in this report includes the categorization of ~1,400 SCG peer-reviewed publications from 2010 to Feb 2017. 3
This report is divided into the following sections Table of Contents Introduction 2 Author biographies 4 Abstract 5 Table of contents 6 3 rd edition: what s new? 7 Model methodology 8 Market segmentation 9 Life science research tools market 10 Single cell genomics overview 11 Executive Summary 12 SCG market 13 SCG competitive trends 14 SCG challenges 16 Publication Analysis 16 Methodology 18 Publication growth rates 19 SCG by field-of-study 20 SCG by application 21 Computational analysis tools 22 SCG by analytical technology 23 SCG by geography 24 Emerging approaches 25 WGA method comparison 29 Novel WGA method 30 RNA-seq method comparison 32 Market Analysis 33 SCG worldwide market 34 SCG market drivers and moderators 35 SCG by customer type 36 SCG competitive segmentation 37 SCG by workflow step 38 SCG by analytical technology 39 SCG by field-of-study 40 SCG by market application 41 Developments in CTC analysis 42 SCG by product type 43 SCG centers worldwide 44 SCG by geography 45 Competitive Analysis 46 Recent deals 47 Emerging companies 49 Company spotlight: Fluidigm 50 Company spotlight: BD 52 Company spotlight: 10X Genomics 53 Company spotlight: Bio-Rad / Illumina 54 Company spotlight: Takara Bio 55 Company spotlight: WaferGen Biosystems 56 Appendix 57 Competitor profiles 58 Abbreviations 114 About DeciBio 115 Related reports 116 4
3 rd edition: What s new? Updated Content* Incorporated the latest trends in the SCG market, based on secondary research and interviews with experts in this space Updated market numbers in light of increased competition and availability of new tools Updated the geographical distribution of SCG centers / core facilities worldwide Expanded our analysis to include emerging players in this space Incorporated recent deals and M&A activity Added ~800 new SCG publications (this report now includes ~1,400 publications from 2010 to February 2017) Updated Market Numbers and Trends* Updated all market size numbers based on secondary research and latest trends Reassessed market trends for: o Methods in light of the growing demand for computational analysis tools capable of handling large SCG datasets o NGS in light of successful commercialization of high-throughput instruments that allow isolation and preparation of tens of thousands of cells in parallel for sequencing Validated and refined our former projections of growth rates in key areas, such as: o Customer type given the establishment of academic SCG core facilities worldwide and early signs of service providers offering single-cell sequencing in the future o Product type given the availability of new instruments / kits and the declining per-cell cost of single-cell transcriptomic analysis o Field-of-study particularly in oncology, given increasing importance of understanding tumor heterogeneity precision medicine Note: * Most significant changes only; additional adjustments have been made based on primary and secondary research data analysis 5
We divided the market along the following 7 key segments Segment Description Subsegments Customer Buyers of SCG instruments, reagents, and consumables from manufacturers Academia Biopharma Applied Markets* Clinical Workflow Individual steps in the SCG analysis process starting from sample and ending with data Single cell isolation Sample preparation Genomic analysis Analytical Technology Genomic technology used to quantify and / or identify the DNA / RNA of each single cell qpcr Sequencing PCR Multiple (i.e., more than one) Microarray Other Field-of-Study Research focus including broad non-disease specific biological area as well as specific disease areas Microbiology Basic cell biology Stem cell biology Oncology Immunology Other Non-specific Application Key scientific research question being investigated Subpopulation characterization Genomic variation Cell differentiation/ reprogramming Method Circulating cells Other Product Type Type of product that manufacturer sells to its customers Instrument (including systems, service contract and software) Reagents (including reagents and consumables) Geography Country / region of the world U.S. Europe Japan China Asia Pacific (APAC) Rest-of-the-world (ROW) Note: Source: *Including AgBio, food safety, animal health, and environmental testing DeciBio interviews and analysis 6