Enduring Understanding
|
|
- Everett Welch
- 5 years ago
- Views:
Transcription
1 Enduring Understanding The processing of genetic information is imperfect and is a source of genetic variation.
2 Objective: You will be able to create a visual representation to illustrate how changes in a DNA nucleotide sequence can result in a change in the polypeptide produced. Do Now: Read the enduring understanding
3 Mutations are the primary source of genetic variation. External factors, including radiation and reactive chemicals, can cause random changes, e.g., mutations in the DNA Mutagens are physical or chemical agents that can cause mutations Describe the basic process by which a change in the DNA sequence results in a change in a peptide sequence
4 First mrna base (5 end of codon) Third mrna base (3 end of codon) Figure 14.6 Second mrna base U C A G U UUU UUC UUA UUG Phe Leu UCU UCC UCA UCG Ser UAU UAC UAA UAG Tyr Stop Stop UGU UGC UGA UGG Cys Stop Trp U C A G C CUU CUC CUA CUG Leu CCU CCC CCA CCG Pro CAU CAC CAA CAG His Gln CGU CGC CGA CGG Arg U C A G A AUU AUC AUA AUG IIe Met or start ACU ACC ACA ACG Thr AAU AAC AAA AAG Asn Lys AGU AGC AGA AGG Ser Arg U C A G G GUU GUC GUA GUG Val GCU GCC GCA GCG Ala GAU GAC GAA GAG Asp Glu GGU GGC GGA GGG Gly U C A G
5 Essential knowledge: Changes in genotype can result in changes in phenotype. Alterations in a DNA sequence can lead to changes in the type or amount of the protein produced and the consequent phenotype.
6 DNA mutations can be positive, negative or neutral This depends on the on the effect or the lack of effect they have on the resulting protein and the phenotypes that are conferred by the protein. Whether or not a mutation is detrimental, beneficial or neutral depends on the environmental context.
7 Types of Small-Scale Mutations Point mutations within a gene can be divided into two general categories Nucleotide-pair substitutions Insertions or Deletions
8 Figure T T 5 5 Met DNA template strand 3 T 5 mrna 5 Protein Amino end (a) Nucleotide-pair substitution Lys Phe Gly A C T T C A A A C C G A T T A T G A A G T T T G G C T A A A U G A A G U U U G G C U A A Met A C T T C A A A C C A A T T A T G A A G T T T G G T T A A A U G A A G U U U G G U U A A Stop Silent (no effect on amino acid sequence) A C T T C A A A T C G A T T A T G A A G T T T A G C T A A A U G A A G U U U A G C U A A Met Missense Lys 3 T A C 5 T U instead of A 5 U G G Met Nonsense A instead of T Phe Ser A T C A A A C C G A T T A G T A G T T T G G C T A A A U A U U U G G U U A A Stop A instead of G U instead of C T instead of C A instead of G Stop Wild type Lys Phe 3 T T T 5 5 Gly A Met C Stop Carboxyl end (b) Nucleotide-pair insertion or deletion Extra A A T T C A A A C C G A T A T G T A A G T T T G G C T A A U G U A A G U U U G G U U A A C T T C A A C C G A T T A T G A A G T T G G C T A A A U G A A G U U G G G U A A Met A Met Extra U Stop Frameshift causing immediate nonsense (1 nucleotide-pair insertion) T T C A C Lys A Phe A A U Leu C C G Gly A Ala Frameshift causing extensive missense (1 nucleotide-pair deletion) A T G T T T G G C T A A A A G missing missing missing missing A U G U U U G G C U A T T A Stop No frameshift, but one amino acid missing (3 nucleotide-pair deletion) T A A
