The Future of LEU in the Global Mo-99 Supply Chain
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1 The Future of LEU in the Global Mo-99 Supply Chain Ira Goldman, Director, Strategic Product Supply High Country Nuclear Medicine Conference Vail Marriott March 2013
2 NRU HFR BR2 Osiris LVR-15 LMI Mo-99 Supply Chain Safari Reactors Mo-99 TARGETS : LEU - OPAL, SAFARI HEU - BR2, HFR, LVR-15, NRU, OSIRIS
3 Nordion IRE LMI Mo-99 Supply Chain NTP Processors Mo-99 TARGETS : LEU ANSTO, NTP HEU IRE, Nordion
4 Lantheus Mo-99 Supply Chain Reactor HFR Reactor Netherlands (1961) Mo-99 Extraction Mo-99 Purification Tc-99m Generator Manufacturer BR2 Reactor Belgium (1961) LVR-15 Reactor Czech Republic (1957) OSIRIS Reactor France (1966) SAFARI Reactor S. Africa (1965) NRU Reactor Canada (1957) OPAL Reactor Australia (2006) AECL Canada IRE Belgium NTP S. Africa ANSTO Australia Nordion Canada
5 LEU and Non-HEU DOE Cooperative Agreements S.99 American Medical Isotopes Production Act of 2011 U.S. Domestic Projects 3 active DOE/NNSA cooperative grants (non-heu projects) GE Hitachi-Clinton power reactor, neutron activation, USA - currently inactive Babcock & Wilcox MIPS aqueous LEU solution reactor seeking new partner SHINE/Morgridge - accelerator-driven LEU solution fission process Northstar Mo-100 accelerators; LSA w/tc-99m generator/separator
6 Other U.S. non-heu Projects Northstar/MURR - Mo-98 NA LSA w/tc-99m separator Coqui Radiopharmaceuticals: fission, 2015? USR (US radiopharmaceuticals), Texas new standard Tc-99m generator supplied by ANSTO Other Fission-based, multi-source Green-Tec: non-enriched uranium; Alabama 2014? Perma-Fix: neutron activation w/separation resins
7 International Mo-99 Supply Developments European processors conversion to LEU targets 2015 Nuclear Security Summit 2012 commitment New European Research Reactors (LEU targets): FRM II Reactor 2015 Jules Horowitz Reactor (replace Osiris) 2016 Pallas Reactor (replace HFR) ? MYRRHA (replace BR2) ? ANM Australia (3600 Ci/week LEU) early 2016 South Africa SAFARI -2 (LEU)
8 International Mo-99 Supply Developments Russia Rosatom/Isotope, (HEU/LEU) South Korea new RR, fission 2017 (LEU) Brazil new reactor & processing, 2017 (LEU) Argentina new reactor & processing, 2018 (LEU) India, China small-scale fission, 2016? (LEU)
9 Lantheus LEU Leadership FIRST to receive FDA approval for LEU Mo-99 in North America: ANSTO: June 2009, May 2011 NTP: September 2010 FIRST to commercially sell a generator made with only LEU Mo-99 (December 2010) FIRST to have LEU Mo-99 as a routine part of blended Tc-99m production (since May 2011) FIRST to commercially ship (Jan. 7, 2013) an all-leu generator (CMS add-on payment compliant) 9
10
11 Lantheus LEU Leadership LMI working in tandem with key customers to implement LEU generator usage LMI actively educating customers on LEU myths vs. facts LEU currently comprises double-digit percentage of total LMI Mo-99 supply on monthly basis New LMI contract with NTP/ANSTO (October 2012 through 2017) will result in substantially greater amounts of LEU in LMI plans to be 100% LEU by end of 2016
12 Lantheus Mo-99 Supply Strategy Strength through Diversity of Supply and LEU LMI has established a balanced and globally diversified Mo-99 supply chain continue to assess opportunities to further diversify and strengthen our supply chain with non-heu technologies actively engaged with U.S. (DOE cooperative agreement and other), Canada (ITAP), and international projects Anticipate future supply agreement with at least one U.S. project production beginning by 2016 and ramp-up for 2017 and beyond LMI positioned for post-nru secure Mo-99 supply
13 Summary U.S. (S.99, CMS add-on) and international community committed to non-heu Mo-99 supply LEU is already part of global Mo-99 supply Further actions underway across the globe to convert to LEU or to establish non-heu production LEU and non-heu technologies will help to assure future stable and reliable supply of medical radioisotopes
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