Title: Head of the Department of Aesthetics and Cosmetology, Technological Educational Institution of Athens

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1 DECLARATION OF INTERESTS Scientific Committee on Consumer Safety Health and Environmental Risks Emerging and Newly Identified Risks (Please note that high quality of scientific expertise is by nature based on prior experience and that therefore having an interest does not necessarily mean having a conflict of interest) Name: Varvaresou Athanasia Position: Member of the Scientific Committee on Consumer Safety Title: Head of the Department of Profession: Associate Professor in [please copy rows as needed for subsequent or parallel activities of the same nature] Nature of Activities Period Organisation Subject matter I. Ownership or other investments, including shares MM/YYYY MM/YYYY Companies or organisations in which the financial interest is placed NO INTEREST

2 II. Member of a Managing Body or equivalent structure YES AS FOLLOWING: MM/YYYY MM/YYYY -Name, Place, private, Function of expert: Function of institution: [Describe e.g. role of yourself and of the institution] Link to website of institution: 1. Responsible for the Laboratory of Cosmetology (3 persons academic staff and 3 persons external members) 2. Responsible for the Division of Aesthetics, Department of Aesthetics and Cosmetology (6 members academic staff and 8 persons external members) Department of Department of I have the responsibility for the undergraduate studies, research activities and projects of the laboratory of the cosmetology. The laboratory of cosmetology belongs to the Department of Cosmetology which provides BS degree to aestheticians and cosmetologists. Also the Department in collaboration with Medical School of, provides master degree entitled Environment and Health. I was responsible for undergraduate studies of the division of aesthetics and cosmetology. I participated in committees for the equipment of the division and for the evaluation of the academic staff. Administrative activity.

3 3. Head of the Department of (8 members academic staff, 2 members administrative staff and 8 external members) III. Member of a Scientific Advisory Body YES Department of 04/ Scientific Committee on Consumer Safety (SCCS) Location: Luxemburg Type:public Responsibility for the activities of the Department of the Cosmetology regarding new equipment, funds and undergraduate studies. Participation in committees for the equipment, for the evaluation of the academic staff etc. Administrative activity. External Member of the Scientific Committee on Consumer Safety (SCCS). The Committee provides scientific advice to the European Commission on risk assessment of non-food consumer products III. Employment IV. YES AS FOLLOWING: 1. Position: Assistant in Research and Education Department of,. 1. Development of new cosmetic formulations, study of preservative efficacy tests (PET), study of the influence of the cosmetic formulations on human skin elasticity, skin microtopography (profilometry), sebum, moisturization, transepidermal water loss and skin pigmentation. Study of the adverse effects of the formulations.

4 2. Position: Assistant Professor in Cosmetology Department of,. Research activities: Projects regarding development of new cosmetic formulations, study of preservative efficacy tests (PET), study of the influence of the cosmetic formulations on human skin elasticity, skin microtopography (profilometry), sebum, moisturization, trnsepidermal water loss and skin pigmentation. Study of the adverse effects of the formulations. Development of preservative-free cosmetics Teaching activities: series of lectures to the undergraduate students regarding basic aspects of cosmetology, cosmetic formulation, cosmetics effuicacy tests. Lectures to master degree students on topics regarding Environment and Health.

5 3. Position: Associate Professor in Cosmetology Department of, Research activities: Projects regarding development of new cosmetic formulations, study of preservative efficacy tests (PET), study of the influence of the cosmetic formulations on human skin elasticity, skin microtopography (profilometry), sebum, moisturization, trnsepidermal water loss and skin pigmentation. Study of the adverse effects of the formulations. Development of preservative-free cosmetics Teaching activities: series of lectures to the undergraduate students regarding basic aspects of cosmetology, cosmetic formulation, cosmetics effuicacy tests. Lectures to master degree students on topics regarding Environment and Health. V. Consultancy/Advisory YES AS FOLLOWING:

6 1. Varvaresou Pharmaceutical Consultancy,, in collaboration with Laboratory of VI. Research funding YES AS FOLLOWING: 04/ /04/2015 -Type: public private and Studies in cosmetics efficacy tests in the laboratory of Cosmetology of, and in adverse reactions of cosmetics (principal investigator in clinical studies) 1. Postgraduate studies School of Pharmacy, Pharmaceutical Chemistry Institute, Heidelberg, Germany Location: Heidelberg, Germany My research was focused on the synthesis of new phostone derivatives and their structure elucidation via NMR spectroscopy.