9 Example of a nucleotide-pair Substitution Silent mutations Would this mutation be positive, negative or neutral?
10 Example of a nucleotide-pair Substitution Missense mutations Would this mutation be positive, negative or neutral?
11 Example of a Nucleotide-Pair Substitution Nonsense mutations When would this mutation be positive?
12 Frameshift mutations can create whole new genes!! Or they can make them useless (deleted)
13 Real World Examples Sickle cell anemia Base pair substitution Cystic Fibrosis (CF)- deletion of three nucleotides that results in the loss of the amino acid phenylalanine and causes an incorrectly folded membrane protein. CF is associated with thick, sticky mucus in the lungs and trouble breathing, salty sweat, infertility in certain individuals, and a shortened life expectancy Cancer
14 Objective: You will be able to describe processes that increase genetic variation. Do Now: Take out your Molecular Evolution of Gene Birth and Death packet
15 Errors in DNA replication or DNA repair mechanisms can cause random changes, e.g., mutations in the DNA.
16 Errors in mitosis or meiosis can result in changes in phenotype. Changes in chromosome number often result in: New phenotypes, including sterility caused by triploidy and increased vigor of other polyploids. Human disorders with developmental limitations Trisomy 21 (Down syndrome) XO (Turner syndrome).
17 Finish Birth and Death of Genes case study Finish packet for homework
18 Objective: You will be able to compare and contrast processes by which genetic variation is produced and maintained in organisms from multiple domains. Do Now:
19 The horizontal acquisitions of genetic information primarily in prokaryotes via: Transformation (uptake of naked DNA), Transduction (viral transmission of genetic information) Conjugation (cell-to-cell transfer) Transposition (movement of DNA segments within and between DNA molecules) All of these increase variation.
20 Figure 13.2 Experiment Living S cells (control) Living R cells (control) Heat-killed S cells (control) Mixture of heat-killed S cells and living R cells Results Mouse dies Mouse healthy Mouse healthy Mouse dies Living S cells
21 Figure Phage infects bacterial donor cell with A + and B + alleles. Transduction Phage DNA A + B + 2 Phage DNA is replicated and proteins synthesized. A + B + Donor cell 3 Fragment of DNA with A + allele is packaged within a phage capsid. A Phage with A + allele infects bacterial recipient cell. Incorporation of phage DNA creates recombinant cell with genotype A + B +. Crossing over Recombinant cell A + A A + B B Recipient cell
22 Figure m Sex pilus
23 Figure 18.7 DNA of genome Transposon is copied Transposon New copy of transposon Insertion Mobile transposon
24 Sexual reproduction in eukaryotes involves Gamete formation, including crossing-over during meiosis The random assortment of chromosomes during meiosis Fertilization
25 Figure Independent Assortment Possibility 1 Possibility 2 Two equally probable arrangements of chromosomes at metaphase I Metaphase II Daughter cells Combination 1 Combination 2 Combination 3 Combination 4
26 Figure Prophase I of meiosis Pair of homologs Chiasma Nonsister chromatids held together during synapsis Synapsis and crossing over Centromere TEM Anaphase I Breakdown of proteins holding sister chromatid arms together Anaphase II Daughter cells Recombinant chromosomes
27 Random Fertilization Each person can make 8.4 million different sex cells from independent assortment That means parents can produce a zygote with about 70 trillion diploid combinations That s without accounting for crossing over
28 Objective: You will be able to construct an explanation of how viruses introduce genetic variation in host organisms. Do Now:
29 Essential knowledge: Viral replication results in genetic variation, and viral infection can introduce genetic variation into the hosts. Viral replication differs from other reproductive strategies and generates genetic variation via various mechanisms.
30 Viral replication differs from other reproductive strategies and generates genetic variation via various mechanisms. Viruses have highly efficient replicative capabilities that allow for rapid evolution and acquisition of new phenotypes Viruses replicate via a component assembly model allowing one virus to produce many progeny simultaneously via the lytic cycle Virus replication allows for mutations to occur through usual host pathways Related viruses can combine/recombine information if they infect the same host cell.
31 Figure Entry and uncoating Replication DNA Capsid HOST CELL VIRUS 3 Transcription and manufacture of capsid proteins Viral DNA mrna Viral DNA Capsid proteins 4 Self-assembly of new virus particles and their exit from the cell
32 Figure This is called the lytic cycle 5 Release 1 Attachment 2 Entry of phage DNA and degradation of host DNA Phage assembly Head Tail Tail fibers 4 Assembly 3 Synthesis of viral genomes and proteins
33 Some viruses are able to integrate into the host DNA and establish a latent (lysogenic) infection.
34 Figure 17.5 Phage Phage DNA The phage injects its DNA. Bacterial chromosome Phage DNA circularizes. Prophage exits chromosome. Daughter cell with prophage Many cell divisions create many infected bacteria. Lytic cycle The cell lyses, releasing phages. Lysogenic cycle Prophage Prophage is copied with bacterial chromosome. Phage DNA and proteins are synthesized and assembled. Phage DNA integrates into bacterial chromosome.
