POLY(ETHYLENE) OXIDE SYNTHETIC POLYMER HYDROGELS FOR MEDICAL APPLICATIONS
|
|
- Edgar McCoy
- 6 years ago
- Views:
Transcription
1 POLY(ETHYLENE) OXIDE SYNTHETIC POLYMER HYDROGELS FOR MEDICAL APPLICATIONS Haryanto University of Muhammadiyah Purwokerto, Indonesia ABSTRACT Recently, syntheticpolymer hydrogels have emerged as a promising biomaterial for biomedical applications because of their biocompatibility, water absorption capability, degradability and better mechanical properties than natural polymer hydrogels. Therefore,the current study was undertaken with the main objective of developing modified poly(ethylene oxide) (PEO) hydrogel films with poly(ethylene glycol) diacrylate (PEGDA), poly(ethylene glycol) dicarboxcylate (PEGDC), poly(ethylene glycol) dimethacrylate (PEGDMA) and hyperbranchpolyglycidol (HPG) with enhancedproperties using electron beam (E -Beam) for three major applications namely wound dressing, anti-adhesion barrier and tissue engineering scaffold. Crosslinked PEGDA/PEO hydrogel was developed for wound dressing application. Thecross-linked PEGDC/PEO and PEGDMA/PEO hydrogels were developed for an anti-adhesion barrier application.and a microporous hydrogel scaffold was developed from HPGand PEO using e-beam induced cross-linking for tissue engineering applications.this study shows the potential ofmodified PEO hydrogel films in biomedical applications especially as wound dressing, anti-adhesion barrier and tissue engineering scaffold. Keywords: crosslinkedhydrogel,e-beam, poly(ethylene) oxide, electron beam,biomedical applications. INTRODUCTION One of the most promising class of biomaterials seem to be hydrogels. The word biomaterial is generally used to recognize materials for biomedical applications. For over thirty years hydrogels have been used in numerous biomedical applications such as drug delivery, cell carriers, wound dressing, tissue engineering scaffold, contact lenses, anti-adhesion barrier and absorbable sutures as well as in many other areas of clinical practice. Hydrogels are polymeric networkswhich have the ability to absorb and hold water from 10 20% (an arbitrary lowerlimit) up to thousands of times their dry weight within the spaces available among the polymeric chains. As the term network implies, crosslinks have to be present to avoid dissolution of hydrophilic polymer chains/segments into the aqueous phase. Hydrogels may be chemically stable or theymay degrade and eventually disintegrate and dissolve [1,2]. The water holding capacity of the hydrogels arise mainly due to the presence of hydrophilic groups, viz. amino, carboxyl and hydroxyl groups, in the polymer chains.higher the number of the hydrophilic groups, higher is the water holding capacity while with an increase in the crosslinking density there is a decrease in the equilibrium swelling due to the decrease in the hydrophilic groups. As the crosslinking density increases, there is a subsequent increase in the hydrophobicity and a corresponding decrease in the stretchability of the polymer network. As mentioned above, hydrogels are crosslinked polymeric networks and hence provide the hydrogel with a 3-dimensional polymeric network structure [3]. The water holding capacity and permeability are the most important characteristic featuresof a hydrogel. The disintegration and/ordissolution could happenedif the network chain or cross-links are 2
2 degradable [4]. The Biodegradable hydrogelscontaining labile bonds, therefore advantageous in applications such as tissueengineering, wound healing and drug delivery.the labile bonds canbe broken under physiological conditions either enzymatically or chemically, in most of thecases by hydrolysis [5,6].Biocompatibility is the third most important characteristic property required by thehydrogel. Biocompatibility calls for compatibility with the immune system of the hydrogeland its degradation products formed, which also should not be toxic.generally, hydrogels possess a good biocompatibility since their hydrophilic surface has alow interfacial free energy when in contact with body fluids, which results in a lowtendency for proteins and cells to adhere to these surfaces. Moreover, the soft and rubberynature of hydrogels minimises irritation to surrounding tissue [7]. In this study, we prove the possibility to develop the facile fabrication of the remarkable modified PEO crosslinked hydrogel film which fullfilled the ideal properties of biomaterial in particular biomedical applications such as wound dressing, anti-adhesion barrier and tissue engineering scaffold using electron beam. EXPERIMENTAL PEO and additive polymer ( PEGDA, PEGDC/PEGDMA, HPG)were used for preparation of the hydrogel films.aqueous solution of additive polymer/peo (5% w/w)was prepared by stirring the solution at room temperature for 24 hours. The solution was made with variouscomposition. The calculated amount of aqueous solution was poured into a petri dish to formdry additive polymer/peo film with a thickness of 0.3 mm for wound dressing and 0.1 mm for anti-adhesion barrier and scaffolds. The solution was dried in the oven at 55 C for 24 hours,and thenremaining moisturewas removed in a vacuum oven for 6 hours at the same temperature. Dry hydrogel films were sealed in an evacuated polyethylene bag, followed by irradiation at 300 kgy using an EB having a beam current of 5 ma and 10 ma with an energy of 0.7 MeV generated from an EB Accelerator. Various parameters were tested for each applications ( wound dressing, anti-adhesion barrier, scaffolds). RESULTS AND DISCUSSION For wound dressing applications, the results indicated that higher content of PEGDA could enhance crosslinking of hydrogel in which high cross linked structure could not sustain much water within the gel structure. It can be seen from fig 1 that the tensile strength of PEO/PEGDA blend hydrogel increased steadily with increasing PEGDA content and reached the maximum point at 0.48 MPa with 10% PEGDA. The water vapor transmission rate of PEO/PEGDA hydrogel was 19 g/m 2 h. The result indicates that the hydrogel could keep moist environment on the interface between the wound and dressing speeding up the healing process. The invivoresult (Fig 2.)showed that a significant reduction of wound size was observed with the hydrogels compared to controlled group after 3 days of post operation. 3
3 Fig 1.Fig 2. In anti-adhesion barrier application, the results showed that 10% PEGDC hydrogel exhibits (Fig 3.) the superlative mechanical strength with the highest elongation at break (69.33 ± 6.87 %). It is also shows the lowest hemolysis activity (6.03± 0.01%) and the highest tissue adherence( Fig 4.) that ensure the film was easily placed onto tissue with good adherence during the wound healing process. The efficacy of 10% PEGDC/PEO cross-linked hydrogel as a barrier for reducing post surgical adhesions was evaluated using a rat cecum model. 4
4 Purwokerto, 28 November 2015, ISBN Fig 3. Fig 4. Moreover, in tissue engineering scaffolds application, the microporous HPG/PEO hydrogel scaffold was successfully developed using a simple e-beam irradiation (Fig 5).The in vitro cytotoxicity results demonstrated that HPG/PEO hydrogel scaffolds exhibited good cell viability and low cytotoxicity, as expected from the materials. Fig 5. CONCLUSION Thedevelopment of modified poly(ethylene oxide) (PEO) hydrogel films with PEGDA,PEGDC, and HPGwas successfully producedd with improvedproperties using electron beam (E-Beam) for three major applications namely wound dressing, anti-adhesion barrier and tissue engineering scaffold. REFERENCES [1] D. Campoccia, P. Doherty, M. Radice, P. Brun, G. Abatangelo, D.F. Williams, Semi Synthetic ResorbableMaterials from HyaluronanEsterification, Biomaterials 19 (1998) [2] G.D. Prestwich, D.M. Marecak, J.F. Marecak, K.P. Ver- cruysse, M.R. Ziebell, Controlled Chemical Modification of Hyaluronic Acid, J. Controlled Release 53 (1998)
5 [3] K. Pal, A.K. Banthia and D.K. Majumdar, Polymeric Hydrogels: Characterization and Biomedical Applications A mini review, Designed Monomer and Polymers 12 (2009), [4] S.K.H. Gulrez, S. Al-Assaf, G.O. Phillips, Hydrogels: Methods of Preparation, Characterisation and Applications, in: A. Carpi (Eds), Progress in Molecular and Environmenta l Bioengineering - From Analysis and Modeling to Technology Applications, InTech., United Kingdom, 2011, [5] W.E. Hennink, C.F. van Nostrum, Novel Crosslinking to Design Hydrogel, Adv. Drug Deliv. Rev. 54 (2002) [6] A.S. Hoffman, Hydrogels for Biomedicals Applications, Adv. Drug Deliv. Rev. 54 (2002) [7] J.M. Anderson, J.J. Langone, Issues and Perspectives on the Biocompatibility and Immunotoxicity Evaluation of Implanted Controlled Release Systems, J Control Release. 57 (1999)
Hydrogel film of polyethylene oxide-polypropylene glycol diacrylate for wound dressing application
IOP Conference Series: Materials Science and Engineering PAPER OPEN ACCESS Hydrogel film of polyethylene oxide-polypropylene glycol diacrylate for wound dressing application To cite this article: Haryanto
More informationSwelling Behavior Study of γ-irradiated Gelatin Hydrogels Prepared in Organic/Aqueous Mixtures
