Metagenomics in Medicine Towards Disease early Diagnosis and Personalized Treatment
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1 Metagenomics in Medicine Towards Disease early Diagnosis and Personalized Treatment Mohamed El-Hadidi, PhD. Assistant Professor of Bioinformatics, CIT School, Nile University, Egypt. Head of Bioinformatics Group, CIS Center, Nile University, Egypt.
2 10 Facts About the Human Microbiome AFSHG - Young Researchers Forum
3 1. Microbes are Significantly Different in Different Body Regions 11/15/2017 AFSHG - Young Researchers Forum
4 Mirobiomes Varies Among Different Geographic Distribution 11/15/2017 AFSHG - Young Researchers Forum
5 3. 10 Trillion Human Cells 100 Trillion Microbial Cells! 11/15/2017 AFSHG - Young Researchers Forum
6 4. Our First Microbial Communities Depend On How We re Born! 11/15/2017 AFSHG - Young Researchers Forum
7 5. Microbes may affect behavior and mental health 11/15/2017 AFSHG - Young Researchers Forum
8 6. Microbes Determine your Response to Drugs 11/15/2017 AFSHG - Young Researchers Forum
9 7. Antibiotics Alter the Structure of Human Gut Microbiome 8. Altering Microbiome Can Cure Diseases 9. Gut Microbiome Can Be Used in Early Diagnosis of Diseases 10. Human Genes Affects the Functionality of Oral and Gut Microbiome 11/15/2017 AFSHG - Young Researchers Forum
10 7. Antibiotics Alter the Structure of Human Gut Microbiome Ciprofloxacin Administration Post-treatment Period Day 0 Day 1 Day 3 Day 6 Day 8 (+2 days after treatment) Day 34 (+28 days after treatment) 11/15/2017 AFSHG - Young Researchers Forum
11 Different Responses, Same Antibiotic! 11/15/2017 AFSHG - Young Researchers Forum
12 Microbial Community Evolution over the Course of Ciprofloxacin Treatment 11/15/2017 AFSHG - Young Researchers Forum
13 8. Altering Microbiome Can Cure Diseases Probiotics Fecal Microbial Transplant 11/15/2017 AFSHG - Young Researchers Forum
14 A Probiotic To Treat Colonization And Prevent Infection with Pseudomonas Aeruginosa 5 mice 6 time points Drinking water was inoculated by pseudomonas aeruginosa Manuscript in preparation: Florian Hölzl, Hristian Hinkov, Mohamed El-Hadidi, Matthias Willmann, Silke Peter, Kerstin Gronbach, Ingo B. Autenrieth, Julia- Stefanie Frick: The role of the gut microbiome in restoring intestinal colonization with Pseudomonas aeruginosa. 11/15/2017 AFSHG - Young Researchers Forum
15 Faster restoration of the major microbial taxa in the human gut with fecal microbial transplantation (FMT) after treatment with an antibiotic (moxifloxacin) 11/15/2017 AFSHG - Young Researchers Forum
16 Faster restoration of the major microbial taxa in the human gut with fecal microbial transplantation (FMT) after treatment with an antibiotic (moxifloxacin) FMT Case with FMT was able to restore its microbiome quickly \ Baseline \ During Antibiotic P-AB \ Post- FMT 11/15/
17 Faster restoration of the major microbial taxa in the human gut with fecal microbial transplantation (FMT) after treatment with an antibiotic (moxifloxacin) Controls without FMT fail to restore their microbiomes 11/15/2017 AFSHG - Young Researchers Forum
18 9. Gut Microbiome Can be Used in Early Diagnosis of Parkinson s Diseases Alpha-synuclein Over Expression Accumulation of Lewy Bodies Healthy PD Patient Reduced Dopamine Problems in Body Movements SNCA Gene Duplication or Mutations Microbiomes of germ-free transgenic mice overexpressing SNCA genes were compared with wild type mice 11/15/2017 AFSHG - Young Researchers Forum
19 Gut Microbiome Can be Used in Early Diagnosis of Parkinson s Diseases Significant P-Value = differences in microbiome can be used as P-Value = P-Value = biomarkers for early diagnosis of PD P-Value = P-Value = Manuscript in Preparation: Nicolas Casadei, Mohamed El Hadidi, Lisa Schwarz, Thomas Hentrich, Zinah Wassouf, Julia Hentrich-Schulze, Daniel Huson, Olaf Riess: Changes in microbiota in rodents overexpressing the human alpha-synuclein under the human SNCA promoter. 11/15/2017 AFSHG - Young Researchers Forum
20 10. Human Genes Affects The Functionality of Oral and Gut Microbiome Host amylase gene copy number impacts human oral and gut microbiomes In revision with! Nature genetics May 1;46(5): /15/2017 AFSHG - Young Researchers Forum
21 Host Amylase Gene Copy Number Impacts Human Oral and Gut Microbiomes Our findings provide an example of a link between host genetic variation and the composition and function of the microbiome 11/15/2017 AFSHG - Young Researchers Forum
22 It is All About Bioinformatics! 11/15/2017 AFSHG - Young Researchers Forum
23 Acknowledgments Institute of Medical Microbiology and Hygiene Prof. Dr. med. Ingo Autenrieth Prof. Dr. med. Julia-Stefanie Frick Dr. med. Matthias Willmann Dr. med. Silke Peter Dr. med. Florian Hölzl Institute of Medical Genetics and Applied Genomics Prof. Dr. med. Olaf Rieß Dr. Nicolas Casadei Prof. Huson s Lab. Prof. Daniel Huson Sina Beier Ania Gorska Rewati Tappu Dr. Monika Balvočiūte Dr. Benjamin Albrecht Caner Bağcı Marine Gaudefroy Bergmann Dr. Hans-Joachim Ruscheweyh Benjamin Buchfink Cornell University Ruth E. Ley Angela C. Poole University of Antwerp Surbhi Malhotra-Kumar Basil Britto Xavier 11/15/2017 AFSHG - Young Researchers Forum
24 Thank you for your attention! 11/15/2017 AFSHG - Young Researchers Forum
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