35 Viruses Can increase genetic variation of their hosts Transduction Recombination of Bacterial and viral DNA can create a new gene for the bacteria Latent viral genomes can result in new properties for the host such as increased pathogenicity in bacteria. Example, a virus can leave behind genes making the bacteria resistant or toxic
36 RNA viruses lack replication error-checking mechanisms, and thus have higher rates of mutation.
37 HIV is a well-studied system where the rapid evolution of a virus within the host contributes to the pathogenicity of viral infection. The rapid mutation rates of retroviruses results from the inaccuracy of the enzyme reverse transcriptase
38 Figure 17.7 Glycoprotein Viral envelope HIV Membrane of white blood cell Capsid Reverse HIV transcriptase RNA (two identical strands) Viral RNA RNA-DNA hybrid DNA HOST CELL Reverse transcriptase 0.25 m HIV entering a cell Chromosomal DNA RNA genome for the next viral generation mrna NUCLEUS Provirus New virus New HIV leaving a cell
1. DNA, RNA structure. 2. DNA replication. 3. Transcription, translation
1. DNA, RNA structure 2. DNA replication 3. Transcription, translation DNA and RNA are polymers of nucleotides DNA is a nucleic acid, made of long chains of nucleotides Nucleotide Phosphate group Nitrogenous
More informationiclicker Question #28B - after lecture Shown below is a diagram of a typical eukaryotic gene which encodes a protein: start codon stop codon 2 3
Bio 111 Handout for Molecular Biology 4 This handout contains: Today s iclicker Questions Information on Exam 3 Solutions Fall 2008 Exam 3 iclicker Question #28A - before lecture Which of the following
More informationLevel 2 Biology, 2017
91159 911590 2SUPERVISOR S Level 2 Biology, 2017 91159 Demonstrate understanding of gene expression 2.00 p.m. Wednesday 22 November 2017 Credits: Four Achievement Achievement with Merit Achievement with
More informationBiomolecules: lecture 6
Biomolecules: lecture 6 - to learn the basics on how DNA serves to make RNA = transcription - to learn how the genetic code instructs protein synthesis - to learn the basics on how proteins are synthesized
More informationProtein Synthesis. Application Based Questions
Protein Synthesis Application Based Questions MRNA Triplet Codons Note: Logic behind the single letter abbreviations can be found at: http://www.biology.arizona.edu/biochemistry/problem_sets/aa/dayhoff.html
More information(a) Which enzyme(s) make 5' - 3' phosphodiester bonds? (c) Which enzyme(s) make single-strand breaks in DNA backbones?
EXAMPLE QUESTIONS AND ANSWERS 1. Topoisomerase does which one of the following? (a) Makes new DNA strands. (b) Unties knots in DNA molecules. (c) Joins the ends of double-stranded DNA molecules. (d) Is
More informationCONVERGENT EVOLUTION. Def n acquisition of some biological trait but different lineages
CONVERGENT EVOLUTION Def n acquisition of some biological trait but different lineages Living Rock cactus Baseball plant THE QUESTION From common ancestor or independent acquisition? By Lineage By Convergence
More informationBiomolecules: lecture 6
Biomolecules: lecture 6 - to learn the basics on how DNA serves to make RNA = transcription - to learn how the genetic code instructs protein synthesis - to learn the basics on how proteins are synthesized
More information7.016 Problem Set 3. 1 st Pedigree
7.016 Problem Set 3 Question 1 The following human pedigree shows the inheritance pattern of a specific disease within a family. Assume that the individuals marrying into the family for all generations
More informationANCIENT BACTERIA? 250 million years later, scientists revive life forms