7 2. PhD studies Synthesis of new azathioxanthones with DNA binding activity and cytotoxic activity Doctoral Fellow Pharmaceutical School, Division of Pharmaceutical chemistry, My research was focused on the development of new methodology for the synthesis of new azathioxanthones, imidazothioxanthones and pyrazoloazathioxanthones. Structure elucidation experiments via NMR and IR techniques were also performed by me. The cytotoxic activity of the compounds was studied. Their DNA binding and triple helix DNA binding was also examined. 3.Research program. Title: Synthesis and study of new compounds with antiviral and antioxidant activities Research Fellow 01/ /1994 Member of the main research group Pharmaceutical School, Division of Pharmaceutical chemistry, My research was focused on the development of synthetic methodology for the synthesis of new organic compounds (benzofurans), the structure elucidation by NMR and IR techniques of the newly synthesized compounds and the study of their antiviral and antioxidant actions.

8 4. Research program. Title: New Indole derivatives with antimicrobial and Central Nervous System activity. Postdoctoral Fellow 03/ /1997 and 03/ /1998 Member of the main research group Pharmaceutical School, Division of Pharmaceutical Chemistry, My research was focused on the development of synthetic methodology for the synthesis of new indole derivatives bearing thiadiazole and triazole moieties, the structure elucidation by NMR and IR techniques of the above compounds, their lipophilicity properties (Quantitative Structure Activity Relationship) and the study of their antimicrobial activity. Their action on the CNS was also in vivo studied Research program. Title: Synthesis of pharmaceutical compounds Postdoctoral Fellow 07/ /1999 Member of the main research group Pharmaceutical School, Division of Pharmaceutical Chemistry, My research was focused on the development of synthetic methodology for the synthesis of new melatonin antioxidant analogs, the structure elucidation by NMR and IR techniques of the above compounds and the study of their melatoninergic and antioxidant activity.

9 6. Research Fellow Member of the main research group Pharmaceutical School, Division of Pharmaceutical Chemistry, My research was focused on the development of synthetic methodology for the synthesis of new pyridoquinoxalines with cytotoxic activity and their structural elucidation via NMR techniques Research program. Title: 1. Incorporation of oligopeptides in cosmetic products-quantitative evaluation of functional-skin parameters with biophysical methods. 2. Development and validation of an ion-pair RP-HPLC method for the determination of oligopeptides in cosmetic products Principal investigator Department of My research was focused on the incorporation of cosmetic oligopeptides in creams, stability tests of the creams, quantitative evaluation of functional-skin parameters with biophysical methods and the potential adverse effects of the formulations.

10 8. Research program. Title: Antiperspirants and Health 03/ Member of the main research group Department of My research was focused on the incorporation of aluminium hydrate in cosmetic creams and the stability tests. Adverse reactions to aluminium cosmetic ingredients were also studied. VII. Intellectual property MM/YYYY MM/YYYY NO VIII. Other membership or affiliation NO MM/YYYY MM/YYYY - -Type: private, public, [Describe activity, function, website]

11 IX. Other Teaching activity, Lectures Master degree: Title of the program: Environment and Health 03/ Medical School, Title: Photoaging and oxidative stress: Topical application of cosmetics Teaching activity, Lectures Master degree: Title of the program: Environment and Health 03/ Medical School, Title: Phthalates in cosmetics

12 Teaching activity, Lectures Master degree: Title of the program: Environment and Health 03/ Medical School, Title: Adverse reactions from preservatives in cosmetics: 3 rd Member of the committee for the dissertation for the Master degree entitled: Indoor air pollution. Legionella Medical School, 3 rd Member of the committee for the dissertation for the Master degree entitled: Cosmetic ingredients with hormone-mimetic activity Medical School, Study of phthalate esters used in cosmetics and their potential hormone-disrupting activity Study of the concentrations of the Legionella in many workplaces