J. Ind. Eng. Chem., Vol. 13, No. 6, (2007) 997-1001 Swelling Behavior Study of γ-irradiated Gelatin Hydrogels Prepared in Organic/Aqueous Mixtures Junhwa Shin, Youn Mook Lim, Joon-Pyo Jeun, and Young Chang
More informationBiocompatible Hydrogel Film of Polyethylene Oxide-Polyethylene Glycol Dimetacrylate for Wound Dressing Application
IOP Conference Series: Materials Science and Engineering PAPER OPEN ACCESS Biocompatible Hydrogel Film of Polyethylene Oxide-Polyethylene Glycol Dimetacrylate for Wound Dressing Application To cite this
More informationCHAPTER 4 CONCLUSIONS AND FUTURE PERSPECTIVES
CHAPTER 4 CONCLUSIONS AND FUTURE PERSPECTIVES Wound infections are the major challenges in the wound care management. Infection can be either due to microbial attack or due to some diseases. This infection
More informationRadiation of Biopolymers. Jaejoon Han
Radiation of Biopolymers Jaejoon Han INTRODUCTION Polymers are macromolecules composed of many small molecules added to each other to form linear, branched, or cross-linked structures. Synthetic origin
More informationStudies on the Effect of Molecular Weight on the Degradation Rate of Biodegradable Polymer Membrane
, pp.390-394 http://dx.doi.org/10.14257/astl.2015. Studies on the Effect of Molecular Weight on the Degradation Rate of Biodegradable Polymer Membrane Yuying Xie 1, Jong-soon Park 2, Soon-kook Kang 1,1
More informationPolymeric hydrogels are of special importance in polymeric biomaterials because of
POLYMERIC HYDROGELS Polymeric hydrogels are of special importance in polymeric biomaterials because of their favorable biocompatibility. Hydrogels are cross-linked macromolecular networks formed by hydrophilic
More informationSurface Characterization of Biomaterials
Surface Characterization of Biomaterials Biomaterials are determined The desire for well-being and long life expectancy goes hand in-hand with the use of non-viable materials to conserve health. 2000 years
More informationBIODEGRADABLE HYDROGEL- ANALYZING THE IMPACT AND SENSITIVITY OF TEMPERATURE AND ph CHANGE
BIODEGRADABLE HYDROGEL- ANALYZING THE IMPACT AND SENSITIVITY OF TEMPERATURE AND ph CHANGE Aayush Goel Department of Polymer Science Chemical Technology Delhi Technological University (Formerly Delhi College
More informationEffect of Strain on Viscoelastic Behavior of PVP-CMC Based Medicated Hydrogels
Effect of Strain on Viscoelastic Behavior of PVP-CMC Based Medicated Hydrogels Niladri Roy a, Nabanita Saha b, Takeshi Kitano b and Petr Saha b a Centre of Polymer Systems,Tomas Bata University in Zlin,
More informationSynthesis and Characterization of Biodegradable Hemostat Gelatin Sponge for Surgery Application
R Iranian Journal of Pharmaceutical Sciences Summer 2008: 4(3): 193-200 www.ijps.ir Original Article Synthesis and Characterization of Biodegradable Hemostat Gelatin Sponge for Surgery Application Rana
More informationLodz University of Technology POLAND
Synthesis, modification and sterilization of polymeric biomaterials expertise Radoslaw Wach BIOMATERIALS group Division of Applied Radiation Chemistry Main directions of investigations 1. radiation chemistry
More informationThe research work highlights the development and evaluation of. bioavailability of drugs. The buccal route can bypass the first-pass
212 9. Summary, conclusion and recommendation 9.1 Summary and conclusion The research work highlights the development and evaluation of novel transbuccal drug antagonist of Famotidine. route have a rapid
More informationSupporting Information
Supporting Information Rebuilding post-infarcted cardiac functions by injecting TIIA@PDA NPs-crosslinked ROS sensitive hydrogels Wei Wang 1,#, Jingrui Chen 2,3,#, Min Li 2,3, Huizhen Jia 1, Xiaoxu Han
More informationCHARACTERIZATION AND APPLICATION OF COLLAGEN-POLYMER BASED COMPOSITE AS WOUND HEALING MATERIAL
th ICAMS 2012 4 International Conference on Advanced Materials and Systems CHARACTERIZATION AND APPLICATION OF COLLAGEN-POLYMER BASED COMPOSITE AS WOUND HEALING MATERIAL DENİZ GÜRLER, EYLEM KILIÇ Uşak
More informationCARBOXYMETHYL CELLULOSE NANOCOMPOSITES
CARBOXYMETHYL CELLULOSE NANOCOMPOSITES YongJae Choi Department of Chemical Engineering and John Simonsen Department of Wood Science & Engineering Oregon State University Outline I. Introduction II. Materials
More informationBiomaterials. Third Edition
Biomaterials Third Edition Joon Park R.S. Lakes Biomaterials An Introduction Third Edition Joon Park Biomedical and Mechanical Engineering University of Iowa Iowa City, IA 52242-1414 USA joon-park@uiowa.edu
More informationContents 1 Mammalian Polysacharides and Its Nanomaterials
