The Emergence of Flow Cytometry as a Routine Diagnostic Testing Technology Right Here in Our Own Back Yard! Mike Reed February 2013
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1 The Emergence of Flow Cytometry as a Routine Diagnostic Testing Technology Right Here in Our Own Back Yard! Mike Reed February 2013
2 Overview Danaher designs, manufactures, and markets innovative products and services to professional, medical, industrial, and commercial customers. Driven by strong core values and a foundation provided by the Danaher Business System, Danaher's associates are pursuing a focused strategy aimed at creating a premier global enterprise. Founded 1984 Headquartered in Washington, DC New York Stock Exchange Listed (DHR) ~58,000 associates worldwide
3 20-Year Total Shareholder Return DHR vs. S&P % 5 Year DHR S&P 500 Difference 31.0% (1.2)% 32.2% 4000% 10 Year 20 Year 202.0% % 30.5% 349.6% 171.5% % DHR 3000% 2000% 1000% S&P 0% Dec-91 Dec-93 Dec-95 Dec-97 Dec-99 Dec-01 Dec-03 Dec-05 Dec-07 Dec-09 Dec-11 Outperforming over the long term
4 DHR Today Niche 17% Test & Measurement 15% Industrial Technologies 12% Dental 13% Tools 32% Motion 21% Environmental 15% Environmental 18% Test & Measurement 21% Life Sciences & Diagnostics 29% Revenue: $3.8B Gross Margin: 38% EPS: $ EPS CAGR DHR 19.0% S&P 7.7% Revenue: $16.1B Gross Margin: ~50% EPS: $2.83 4X revenue base and continuing to evolve the portfolio while outperforming the market
5 Multi-Industry with Strong Brands
6 Life Sciences & Diagnostics Overview ~$34B Market Size 5-7% Long Term Market Growth $4.6B 2011 Sales 65% Instruments 35% Consumables / Service Brand Market Position #1 / #2 #2 #1 #1 8.7% 2011 Operating Margin 31% ROW Geographic Mix (as % of 2011 sales) 37% NA Customers Hospitals Reference labs Government/academic research #1 / #2 32% EU Food & beverage, pharmaceuticals, forensics Leading global brand serving attractive microscopy & histopathology markets
7 Helping customers unlock tomorrow's discoveries
8 Beckman Coulter Beckman and Coulter: Two of the most respected names in the industry Arnold O. Beckman, Ph.D.: inventor of the acidimeter Wallace and Joseph Coulter: discovered the Coulter Principle Created a company dedicated to improving patient health and reducing the cost of care More than 275,000 systems operate in laboratories on every continent Our inspiration: Improving patient health and reducing the cost of care
9 Diagnostics Technology Leadership > Chemistry > Immunoassay > Hematology > Information Systems > Clin Lab Automation > Molecular Diagnostics We enable physicians to make patient healthcare decisions
10 Life Sciences Technology Leadership > Flow Cytometry > Centrifugation > Life Science Automation > Capillary Electrophoresis > Particle Characterization > Genomics We empower researchers with solutions to accelerate scientific breakthroughs
11 Locations/Global Reach Marseille Galway Danvers Miami Indianapolis Fort Collins Carlsbad Brea
12 Life Sciences Flow Cytometry
13 What is Flow Cytometry? + Sample: Cells +/- Fluorescent labels Flow Cell Laser light source Fluorescent light collected Reflected and transmitted light collected
14 Beckman Coulter Flow Cytometry #2 in the market Global Development & Manufacturing Basic research and biomarker discovery 15% 60% Clinical diagnostics Clinical studies and trials 25% Primary Customers
15 Beckman Coulter Flow Cytometry EPICS 1V 2 lasers, 3 colors EPICS Profile II benchtop Cytometer EPICS XL Fully automated clinical cytometer FC500 advanced cytometer (5 color) Navios/Gallios advanced cytometer (10 color) EPICS II First Laser Analyzer TPS EPICS laser sorter Q-PREP TM introduced 1st automated flow prep EPICS Altra TM Sorter PrepPlus TM Sample preparation for flow cytometry FP1000 cytometry auto prep Astrios 7 laser sorter
16 Reagent development and manufacturing for Flow Cytometry Marseille, France
17 Hardware and reagent manufacturing and development for Flow Cytometry Kendall, Hialeah, Pembroke Pines Miami, Florida
18 Product design and development for Flow Cytometry Sorters Ft. Collins, Colorado
19 Our Portfolio TQ-Prep TQ-Prep KALUZA 1.2 FP1000 Software Sample Prep Analyzer Sorter Reagents Navios CyAn Gallios FC IVD/CE-IVD products 473 ASR products 1,900 RUO products Multicolor Combinations Custom Design Service Contract Manufacturing Service
20 TQ-Prep New Products Launched in 2012 TQ-Prep KALUZA 1.2 FP1000 Software Sample Prep ACPrep 3000 M&A Analyzer AQUIOS C and CL Sorter Reagents Navios CyAn Gallios FC500 Gallios IVD/CE-IVD products 473 ASR products 1,900 RUO products Multicolor Combinations Custom Design Service Contract Manufacturing Service
21 Surface, Intracellular, and Functional Analysis Providing complete solutions for specimen and data handling to study: T cells, B cells, monocytes, macrophages, granulocytes, stem cells, cancer, microparticles, platelets Surface Marker Analysis (Constitutive and activation-dependent receptors) Cell Function Analysis (Pathway activation and inhibition) Intracellular Marker Analysis (Cytosolic and nuclear markers)
22 Testing for HIV+ progression to AIDS CD4 enumeration What is it used for?
23 FOR RESEARCH USE ONLY Fully Automated Load & Go
24 Aquios Simple Fully automated process Easy to learn; Easy to use Smart Quality results Reagent monitoring Safe to operate Efficient Higher Throughput Reduced Labor More Compact Lower Overall Cost Aquios CL System FOR RESEARCH USE ONLY
25 NHLS & BEC s South African Solution
26 NHLS & BEC s South African Solution Automated PLG >300 samples per 8 hour shift 5 min technician time Sample to Answer Flow Aquios
27 Leukemia and Lymphoma Diagnosis What is it used for?
28 Interrogating Intra-cellular Signaling Pathways What is it used for?
29 Immune monitoring for Bone Marrow Transplant patients What is it used for?
30 Immune monitoring for autoimmune disease patients What is it used for?
31 Immune monitoring for Solid Organ Transplant patients What is it used for?
32 A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation
33 A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation
34 We are what we repeatedly do. Excellence, therefore, is not an act, but a habit. Aristotle
35 Our process begins and ends with the customer We re better together
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