BioProcess Media Planner. Print Media Digital Media Custom Publishing Live Events Interactive

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1 BioProcess TM I N T E R N A T I O N A L 2016 Media Planner Print Media Digital Media Custom Publishing Live Events Interactive

2 BPI Print Media BioProcess International s success is derived from its unique ability to consistently acquire, present, and publish the most relatable and applicable scientific information to its 30,010 BPA qualified print and 80,000 total biopharmaceutical subscribers. Whether it s a main scientific issue, a dedicated supplement, focused special report, or custom publishing effort, BPIs readers understand and expect that every print edition they receive contains information they can use to improve their current process. In this science-based market, print media continues to grow as the top information resource. In fact, 82.6% of BioProcess International s readers (that s up 4% vs. year prior!) read and use print media to gather information about new bioprocess applications and technologies. This is where BioProcess International excels. This is our expertise. Main Scientific Issues Every edition is dedicated to the core pillars of bioprocessing: Upstream Processing, Downstream Processing, and Manufacturing. Every peer-reviewed article is carefully selected and designed to ensure it educates and delivers the appropriate balance of cutting-edge experiences, personal insight and scientific results. Utilize BPI s main issues to strategically position your expertise within the right scientific environment and connect with your target audience to introduce and reinforce the impact of your solutions. Dedicated Technology Supplements Only BioProcess International has the experience to identify, create and deliver entire single-themed supplements dedicated to championing the most important science, technology, and business breakthroughs impacting present and future decision-making. In 2016, BPI s technology supplement series is dedicated to championing three core technologies: Cell Therapies, Single-Use Technologies, and Outsourcing Partnerships. CMC Strategy Forum Series A 12-year educational collaboration between BioProcess International and CASSS, the CMC Strategy Special Reports provide leading industry, academic, and regulatory professionals with unique perspective and expert opinion on relevant chemistry, manufacturing, and control (CMC) issues throughout a products lifecycle in order to ensure that biopharmaceutical products manufactured in a regulated environment will continue to be safe and efficacious. In 2016, the 4-part CMC Strategy Forum Series will focus on process and product-related impurities. Special Reports These unique 7 x9 digest size reports provide BioProcess International with a proper format to editorially target and educate the market on cutting-edge techniques and technologies. These reports are printed on heavy paper stock, inserted into main scientific issues and delivered to BPI s full print and electronic readership, and as a bonus, are distributed independently to every industry conference and event BPI s attends throughout the year. In 2016, BioProcess International s special report series will focus on four themes: Immunotherapies, Continuous Processing, Antibody-Drug Conjugates (ADCs) and Women in Bio (a 4-part series)

3 Dedicated Technology Supplements Single-Use Technologies (March and November) MARCH 2016: Single-Use Supply Chains Emerging Guidelines for Supplier Change Notifications As single-use technologies (SUTs) enhance bioprocess operations, suppliers and users are embracing elements of standardization that many were unwilling to consider before. This special issue explores critical new initiatives to ensure robust supply chains throughout a product s lifetime by developing best practices for supplier change notifications. NOVEMBER 2016: Single-Use Technologies Key Decisions Behind Implementation Building on the March supplement theme, this edition focuses on how supplier change notifications and existing approaches to supply-chain assurance may encourage or discourage single-use implementation. This issue examines the single-use vs fixed equipment business decision and how such decisions can be influenced by stability and consistency of component sources and how standardization efforts are increasing confidence in single-use sourcing. Cell Therapy BioProcessing (April and October) APRIL 2016: Cell Therapies Fine Tuning Strategies for Commercial Success To create blockbuster therapies, the cell therapy market must recognize and design solutions to the technical and operational gaps that currently exist in commercial strategies. The pipeline is maturing. To be successful, the time is now for companies to address critical needs necessary for commercial success, including: controlling costs, manage supply chains, adapting existing biotechnologies for scale-up, and contamination control just to name a few. The discussion creates a perfect environment to showcase your company s solutions. OCTOBER 2016: Cell Therapies Critical Advances in Technologies and Processes Advances in technologies, materials, and processes are needed to position cell therapies and other regenerative medicines for commercial success. But unless developers can trim costs of production, scale-up, and distributions, these therapies may not achieve their potential. This issue explores current progress in cell expansion and bioprocessing and efforts to lower overall development and manufacturing costs. Outsourcing Partnerships (May and September) MAY 2016: Outsourcing Technologies What Do CROs/CMOs/CDMOs Do Best, and Why? Certain aspects of biopharmaceutical development and manufacturing are more often outsourced than not: e.g., viral safety, drug-product manufacturing, and antibody drug conjugation. This investigative issue will address the technological side of outsourcing from analytical methods and bioprocess operations to transferring product and process and information. The issue will also focus on what can contract manufacturers teach drug developers about the future of multiproduct facilities. SEPTEMBER 2016: Outsourcing Strategy When, Where, and How to Manage Contract Projects The modern question is less about whether to outsource biopharmaceutical projects and more about when to do so, where to go with them, and how to manage the resulting contract relationships. How do you make the most of your in-house expertise while leveraging partner capabilities? This issue will address these strategic issues in relation to contract research, development, and manufacturing.