Contents 1 Mammalian Polysacharides and Its Nanomaterials... 1 1.1 Introduction... 1 1.1.1 Polysaccharide-Based Nanoparticles... 2 1.2 Hydrophobically Modified Hyaluronic Acid... 2 1.3 Chemically Crosslinked
More informationDevelopment of Elastic Polylactic Acid Material Using Electron Beam Radiation
ELECTRONICS Development of Elastic Polylactic Acid Material Using Electron Beam Radiation Shinichi KANAZAWA Sumitomo Electric Fine Polymer has developed a technology for fabricating a brand new elastic
More informationAdditive manufacturing for long term implants. Presentation Content
Additive manufacturing for long term implants Jac Koenen DSM Amsterdam February 4, 2015 Presentation Content DSM and DSM 3D printing of medical devices/implants Advantages Unique DSM materials Some Relevant
More informationSoft Fabrication and Polymers
Introduction to BioMEMS & Medical Microdevices Soft Fabrication and Polymers Companion lecture to the textbook: Fundamentals of BioMEMS and Medical Microdevices, by Prof., http://saliterman.umn.edu/ R012408
More informationModeling poly(ethylene glycol) Diacrylate Hydrogels Synthesized by EosinY/TEA Visible Light Photopolymerization
Modeling poly(ethylene glycol) Diacrylate Hydrogels Synthesized by EosinY/TEA Visible Light Photopolymerization Chu-Yi Lee, Georgia Papavasiliou, Omar Khalil and Fouad Teymour Department of Biomedical
More informationDESIGN, FUNCTION AND USES. R. James Christie Oct. 4, 2008 Utsunomiya Girls High School
BIOCOMPATIBLE POLYMERS: DESIGN, FUNCTION AND USES R. James Christie Oct. 4, 2008 Utsunomiya Girls High School Biomaterials: Materials that Function with Living Organisms Materials that imitate natural
More informationCourse Syllabus. BMEN 4360: Biomaterials and Medical Devices Fall Course Information
Course Syllabus Course Information Course Number/Section: BMEN 4360.001 Biomaterials and Medical Devices Term: Spring 2017 Days &Times: Class meets in ECSS 2.305 on Mondays and Wednesdays, 8:30 AM 9:45
More informationApplications of self-assembling peptides in controlled drug delivery
Applications of self-assembling peptides in controlled drug delivery Sotirios Koutsopoulos, Ph.D. Problems associated with drug administration Drug concentration in blood C toxic C effective Time 1 The
More informationCHAPTER 4 WATER ABSORPTION BEHAVIOR AND ACCELERATED AGING EFFECTS
1 CHAPTER WATER ABSORPTION BEHAVIOR AND ACCELERATED AGING EFFECTS.1 INTRODUCTION The mechanical properties of the polymer matrix composites depend on the properties of their constituents and their interaction
More informationapplications J.C. Huang 1, J.S.C. Jang 2, C.H. Lin 1, C.H. Chen 3, C.H. Huang 1, R.F. Chuang 1 National Sun Yat-Sen University
Ti and Ta based metallic glasses for biomedical applications J.C. Huang 1, J.S.C. Jang 2, C.H. Lin 1, C.H. Chen 3, C.H. Huang 1, R.F. Chuang 1 1 National Sun Yat-Sen University 2 National Central University
More informationBiomedical applications of inkjet printing at the UoN
Biomedical applications of inkjet printing at the UoN Content Why Material Jetting? Printability requirement Material Jetting at UoN Polycaprolactone: inkjet printing of bioresorbable material 3D printing
More informationDefense Technical Information Center Compilation Part Notice
UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP019726 TITLE: N-Isopropylacrylamide-Based Copolymers with Time-Dependent LCST for a Bioresorbable Carrier DISTRIBUTION: Approved
More informationThe Effects of Scaffold Rigidity on Retinal Pigment Epithelial Cells. Corina White Symposium on Biomaterials Science 24 October 2016
The Effects of Scaffold Rigidity on Retinal Pigment Epithelial Cells Corina White Symposium on Biomaterials Science 24 October 2016 Background Physiology The retina is the light-responsive tissue layer
More informationWater-based Modification of Cellulose Nano Fibrils for Packaging Applications. Kendra Fein Doug Bousfield William Gramlich
Water-based Modification of Cellulose Nano Fibrils for Packaging Applications Kendra Fein Doug Bousfield William Gramlich 1 Motivation Environmental Plastic Microplastics in oceans centuries to degrade
More informationBIOLOGICAL PERFORMANCE of MATERIALS
FOURTH EDITION BIOLOGICAL PERFORMANCE of MATERIALS Fundamentals of Biocompatibility Jonathan Black QfP) Taylor &. Francis >^ J Taylor & Francis Group Boca Raton London New York A CRC title, part of the
More informationTrusted, Innovative, Global
3M Medical OEM Trusted, Innovative, Global 3M is a diversified technology company, with sales of over 20 billion in 200 countries. The 3M Health Care business group, with more than 50 years experience,
More informationHydrogels. Soft materials for tissue repair Contact lenses Slow or smart drug release implants Diaper absorbent Toys (slime) food