13 3 rd Member of the committee for the dissertation for the PhD Thesis entitled: Study and chemical analysis of substances with cosmetic activity Department of and Pharmaceutical School, Division of Pharmaceutical Chemistry,. My research interest as 3d supervisor is focused on the incorporation of cosmetic oligopeptides in creams and their influence and possible synergistic activity on human skin properties. Secondly the stability of the peptides in the cream are evaluated by HPLC. Type-public

14 3 rd Member of the committee for the dissertation for the PhD Thesis entitled: Study of substances with cosmetic action Department of and Medical School,. Type-public My research interest as 3d supervisor is on per os intake of Lipoic Acid tablets, determination of the concentration of lipoic acid and its metabolites in the blood by HPLC and correlation of the influence of lipoic acid with human skin properties. 1 st supervisor of 20 dissertations regarding cosmetic ingredients Department of Supervision of the undergraduate students for the preparation of studies in development of cosmetic formulations, efficacy tests, physicochemical properties of cosmetic ingredients and self-preserving cosmetics

15 Instrumental experience: ΝΜR Bruker AC 400 MHz, ΝΜR Bruker 200 MHz, IR Perkin -Elmer 883, UV Perkin- ElmerModelLambda 4B, HPLC WatersAssociatesModel 600E, HPLC GBCLC 1210, HPLC Waters 1525 Cutometer SEM 474, Sebumeter SM 810, Corneometer CM 8, Μexameter, Visioscan, Skin Visiometer, Tewameter, Skin phmeter, Determination SPF in vitro, Transdermal delivery (Franz cells) ) Department of public 2) Pharmaceutical School, Division of Pharmaceutical Chemistry, -public Performing experiments in NMR, IR and UV instruments in order to explore the structure of newly synthesized compounds. Performing experiments in HPLC for lipophilicity studies Performing experiments for the evaluation of influence of the cosmetics on human skin elasticity, sebum, moisturization, transepidermal water loss, skin ph, melanin and erythema and skin microtopography (fine lines). Determination of Sun Protection Factor in vitro. Transdermal delivery by Franz cells

16 Author «Specific Cosmetology», KAFKAS Publications, 2011, ISBN: (Monography) 2011 Department of (Academic writing for the students of 5 th semester) Cosmetic claims, methodology for the design of clinical studies for cosmetics efficacy, experimental methodology suggested from COLIPA for the cosmetics efficacy evaluation. 2nd co-author «Basic Aspects in Cosmetology», PARISIANOS Publications, 2013, ISBN: Department of (Academic writing for the students of 2nd semester) Emulsification, Solubilization, Dispersion, Antioxidants, Preservatives-adverse effects, Preservative-free cosmetics, colors in cosmetics-adverse effects, cosmetic dyes, hair dyes, manufacture of cosmetics.

17 Reviewer: Food and Chemical Toxicology (Elsevier), Household and Personal Care (Tecnoscienze), Current Microbiology (Springer) and Process Biochemistry (Elsevier), International Journal of Cosmetic Science (Wiley) Elsevier, Springer, Wiley, Technoscienze Type-private Review of scientific articles regarding cosmetics, and pharmaceutical chemistry, DNA-drug interactions X. Interests of close family members NO MM/YYYY MM/YYYY NO INTEREST I hereby declare that I have read both the Guidance Document on Declarations of Interests and the Rules and Procedure related to Independence (section V of the Rules of Procedure) and that the above Declaration of Interests is complete. Done at Date: 22/04/2015 Signature:

MASTER IN PHARMACEUTICAL SCIENCES (Thesis Track)

MASTER IN PHARMACEUTICAL SCIENCES (Thesis Track) I. GENERAL RULES CONDITIONS: Plan Number 1 \ 12 70 2005 T 1. This plan conforms to the valid regulations of the programs of graduate studies. 2. Areas of