ANCIENT BACTERIA? 250 million years later, scientists revive life forms Thursday, October 19, 2000 U.S. researchers say they have revived bacteria that have been dormant for more then 250 million years,
More informationBioinformatics CSM17 Week 6: DNA, RNA and Proteins
Bioinformatics CSM17 Week 6: DNA, RNA and Proteins Transcription (reading the DNA template) Translation (RNA -> protein) Protein Structure Transcription - reading the data enzyme - transcriptase gene opens
More informationFishy Amino Acid Codon. UUU Phe UCU Ser UAU Tyr UGU Cys. UUC Phe UCC Ser UAC Tyr UGC Cys. UUA Leu UCA Ser UAA Stop UGA Stop
Fishy Code Slips Fish 1 GGTTATAGAGGTACTACC Fish 2 GGCTTCAGAGGTACTACC Fish 3 CATAGCAGAGGTACTACC Fish 4 GGTTATTCTGTCTTATTG Fish 5 GGCTTCTCTGTCTTATTG Fish 6 CATAGCGCTGCAACTACC Fishy Amino Acid Codon UUU Phe
More informationDegenerate Code. Translation. trna. The Code is Degenerate trna / Proofreading Ribosomes Translation Mechanism
Translation The Code is Degenerate trna / Proofreading Ribosomes Translation Mechanism Degenerate Code There are 64 possible codon triplets There are 20 naturally-encoding amino acids Several codons specify
More informationJust one nucleotide! Exploring the effects of random single nucleotide mutations
Dr. Beatriz Gonzalez In-Class Worksheet Name: Learning Objectives: Just one nucleotide! Exploring the effects of random single nucleotide mutations Given a coding DNA sequence, determine the mrna Based
More informationImportant points from last time
Important points from last time Subst. rates differ site by site Fit a Γ dist. to variation in rates Γ generally has two parameters but in biology we fix one to ensure a mean equal to 1 and the other parameter
More informationFolding simulation: self-organization of 4-helix bundle protein. yellow = helical turns
Folding simulation: self-organization of 4-helix bundle protein yellow = helical turns Protein structure Protein: heteropolymer chain made of amino acid residues R + H 3 N - C - COO - H φ ψ Chain of amino
More informationProtein Synthesis: Transcription and Translation
Review Protein Synthesis: Transcription and Translation Central Dogma of Molecular Biology Protein synthesis requires two steps: transcription and translation. DNA contains codes Three bases in DNA code
More information3.C Genetic Variation
3.C Genetic Variation Big Idea 3: Living systems store, retrieve, transmit and respond to information essential to life processes. EU 3.A: Heritable information provides for continuity of life. EU 3.B:
More informationHow life. constructs itself.
How life constructs itself Life constructs itself using few simple rules of information processing. On the one hand, there is a set of rules determining how such basic chemical reactions as transcription,
More informationUNIT I RNA AND TYPES R.KAVITHA,M.PHARM LECTURER DEPARTMENT OF PHARMACEUTICS SRM COLLEGE OF PHARMACY KATTANKULATUR
UNIT I RNA AND TYPES R.KAVITHA,M.PHARM LECTURER DEPARTMENT OF PHARMACEUTICS SRM COLLEGE OF PHARMACY KATTANKULATUR RNA, as previously mentioned, is an acronym for ribonucleic acid. There are many forms
More informationA Zero-Knowledge Based Introduction to Biology
A Zero-Knowledge Based Introduction to Biology Konstantinos (Gus) Katsiapis 25 Sep 2009 Thanks to Cory McLean and George Asimenos Cells: Building Blocks of Life cell, membrane, cytoplasm, nucleus, mitochondrion
More informationThe combination of a phosphate, sugar and a base forms a compound called a nucleotide.
History Rosalin Franklin: Female scientist (x-ray crystallographer) who took the picture of DNA James Watson and Francis Crick: Solved the structure of DNA from information obtained by other scientist.
More informationDescribe the features of a gene which enable it to code for a particular protein.