Hydrogels A hydrogel is a gel in which water is the dispersed media Hydrogel is typically a 3D network of hydrophilic polymer molecules that attract water molecules Many applications, including Soft materials
More informationPEEK Biomaterials Handbook, Steven M. Kurtz
PEEK Biomaterials Handbook, Steven M. Kurtz PEEK Biomaterials Handbook, 1437744648, 9781437744644, 306 pages, 2011, William Andrew, 2011, Steven M. Kurtz, PEEK biomaterials are currently used in thousands
More informationPROCESS FOR MANUFACTURING A HIGH PERFORMANCE NATURAL FIBER COMPOSITE BY SHEET MOLDING
PROCESS FOR MANUFACTURING A HIGH PERFORMANCE NATURAL FIBER COMPOSITE BY SHEET MOLDING T.Behzad and M. Sain a Centre for Biocomposites and Biomaterials Processing and Department of Chemical Engineering
More informationArtificial blood vessels
Artificial blood vessels S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Joint Initiative of
More informationBME Polymer Lab
BME 383 - Polymer Lab Background Information Hydrogels, which are water-swollen, cross-linked polymer networks, have emerged as an important class of materials in biomedical engineering. Methods of preparation
More informationADVANCED WOUND CARE MANAGEMENT
POREX, FILTRATION GROUP ADVANCED WOUND CARE MANAGEMENT Innovative medical grade foams for acute and chronic wounds POREX Wound Care Foams The ideal wound care solution Our high performance medical grade
More informationMesenchymal Stem Cell Response to Static Tension, Cyclic Tension, and Vibration Brooke McClarren, Ayesha Aijaz, Matthew Teryek, Ronke Olabisi
Mesenchymal Stem Cell Response to Static Tension, Cyclic Tension, and Vibration Brooke McClarren, Ayesha Aijaz, Matthew Teryek, Ronke Olabisi Department of Biomedical Engineering, Rutgers University, New
More informationMedical Device Solutions: Thermoplastic Polyurethane (TPU)
Medical Device Solutions: Thermoplastic Polyurethane (TPU) Table of Contents Page About Lubrizol Lifesciences...4 Medical Grade TPU...5 Tecothane and Pellethane - Aromatic TPU for Processing and Performance...6-7
More informationCourse Syllabus. BMEN 4360: Biomaterials and Medical Devices Fall Course Information
Course Syllabus Course Information Course Number/Section: BMEN 4360.001 Biomaterials and Medical Devices Term: Fall 2016 Days &Times: Class meets in JSOM 2.902 on Mondays and Wednesdays, 8:30 AM 9:45 AM
More informationSoft Solids Research
Soft Solids Research Hydrogels for load-bearing applications Gavin Braithwaite Cambridge Polymer Group, 56 Roland Street, Suite 310 Boston, MA 02129 Cambridge Polymer Group, Inc. Testing, Consultation,
More informationTissue Engineering: The art of growing body parts. Robby Bowles, Ph.D Cornell University
Tissue Engineering: The art of growing body parts Robby Bowles, Ph.D Cornell University What is Tissue Engineering? What is Tissue Engineering? TE is an interdisciplinary field that applies the principles
More informationSupporting Information. Self-Supporting Nanoclay as Internal Scaffold Material for Direct Printing of Soft Hydrogel Composite Structures in Air
Supporting Information Self-Supporting Nanoclay as Internal Scaffold Material for Direct Printing of Soft Hydrogel Composite Structures in Air Yifei Jin 1, Chengcheng Liu 2, Wenxuan Chai 1, Ashley Compaan
More informationRadiation Processing of Natural and Synthetic Polymers for Potential Applications El-Sayed A. Hegazy Former Chairman, National Center for Radiation
Radiation Processing of Natural and Synthetic Polymers for Potential Applications El-Sayed A. Hegazy Former Chairman, National Center for Radiation Research and Technology Atomic Energy Authority Cairo,
More informationAnalysis of a Hydrogel using both a Q-Series and a Nano DSC
Analysis of a Hydrogel using both a Q-Series and a Nano DSC Nathan Hesse, Ph.D. and Tianhong Chen, Ph.D. TA Instruments, 159 Lukens Drive, New Castle, DE 19720, USA Abstract Gelatin-based hydrogels consist
More information3D printed Nanocellulosic materials and their composite
3D printed Nanocellulosic materials and their composite By Vincent Li 1, 2 Advised by Professor H.Qi 1,3, and Professor Y. Deng 1, 2 1 Renewable Bioproducts Institute 2 School of Chemical and Biomolecular
More informationSwelling Behavior of Acrylamide-2-Hydroxyethyl Methacrylate Hydrogels
Turk J Chem 24 (2000), 147 156. c TÜBİTAK Swelling Behavior of Acrylamide-2-Hydroxyethyl Methacrylate Hydrogels Belma IŞIK Hacettepe University, Chemistry Department, 06532, Beytepe, Ankara-TURKEY Received
More informationIK4 BIOTECHNOLOGY & BIOMATERIALS. Research Alliance.
