FLOW CYTOMETRY: PRODUCTS, TECHNOLOGIES AND GLOBAL MARKETS

Transcription

1 FLOW CYTOMETRY: PRODUCTS, TECHNOLOGIES AND GLOBAL MARKETS BIO085C May 2016 John Richard Rahn Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY BACKGROUND 2 STUDY GOALS AND OBJECTIVES 2 INTENDED AUDIENCE 2 SCOPE AND FORMAT 3 RESEARCH METHODOLOGY AND INFORMATION SOURCES 3 ANALYST'S CREDENTIALS 4 RELATED BCC RESEARCH REPORTS 4 BCC RESEARCH WEBSITE 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 SUMMARY TABLE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE, SUMMARY FIGURE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE, CHAPTER 3 MARKET OVERVIEW 9 CURRENT MARKET DYNAMICS 10 OUTLOOK THROUGH FORECAST PERIOD 11 MARKET DRIVERS 11 RECENT CONSOLIDATION WITHIN THE INDUSTRY 11 PRODUCT/TECHNOLOGY INNOVATIONS 12 Acoustically-Enhanced Hydrodynamic Focusing 12 Highly Sensitive RNA Probes 13 Color-Space-Time Coding 14 EMERGING MAINSTREAM ROLE IN DRUG DISCOVERY AND DEVELOPMENT 14 WIDE RANGE OF APPLICATIONS 15 CONTRACT RESEARCH AND CLINICAL TRIAL ORGANIZATIONS 15 EXPECTED FURTHER M&A ACTIVITY WITHIN THE INDUSTRY 16 HIGH COST OF INSTRUMENTS 16 LACK OF AWARENESS 17 REQUIREMENT OF HIGHLY TRAINED PERSONNEL 17 OPPORTUNITIES 17 EVOLUTION OF FLOW CYTOMETRY 18 ANALYSIS OF FLOW CYTOMETRY'S CAPABILITIES 18 FLOW CYTOMETRY IMMUNOPHENOTYPING 20 FIGURE 1 IMMUNOPHENOTYPING TECHNIQUES OF FLOW CYTOMETRY- IMMUNOPHENOTYPING VERSUS CONVENTIONAL MICROSCOPY FIGURE 2 DISEASE DIAGNOSIS AND MANAGEMENT POTENTIAL OF FLOW CYTOMETRY IMMUNOPHENOTYPING USE OF FLOW CYTOMETRY IN RESOURCE-POOR REGIONS IS GAINING IMPORTANCE ACQUISITION SUMMARY AND MARKET IMPLICATIONS 23 MERCK PURCHASE OF SIGMA-ALDRICH 23 SYSMEX ACQUIRES PARTEC

3 THERMO FISHER ACQUIRES AFFYMETRIX AND LIFE TECHNOLOGIES 24 ANALYSES: KEY PLAYERS, COMPETITORS AND MARKET 24 FIGURE 3 GLOBAL MARKET SHARES OF FLOW CYTOMETRY BY PRODUCT TYPE, 2015 (%) FIGURE 4 STRATEGIES AND DEVELOPMENTS OF MARKET PLAYERS, EMERGING ECONOMIES AND TECHNOLOGY ADOPTION 27 STRATEGIC RECOMMENDATIONS 28 PATENT ANALYSIS 29 FIGURE 5 PATENT ANALYSIS BY TYPE OF PRODUCT, (%) 29 FIGURE 6 INSTRUMENTATION PATENTS BY, (%) CHAPTER 4 GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS 33 TABLE 1 GLOBAL MARKET FOR FLOW CYTOMETRY BY REGION, THROUGH 2020 ($ MARKET FOR FLOW CYTOMETRY INSTRUMENTS 33 TABLE 2 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS, THROUGH 2020 ($ TABLE 3 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS BY REGION, MARKET DRIVERS 34 TECHNOLOGICAL ADVANCES IN INSTRUMENT COMPONENTS ARE BOOSTING DEMAND GROWING ADOPTION OF BENCHTOP FLOW CYTOMETERS 35 MARKET RESTRAINTS 36 MAINTENANCE AND SERVICES COSTS 36 CYTOMETRY PLATFORMS 36 TABLE 4 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS, THROUGH 2020 ($ TABLE 5 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS BY REGION, FLOW CYTOMETRY CELL SORTERS 37 TABLE 6 GLOBAL MARKET FOR FLOW CYTOMETRY CELL SORTERS BY REGION, FLOW CYTOMETRY ANALYZERS 38 TABLE 7 GLOBAL MARKET FOR FLOW CYTOMETRY ANALYZERS BY REGION, REPLACEABLE COMPONENTS 39 TABLE 8 GLOBAL MARKET FOR REPLACEABLE COMPONENTS OF FLOW CYTOMETERS, TABLE 9 GLOBAL MARKET FOR REPLACEABLE COMPONENTS OF FLOW CYTOMETERS BY REGION, FILTERS 40 TABLE 10 GLOBAL MARKET FOR REPLACEABLE FILTERS USED IN FLOW CYTOMETERS BY REGION, LASERS 40 TABLE 11 GLOBAL MARKET FOR FLOW CYTOMETRY LASERS BY REGION, THROUGH DETECTORS 41 TABLE 12 GLOBAL MARKET FOR FLOW CYTOMETRY DETECTORS BY REGION,