4 CMC Strategy Forum Series Process and Product-Related Impurities JANUARY 2016: Defining Your Product Profile and Maintaining Control Over It Topics address challenges presented by host-cell protein impurities and characterizing and minimizing aggregation. Current commentary from some of the original authors and/or BPI advisors will update key issues. APRIL 2016: Mycoplasma In-Process and Lot Release Testing To PCR or Not to PCR An early CMC Strategy Forum sought consensus regarding testing for mycoplasma infection. Such contamination threatens a product s safety, purity, potency, and consistency. Rapid microbial test methods and characterization focused on applications of polymerase chain reaction methods (PCR). New commentary will explore how these consensus points have stood the test of time. SEPTEMBER 2016: Extractable and Leachables Challenges and Strategies in Biopharmaceutical Development A recent CMC Strategy Forum presented stage-of-the-art technologies for extractables and leachables analysis, stability studies, acceptance limits, and container-closure systems. It coincided with heightened interest in the topic among early proponents of single-use technologies. Follow-up interviews will place this consensus paper in current perspective, highlighting progress made and issues yet to be resolved. NOVEMBER 2016: A Practical Approach to the Analysis and Immunogenic Potential of Aggregates and Particles A CMC Forum paper presented technologies for detecting and analyzing particulates in biopharmaceutical products. How are bioprocessers gaining product-specific knowledge for assessing aggregation risks on product quality, safety, and efficacy? What control strategies support lot release, stability, and comparability assessments? Interviews will discuss advancements made since this original publication.

5 Special Report Series Technical Series MARCH 2016: Immunotherapies Can BioProcess Technology Help Resolve Pricing Dilemmas? Immunotherapies (biologics/cell therapies/vaccines) are among the most promising treatments in development. But many people warn that unless such products are priced so as to be reimbursable, they may never achieve their full market potential. This report focuses on cancer immunotherapies in development to show how companies are using technology to address economic realities. MAY 2016: Continuous Processing Approaches, Technologies, and Economics Although continuous bioprocessing has been proposed for many years, progress appears to be accelerating thanks especially to applications of perfusion technologies. But many questions remain: Where are new approaches taking hold? Is more progress being made upstream than downstream? How will continuous processes at one phase affect those at following phases? How continuous can continuous become? This report will provide answers to these and many more questions NOVEMBER 2016: Antibody Drug Conjugates (ADCs) Addressing Development and Manufacturing Challenges The highly potent chemical components of ADCs lend both promise and complexity to this emerging class of biopharmaceuticals. Related technologies continue to advance, but concerns about worker safety, training, and product characterization remain. BPI will update the industry in recent advances in development and point to technical and scientific tasks still to be elucidated. Women in Bio Series FEBRUARY 2016: JUNE 2016: OCTOBER 2016: Focus on Education Focus on Entrepreneurship Focus on Science and Business DECEMBER 2016: Focus on Careers

6 Interactive Electronic Media A balanced marketing strategy is key to generating the lead generation and ROI you need, demand and expect. Utilize BioProcess International s unique portfolio of online, electronic, and interactive products to reach and impact BPI s 50,000+ electronic readers in North America, Europe, and Asia-Pacific. Banner advertising on bioprocessintl.com In 2015 (Jan-October), BioProcess International s website averaged 90,000+ page views per month. BPI s issue and supplement landing pages averaged 3,700+ monthly page views. Top 5 landing pages: Archives, Events Calendar, Multimedia/Webinars, News, and the 2014 BPI Awards. Top 5 scientific landing pages: Upstream Processing, Downstream Processing, Manufacturing, Analytical, and Business. SEO stats: 58% organic search (google), 32% direct, and 5% referral. North America accounted for 46% of all visitors, Europe - 23%, ROW 31%. 63% were first time visitors, 84% used a desktop (vs. mobile device). To date, bioprocessintl.com has registered 10,585 site users. Scientific enewsletter Series Designed to compliment BPI s new website, the enewsletter Series electronically delivers targeted and themed scientific information on a weekly schedule to 50,000+ biopharmaceutical professionals in North America, Europe, and Asia-Pacific. Each enewsletter focuses on the three main pillars of bioprocessing: upstream processing, downstream processing manufacturing, and Asia-Pacific. enewsletter sponsors are limited to six per edition. Ask the Expert Webcast Series This unique turnkey program combines the lead generation of a traditional webcast with the prominence of a published full page article in BioProcess International. The program begins with a ten minute webcast followed by a five minute Q&A. This combination provides your company with an effective opportunity to introduce your equipment and expertise, generate qualified leads, and directly interact and engage in Q&A with qualified biopharmaceutical decision makers. The webcast is recorded, then transcribed, edited and published as a full page Ask the Expert article in a pre-determined scientific issue BioProcess International. Outbound Multimedia Alerts BPI s Multimedia Alerts, delivered weekly to BPI s qualified opt-in readership, then hosted on BPI s multimedia page up to a full year, provide sponsors with the opportunity to electronically connect your expertise to the market. Required registration provides detailed lead generation.

7 Live Events The BPI BIO As the biopharmaceutical industry continues to mature and grow, so too does the need to educate a broader audience of biopharmaceutical professionals interested in hearing, understanding, and applying the latest science and technology trends that support and in many cases are transforming today s bioprocesses. Since 2008, the BPI BIO has provided standing room only audiences with the opportunity to interact with leading biopharmaceutical industry experts as the present, discuss, and debate the impact of the latest scientific and technology trends impacting the three pillars of biopharmaceutical development: upstream processing, downstream processing, and manufacturing. The BPI BIO, a dedicated amphitheater located on the exhibition floor at the heart of the BioProcess Zone, is designed to supplement BIO s main educational program and provide convention attendees with daily, complimentary scientific programming while providing a destination for biopharmaceutical professionals to meet, learn, and network. In 2016, reserve your speaking sponsorship and receive the following benefits: 25 minute presentation within scientific track of choice; Publishing of presentation (w/link to on-demand VOPP) in BPI s Theater supplement (August 2016) Full page advertisements in BIO show issue (May 2016) and BPI Theater Supplement (August 2016) Lead generation for a full year Corporate profile in the Roadmap the BioProcess Zone and Theater 2015 BPI BIO webcasts: bpi-theater-bio-2015/ 2016 BPI Awards The mission of BioProcess International is to consistently deliver valuable information that allows the biotechnology community to continue on the path towards scientific advancements, revolutionary technological applications, and strategic partnerships and collaborations. The mission of the BioProcess International Awards is to provide the industry with a chance to pause and recognize and honor the outstanding people, organizations, and technologies that have significantly influenced and advanced the efficiency of biotherapeutic development and manufacturing processes, ultimately allowing the industry to deliver better, more effective treatments to a global patient base. In 2016, The BioProcess International Awards will introduce and honor an exclusive group of finalists that represent the very best technologies, applications, collaborations, and thought-leaders the bioprocessing industry has to offer. The 2016 award categories include: THE PEOPLE Best Collaboration Excellence in Leadership BPI Honors Industry Champions ORGANIZATIONS Excellence in Facility Design or Retrofit Emerging Company Corporate Citizenship TECHNOLOGIES (User or Supplier) Best Upstream Technology Application Best Downstream Technology Application Best Analytical Technology Application 2016 BPI Awards sponsors receive: Pre-event visibility (March October) Positioning within finalist insert (September) Dedicated awards ceremony table (October) Advertisement in BPI Awards special report (December) 2016 BPI Awards Timeline Nominations open January Sponsors announced March 2016 Nominations close June 2016 Finalists announced September 2016 Awards Dinner and Ceremony October 2016 (at the BPI Conference)

8 Custom Publishing and Annual Resources Custom Publishing Services Marketing your expertise in BioProcess International s published products are designed to deliver the impact, visibility, and return you need to support your sales strategy and deliver your revenue objectives. When you need a bigger platform to showcase and reinforce your company s corporate philosophy, brand, vision, commitment, capabilities, and leadership, turn to BPI s custom publishing services to create dedicated products to effectively differentiate your company from the rest of the industry. BioProcess International s custom publishing services can include licensing and use of BPI branding, corporate/ executive interviews, complete production, editing, printing, logistics, distribution, and marketing. Custom platforms include: all size supplements, special reports, inserts, electronic and online media. Space is limited, so talk to your strategic marketing consultant about timing and availability. Sales Contact Information Annual Resource Issuess BioProcess International s annual resource issues provide suppliers with unique, once-ayear opportunities to introduce and promote your science, your expertise, your vision to the biopharmaceutical market. These issues are dedicated to you. Be a part of it! Industry Yearbook (August 2016) The Annual Industry Yearbook is designed to showcase and promote and promoting this industry s premier suppliers. The format is dedicated to publishing supplier application note(s) stand alone, or pair them with advertisements to create the perfect educational environment to introduce your new technologies, support existing partnerships, and expand your business. Whether you are a regular or a first-time advertiser, BioProcess International s Annual Industry Yearbook issue can serve as a centerpiece of your marketing campaign. Poster Hall (December 2016) Scientific posters are a tremendous resource to biopharmaceutical professionals. Their unique format take industry professionals on a visual journey through the latest experiment results and technology performance that can help biopharmaceutical companies improve existing techniques and processes. However, while your company invests significant time and resources to create posters, they are often difficult to find and access, which significantly limits their lifespan - and your ROI. BioProcess International s Poster Hall issue solves this problem. This unique issue takes biopharmaceutical professionals on an interactive visual and audio journey through the latest case studies, scientific experiments and technology performances that can help the biopharmaceutical industry improve existing techniques, processes and results. Let s get your science published in BPI s 2016 Interactive Poster Hall! Visit the online poster hall: category/posters/ Brian J. Caine Co-Founder and Publisher bcaine@bioprocessintl.com Christopher Johnson Strategic Marketing Consultant (Eastern) cjohnson@bioprocessintl.com Mike Kelly Strategic Marketing Consultant (Western) mkelly@bioprocessintl.com Joanna Taylor Strategic Marketing Consultant (Europe) +44 (0) joanna.taylor@informa.com