IK4 Research Alliance BIOTECHNOLOGY & BIOMATERIALS www.ik4.es BIOTECHNOLOGY AND BIOMATERIALS, CROSS-CUTTING TECHNOLOGIES The biotechnology and biomaterials fields are characterised by the fact that they
More informationChitosan-g-Poly(Acrylic Acid)/Kaolin Superabsorbent Composite: Synthesis and Characterization
Chitosan-g-Poly(Acrylic Acid)/Kaolin Superabsorbent Composite: Synthesis and Characterization Chitosan-g-Poly(Acrylic Acid)/Kaolin Superabsorbent Composite: Synthesis and Characterization A. Pourjavadi*
More informationProtein Interaction with Novel Hydrogel Biomaterials
Iranian Polymer Journal / volume 6 Number 2 (1997) 10261265197 Protein Interaction with Novel Hydrogel Biomaterials Reyhaneh Sariri Chemistry Department, Gilan University, Rasht, I.R.Iran Received: 18
More informationEngineering The Future
Engineering The Future The world s preferred supplier of biodegradable polymers, polymer-based technologies, and polymeric products for the drug delivery and medical device industries. Greetings When I
More informationAIT/Athlone Institute of Technology
Technology Complete denomination: Higher Education Institute Location (city, country): Athlone, Ireland President: Prof.Ciaran O Cathain GENERAL PRESENTATION Contact person in NEWGEN: Dr. Declan Devine:
More informationThe University of North Texas Department of Materials Science & Engineering
The University of North Texas Department of Materials Science & Engineering 2017 Spring Semester Course Title: MTSE 4020, Materials in Medicine Instructor: Narendra B. Dahotre, Office DP C136E, Phone:
More informationPRINCIPLES AND PRACTICE OF TISSUE ENGNEERING:
Harvard-MIT Division of Health Sciences and Technology HST.535: Principles and Practice of Tissue Engineering Instructor: Myron Spector Massachusetts Institute of Technology Harvard Medical School Brigham
More informationPolymers against Microorganisms
Polymers against Microorganisms Juan Rodríguez-Hernández Polymers against Microorganisms On the Race to Efficient Antimicrobial Materials Juan Rodríguez-Hernández Institute of Polymer Science & Technology
More informationFunctional Polysaccharide Materials. Nathan S. Mosier Ag. and Bio. Engineering Purdue University
Functional Polysaccharide Materials Nathan S. Mosier Ag. and Bio. Engineering Purdue University Glycoscience in Mammalian Systems Attached to cells and enzymes mportant for protein function and cell-to-cell
More informationRegenerez : A Next-Generation Material for Functional Bioresorbable Coatings. by Carissa Smoot and Jeremy Harris, Ph.D, Secant Medical, Inc.
Regenerez : A Next-Generation Material for Functional Bioresorbable Coatings by Carissa Smoot and Jeremy Harris, Ph.D, Secant Medical, Inc. Coatings consisting of natural and synthetic origin play an important
More informationWhite Paper: Designing Functional Fabrics for Today s Heart Valves and Beyond
White Paper: Designing Functional Fabrics for Today s Heart Valves and Beyond Ryan Heniford Business Development Director Peter Gabriele Director, Emerging Technology How fabrics can be used in heart valves,
More informationEnzymatic Hydrolysis of Silk Fibroin Peptide for Hemorrhage Control
2015 2 nd International Conference on Material Engineering and Application (ICMEA 2015) ISBN: 978-1-60595-323-6 Enzymatic Hydrolysis of Silk Fibroin Peptide for Hemorrhage Control Jingjing Li 1,2, Hailin
More informationLEE GOETZ ART RAGAUSKAS
Cellulose Based Hydrogels and Absorbents LEE GETZ ART RAGAUSKAS Hypothesis Cellulosics can be crosslinked with poly (methyl vinyl ether-co-maleate) (PMVEMA) poly ethylene glycol (PEG) and will exhibit
More informationRESEARCH REPOSITORY.
RESEARCH REPOSITORY This is the author s final version of the work, as accepted for publication following peer review but without the publisher s layout or pagination. The definitive version is available
More informationFebruary 15, 2018 Victoria Tran Industries
February 15, 2018 Victoria Tran Industries 1 Device Protection Solutions Specialty Printing Cleanroom Tapes & Labels Manufactures proprietary polymers and films Used to protect, process and transport fragile,
More informationAdvanced Biomaterials and Nanotechnologies in Drug Delivery
NANOTECHNOLOGY & ADVANCED MATERIALS SYMPOSIUM Advanced Biomaterials and Nanotechnologies in Drug Delivery Date : 25 September 2015 (Friday) Time : 2:00pm 5:00pm (Registration starts at 1:45pm) Venue :
More informationSummary and conclusions
Chapter 6 Wound which refers to a sharp injury damaging the dermis of the skin is a common problem in day to day life. Wound management is careful and accurate assessment of the wound with the use of proper
More informationSurface Construction Of Zn Doped Hydroxyapatite/mgf2 Multilayer Coatings For The Biomedical Mg Materials By A Novel Conversion/sol-gel Method
Surface Construction Of Zn Doped Hydroxyapatite/mgf2 Multilayer Coatings For The Biomedical Mg Materials By A Novel Conversion/sol-gel Method Heng Jui Liu 1, Da Jun Lin 1, Subhaini jakfar 2, Fei Yi Hung
More informationExperimental Characterisation of the Alginate Gelation Process for Rapid Prototyping