4 OTHERS 42 TABLE 13 GLOBAL MARKET FOR OTHER REPLACEABLE COMPONENTS OF FLOW CYTOMETERS BY REGION, FLOW CYTOMETRY ACCESSORIES 43 TABLE 14 GLOBAL MARKET FOR FLOW CYTOMETRY ACCESSORIES BY REGION, MARKET FOR FLOW CYTOMETRY REAGENTS AND CONSUMABLES 43 TABLE 15 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS, THROUGH 2020 ($ TABLE 16 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS BY REGION, DRIVERS AND CHALLENGES 44 ANTIBODIES 45 TABLE 17 GLOBAL MARKET FOR FLOW CYTOMETRY ANTIBODIES BY REGION, DYES AND FLUOROCHROMES 46 TABLE 18 GLOBAL MARKET FOR FLOW CYTOMETRY DYES BY REGION, THROUGH BEADS 48 TABLE 19 GLOBAL MARKET FOR FLOW CYTOMETRY BEADS BY REGION, THROUGH OTHERS 49 TABLE 20 GLOBAL MARKET FOR OTHER FLOW CYTOMETRY REAGENTS BY REGION, SOFTWARE MARKET 49 TABLE 21 GLOBAL MARKET FOR FLOW CYTOMETRY SOFTWARE BY TYPE, THROUGH TABLE 22 GLOBAL MARKET FOR FLOW CYTOMETRY SOFTWARE BY REGION, WITHIN-SYSTEM SOFTWARE 52 TABLE 23 GLOBAL MARKET FOR WITHIN-SYSTEM FLOW CYTOMETRY SOFTWARE BY REGION, THIRD-PARTY SOFTWARE 52 TABLE 24 GLOBAL MARKET FOR THIRD-PARTY FLOW CYTOMETRY SOFTWARE BY REGION, SERVICES 53 TABLE 25 GLOBAL MARKET FOR FLOW CYTOMETRY SERVICE BY REGION, CHAPTER 5 GLOBAL MARKET FOR APPLICATIONS OF FLOW CYTOMETRY 56 TABLE 26 GLOBAL MARKET FOR FLOW CYTOMETRY BY APPLICATIONS, THROUGH TABLE 27 GLOBAL MARKET FOR FLOW CYTOMETRY APPLICATIONS BY REGION, MARKET DRIVERS 57 GOVERNMENT INITIATIVES AND AVAILABILITY OF RESEARCH FUNDING 57 PRESSING NEED FOR PATIENT AND DISEASE MANAGEMENT 58 EXPANDING END-USER BASE 58 NEED FOR HIGH-THROUGHPUT SCREENING/HIGH-CONTENT SCREENING 58 MARKET RESTRAINTS

