According to EC Directive 91/155/EEC Date of issue: Supersedes edition of

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1 Safety Data Sheet Date of issue: Supersedes edition of Identification of the substance/preparation and of the company/undertaking Identification of the product Product name: Acetic acid (glacial) 100% anhydrous GR for analysis ACS,ISO,Reag. Ph Eur Use of the substance/preparation Company/undertaking identification Reagent for analysis Chemical production Pharmaceutical production and analysis Company: Merck KGaA * Darmstadt * Germany * Phone: Emergency telephone No.: Please contact the regional Merck representation in your country. 2. Composition/information on ingredients CAS-No.: EC-Index-No.: M: g/mol EC-No.: Formula Hill: C 2 H 4 O 2 Chemical formula: CH 3 COOH 3. Hazards identification Flammable. Causes severe burns. 4. First aid measures After inhalation: fresh air. Call in physician. After skin contact: wash off with plenty of water. Dab with polyethylene glycol 400. Immediately remove contaminated clothing. After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid held wide open. Immediately call in ophtalmologist. After swallowing: make victim drink plenty of water (if necessary several litres), avoid vomiting (risk of perforation!). Immediately call in physician. Do not attempt to neutralize. The Safety Data Sheets for catalog items are also available at Page 1 of 6

2 5. Fire-fighting measures Suitable extinguishing media: Water, CO 2, foam, powder. Special risks: Combustible. Vapours heavier than air. Forms explosive mixtures with air at elevated temperatures. Development of hazardous combustion gases or vapours possible in the event of fire. The following may develop in event of fire: Acetic acid vapours. Special protective equipment for fire fighting: Do not stay in dangerous zone without self-contained breathing apparatus. In order to avoid contact with skin, keep a safety distance and wear suitable protective clothing. Other information: Contain escaping vapours with water. Cool container with spray water from a save distance. Prevent fire-fighting water from entering surface water or groundwater. 6. Accidental release measures Person-related precautionary measures: Do not inhale vapours/aerosols. Avoid substance contact. Ensure supply of fresh air in enclosed rooms. Environmental-protection measures: Do not allow to enter sewerage system; risk of explosion! Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up affected area. 7. Handling and storage Handling: Notes for prevention of fire and explosion: Keep away from sources of ignition. Take measures to prevent electrostatic charging. Storage: Tightly closed in a well-ventilated place, away from sources of ignition and heat. At +15 C to +25 C. 8. Exposure controls/personal protection Specific control parameter EC Name acetic acid Value 10 ml/m 3 25 mg/m 3 Personal protective equipment: Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. The Safety Data Sheets for catalog items are also available at Page 2 of 6

3 Respiratory protection: Eye protection: Hand protection: required when vapours/aerosols are generated. filter E-(P2) required In full contact: Glove material: butyl rubber Layer thickness: 0.7 mm Breakthrough time: > 480 Min. In splash contact: Glove material: natural latex Layer thickness: 0.6 mm Breakthrough time: > 30 Min. The protective gloves to be used must comply with the specifications of EC directive 89/686/EEC and the resultant standard EN374, for example KCL 898 Butoject (full contact), 706 Lapren (splash contact). The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet and supplied by us as well as to the purpose specified by us. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D Eichenzell, Internet: Other protective Suitable protective clothing. equipment: Industrial hygiene: Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. 9. Physical and chemical properties Form: liquid Colour: colourless Odour: pungent ph value at 50 g/l H 2 O (20 C) 2.5 Viscosity dynamic (20 C) 1.22 mpa*s Viscosity kinematic (20 C) 1.17 mm 2 /s Melting point 17 C Boiling point (1013 hpa) C Ignition temperature 485 C Flash point 39 C c.c. Explosion limits lower 4 Vol% upper 19.9 Vol% Vapour pressure (20 C) 15.4 hpa Relative vapour density 2.07 Density (20 C) 1.05 g/cm 3 Solubility in water (25 C) 1000 g/l log Pow (experimental) (Lit.) The Safety Data Sheets for catalog items are also available at Page 3 of 6