1. Answers should be written in continuous prose. Credit will be given for biological accuracy, the organisation and presentation of the information and the way in which the answer is expressed. Cancer
More informationHuman Gene,cs 06: Gene Expression. Diversity of cell types. How do cells become different? 9/19/11. neuron
Human Gene,cs 06: Gene Expression 20110920 Diversity of cell types neuron How do cells become different? A. Each type of cell has different DNA in its nucleus B. Each cell has different genes C. Each type
More informationChapter 10. The Structure and Function of DNA. Lectures by Edward J. Zalisko
Chapter 10 The Structure and Function of DNA PowerPoint Lectures for Campbell Essential Biology, Fifth Edition, and Campbell Essential Biology with Physiology, Fourth Edition Eric J. Simon, Jean L. Dickey,
More informationHonors packet Instructions
Honors packet Instructions The following are guidelines in order for you to receive FULL credit for this bio packet: 1. Read and take notes on the packet in full 2. Answer the multiple choice questions
More informationp-adic GENETIC CODE AND ULTRAMETRIC BIOINFORMATION
p-adic GENETIC CODE AND ULTRAMETRIC BIOINFORMATION Branko Dragovich http://www.phy.bg.ac.yu/ dragovich dragovich@ipb.ac.rs Institute of Physics, Mathematical Institute SASA, Belgrade 6th International
More informationChemistry 121 Winter 17
Chemistry 121 Winter 17 Introduction to Organic Chemistry and Biochemistry Instructor Dr. Upali Siriwardane (Ph.D. Ohio State) E-mail: upali@latech.edu Office: 311 Carson Taylor Hall ; Phone: 318-257-4941;
More informationDeoxyribonucleic Acid DNA. Structure of DNA. Structure of DNA. Nucleotide. Nucleotides 5/13/2013
Deoxyribonucleic Acid DNA The Secret of Life DNA is the molecule responsible for controlling the activities of the cell It is the hereditary molecule DNA directs the production of protein In 1953, Watson
More informationCodon Bias with PRISM. 2IM24/25, Fall 2007
Codon Bias with PRISM 2IM24/25, Fall 2007 from RNA to protein mrna vs. trna aminoacid trna anticodon mrna codon codon-anticodon matching Watson-Crick base pairing A U and C G binding first two nucleotide
More informationChapter 10. The Structure and Function of DNA. Lectures by Edward J. Zalisko
Chapter 10 The Structure and Function of DNA PowerPoint Lectures for Campbell Essential Biology, Fifth Edition, and Campbell Essential Biology with Physiology, Fourth Edition Eric J. Simon, Jean L. Dickey,
More informationINTRODUCTION TO THE MOLECULAR GENETICS OF THE COLOR MUTATIONS IN ROCK POCKET MICE
The Making of the The Fittest: Making of the Fittest Natural Selection Natural and Adaptation Selection and Adaptation Educator Materials TEACHER MATERIALS INTRODUCTION TO THE MOLECULAR GENETICS OF THE
More informationBIOL591: Introduction to Bioinformatics Comparative genomes to look for genes responsible for pathogenesis
BIOL591: Introduction to Bioinformatics Comparative genomes to look for genes responsible for pathogenesis Reading: (1) Scenario 2: (Course web site) Read this first! (2) Perna, N. T., G. Plunkett, 3rd,
More informationBasic Biology. Gina Cannarozzi. 28th October Basic Biology. Gina. Introduction DNA. Proteins. Central Dogma.
