VIBRANCE A Novel Seedcare Compound for Root Health

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1 VIBRANCE A Novel Seedcare Compound for Root Health Dr. Christian Schlatter, Global Seedcare business manager Dr. Ronald Zeun, Teamleader Seedcare Fungicides

2 AGENDA Root Health and VIBRANCE VIBRANCE technical positioning Market demand creation and worldwide launch plans

3 Root Health: untapped potential for better crop productivity New and challenging research area; still a lot to discover New industry practices further increase prevalence of soil-borne pathogens and pests Imperative to take a holistic view of the root space Enhanced capability to resist to biotic and abiotic stresses The foundations for higher, more consistent yields

4 Threats to Root Health: It s a complex underground world! Key targets for new compound Soilborne pathogens. Rhizoctonia, Pythium, Fusarium, etc. Underground insects. Wireworms, white grubs, corn rootworms, elasmopalpus, fleabeetle, shootfly, etc. Nematodes. Feed on roots, weaken plant resistance to stresses and secondary infections Abiotic stresses. Drought, cold, lack of nutrients

5 Discovering the first Root Health compound has been quite a journey Evaluation Launch 1 Discovery Profiling Launching new molecule... > 8 years of research ( ) > $200m R&D investment Only 1/100,000 molecule makes it to the market

6 VIBRANCE Novel Compound for Root Health Higher crop performance, right from the start SDHI next-generation fungicides; broad spectrum Root Health key to Crop Productivity Root biostimulant effect; photosynthesis efficiency RootingPower: stronger & healthier roots Enhanced biotic/abiotic stress management foundation for higher, more consistent yield Better roots results in visible differences on the field market standard

7 AGENDA Root Health and VIBRANCE VIBRANCE technical positioning Market demand creation and worldwide launch plans

8 VIBRANCE belong to disease control and ASM/CE categories

9 SDHI MoA* will play a key role in fungicides over the next 10 years Broad industry interest in complex II inhibition MoA to cover the evolving market needs Syngenta at the forefront of SDHI research with several new molecules in early launch phase Strobilurins SDHIs Triazoles Isopyrazam Solatenol and more in the development pipeline 1990s 2000s 2010s SDHIs complex II inhibition MoA * Mode of Action

10 Soil movement of radiolabelled VIBRANCE (Sandy soil or 50% organic matter soil) Sandy soil High organic matter soil Radioactivity concentration High Low 1 watering event 10 watering events Long-lasting soil protection under a broad range of conditions Location of Vibrance radiolabel

11 In vivo Spectrum of VIBRANCE on Cereals Seed borne fungi Activity Foliar & soil borne fungi Activity Ustilago nuda Tilletia caries Monographella nivalis Pyrenophora graminea Cochliobolus sativus Fusarium spp. Septoria nodorum* Puccinia recondita* Erysiphe graminis* Rhizoctonia solani Typhula incarnata Gäumannomyces graminis rate of 10g/100kg excellent good some effect inactive

12 In vivo Spectrum of VIBRANCE on other Crops Seed - & soil borne fungi Activity Foliar & soil borne fungi Activity Rhizoctonia spp. - many crops Sclerotium spp. - peanut, SB Phoma spp. - SB, canola Macrophomina - Soya Fusarium spp. - many crops Sphacelotheca - corn Phakopsora - soya Helminthosporium - rice H. solani - potato Colletotrichum - onion excellent good some effect inactive

13 Rhizoctonia as a pathogen Rhizoctonia is known as an important pathogen in many field crops, including cereals, corn, soy beans, rice, potato and sugar beet. Crop rotation may not help to decrease the inoculum in the soil Infection leads to nutrient and water stress of the crop It is found world-wide and across different soil types, upper cm Cold soils, poor nutrition, compacted soils are favourable for the disease Rhizoctonia is causing stem and root rot, pre and post emergence damping-off and foliar blight Best known are Rhizoctonia solani and Rhizoctonia cerealis, both leading to heavy crop damages

14 Rhizoctonia solani / corn: field damage

15 Rhizoctonia solani / corn: stem base symptoms

16 Rhizoctonia solani / corn: root symptoms

17 Vibrance, novel Seedcare compound with outstanding activity against Rhizoctonia solani on corn Vibrance Untreated Inoculated with Rhizoctonia solani

