Present and Future ehealth Research Activities supported by DG INFSO. Gérard Comyn,

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1 Present and Future ehealth Research Activities supported by DG INFSO Gérard Comyn, Head of Unit, ICT for Health, European Commission

2 Some facts Health care expenditure worldwide is around 3,000 billion Employs 9.3 % of total workforce in the EU, more than15 Mil people (compared to retail 13.0m, business services 13.3m) The combined market of BME/eHealth in EU is 70 Billion Current funding of European Commission-BME/eHealth ~ 550 Million (Information Society, Life sciences and Nonotechnologies Programmes) ehealth is a third largest industrial pillar of Healthcare (after pharma and med. devices) whose market will correspond to 5% of HC expenditure within the next 10 years.

3 20 Years of ehealth R&D & Policy PAST 10 years ( ) NEXT 10 years ( ) Computer Applications for Doctors Telemedicine systems and services Regional Health Info Networks Home-care systems Personal Health Systems Support to deployment Budget 20M Projects 30 Results Feasibility Study Budget 100M Projects 63 Results AIM Community Budget 140M Projects 158 Results 1 st batch of Products Budget 200M Projects 125 Results EU Health Telematics Industry i2010 initiative ehealth Communication and Action Plan COM (2004) 356 Yearly Ministerial ehealth Conferences, next conference May10-12, 2006 Malaga, Spain

4 20 Years of ehealth R&D & Policy PAST 10 years ( ) FP2 FP3 FP4 FP5 Computer Applications for Doctors Telemedicine systems and services Budget 20M Projects 30 Results Feasibility Study Budget 100M Projects 63 Results AIM Community Regional Health Info Networks Home-care systems Personal Health Systems Budget 140M Projects 158 Results 1 st batch of Products Budget 200M 125 Results EU Health Telematics Industry NEXT 10 years ( ) FP6 Research activities Personal health systems (Wearable & Implantable) based on biosensors Health Knowledge Infostructure & HealthGrid Decision Support Systems Biomedical Informatics support to Molecular and genomics Medicine Currently preparing FP7 activities ( )

5 Key facilitators for: Characteristics of Personal Health Systems - Continuity of care (prevention rehabilitation) - Citizen-centred care citizen empowerment to manage own health status provision of personalised care emphasis in preventative lifestyle early diagnosis management of chronic diseases independent living In the form of: - Wearable systems - Implantable systems - Mobile / portable systems - Point-of of-care systems for in-vitro diagnostics

6 Personal Health Systems FP6 efforts - Work under FP6 Move from development of technology and components to integrated systems and services Personalisation of health systems and care Personalised mobile applications and algorithms Activity areas: Health status monitoring Closed-loop drug delivery systems In-vitro diagnostics (predisposition to cancer) - MYHEART project MYHEART project - application oriented research - intelligent clothes - context awareness - integrated system and services - interaction with users and medical professionals

7 Biomedical Informatics- Background Biomedical information is collected, stored and processed on / in 1) Different Levels (molecule, cell, tissue, organ, person, population) 2) Different Context - (care, research, education, policy/management) 3) Different Representation (format, structures, ontologies) 4) Many many different places - Clinical info resources (health records, personal/wearable health systems, clinical research databases, drug/pharma databases, NLM, ) - Biomolecular Info resources (DNA & protein sequences, microrarray data, protein interactions, human genome annotations..) - Public health info resources (epidemiological data and studies, national and WHO databases on diseases, ) - Environmental/Chemical/Biodiversity info resources

8 Biomedical Informatics: synthesizes knowledge at all levels Public Health Informatics Population Medical Informatics Patient Tissue, organ Genome Epidemiology Cell Bioinformatics Molecule Gene, Protein

9 Biomedical Informatics (BMI) Research roadmaps First roadmap (2002): Bioinfomed, Second roadmap (expected in 2006) Synergies between medical informatics and Bioinformatics Coordinator: EMBL-EBI EBI Running: 3 Networks of excellence (Started 1/1/04) BIOPATTERN: INFOBIOMED: SEMANTIC MINING: And launching 20 projects 1/1/06 info available soon

10 Timeline WP03-04 WP05-06 Call1 Call4 Call2 Call3 Call5 Call6 (tbc) FP FP7 Communication: "Preparing the future: reinforcing European research policy" (12/05/04) Proposals on FP, SPs Adoption New Financial Perspectives WP + Calls Communication Building our common future: Policy challenges and Budgetary means of the Enlarged Union " (10/02/04)

11 ICT for Health in FP7 New perspectives in ICT drawing on other science and technology disciplines, including insights from physics, biotechnologies, materials- and life-sciences, for miniaturisation of ICT devices to sizes compatible and interacting with living organisms,, to increase performance of systems engineering and information processing, and for modelling and simulation of the living world. ICT meeting societal challenges: : New systems and services in areas of public interest improving quality, efficiency, access and inclusiveness; user friendly applications, integration of new technologies and initiatives such as ambient assisted living. for health, improving disease prevention, early diagnosis and personalisation; autonomy, safety and mobility of patients; health information space for knowledge discovery.