Cannarozzi 28th October 2005 Class Overview RNA Protein Genomics Transcriptomics Proteomics Genome wide Genome Comparison Microarrays Orthology: Families comparison and Sequencing of Transcription factor
More informationMechanisms of Genetics
2.B.6.A of nucleic acids and the principles of Mendelian Genetics. The student is expected to (A) identify components of DNA, and describe how information for specifying the traits of an organism is carried
More informationPROTEIN SYNTHESIS Study Guide
PART A. Read the following: PROTEIN SYNTHESIS Study Guide Protein synthesis is the process used by the body to make proteins. The first step of protein synthesis is called Transcription. It occurs in the
More information7.013 Problem Set
7.013 Problem Set 4-2013 Question 1 The following human pedigree shows the inheritance of a specific disease. Please note: The filled squares or circles represent the abnormal phenotype. The individuals
More informationUNIT (12) MOLECULES OF LIFE: NUCLEIC ACIDS
UNIT (12) MOLECULES OF LIFE: NUCLEIC ACIDS Nucleic acids are extremely large molecules that were first isolated from the nuclei of cells. Two kinds of nucleic acids are found in cells: RNA (ribonucleic
More informationCMPS 6630: Introduction to Computational Biology and Bioinformatics. Gene Prediction
CMPS 6630: Introduction to Computational Biology and Bioinformatics Gene Prediction Now What? Suppose we want to annotate a genome according to genetic traits. Given a genome, where are the genes? Given
More informationCISC 1115 (Science Section) Brooklyn College Professor Langsam. Assignment #6. The Genetic Code 1
CISC 1115 (Science Section) Brooklyn College Professor Langsam Assignment #6 The Genetic Code 1 Deoxyribonucleic acid, or DNA, is a molecule that contains the instructions used in the development and functioning
More informationPRINCIPLES OF BIOINFORMATICS
PRINCIPLES OF BIOINFORMATICS BIO540/STA569/CSI660, Fall 2010 Lecture 3 (Sep-13-2010) Primer on Molecular Biology/Genomics Igor Kuznetsov Department of Epidemiology & Biostatistics Cancer Research Center
More informationBIOSTAT516 Statistical Methods in Genetic Epidemiology Autumn 2005 Handout1, prepared by Kathleen Kerr and Stephanie Monks
Rationale of Genetic Studies Some goals of genetic studies include: to identify the genetic causes of phenotypic variation develop genetic tests o benefits to individuals and to society are still uncertain
More informationCHAPTER 12- RISE OF GENETICS I. DISCOVERY OF DNA A. GRIFFITH (1928) 11/15/2016
CHAPTER 12- RISE OF GENETICS KENNEDY BIOL. 1AB I. DISCOVERY OF DNA DNA WAS FIRST DISCOVERED IN 1898 BY MIESHNER. HE USED PROTEASE TO DIGEST THE PROTEIN AWAY FROM WHITE BLOOD CELLS. HE DESCRIBED WHAT HE
More informationIt has not escaped our notice that the specific paring we have postulated immediately suggest a possible copying mechanism for the genetic material
5-carbon sugar hosphate functional group Nitrogenous base 2 types urines = 2 rings 5 & 6 member N containing ring yrimidines = 1 ring 6 member N containing ring Geometry and space requires complimentary
More informationRNA and PROTEIN SYNTHESIS. Chapter 13
RNA and PROTEIN SYNTHESIS Chapter 13 DNA Double stranded Thymine Sugar is RNA Single stranded Uracil Sugar is Ribose Deoxyribose Types of RNA 1. Messenger RNA (mrna) Carries copies of instructions from
More informationDNA Begins the Process
Biology I D N A DNA contains genes, sequences of nucleotide bases These Genes code for polypeptides (proteins) Proteins are used to build cells and do much of the work inside cells DNA Begins the Process
More information7.013 Exam Two
Recitation Section or TA: 7.013 Exam Two -- 2007 Exam starts at 11:05 am and ends at 11:55 am. There are 11 pages including this cover page. Please write your name on each page. Only writing on the FRONT
More informationMutations. Lecture 15
Mutations Lecture 15 Objectives 1: Mutation Define mutation. Describe the types of mutations and their effects on the protein that is produced Distinguishing between spontaneous and induced mutations.
More informationFrom Gene to Protein. How Genes Work
From Gene to Protein How Genes Work 2007-2008 The Central Dogma Flow of genetic information in a cell How do we move information from DNA to proteins? DNA RNA protein replication phenotype You! Step 1:
More informationMULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
Ch 17 Practice Questions MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria
More informationEmergence of the Canonical Genetic Code
Emergence of the Canonical Genetic Code Fall 2009 Emergent States of Matter Term Essay Samuel O. Skinner Abstract I will review literature that expands the theory that the canonical genetic code was not
More informationDNA sentences. How are proteins coded for by DNA? Materials. Teacher instructions. Student instructions. Reflection
DNA sentences How are proteins coded for by DNA? Deoxyribonucleic acid (DNA) is the molecule of life. DNA is one of the most recognizable nucleic acids, a double-stranded helix. The process by which DNA
More informationBioinformation by Biomedical Informatics Publishing Group
Study of codon bias perspective of fungal xylanase gene by multivariate analysis Smriti Shrivastava, Raju Poddar, Pratyoosh Shukla*, Kunal Mukhopadhyay Department of Biotechnology, Birla Institute of Technology
More informationMolecular Level of Genetics
Molecular Level of Genetics Most of the molecules found in humans and other living organisms fall into one of four categories: 1. carbohydrates (sugars and starches) 2. lipids (fats, oils, and waxes) 3.