4 Bioconcentration factor < 1 (calculated) (HSDB) Refractive index (20 C) Stability and reactivity Conditions to be avoided Heating. Substances to be avoided Risk of explosion with: strong oxidizing agents (i.a. CrO 3, potassium permanganate, peroxi compounds, perchloric acid, chromosulfuric acid), nitrates / warmth/heat, fuming sulfuric acid, phosphorus halides, hydrogen peroxide. Violent reactions possible with: metals (iron, zinc, magnesium (generation of hydrogen)), alkali hydroxides, nonmetallic halides, ethanolamine, acetic acid anhydride / water, aldehydes, alcohols, halogen-halogen compounds, chlorosulfonic acid, strong alkalis, nitric acid. Hazardous decomposition products in the event of fire: See chapter 5. Further information incompatible with various metals. explosible with air in a vaporous/gaseous state when heated 11. Toxicological information Acute toxicity LC 50 (inhalation, rat): 11.4 mg/l /4 h (IUCLID). LCLo (inhalation, rat): ppm(v) /4 h (RTECS). LD 50 (dermal, rabbit): 1060 mg/kg (IUCLID). LD 50 (oral, rat): 3310 mg/kg (RTECS). Specific symptoms in animal studies: Skin irritation test (rabbit): burns (IUCLID). The literature data available to us do not conform with the labelling prescribed by the EC. The EC has dossiers which have not been published. Subacute to chronic toxicity Bacterial mutagenicity: Salmonella typhimurium: negative. (National Toxicology Program) No teratogenic effect in animal experiments. (IUCLID) The Safety Data Sheets for catalog items are also available at Page 4 of 6

5 Further toxicological information After inhalation of vapours: Irritation symptoms in the respiratory tract. pneumonia bronchitis. Inhalation may lead to the formation of oedemas in the respiratory tract. (Latency time until onset of action.) After skin contact: Burns. After eye contact: Burns. Risk of blindness! Risk of corneal clouding. Risk of perforation! After swallowing: burns in mouth, throat, oesophagus and gastrointestinal tract. Risk of perforation in the oesophagus and stomach. Nausea, vomiting. Pulmonary failure possible after aspiration of vomit. Systemic effects: dyspnoea, gastric spasms, shock, cardiovascular failure, acidosis. Possible damages: Damage of: kidneys. Further data The product should be handled with the care usual when dealing with chemicals. 12. Ecological information Biologic degradation: Biodegradation: 99 % /30 d (closed bottle test) (HSDB). Readily biodegradable. Behavior in environmental compartments: Distribution: log Pow: (experimental) (Lit.). No bioaccumulation is to be expected (log Pow <1). Passage from aqueous solution into the atmosphere is not to be expected. Ecotoxic effects: Biological effects: Harmfull effect on aquatic organisms. Harmful effect due to ph shift. Caustic even in diluted form. Fish toxicity: L.macrochirus LC 50 : 75 mg/l /96 h (Lit.). Daphnia toxicity: Daphnia magna EC 50 : 47 mg/l /24 h (Lit.). Bacterial toxicity: Photobacterium phosphoreum EC 50 : 11 mg/l /15 min microtox test (IUCLID). Maximum permissible toxic concentration: Algeal toxicity: Sc.quadricauda IC 5 : 4000 mg/l /16 h (Lit.). Bacterial toxicity: Ps.putida EC 5 : 2850 mg/l /16 h neutral (Lit.). Protozoa: E.sulcatum EC 5 : 78 mg/l /72 h neutral (Lit.). Further ecologic data: Do not allow to enter waters, waste water, or soil! 13. Disposal considerations Product: Chemicals must be disposed of in compliance with the respective national regulations. Under you will find country- and substance-specific information as well as contact partners. Packaging: Merck product packaging must be disposed of in compliance with the country-specific regulations or must be passed to a packaging return system. Under you will find special information on the respective national conditions as well as contact partners. The Safety Data Sheets for catalog items are also available at Page 5 of 6

6 14. Transport information Road & Rail ADR, RID UN 2789 ESSIGSAEURE, 8 (3), II Inland waterway ADN, ADNR not tested Sea IMDG-Code UN 2789 ACETIC ACID, GLACIAL, 8 (3), II Ems F-E S-C Air CAO, PAX UN 2789 ACETIC ACID, GLACIAL, 8 (3), II The transport regulations are cited according to international regulations and in the form applicable in Germany. Possible national deviations in other countries are not considered. 15. Regulatory information Labelling according to EC Directives Symbol: C Corrosive R-phrases: Flammable. Causes severe burns. S-phrases: Do not breathe vapour. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). EC-No.: EC label Reduced labelling (1999/45/EC,Art.10,4) Symbol: C Corrosive R-phrases: Flammable. Causes severe burns. S-phrases: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). 16. Other information Reason for alteration Chapter 11: toxicological information. Chapter 12: ecological information. Chapter 8: specific control parameter. General update. Regional representation: This information is given on the authorised Safety Data Sheet for your country. The information contained herein is based on the present state of our knowledge. It characterizes the product with regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product. The Safety Data Sheets for catalog items are also available at Page 6 of 6