What can we do with ips cells? Gabriella Boulting

Transcription

1 What can we do with ips cells? Gabriella Boulting

2 Pluripotent Stem Cells embryo ES cells liver cell heart cell Reprogramming A person s skin cells ips cells Induced pluripotent stem cells brain cell

3 ALS (a.k.a. Lou Gehrig s Disease) affects motor neurons.

4 ALS (a.k.a. Lou Gehrig s Disease) affects motor neurons. healthy ALS patient

5 Patient Specific ips cells skin sample Patient skin cells reprogramming patient specific ips cells

6 Patient Specific ips cells skin sample Patient liver cell heart cell motor neuron skin cells reprogramming patient specific ips cells

7 Patient Specific ips cells skin sample Patient Study disease & Test new therapies liver cell heart cell motor neuron skin cells reprogramming patient specific ips cells

8 Patient Specific ips cells skin sample Patient Study disease & Test new therapies liver cell heart cell motor neuron skin cells Directed Differentiation reprogramming patient specific ips cells

9 Directed Differentiation: opposite of reprogramming heart cells gni mmar gor pe R ips cells skin cells motor neuron

10 Patient Specific ips cells skin sample Patient Study disease & Test new therapies liver cell heart cell motor neuron skin cells reprogramming Directed Differentiation patient specific ips cells

11 Studying Disease in a Dish healthy person ALS patient

12 Studying Disease in a Dish healthy person healthy ips cells ALS patient ALS ips cells

13 Studying Disease in a Dish healthy motor neurons healthy person healthy ips cells ALS patient ALS ips cells sick motor neurons

14 Sophie DeBoer, Evangelos Kiskinis, Kevin Eggan. unpublished data, May 25, 2011

15 Studying Disease in a Dish healthy motor neurons healthy person healthy ips cells ALS patient ALS ips cells sick motor neurons

16 Studying Disease in a Dish healthy motor neurons healthy person healthy ips cells ALS patient ALS ips cells sick motor neurons

17 Studying Disease in a Dish healthy motor neurons healthy person healthy ips cells ALS patient ALS ips cells sick motor neurons

18 Studying Disease in a Dish healthy motor neurons healthy person healthy ips cells New potential medicine for ALS! ALS patient ALS ips cells sick motor neurons

19 Predicting side-effects

20 Predicting side-effects healthy ips cells patient specific ips cells

21 Predicting side-effects healthy ips cells patient specific ips cells beating heart cells

22 Predicting side-effects healthy ips cells patient specific ips cells beating heart cells

23 Itzhaki, et al., Nature, Jan

24 Patient Specific ips cells skin sample Patient Study disease & Test new therapies liver cell heart cell motor neuron skin cells reprogramming Directed differentiation patient specific ips cells

25 Patient Specific ips cells skin sample Patient Study disease & Test new therapies liver cell heart cell motor neuron skin cells reprogramming Directed differentiation patient specific ips cells

26 Patient Specific ips cells Cell replacement therapy skin sample Patient Study disease & Test new therapies liver cell heart cell motor neuron skin cells reprogramming Directed differentiation patient specific ips cells

27 Maybe in the next 20 years More diseases treated!

28 Maybe in the next 20 years More diseases treated! Have your own stem cells made!

29 Maybe in the next 20 years More diseases treated! Have your own stem cells made! Be your own organ donor!

30 Summary Daisy Gabriella -What is a stem cell? -Patient specific ips cells -Adult stem cells Luis -Directed differentiation -Embryonic stem cells (ES cells) -DNA: all the information -Studying disease in a dish -Reprogramming -Induced Pluripotent stem cells (ips cells)

31 Thank you! SITN would like to acknowledge the following organizations for their generous support. Harvard Medical School Office of Communications and External Relations Division of Medical Sciences The Harvard Graduate School of Arts and Sciences (GSAS) The Harvard Biomedical Graduate Students Organization (BGSO) The Harvard/MIT COOP Restaurant Associates