Introduction to BIOINFORMATICS
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1 COURSE OF BIOINFORMATICS a.a Introduction to BIOINFORMATICS
2 What is Bioinformatics? (I) The sinergy between biology and informatics
3 What is Bioinformatics? (II) From:
4 (some) Features of Bioinformatics Interdisciplinary Rapidly growing field Highly required expertise Increasingly necessary
5 Bioinformatics Challenges (I) The challenge is: providing researchers with better access to analysis and computing tools in order to advance understanding of genetic data and their interplay in health and diseases finding new approaches to deal with the volume and complexity of data
6 Biological Complexity (I) From:
7 Biological Complexity (II) GWAS (Genome- wide associa/on studies) DATABASES Gene Expression (Microarray expression profile) CNV (Copy- number varia/ons) Protein Interac:on or Protein Complexes ChIP- seq
8 Speed in the capability of Data production Data interpretation
9 Components of Bioinformatics From:
10 What is an Algorithm? Is a finite list of well-defined instructions for calculating a function
11 Bioinformatics: Components and Aims Databases: allowing the storage and management of large biological data sets Algorithms: to determine relationships among members of large data sets The use of these tools for the analysis and interpretation and integration of various types of biological data, including DNA, RNA and protein sequences, protein structures, gene expression profiles, and biochemical pathways
12 Bioinformatics Developers They develop tools for bioinformatics Experts in Mathematics, Statistics and Informatics Computational biologists Bioinformatics Users They use the tools of bioinformatics Researchers (Biologists, Biotechnologist. )
13 Bioinformatics Applications Sequence analysis Genome annotation Literature analysis Analysis of gene expression Analysis of regulation Analysis of protein expression Analysis of mutations in cancer Comparative genomics Computational evolutionary biology Modeling biological systems High-throughput image analysis
14 Bioinformatics Applications: Example (I) To which mouse chromosome this sequence belong?? GTATTAGAGGGTGAAGAAGGCTCTGGAGGCTGCTTCTGGGGAGTGGCTGAGGGACTAGGGCAGCTAATTG CCCATAGCCCCATCCTAGGGGCTTCAGGGACAGTGGCAGCAATGAGAGATTTGAGACTTGGTGTGTTCGT GGGGCCGTAGGCAGGTGCTGTTAACTTGTGTGGGTGTGAGTGGGGACTGAAACAGCGACAGCGAAGGCTG AGAGATGGATGGGTGGACTGAGTTAGAGGACAGAGGTGAGGAAGGCAGGTTGGGAGAGGGGACACTGGCT CCTTGCCAAGTAGCTTGGGGAGGACAGGGTGCTGCAGCTGCCTGCAGCAGTCCTAGCTAGCTCAGATGCC TGCTTGATAAAGCACTGTGGGGGTAACGTGGGTGTGTGTGCCCCTTCTGCAGGGCAGCCTGTGGGAGAAG GGGTATTGGGCAGAAGGAAGGTAAGCCAGCAGGTGGTACCTTGTAGATTGGTTCTCTTGAAGGCTGCTCT TGACATCCCAGGGCACTGGCTTCTTCCTCCCTCCCCGCAAGGTGGGAGGTCCTGAGCGAGGTGTTTCCCT TCGCTCCCACAGGAAAAGCTGCTTTACTGAGTTCTCAAGTTTGGAACTACAGCCATGATTTGGCCACCAT TACAGACCTGGGACTTTAGGGCTAACCAGATCTTTGTAAGGACTTGTGCCTCTTGGGGGACCTCTGCCTG TTCTCATGCTTGGCCCTCTGGCACTTCTGTAGTGGGAGGGATGGGGGGTGGTATTCTGGGATGTGGGTCC CAGGCCTCCCATCCCTCACACAGCCACTGTATCCCCTCTCTCTGTCCTATCATGCCCACGTCTGCCACGA GAGCTAGTCACTGCCGTCCGTACATCACGTCTCACTGTCCTGAGTGCCATGCCTCTCCCAGCCCCCATCC CTGGCCCCTGGGTAGATATGGGCAATATCTGCTCTACACTAGGGGTTGGAGTCCAGGGAAGGCAAAGATT TGGGCCTCAGTCTCTAGTCCTACGTTCCACGAATCCAACCAGTGTGCCTCCCACAAGGAACCTTACGACC TTGTTTGGTTCACTCCATTACTTCCTATCCTGGATGGGAACTGGTGTGTGCCTGCCTGGGGATGACCTTG GACCTCTGCCTTTTCTTTTATCTAAGTGGATGCCTCCTAGGCCTGACTCCTTGTGTTGAGCTGGAGGCAG CCAAGTCAGGTGCCAATGTCTTGGCATCAGTAAGAACAGTCAAGAGTCCCAGGGCAGGGCCACACTTCTC CCATCTTTCGCTTCCACCCCAGCTTGTGATCGCTAGCCTCCCAGAGCTCAGCTGCCATTAAGTCCCCATG How could you know it experimentally?? How could you know it bioinformatically??
15 Bioinformatics Applications: Example (I) Experimentally.. Think about costs, time, pitfalls
16 Bioinformatics Applications: Example (I) Bioinformatically.. costs, time, pitfalls
17 Bioinformatics Applications: Example (II) Is your gene of interest subjected to alternative splicing events? How could you know it experimentally?? How could you know it bioinformatically??
18 Bioinformatics Applications: Example (II) Experimentally.. Is exon 11 alternatively spliced? 10
19 Bioinformatics Applications: Example (II) Bioinformatically..
20 Do you have any Doubt?? Any questions?? Do you need more information??
21 What is Bioinformatics? (III) From:
22 Biological Complexity (III): next generation sequencing From:
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