THE FIRST OBSERVATIONS

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2 THE FIRST OBSERVATIONS ROBERT HOOK FIRST TO SEE CELLS WHILE OBSERVING A THIN SLICE OF CORK MARKED THE BEGINNING OF THE CELL THEORY: THEORY THAT ALL LIVING THINGS ARE COMPOSED OF CELLS ANTON VAN LEEUWENHOEK FIRST TO OBSERVE LIVE ORGANISMS THROUGH A MICROSCOPE ANIMALCULES

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4 THE DEBATE OVER SPONTANEOUS GENERATION AT ONE TIME MANY BELIEVED THAT SOME FORMS OF LIFE COULD ARISE SPONTANEOUSLY FROM NONLIVING MATTER (SPONTANEOUS GENERATION)

5 FRANCESCO REDI

6 NEEDHAM AND SPALLANZANI Needham Microbes developed spontaneously from the fluids Spallanzani Needham responded: The vital force necessary for spontaneous generation had been destroyed by the heat and was kept out of the flasks by the seals.

7 THE THEORY OF BIOGENESIS RUDOLF VIRCHOW: CHALLENGED SPONTANEOUS GENERATION WITH BIOGENESIS (THE CONCEPT THAT LIVING CELLS CAN ARISE ONLY FROM PREEXISTING LIVING CELLS) ARGUMENTS CONTINUED UNTIL THE ISSUE WAS RESOLVED BY LOUIS PASTEUR

8 LOUIS PASTEUR

9 LOUIS PASTEUR MICROORGANISMS CAN BE PRESENT IN NONLIVING MATTER MICROBIAL LIFE CAN BE DESTROYED BY HEAT METHODS CAN BE DEVISED TO BLOCK THE ACCESS OF AIRBORNE MICROORGANISMS TO NUTRIENT ENVIRONMENTS FORM THE BASIS OF ASEPTIC TECHNIQUES PREVENT CONTAMINATION BY UNWANTED MICROORGANISMS ANY APPEARANCE OF SPONTANEOUS LIFE IN NONLIVING SOLUTIONS CAN BE ATTRIBUTED TO MICROORGANISMS THAT WERE ALREADY THERE

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11 ROBERT KOCH FIRST PROOF THAT BACTERIA CAUSE DISEASE ESTABLISHED A SEQUENCE OF EXPERIMENTAL STEPS FOR DIRECTLY RELATING A SPECIFIC MICROBE TO A SPECIFIC DISEASE: KOCH S POSTULATES

12 GOLDEN AGE OF MICROBIOLOGY EXPLOSION OF DISCOVERIES IN MICROBIOLOGY RAPID ADVANCES LED TO THE ESTABLISHMENT OF MICROBIOLOGY AS A SCIENCE

13 FERMENTATION & PASTEURIZATION PASTEUR FOUND THAT MICROORGANISMS CALLED YEASTS CONVERT THE SUGARS IN ALCOHOL IN THE ABSENCE OF AIR (FERMENTATION) USED TO MAKE WINE AND BEER SOURING AND SPOILAGE ARE CAUSED BY BACTERIA. BACTERIA CHANGE THE ALCOHOL INTO VINEGAR (ACETIC ACID) PASTUER S SOLUTION: HEAT THE BEER AND WINE JUST ENOUGH TO KILL MOST OF THE BACTERIA THAT CAUSED THE SPOILAGE (PASTEURIZATION)

14 THE GERM THEORY OF DISEASE IDEA THAT MICROORGANISMS CAUSE DISEASE AGOSTINO BASSI: MADE 1 ST ASSOCIATION BETWEEN A MICROORGANISM AND A DISEASE BY PROVING THAT A FUNGUS WAS THE CAUSE OF A SILKWORM DISEASE PASTUER FOUND THAT ANOTHER SILKWORM DISEASE WAS CAUSED BY A PROTOZOAN

15 JOSEPH LISTER APPLIED GERM THEORY TO MEDICAL PROCEDURES BEGAN TREATING SURGICAL WOUNDS WITH A PHENOL SOLUTION (KNOWN TO KILL BACTERIA) REDUCED INFECTIONS AND DEATHS AND SOON ADOPTED BY OTHER SURGEONS

16 VACCINATION EDWARD JENNER SHOWED THAT THE MILD DISEASE COWPOX GAVE IMMUNITY TO SMALLPOX INOCULATED PEOPLE WITH COWPOX MATERIAL BY SCRATCHING THEIR ARM WITH A COWPOX-INFECTED NEEDLE BECAME KNOWN AS VACCINATION: PROCESS OF CONFERRING IMMUNITY BY ADMINISTERING A VACCINE VACCINE: A PREPARATION OF KILLED, INACTIVATED, OR ATTENUATED MICROORGANISMS OR TOXOIDS TO INDUCE ARTIFICIALLY ACQUIRED ACTIVE IMMUNITY IMMUNITY: PROTECTION FROM DISEASE THAT VACCINATION PROVIDES PASTEUR THEN SHOWED WHY VACCINATIONS WORK

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18 THE BIRTH OF MODERN CHEMOTHERAPY: DREAMS OF A MAGIC BULLET CHEMOTHERAPY: TREATMENT OF DISEASE BY CHEMICAL SUBSTANCES SYNTHETIC DRUGS: PREPARED FROM CHEMICALS IN A LABORATORY ANTIBIOTICS: PRODUCED NATURALLY BY BACTERIA AND FUNGI PAUL EHRLICH: SPECULATED ABOUT A MAGIC BULLET THAT WOULD DESTROY A PATHOGEN WITHOUT HARMING THE HOST FOUND SALVARSAN, AN ARSENIC DERIVATIVE THAT WAS EFFECTIVE AGAINST SYPHILIS

19 THE BIRTH OF MODERN CHEMOTHERAPY: DREAMS OF A MAGIC BULLET FIRST ANTIBIOTIC DISCOVERED BY ACCIDENT ALEXANDER FLEMING OBSERVED THE INHIBITION OF BACTERIAL GROWTH BY THE MOLD Penicillium notatum. THE INHIBITOR (PENICILLIN) WAS MASS PRODUCED AND CLINICALLY TESTED IN THE 1940S.

20 MODERN DEVELOPMENTS IN MICROBIOLOGY BACTERIOLOGY: THE STUDY OF BACTERIA MYCOLOGY: THE STUDY OF FUNGI PARASITOLOGY: THE STUDY OF PROTOZOA AND PARASITIC WORMS IMMUNOLOGY: THE STUDY OF IMMUNITY VIROLOGY: THE STUDY OF VIRUSES

21 RECOMBINANT DNA TECHNOLOGY GENETIC ENGINEERING BACTERIA PREFERRED BECAUSE OF THEIR SIMPLICITY AND RAPID REPRODUCTION RATE MICROORGANISMS CAN NOW BE GENETICALLY ENGINEERED TO MANUFACTURE LARGE AMOUNTS OF HUMAN HORMONES & OTHER MEDICAL SUBSTANCES FRAGMENTS OF HUMAN OR ANIMAL DNA CAN BE ATTACHED TO BACTERIAL DNA WHEN INSERTED INTO BACTERIA, IT CAN BE USED TO MAKE LARGE QUANTITIES OF THE DESIRED PROTEIN

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23 Recycling Vital Elements (CO2, N) Sewage Treatment Microbes & Human Welfare Bioremediation (clean up pollutants) Insect Pest Control

24 MICROBES & HUMAN DISEASE NORMAL MICROBIOTA (FLORA): THE MICROORGANISMS THAT COLONIZE A HOST WITHOUT CAUSING DISEASE DO NOT HARM US.MAY BENEFIT US PREVENT GROWTH OF HARMFUL MICROBES PRODUCE USEFUL SUBSTANCES (VITAMINS) THE DISTINCTION BETWEEN HEALTH AND DISEASE IS PART OF A BALANCE BETWEEN THE NATURAL DEFENSES OF THE BODY AND THE DISEASE- PRODUCING PROPERTIES OF MICROORGANISMS DEPENDS ON OUR RESISTANCE (THE ABILITY TO WARD OFF DISEASES)

25 INFECTIOUS DISEASES PATHOGENS INVADE A SUSCEPTIBLE HOST AND CARRY OUT AT LEAST PART OF THEIR LIFE CYCLE IN THAT HOST EMERGING INFECTIOUS DISEASES: NEW OR CHANGING DISEASE THAT IS INCREASING OR HAS THE POTENTIAL TO INCREASE IN THE NEAR FUTURE