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1 4DM Integrated 4DM Personal A high level overview of 4DM functionality and the different ways the software can be installed on your workstation.

2 What is 4DM? Nuclear Cardiac Quantification, Review, & Reporting Software 4DM quantifies perfusion and function. In simplified terms, 4DM assigns values to parts of the heart based on how much blood the heart muscle retains at rest vs stress perfusion and how well the heart expands and contracts at rest vs stress function. This quantification enables physicians to assess a patient s cardiac health by reviewing patient images and 4DM values all in a single, convenient and configurable application. Integrated reporting within 4DM or with your PACS platform further streamlines the workflow. 4DM fits seamlessly into your current nuclear imaging workflow, receiving data from PET and SPECT cameras and exporting to PACS and EMRs. Patient Scan 4DM PACS EMR 4DM Quantification Results of Significance Systolic Function: LV Volumes (indexed and unindexed), EF, Cardiac Output Diastolic Function: Peak Filling and Emptying Rates Regional Wall Thickening, Motion, and Time to Peak Contractility Transient Ischemic Dilation (TID) Myocardial Perfusion Quantification (Extent and Severity) Semiquantitative Scoring (SSS, SRS, SDS, VS, SS) Viability Quantification (delineate between ischemic, hibernating, and scar tissue) Standard Uptake Value (SUV) for FDG PET imaging Calcium quantification: Agatston score, volume, and lesions Fully-Automated CFR quantification Inflammatory quantification for cardiac sarcoidosis Supported Patient Data Nuclear Medicine: Static, Gated, Dynamic, Whole Body SPECT Perfusion: Tomo, Recon Tomo, Gated Tomo, Gated Recon Tomo, Dynamic (SA, HLA, VLA, Transverse) SPECT MUGA: Gated Tomo, Gated Recon Tomo (SA, HLA, VLA, Transverse) PET: Static, Gated, Dynamic, Recon Tomo (SA, HLA, VLA, Transverse) CT, SPECT-CT, PET-CT Attenuation Correction Maps 8- and 24-bit DICOM Static and Multi-Frame Screen Captures 4DM@inviasolutions.com x209

3 Supported Cameras SPECT Cameras SPECT-CT Cameras PET Cameras PET-CT Cameras 4DM Integrated vs 4DM Personal Same Application. Two Ways to Get It. 4DM Licenses Manufacturer Model SPECT PET Hybrid-CT CFR Digirad Cardius XPO, Cardius XPO w/xact AC GE Healthcare Millenium; Infinia; Ventri; Discovery 630 GE Healthcare Discovery 530c - Alcyone Mediso Nucline Series; AnyScan S MiE ECAM SCINTRON Philips Cardio 60; CardioMD; Vertex, Vertex Plus; Axis/Irix; Skylight; Prism 1000/2000/3000; Forte; BrightView Siemens Multispect II/III; c.cam; e.cam; Evo, Evo Excel; Symbia S or E Spectrum Dynamics DSPECT Toshiba GCA Series; t.cam GE Healthcare Discovery 570c - Alcyone GE Healthcare Discovery 670; Infinia Hawkeye; Optima 640 Mediso AnyScan Mediso AnyScan SC Philips Precedence; BrightView CT Siemens Symbia T2, T6, T16; Intevo 2, 6, 16 GE Healthcare Advance NXi (BGO) MiE ECAT 47, HR+, ACCEL SCINTRON Philips C-PET; Allegro Positron Attrius Siemens ECAT Exact, HR/HR+, Accel GE Healthcare Discovery LS (BGO) GE Healthcare Discovery ST (BGO), STE (BGO), RX (LYSO); 600 (BGO); 690 (LYSO); 710; Discovery IQ PET (BGO) 3R, 4R, 5R Mediso AnyScan PC Philips Gemini; Gemini GXL, TF; Ingenuity TF; Vereos PET/CT Siemens Biograph Duo/B16 Siemens Biograph TruePoint 3R/4R, mct 3R/4R, mct Flow 4DM is available integrated on the platforms of our many reseller partners, who range from large camera manufacturers, to review workstation providers and integrated PACS developers. Our resellers and INVIA also offer a stand-alone solution 4DM Personal. 4DM Personal has the complete functionality of 4DM Integrated and installs on Windows laptops or workstations.* *For recommended system requirements, refer to the 4DM Personal Overview. 4DM@inviasolutions.com x209

4 Product Features Single Review Environment Integrated Myocardial Perfusion with Function Planar and SPECT Blood Pool Quantification Multiple image formats (Splash, Three Short Axis) 2D and 3D Polar Maps (Ungated, ED, ES Perfusion, Thickening, Motion, Contractility, Viability, SUV; Raw, Normalized, Severity, Blackout, Defect Severity, Normalized Mean, Normalized Standard Deviation, and Thresholds) Segmental Scoring Overlays Auto-selected user-defined workflows and screens Multi-monitor support Quality Assurance & Quantification Automatic quantification and cardiac reorientation User selectable processing algorithms Integrated quantification and review screens Volumetric Co-registration of supported data Tomo QA display (Cine Review, Sinogram, Linogram, Beat Histogram, Count Histogram, Gating Parameters) Beyond SPECT & PET Hybrid-CT (includes whole body CT Review, Calcium Scoring, Vessel and Calcium Fusion) SPECT Reconstruction (Filtered Backprojection, Filtering, Reorientation) Coronary Flow Reserve (Rb-82 and Ammonia PET Tracers and Tc-99m SPECT Tracer) Dual and Quad monitor support Export results and findings in varying formats - XML and Delimited Text Integrated Reporting Simple interface for entering Patient Information and Stress / EKG results Quantifications and images auto-filled from 4DM Standard and user-customizable report templates Auto-text generation based on quantifications Real-time report preview with editing capabilities View EKG data in 4DM while entering findings into 4DM Reporting Print and export reports in XML, RTF, PDF, Encapsulated PDF, HL7 v2, and HL7 v2 Referenced PDF directly from 4DM Automatic report selection based on imaging protocol Normals Databases SPECT Protocol Databases: One and 2-day Tc-99m, Dual Isotope (Tc-99m and Tl-201), Tl-201 Stress/Rest/Redistribution PET Protocol Databases: Rb-82 Distribution, FDG Viability (Statistically Generated), Ammonia (N-13) Camera Specific SPECT Databases (C.CAM, C.Clear, Profile AC, Symbia AC, IQ SPECT, cardiusx act, 530C, D-SPECT, Astonish AC) Iterative Reconstruction for SPECT (Astonish, Evolution, Flash3D, and nspeed) User-defined database generation and editing Configurable Change screen layouts or create custom screens Create a custom workflow Change colorbar preferences Multi-location and multiple user support Native Language Support 4DM interface translation into: Chinese, Czech, Danish, Dutch, Finnish, French, German, Hungarian, Indonesian, Italian, Japanese, Korean, Norwegian, Polish, Portuguese, Romanian, Russian, Spanish, Swedish, and Turkish 4DM Reporting interface translation into: French and German 4DM@inviasolutions.com x209

5 One Application Endless Possibilities SPECT PET Gated Blood Pool (GBP) Coronary Flow Reserve (CFR) Enhanced in v2017 Hybrid-CT 4DM Reporting* *Included with all 4DM Personal puchases. May or may not be included with 4DM Integrated x209

6 Our mission is to develop advanced imaging software for medical professionals to optimize patient care. PC_ A INVIA, LLC

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