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13 Focus on: Personal Health Systems Potential RTD directions in FP7 Multi-parameter physiological monitoring vital body signals and functions (e.g. heart & respiratory rate, ECG, temperature etc.) chemical & biological substances Non-invasive multi-parameter blood analysis e.g. glucose, lactate, amino acids, etc. Substituting missing or degraded organ functionality wearable/portable/implantable artificial organs closed-loop drug delivery systems Multi-analyte screening at GP offices or home DNA, mrna based methods Remote monitoring Independent Living

14 Personal Health Systems Potential RTD directions in FP7 Major enabling technologies - Sensors Molecular and cellular biosensors (biosensor arrays) multi-analyte screening applications / multi-target detection predisposition to diseases Biochemical and non-contact sensors continuous multi-parameter physiological monitoring optical (NIRS), ultrasonic (CMUTs) or radio (UWB) technologies imaging capabilities for home diagnostic devices (e.g. M-mode imaging of heart valves, blood flow) Transdermal sensors non-invasive multi-parameter blood analysis ( blood readers ) assess the immune state, detect trends or trigger alarms indicate need for dietary adjustments (e.g. amino acid supplements) targeted closed-loop drug delivery

15 Personal Health Systems Potential RTD directions in FP7 Major enabling technologies Modelling and Simulation First prototypes of wearable/portable/implantable artificial organs increase mobility, autonomy and independence of people in need ambitious multidisciplinary research: ICT, biology and materials engineer the first generation of wearable artificial kidney? Virtual Physiological Human: modelling and simulation of the function of real physiological organs help design artificial organs tailored to the individual s needs

16 Personal Health Systems Potential RTD directions in FP7 Major enabling technologies Communications Underpin all remote monitoring solutions Converged fixed, wireless, mobile services for care outside hospitals Interaction between user/patient and healthcare professional mobile phones or PDAs with embedded sensors services over web portals - PCs and interactive TV broadband, UMTS, RFID, ZigBee, UWB, WiMAX

17 Personal Health Systems Potential RTD directions in FP7 Integrated approach Adopt a comprehensive approach from technology development to integration of dependable, secure and interoperable solutions in healthcare provide genuine end-to-end services Understand user s needs & involve users in development phase Validation and assessment of new solutions and services, with user participation Reliability of data acquisition and wireless communications Security of personal data, privacy and confidentiality Connectivity to Health Information Systems and Electronic Health Records Interoperability with other ehealth systems

18 Virtual (Digital) Physiological Human Computational framework for multiscale in silico model(s) of the human physiology and a toolbox for simulation and visualisation Patient specific model from biosignals and (multimodal) images including molecular images New basis for medical research and healthcare First workshop: June 1-2, 2005, Barcelona, Spain s/health/events/index_en.htm Roadmap:

19 Computational Models of the Human Body Reproduce Anatomical and Functional properties of nano physiological systems at various scales ATP sarcomeres micro molecules, proteins, cells, tissues, organs, systems, body, etc. Integrate Geometry, Physics, Chemistry, Physiology fibers organ meso macro INRIA in silico electromechanical cardiac model Help understand normal or pathological evolutions : systems : cardio-vascular, Central Nervous, Digestive, Reproductive, etc. N. Ayache, INRIA

20 The challenge Modelling and coupling phenomena which occur on many different length and time scales 1m 1mm 1μm 1nm Range = 10 9 person tissue morphology cell function pore diameter of a membrane protein 10 9 s (years) human lifetime 10 7 s (months) cancer development 10 6 s (days) protein turnover 10 3 s (hours) digest food 1 s heart beat 1 ms ion channel gating 1 μs Brownian motion Range = 10 15

21 Virtual Physiological Human Main challenges Methodology, Modelling of complex systems Integration of existing creation of new DBs,, Libraries, Biobanks Toolbox for simulation and visualisation Verification, Validation Pilots & Deployment policy &funding

22 Virtual (Digital) Physiological Human The Grand challenge Basis is the physiome project ( Many projects on cellular (ecell) and organ level (heart, kidney, lungs, musculosceleton) Examples in US: virtual soldier, virtual human The research agenda to be followed by new project STEP ( under negociation) June Conference, Brussels (in cooperation with DG RTD)

23 Series of workshops for preparation of FP7 ICT at cross road with Life sciences, Brussels, October 12, Future ICT systems inspired by nature DNA circuits, sensory data processing, self repair systems ICT in support of new biomedical systems and knowledge Biochips, artificial organs, Virtual physiological human (VPH) Mullilevel Modelling and Simulation of Human Physiology Barcelona June 1, 2005 White paper and presentations available at: s/

24 Conclusions European Commission DG Information Society supports 1) Beneficial uptake ehealth Communication - coordination of Member states activities - closer collaboration with other policy commission services 2) R&D in ICT for health with aim to contribute to Public health, Prevention, Patient safety, Molecular medicine 3) Events: PHealth, Lucern, Switzerland, Jan30-Feb 2, 2006 Ministerial ehealth Conference, malaga, Spain May 2006 ICT for Biomedical Sciences, Brussels, June 29-30, 2006 //europa.eu.int/information_society/activities/health/events/index_en.htm

25 To find more on ICT for Health / ehealth? Policy site: ehealth R&D Newsletter (monthly issues): newsletter/index_en.htm Research site: