Introduction to ELIXIR Andy Smith, ELIXIR Hub 18 March 2015 Wageningen

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1 Introduction to ELIXIR Andy Smith, ELIXIR Hub 18 March 2015 Wageningen European Life Sciences Infrastructure for Biological Information europe.org

2 ELIXIR connects national bioinformatics centres and EMBL EBI into a sustainable European infrastructure for biological research data medicine agriculture 2 environment bioindustries ELIXIR underpins life science research across academia and industry

3 The data challenge: Volume Gigabytes N Databases

4 The data challenge: Geographically disperse Data production sites increasing across Europe European Illumina sales up 20% 2o14 Source: 4

5 The data challenge: diversity databases Diverse Plentiful Disperse Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in MY Galperin, GR Cochrane Nucleic Acids Research, 2011

6 An international distributed infrastructure for Data Standards Tools Compute Training Industry

7 A distributed infrastructure scales with the challenges ELIXIR deliver services through national ELIXIR Nodes ELIXIR Nodes build local bioinformatics capacity throughout Europe ELIXIR Nodes build on national strengths and priorities 7

8 ELIXIR funding Hub funded jointly by ELIXIR member states Nodes funded by national agencies Joint applications to EU funding

9 ELIXIR Nodes Over 100 institutes involved in ELIXIR Nodes Collaboration Agreements to be signed between Hub and Nodes Nodes that are national networks are developing own internal Node agreements 9

10 ELIXIR Core Data Resources Small subset of ELIXIR data resources and archives Fundamental importance to life science Long term preservation and reuse of biological data Focal point of ELIXIR s technical and science policy actions for data sustainability

11 ELIXIR Named Services Quality indicator of the Service or Tool have clearly outlined terms of usage, declared service levels and monitoring vetted by the ELIXIR SAB as part of Node application Sustainability & Commitment to Service Described in Service Delivery Plans annexed to the Hub Node Collaboration Agreements

12 ELIXIR tools and data registry

13 Integration and interoperability of resources typically 40% of our effort in biomarker discovery is data integration J. Wojcik, CEO, Quartz Bio Formats, Ontologies, Guidelines, 13 Professional skills for managing and exploiting data

14 Data interoperability Human Protein Atlas The Human Protein Atlas portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in 46 different normal human tissues and 20 different cancer types, as well as 47 different human cell lines.

15 ELIXIR pilots to address key challenges in biomedical research: 1. Cloud computing Embassy cloud : Access reference data in a virtual environment work as though you are at EMBL-EBI or SIB, Switzerland 2. Authentication & Authorisation Improved methods and processes for access to clinical data 3. High-Performance Computing Lightpath : Connections for on-demand reference data to remote HPC centres at EMBL-EBI and CSC Finland

16 ELIXIR prioritised by ESFRI and Council of EU

17 ELIXIR EXCELERATE ELIXIR s application following ESFRI Prioritisation in 2014 Results expected in Spring; project start Summer Eur 19 million 4 year project Focus on accelerating the implementation of ELIXIR Use case on Plant Sciences: Integrating Genomic and Phenotypic Data for Crop and Forest Plants

18 ELIXIR Industry Advisory Committee Philippe Sanseau, GlaxoSmithKline, UK Wendy Filsell, Unilever R&D, UK (Vice Chair) Angel Pizarro, Amazon Web Services, USA Jakob de Vlieg, Bayer CropSciences Innovation Center, Belgium Martin Ebeling, Hoffmann La Roche, Switzerland Anita Eliasson, Biocomputing Platforms Ltd, Finland Mark Forster, Syngenta, UK (Chair) Montserrat Vendrell, Biocat, Spain Natalia Jiménez Lozano, Bull and Atos, Spain Iain Hrynaszkiewicz, Nature Publishing Group Macmillan, UK Claus Stie Kallesøe, Gritsystems A/S, Denmark 18

19 Industry Advisory Committee

20 Public data: a foundation for innovation Supporting Europe s SMEs that build services on top of the public bioinformatics resources understanding impact ELIXIR Core Resources and Named Services Facilitating integration through Pilot Actions

21 Innovation and SME programme Copenhagen, November 2014 Focussed on pharma and ELIXIR resources for drug discovery Wageningen, March 2015 Data driven growth in the agri food industries Basel, 9 June 2015 Pharma and biotech Future events? Marine informatics HPC suppliers

22 Benefit of ELIXIR to industry supplier The life science sector as a consumer of HPC is already high and set to increase further 22

23 ELIXIR industry distribution channel Mailing list of around 200 companies and SME Associations Events, news and industry/academia funding opportunities from across ELIXIR Content, reach and frequency to expand through 2015

24 ELIXIR webinars Regular series of updates from ELIXIR Typically 3 rd Wednesday of month 30 minute talk: 30 min questions Future webinars: Data and Software carpentry Aleksandra Pawlik Marine metagenimics: towards user centric services Nils Peder Willassen Run using WebEx for live or recorded viewing Full programme: elixir europe.org/webinar 24

25 Thank you europe.org