18 Vibrance, novel Seedcare compound with outstanding activity against Rhizoctonia cerealis on wheat Rhizotrone study at the Seed Care Institute Stein Wheat cv. Arina Field soil inoculated with Rhizoctonia cerealis Growth conditions 10 C, 12h light Picture taken 78 DAP Positive impact of Vibrance Gold on emergence, shoot and root growth UTC Vibrance Gold

19 Activity of Vibrance against Rhizoctonia solani on corn Ø of 3 field trials in D and PL 2013, DAS Disease Incidence % Activity Kontrolle Nicht inokuliert Kontrolle Inokuliert MAXIM XL 12,5 ML/Unit SEDAXANE 1.5g AI/Unit MAXIM XL + SEDAXANE

20 Efficacy of Vibrance Gold against Monographella nivalis Field Trial Czech Republic (2012 broad acre conditions) UNTREATED VIBRANCE GOLD

21 Efficacy of Vibrance Gold against Monographella nivalis Field Trial Czech Republic (2012 broad acre conditions) % Efficacy Competitor Lamador 1 Competitor Kinto Duo 2 Vibrance Gold Pest incidence: 46%

22 Efficacy of Vibrance CT against Typhula incarnata in barley (n=6) VIBRANCE CT (0,2 l/dt) VM (0,4 l/dt) Pest incidence: 28% % Activity Bonitur: BBCH Varieties: Holmes, Bartosz, Fridericus, Merlot, Naomie, Horus Classification: INTERNAL USE ONLY

23 VIBRANCE belong to disease control and ASM/CE categories

24 VIBRANCE demonstrated biostimulant effect on wheat BIOtransfer publication % increase in root biomass under sterile conditions on two wheat varieties (root assessment 30 and 60 DAP) Isengrain left: untreated right: Vibrance (10g SDX/100kg seed) Inoui left: untreated right: Vibrance (10g SDX/100kg seed)

25 Vibrance increases photosynthetic efficiency of wheat grown under drought stress 1 Photosynthesis (µmol CO 2 m -2 s -1 ) VIBRANCE untreated VIBRANCE reduces nonphotochemical quenching (NPQ) Induction of genes in photosynthesis pathway First time such effect is demonstrated for a seed treatment compound 2 This proves that VIBRANCE can help prevent drought stress in wheat at early stages VIBRANCE has biostimulant effect on plant physiology and goes beyond disease control Photon flux density (µmol m -2 s -1 ) 1 Source: Nottingham University research, UK, 2014, winter wheat Gallant 2 Similar effect was demonstrated for foliar SDHIs e.g. Isopyrazam

26 Cereals Argentina Disease control + ASM / CE Higher, more consistent yield Soybean Brazil Corn USA

27 AGENDA Root Health and VIBRANCE VIBRANCE technical positioning Market demand creation and worldwide launch plans

28 VIBRANCE successful journey leading to >$200m sales : 1 st regulatory submission 2012: USA/CAN launch 2011: 1 st launch worldwide VIBRANCE: >$200m sales achieved in 2014 (2014 SYT results

29 Root Health - VIBRANCE focuses on the combination of Biotic and ASM/CE benefits Execution examples: Biotic Broad spectrum Disease Control «Hard» claims ASM Root Stimulation Photosynthesis efficiency under drough «Soft» claims The Power is in the Combination Stronger, healthier roots Higher and more consistent yield Market standard

30 Three key pillars for Market Demand Creation Technical credibility Root Health Leadership Regional/Global Root Health Forums Latest Root Health metodologies Scientific publications Create emotion roots matter Engaging A&P campaigning Innovative visuals tools & campaign, emotional trailer,... Create and support local excitement New communication channels Increased use of emedia E.g. LinkedIn, 700 members Classification: public

31 Create emotion roots matter

32 VIBRANCE will be launched across all major crops and geographies* Now expanding to new crops and territories! Classification: PUBLIC

33 VIBRANCE Novel Seedcare Compound for Root Health Thank you! Scan this code to visit the VIBRANCE mobile site. Simply download a free QR Code reader to your smartphone Syngenta, Basel, Switzerland. All rights reserved. Important: Use seed treatment products safely. Always read the label and product information before use. Labels contain important conditions of sale, including limitations of warranty and remedy. VIBRANCE is currently only registered for sale and use in Argentina and France. Registrations are pending in other countries throughout the world; please check with your local regulatory authority for further information. VIBRANCE, the SYNGENTA Logo, the PURPOSE ICON, the ALLIANCE FRAME and the Seedcare Icon are Trademarks of a Syngenta Group Company

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