5 FLOW CYTOMETRY REQUIRES A HIGH DEGREE OF CLINICAL AND MANUFACTURING EXPERTISE CLINICAL APPLICATIONS ARE SUBJECT TO REGULATORY APPROVAL 59 RESEARCH APPLICATIONS 59 TABLE 28 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS, TABLE 29 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS BY REGION, CELL CYCLE ANALYSIS AND CELL PROLIFERATION 60 TABLE 30 GLOBAL MARKET FOR CELL CYCLE ANALYSIS AND CELL PROLIFERATION USING FLOW CYTOMETRY BY REGION, APOPTOSIS 62 TABLE 31 GLOBAL MARKET FOR APOPTOSIS ANALYSIS USING FLOW CYTOMETRY BY REGION, CELL SORTING 63 TABLE 32 GLOBAL MARKET FOR CELL SORTING WITH FLOW CYTOMETRY BY REGION, TRANSFECTION AND CELL VIABILITY 65 TABLE 33 GLOBAL MARKET FOR ANALYZING TRANSFECTION AND CELL VIABILITY USING FLOW CYTOMETRY BY REGION, OTHERS 66 TABLE 34 GLOBAL MARKET FOR OTHER APPLICATIONS OF FLOW CYTOMETRY BY REGION, CLINICAL APPLICATIONS 67 TABLE 35 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY, TABLE 36 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY BY REGION, ORGAN TRANSPLANTATION 68 TABLE 37 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN ORGAN TRANSPLANTS BY REGION, HEMATOLOGY 70 TABLE 38 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN HEMATOLOGY BY REGION, CANCER AND SOLID TUMOR IMMUNOLOGY 71 TABLE 39 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN ONCOLOGY AND TUMOR IMMUNOLOGY BY REGION, IMMUNODEFICIENCY DISEASE-HIV INFECTION 72 TABLE 40 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN HIV BY REGION, OTHERS 74 TABLE 41 GLOBAL MARKET FOR "OTHER" CLINICAL APPLICATIONS OF FLOW CYTOMETRY BY REGION, CHAPTER 6 GLOBAL MARKET FOR FLOW CYTOMETRY TECHNOLOGY 76 FLOW CYTOMETRY TECHNOLOGY 76 TABLE 42 GLOBAL MARKET FOR FLOW CYTOMETRY BY TECHNOLOGY, THROUGH TABLE 43 GLOBAL MARKET FOR FLOW CYTOMETRY TECHNOLOGY BY REGION, CELL-BASED FLOW CYTOMETRY

6 TABLE 44 GLOBAL MARKET FOR CELL-BASED FLOW CYTOMETRY BY REGION, DRIVERS 78 Increasing HIV/AIDS Awareness 78 Several Clinical Applications 78 BEAD-BASED FLOW CYTOMETRY 78 TABLE 45 GLOBAL MARKET FOR BEAD-BASED FLOW CYTOMETRY BY REGION, MARKET DRIVERS 80 Rapid Progress and Increasing Application in Proteomics 80 Application in Genomics 80 Competitive Edge over ELISA Technique and Microarrays 80 MARKET RESTRAINTS 80 Obtaining Quality Data Poses a Challenge CHAPTER 7 FLOW CYTOMETRY END-USER MARKET 84 FLOW CYTOMETRY END-USER MARKET 84 FIGURE 7 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER, 2015 AND 2020 (%) TABLE 46 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER, TABLE 47 GLOBAL MARKET FOR FLOW CYTOMETRY END USERS BY REGION, COMMERCIAL ORGANIZATIONS 86 TABLE 48 GLOBAL MARKET FOR COMMERCIAL END USERS OF FLOW CYTOMETRY BY REGION, ACADEMIC INSTITUTIONS 87 TABLE 49 GLOBAL MARKET FOR ACADEMIC END USERS OF FLOW CYTOMETRY BY REGION, HOSPITALS 88 TABLE 50 GLOBAL MARKET FOR HOSPITAL END USERS OF FLOW CYTOMETRY BY REGION, MEDICAL SCHOOLS AND CLINICAL TESTING LABS 89 TABLE 51 GLOBAL MARKET FOR MEDICAL SCHOOL/CLINICAL LABORATORY END USERS OF FLOW CYTOMETRY BY REGION, OTHERS 90 TABLE 52 GLOBAL MARKET FOR "OTHER" END USERS OF FLOW CYTOMETRY BY REGION, CHAPTER 8 COMPETITIVE LANDSCAPE 92 RECENT FLOW CYTOMETRY INDUSTRY DEVELOPMENTS 92 ACQUISITIONS 92 Absorption of Disruptive Technologies into Larger Firms 92 Consolidation of Large Firms 93 PRODUCT LAUNCHES 94 AGREEMENTS/PARTNERSHIPS/COLLABORATIONS 95 CHAPTER 9 GEOGRAPHIC ANALYSIS OF THE GLOBAL FLOW CYTOMETRY MARKET 97 EUROPE 97

