Criteria for Selection and Responsibilities of Regional Leading Laboratory
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1 Criteria for Selection and Responsibilities of Regional Leading Laboratory Samia Metwally, DVM, PhD (FAO) Gregorio Torres, DVM, MVM (OIE)
2 Lab Network- One Tool of the Global Strategy 1. Develop, maintain and strengthen an integrated international, regional and national network of laboratories that can respond quickly to needs for rapid and accurate testing, and timely notification I. Gain more intelligence on FMD virus strains circulating in regions II. III. Improve vaccine selection supporting both endemic and free countries and essential to progressive control Enhance diagnostic capability for other priority diseases in the region
3 FMD Lab and Epidemiology Networks Diagnostic analysis Surveillance, monitoring, and disease tracking
4 OIE-FAO FMD Ref Lab Network FMD Seven Regional Virus Pools WRL- FMD Reference lab/centers
5 Current Status of FMD Reference Lab Network OIE/FAO FMD reference lab network One world and twelve reference labs/centers Annual meeting, training and work plans Provide diagnostic services Share disease status information in respective regions Create a comprehensive FMD report on an annual basis
6 Diagnostics Requirements for PCP Stages 1 2 Identify risk and control options 3 Implement risk-based control 4 Implement Control strategy to eliminate circulation Maintain zero circulation and incursions Screening ELISA /PCR 5 Maintain zero circulation; withdraw vaccination VI, characterization, molecular dx, vaccine matching (Biocontainment) Typing and SP ELISA VP1 sequencing In country Region/reference
7 Surveillance Approaches Virological Methods Random or nonrandom approaches Clinical Methods Serological Methods
8 Regional Leading Laboratory Selection Criteria 1. Creditability and acceptance by countries of the region 2. Commitment from the government to support and sustain lab functions as described in the terms of reference 3. Lab capacity and capability to perform diagnostics for FMD/PPR/other TADs 4. Capability to handle exotic viruses from other countries in the region 5. Certification to ship and receive international diagnostic samples 6. Participated or willingness to take part in OIE twinning program 7. Keen interest to be designated as a FAO/OIE reference center 8. Established link with FMD reference laboratorty 9. Maintain good performance on proficiency testing carried by reference center
9 Regional Leading Laboratory Terms of Reference 1. Produces diagnostic reagents, SOPs and protocols 2. Provides training to national laboratories using train the trainers approach 3. Coordinates proficiency testing for the region (limited to screening tests) 4. Receives and processes samples for diagnostics from countries of the region 5. Ships samples to FAO/OIE reference centers for full characterization 6. Ensures and assist in regional procurement of essential diagnostic reagents for emergency release 7. Participates in regional laboratory network activities (potential leader) 8. Links with the regional epidemiology network
10 Regional Leading Laboratory Procedures for Nomination Acceptance by countries of the region Meeting the selection criteria Government official commitment to support terms of reference/responsibilities
11 Proposed Process for Selection of RLL Self-nominated laboratory (ies) will be voted on by countries during the roadmap meeting; FMD-questionnaire to be filled out to address their capacity and capabilities; Possible involvement of the OIE-FAO reference laboratories to analyze the results of the questionnaire against the above criteria and terms of reference Recommendation by the reference centre will be submitted by the FMD working group to the regional advisory group for advice; The regional advisory group to announce the final selection to the countries in the region for final acceptance. The regional advisory group to propose for final aceptance by the countries in the region
12 Items to be addressed by breakout groups Session 5 1. Does the region need leading laboratory? 2. List major activities should be taken on by the regional laboratory 3. Suggest a probable method to select the RLL for the region 4. Enumerate top three priorities should be on Lab network work plan for Enumerate top three priorities should be on Epi network work plan for
13 Thank you for your attention
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