Experimental Characterisation of the Alginate Gelation Process for Rapid Prototyping R.A. Rezende 1,2, P.J. Bártolo 1, A. Mendes 1, R. Maciel Filho 2 1 Centre for Rapid and Sustainable Product Development
More informationPhoto-crosslinkable, thermo-sensitive and biodegradable Pluronic hydrogels for sustained release of protein
J. Biomater. Sci. Polymer Edn, Vol. 15, No. 12, pp. 1571 1583 (2004) VSP 2004. Also available online - www.vsppub.com Photo-crosslinkable, thermo-sensitive and biodegradable Pluronic hydrogels for sustained
More informationControlled Drug Release Using Core-shell Hydrogel Nanoparticles for Pancreatic Cancer
Controlled Drug Release Using Core-shell Hydrogel Nanoparticles for Pancreatic Cancer Funded by Mayo-UCF Seed Grant Program Santanu Bhattacharya, Ph.D. Associate Consultant Biochemistry and Molecular Biology
More informationCourse Handbook MSc in Bioengineering Tissue Engineering Specialisation
Course Handbook 2013-2014 MSc in Bioengineering Tissue Engineering Specialisation 1 Course Objectives & Learning Outcomes This programme aims to give a sound and broad basis in tissue engineering. In particular,
More informationBiodegradable Polymers for Medical Applications
University of Wollongong Research Online Faculty of Engineering and Information Sciences - Papers: Part B Faculty of Engineering and Information Sciences 2016 Biodegradable Polymers for Medical Applications
More informationChapter 1. Introduction
Chapter 1 Introduction Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional
More informationCHARACTERIZATION AND DETERMINATION OF BIOFILM FORMING POTENTIAL OF A WASTE SERICIN-RICH PROTEIN MIXTURE
CHARACTERIZATION AND DETERMINATION OF BIOFILM FORMING POTENTIAL OF A WASTE SERICIN-RICH PROTEIN MIXTURE Goksen Capar 1,2,a, S.Saniye Aygun 1, M. Ruşen Geçit 1 and Kang Li 3 1 Middle East Technical University,
More informationSynthetic Bioabsorbable Polymers for Implants
STP 1396 Synthetic Bioabsorbable Polymers for Implants C. Mauli Agrawal, Jack E. Parr, and Steve T. Lin, editors ASTM Stock Number: STP1396 ASTM 100 Barr Harbor Drive PO Box C700 West Conshohocken, PA
More informationElectron Beam Applications in Korea. Bumsoo Han, SungMyun Kim, and JinKyu Kim
Electron Beam Applications in Korea Bumsoo Han, SungMyun Kim, and JinKyu Kim EB TECH Co., Ltd. 550 Yongsan-dong Yuseong-gu, Daejeon 305-500, Rep. of Korea Electron accelerators were introduced in Korea
More informationDressing Material Moisture facilitate
Wound Healing Concept Dressing Material นพ.ส ทธ ส ทธ ส ณห ส ณห จ นทร ขจร ศ ลยศาสตร ตกแต ง โรงพยาบาลพระมงก ฎเกล า Moisture facilitate - Epidermal migration - Angiogenesis - Connective tissue synthesis -
More informationSelf-Healing Bitumen Using Biomimetic Capillaries Hollow Fibers: Fabrication, Microstructure and Properties
Self-Healing Bitumen Using Biomimetic Capillaries Hollow Fibers: Fabrication, Microstructure and Properties Jun-Feng Su*, Shan Han, Xiao-Long Zhang, Ying-Yuan Wang School of Material Science and Engineering,
More informationBiomaterials in Medical device design
Biomaterials in Medical device design 1 Dr Joseph Buhagiar B. E n g ( H o n s. ) P h D ( B h a m ) D e p a r t m e n t o f M e t a l l u r g y a n d M a t e r i a l s E n g i n e e r i n g U n i v e r
More information5.1 Essentials of Polymer Composites
5 Polymer Composites Polymer modification can follow from the mixing of two or more macromolecular compounds or their filling with reinforcing materials of inorganic or organic substances. It enables the
More informationSupplementary Figure S1. Swelling and mechanical properties as a function of the PS-b- PAA block copolymer composition. a, Swelling kinetics of PAA
Supplementary Figure S1. Swelling and mechanical properties as a function of the PS-b- PAA block copolymer composition. a, Swelling kinetics of PAA homopolymer and PS-b-PAAs (4 mm disc with 1 mm thickness)
More informationMECHANICAL PROPERTIES OF SURFACTANT-COATING CARBON NANOFIBER/EPOXY COMPOSITE
International Journal of Nanoscience, Vol. 1, Nos. 5 & 6 (2002) 1 6 c World Scientific Publishing Company MECHANICAL PROPERTIES OF SURFACTANT-COATING CARBON NANOFIBER/EPOXY COMPOSITE ZHE YING,, JIN-HONG
More informationKick-off meeting. Introducing: INNOVENT e. V. Barcelona, 3-5 March 2014
DEVELOPMENT OF SUSTAINABLE INTERRELATIONS BET- WEEN EDUCATION, RESEARCH AND INNOVATION AT WBC UNIVERSITIES IN NANOTECHNOLOGIES AND ADVANCED MATERIALS WHERE INNOVATION MEANS BUSINESS Introducing: INNOVENT
More informationPreparation of Biodegradable Gradient Polymer by Microwave
Advanced Materials Research Online: 2011-05-12 ISSN: 1662-8985, Vols. 236-238, pp 1949-1953 doi:10.4028/www.scientific.net/amr.236-238.1949 2011 Trans Tech Publications, Switzerland Preparation of Biodegradable
More informationThiolatedpoly(aspartic acid) polymers in ophthalmic therapy
Thiolatedpoly(aspartic acid) polymers in ophthalmic therapy Gabriella Horvát 1, Benjámin Gyarmati 2, Barnabás Szilágyi 2, András Szilágyi 2, Szilvia Berkó 1, Erzsébet Csányi 1,Piroska Szabó-Révész 1, GiuseppinaSandri
More informationPolyphosphoesters: New Biocompatible, Biodegradable Polymers for Biomedical Applications. Jeniree A. Flores. Advisor: Prof. Karen L.