7 UNITED STATES 97 ASIA AND ROW 98 CHAPTER 10 COMPANY PROFILES 100 ACEA BIOSCIENCES INC. 100 ADVANCED CELL DIAGNOSTICS 100 AGILENT TECHNOLOGIES 101 ALPCO DIAGNOSTICS 101 TABLE 53 RECENT DEVELOPMENTS-ALPCO DIAGNOSTICS 101 APOGEE FLOW SYSTEMS 102 APPLIED CYTOMETRY 102 BANGS LABORATORY INC. 102 BECKMAN COULTER (DANAHER) 103 TABLE 54 RECENT DEVELOPMENTS-BECKMAN COULTER INC. 104 BECTON, DICKINSON AND CO. 104 TABLE 55 RECENT DEVELOPMENTS-BECTON, DICKINSON AND CO. 105 BIOCYTEX 105 BIOLEGEND 106 TABLE 56 RECENT DEVELOPMENTS-BIOLEGEND 106 BIO-RAD 107 TABLE 57 RECENT DEVELOPMENTS-BIO-RAD 108 BIOSTATUS 108 BIO-TECHNE CORP. 109 BIOVISION INC. 109 CELL SIGNALING TECHNOLOGY 110 TABLE 58 RECENT DEVELOPMENTS-CELL SIGNALING TECHNOLOGY 110 COHERENT INC. 111 CYTEK DEVELOPMENT INC. 111 CYTOBUOY BV 111 CYTONOME 112 DAKO (AGILENT TECHNOLOGIES) 112 DE NOVO SOFTWARE 113 DHARMACON (GE LIFE SCIENCES) 113 DVS SCIENCES 113 EBIOSCIENCE (AFFYMETRIX) 113 EMD MILLIPORE (MERCK/MILLIPORESIGMA) 114 FLOWJO LLC 114 FLUIDIGM 115 FLUOROFINDER 115 HAMAMATSU PHOTONICS K.K. 116 ICYT MISSION TECHNOLOGY INC. 116 INIVAI TECHNOLOGIES 116 INTELLICYT CORP. 116 TABLE 59 RECENT DEVELOPMENTS-INTELLICYT CORP. 117 INTREXON 117 INVITROGEN (THERMO FISHER SCIENTIFIC) 118 LUMINEX CORP. 118

8 TABLE 60 RECENT DEVELOPMENTS-LUMINEX CORP. 119 MATERION PRECISION COATINGS (MATERION CORP.) 120 MELLES GRIOT (IDEX OPTICS AND PHOTONICS) 120 MILLIPORESIGMA (MERCK) 120 MILTENYI BIOTEC 121 TABLE 61 RECENT DEVELOPMENTS-MILTENYI BIOTEC 121 NANOCELLECT BIOMEDICAL INC. 122 OMEGA OPTICAL INC. 122 ON-CHIP BIOTECHNOLOGIES CO. LTD. 122 PARTEC GMBH 123 POINTCARE TECHNOLOGIES INC. 123 PROMEGA CORP. 123 TABLE 62 RECENT DEVELOPMENTS-PROMEGA CORP. 124 QUANTACYTE 124 R&D SYSTEMS INC 125 SANTA CRUZ BIOTECHNOLOGY INC. 125 SEMROCK INC. (IDEX HEALTH & SCIENCE LLC) 125 SIGMA-ALDRICH CORP. (MERCK/MILLIPORESIGMA) 126 TABLE 63 RECENT DEVELOPMENTS-SIGMA-ALDRICH CORP. 127 SIRIGEN (BECTON DICKINSON) 127 SONY BIOTECHNOLOGY INC. 128 SOUTHERN BIOTECH 128 SPHEROTECH INC. 129 STRATEDIGM INC 129 SYSMEX PARTEC GMBH 129 TONBO BIOSCIENCES 130 TREE STAR 130 UNION BIOMETRICA INC. 131 VERITY SOFTWARE HOUSE 131 CHAPTER 11 U.S. PATENTS AND PATENT APPLICATIONS 133 TABLE 64 PATENTS FOR APPLICATIONS OF FLOW CYTOMETRY, TABLE 65 PATENTS FOR FLOW CYTOMETRY PLATFORMS, TABLE 66 PATENTS FOR FLOW CYTOMETRY REAGENTS, TABLE 67 PATENTS FOR FLOW CYTOMETRY DATA ANALYSIS,

9 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE, TABLE 1 GLOBAL MARKET FOR FLOW CYTOMETRY BY REGION, THROUGH 2020 ($ TABLE 2 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS, THROUGH 2020 ($ TABLE 3 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS BY REGION, TABLE 4 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS, THROUGH 2020 ($ TABLE 5 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS BY REGION, TABLE 6 GLOBAL MARKET FOR FLOW CYTOMETRY CELL SORTERS BY REGION, TABLE 7 GLOBAL MARKET FOR FLOW CYTOMETRY ANALYZERS BY REGION, TABLE 8 GLOBAL MARKET FOR REPLACEABLE COMPONENTS OF FLOW CYTOMETERS, TABLE 9 GLOBAL MARKET FOR REPLACEABLE COMPONENTS OF FLOW CYTOMETERS BY REGION, TABLE 10 GLOBAL MARKET FOR REPLACEABLE FILTERS USED IN FLOW CYTOMETERS BY REGION, TABLE 11 GLOBAL MARKET FOR FLOW CYTOMETRY LASERS BY REGION, THROUGH TABLE 12 GLOBAL MARKET FOR FLOW CYTOMETRY DETECTORS BY REGION, TABLE 13 GLOBAL MARKET FOR OTHER REPLACEABLE COMPONENTS OF FLOW CYTOMETERS BY REGION, TABLE 14 GLOBAL MARKET FOR FLOW CYTOMETRY ACCESSORIES BY REGION, TABLE 15 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS, THROUGH 2020 ($ TABLE 16 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS BY REGION, TABLE 17 GLOBAL MARKET FOR FLOW CYTOMETRY ANTIBODIES BY REGION, TABLE 18 GLOBAL MARKET FOR FLOW CYTOMETRY DYES BY REGION, THROUGH TABLE 19 GLOBAL MARKET FOR FLOW CYTOMETRY BEADS BY REGION, THROUGH TABLE 20 GLOBAL MARKET FOR OTHER FLOW CYTOMETRY REAGENTS BY REGION, TABLE 21 GLOBAL MARKET FOR FLOW CYTOMETRY SOFTWARE BY TYPE, THROUGH TABLE 22 GLOBAL MARKET FOR FLOW CYTOMETRY SOFTWARE BY REGION, TABLE 23 GLOBAL MARKET FOR WITHIN-SYSTEM FLOW CYTOMETRY SOFTWARE BY REGION, TABLE 24 GLOBAL MARKET FOR THIRD-PARTY FLOW CYTOMETRY SOFTWARE BY REGION,