Polyphosphoesters: New Biocompatible, Biodegradable Polymers for Biomedical Applications Jeniree A. Flores Advisor: Prof. Karen L. Wooley November 12 th, 2012 Polyphosphoesters (PPEs) are phosphorous containing
More informationThe Effect of Electron Beam Irradiation on PE-g-MA Compatibilised Linear Low-density Polyethylene/Soya Powder Blends
Journal of Engineering Science, Vol. 9, 51 59, 2013 51 The Effect of Electron Beam Irradiation on PE-g-MA Compatibilised Linear Low-density Polyethylene/Soya Powder Blends Sam Sung Ting 1*, Lokman Hakim
More informationControlled Release Drug Delivery from Hydrogels
Controlled Release Drug Delivery from Hydrogels Teacher s Guide Keith Neeves CSIP Graduate Fellow Cornell University 1 Overview The objective of this project is to introduce students to the concepts of
More informationArticle Electrically Conductive Polyacrylamide-Polyaniline Superabsorbing Polymer Hydrogels
OPEN ACCESS http://sciforum.net/conference/ecm-1 Article Electrically Conductive Polyacrylamide-Polyaniline Superabsorbing Polymer Hydrogels Nedal Abu-Thabit 1,* and Yunusa Umar 2 1 Department of Chemical
More informationPittsburgh Tissue Engineering Initiative Annual Progress Report: 2010 Formula Grant
Pittsburgh Tissue Engineering Initiative Annual Progress Report: 2010 Formula Grant Reporting Period July 1, 2011 December 31, 2011 Formula Grant Overview The Pittsburgh Tissue Engineering Initiative,
More informationSUCCIPACK Development of active, intelligent and sustainable food PACKaging using Polybutylenesuccinate
Page 1 / 13 SUCCIPACK Development of active, intelligent and sustainable food PACKaging using Polybutylenesuccinate Project co-funded by the European Commission within the Seventh Framework Programme (2007-2013)
More informationBone Tissue Engineering
Bone Tissue Engineering Miqin Zhang University of Washington Dept of Materials Science and Engineering Funded by UWEB: A National Science Foundation Engineering Research Center (NSF-EEC 9529161) Bone Defects
More informationHyaluronic Acid Based Hydrogels
Marie Skłodowska-Curie Actions (MSCA) Innovative Training Networks (ITN) H2020-MSCA-ITN-2014 Hyaluronic Acid Based Hydrogels Evgenia Tsanaktsidou, Engineering Responsive and Biomimetic Hydrogels for Biomedical
More informationBiodegradable Polymers
Polymers Research Group Prof. Dr. Maria Isabel Felisberti misabel@iqm.unicamp.br Universidade Estadual de ampinas - Unicamp hemistry Institute Biodegradable Polymers Dr. Juliana Aristéia de Lima julima@iqm.unicamp.br
More informationW BIOENGINEERING. Nanomaterials Applications in Biology and Medicine. Topics:
Nanomaterials Applications in Biology and Medicine Obejctive: Develop a firm understanding of the fundamental materials science and engineering principles underlying synthetic/engineered materials used
More informationPolitecnico di Torino Dipartimento di Scienza dei Materiali e Ingegneria Chimica
22nd IFATCC INTERNATIONAL CONGRESS 5-7 May 2010 Ing. Monica PERIOLATTO Prof. Franco FERRERO Politecnico di Torino Dipartimento di Scienza dei Materiali e Ingegneria Chimica 1 Presence of bacteria, gram
More informationContents 1 Nanotechnology and Its Drug Delivery Applications
Contents 1 Nanotechnology and Its Drug Delivery Applications... 1 1.1 Introduction... 1 1.2 Historical Prospects of Nanotechnology... 2 1.3 Promising Role in Drug Delivery... 3 1.3.1 Nanoparticles and
More informationRADIATION EFFECTS ON THE PROPERTIES OF POLYETHYLENE FOAMS CROSSLINKED BY ELECTRON BEAM
RADIATION EFFECTS ON THE PROPERTIES OF POLYETHYLENE FOAMS CROSSLINKED BY ELECTRON BEAM D. B. Dias, E. S. Pino, L. G. Andrade e Silva Instituto de Pesquisas Energéticas e Nucleares IPEN/CNEN-SP Centro de
More informationPHARMA SCIENCE MONITOR
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES SYNTHESIS, CHARACTERIZATION AND ELECTRICAL STIMULUS SENSITIVE BEHAVIOR OF psy-cl-poly(aa) HYDROGEL Deepak Prashar * 1, Shalini
More informationPatterning of PEG-based Hydrogels - Engineering Spatial Complexity
Page 1 of 5 Page 1 of 5 Return to Web Version Patterning of PEG-based Hydrogels - Engineering Spatial Complexity By: Mariah S. Hahn, Material Matters 2010, 5.3, 62. Department of Chemical Engineering,
More information