10 TABLE HEADING TABLE 25 GLOBAL MARKET FOR FLOW CYTOMETRY SERVICE BY REGION, THROUGH TABLE 26 GLOBAL MARKET FOR FLOW CYTOMETRY BY APPLICATIONS, THROUGH TABLE 27 GLOBAL MARKET FOR FLOW CYTOMETRY APPLICATIONS BY REGION, TABLE 28 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS, TABLE 29 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS BY REGION, TABLE 30 GLOBAL MARKET FOR CELL CYCLE ANALYSIS AND CELL PROLIFERATION USING FLOW CYTOMETRY BY REGION, TABLE 31 GLOBAL MARKET FOR APOPTOSIS ANALYSIS USING FLOW CYTOMETRY BY REGION, TABLE 32 GLOBAL MARKET FOR CELL SORTING WITH FLOW CYTOMETRY BY REGION, TABLE 33 GLOBAL MARKET FOR ANALYZING TRANSFECTION AND CELL VIABILITY USING FLOW CYTOMETRY BY REGION, TABLE 34 GLOBAL MARKET FOR OTHER APPLICATIONS OF FLOW CYTOMETRY BY REGION, TABLE 35 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY, TABLE 36 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY BY REGION, TABLE 37 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN ORGAN TRANSPLANTS BY REGION, TABLE 38 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN HEMATOLOGY BY REGION, TABLE 39 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN ONCOLOGY AND TUMOR IMMUNOLOGY BY REGION, TABLE 40 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN HIV BY REGION, TABLE 41 GLOBAL MARKET FOR "OTHER" CLINICAL APPLICATIONS OF FLOW CYTOMETRY BY REGION, TABLE 42 GLOBAL MARKET FOR FLOW CYTOMETRY BY TECHNOLOGY, THROUGH TABLE 43 GLOBAL MARKET FOR FLOW CYTOMETRY TECHNOLOGY BY REGION, TABLE 44 GLOBAL MARKET FOR CELL-BASED FLOW CYTOMETRY BY REGION, TABLE 45 GLOBAL MARKET FOR BEAD-BASED FLOW CYTOMETRY BY REGION, TABLE 46 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER, TABLE 47 GLOBAL MARKET FOR FLOW CYTOMETRY END USERS BY REGION, TABLE 48 GLOBAL MARKET FOR COMMERCIAL END USERS OF FLOW CYTOMETRY BY REGION, TABLE 49 GLOBAL MARKET FOR ACADEMIC END USERS OF FLOW CYTOMETRY BY REGION, TABLE 50 GLOBAL MARKET FOR HOSPITAL END USERS OF FLOW CYTOMETRY BY REGION,

11 TABLE HEADING TABLE 51 GLOBAL MARKET FOR MEDICAL SCHOOL/CLINICAL LABORATORY END USERS OF FLOW CYTOMETRY BY REGION, TABLE 52 GLOBAL MARKET FOR "OTHER" END USERS OF FLOW CYTOMETRY BY REGION, TABLE 53 RECENT DEVELOPMENTS-ALPCO DIAGNOSTICS 101 TABLE 54 RECENT DEVELOPMENTS-BECKMAN COULTER INC. 104 TABLE 55 RECENT DEVELOPMENTS-BECTON, DICKINSON AND CO. 105 TABLE 56 RECENT DEVELOPMENTS-BIOLEGEND 106 TABLE 57 RECENT DEVELOPMENTS-BIO-RAD 108 TABLE 58 RECENT DEVELOPMENTS-CELL SIGNALING TECHNOLOGY 110 TABLE 59 RECENT DEVELOPMENTS-INTELLICYT CORP. 117 TABLE 60 RECENT DEVELOPMENTS-LUMINEX CORP. 119 TABLE 61 RECENT DEVELOPMENTS-MILTENYI BIOTEC 121 TABLE 62 RECENT DEVELOPMENTS-PROMEGA CORP. 124 TABLE 63 RECENT DEVELOPMENTS-SIGMA-ALDRICH CORP. 127 TABLE 64 PATENTS FOR APPLICATIONS OF FLOW CYTOMETRY, TABLE 65 PATENTS FOR FLOW CYTOMETRY PLATFORMS, TABLE 66 PATENTS FOR FLOW CYTOMETRY REAGENTS, TABLE 67 PATENTS FOR FLOW CYTOMETRY DATA ANALYSIS,

12 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE, FIGURE 1 IMMUNOPHENOTYPING TECHNIQUES OF FLOW CYTOMETRY- IMMUNOPHENOTYPING VERSUS CONVENTIONAL MICROSCOPY FIGURE 2 DISEASE DIAGNOSIS AND MANAGEMENT POTENTIAL OF FLOW CYTOMETRY IMMUNOPHENOTYPING FIGURE 3 GLOBAL MARKET SHARES OF FLOW CYTOMETRY BY PRODUCT TYPE, 2015 (%) FIGURE 4 STRATEGIES AND DEVELOPMENTS OF MARKET PLAYERS, FIGURE 5 PATENT ANALYSIS BY TYPE OF PRODUCT, (%) 29 FIGURE 6 INSTRUMENTATION PATENTS BY, (%) 30 FIGURE 7 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER, 2015 AND 2020 (%)