More informationSUPPLEMENTARY INFORMATION
ARTICLE NUMBER: 16045 Highly heterogeneous mutation rates in the hepatitis C virus genome Ron Geller, Úrsula Estada, Joan B. Peris, Iván Andreu, Juan-Vicente Bou, Raquel Garijo, José M. Cuevas, Rosario
More informationChapter 7 DNA Structure and Gene Function
Chapter 7 DNA Structure and Gene Function DNA bursting from bacterial cell Dr. Gopal Murti/Science Source Copyright McGraw-Hill Education. All rights reserved. No reproduction or distribution without the
More informationMULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
Exam Chapter 17 Genes to Proteins Name MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. The following questions refer to Figure 17.1, a simple metabolic
More informationProblem Set 3
Name: 1 Topic 1. 2007 7.013 Problem Set 3 Due before 5 PM on FRIDAY, March 16, 2007. Turn answers in to the box outside of 68-120. PLEASE WRITE YOUR ANSWERS ON THIS PRINTOUT. You have been studying transcription
More informationDisease and selection in the human genome 3
Disease and selection in the human genome 3 Ka/Ks revisited Please sit in row K or forward RBFD: human populations, adaptation and immunity Neandertal Museum, Mettman Germany Sequence genome Measure expression
More informationPGRP negatively regulates NOD-mediated cytokine production in rainbow trout liver cells
Supplementary Information for: PGRP negatively regulates NOD-mediated cytokine production in rainbow trout liver cells Ju Hye Jang 1, Hyun Kim 2, Mi Jung Jang 2, Ju Hyun Cho 1,2,* 1 Research Institute
More informationMaterials Protein synthesis kit. This kit consists of 24 amino acids, 24 transfer RNAs, four messenger RNAs and one ribosome (see below).
Protein Synthesis Instructions The purpose of today s lab is to: Understand how a cell manufactures proteins from amino acids, using information stored in the genetic code. Assemble models of four very
More informationEvolution of protein coding sequences
Evolution of protein coding sequences Kinds of nucleo-de subs-tu-ons Given 2 nucleo-de sequences, how their similari-es and differences arose from a common ancestor? We assume A the common ancestor: Single
More informationLac Operon contains three structural genes and is controlled by the lac repressor: (1) LacY protein transports lactose into the cell.
Regulation of gene expression a. Expression of most genes can be turned off and on, usually by controlling the initiation of transcription. b. Lactose degradation in E. coli (Negative Control) Lac Operon
More informationChapter 13 From Genes to Proteins
Chapter 13 From Genes to Proteins True/False Indicate whether the sentence or statement is true(a) or false(b). 1. RNA nucleotides contain the sugar ribose. 2. Only DNA molecules contain the nitrogen base
More informationLecture #18 10/17/01 Dr. Wormington
Lecture #18 10/17/01 Dr. Wormington DNA Replication The Story So Far Semiconservative Hydrolysis of 5' dntp 3' HO N 4 pn 3 pn 2 pn 1 p5'... + PP i 2P i Provides Energy for Phosphodiester Bond Formation
More informationMCB 407 (MICROBIAL GENETICS)
MCB 407 (MICROBIAL GENETICS) FUNAI WEEK TWO Course content: NUCLEIC ACIDS AND DNA REPLICATION BY ELEMBA, O. M. Overview GENOME GENE GENETICS. Microbial Genetic GENOMICS Nucleic acids Nucleic acids are
More informationBiology'AHA' 4 th 'Marking'Period'' Benchmark'Review'
BiologyAHA 4 th MarkingPeriod BenchmarkReview TableofContents Topic& Packet&Page& Supplementary& 1. Asexualvs. Sexual Reproduction Reading&in&Textbook& 2 2. Mitosis Between2and3 578I580 3. Meiosis 3I4
More informationBIOLOGY. Gene Expression. Gene to Protein. Protein Synthesis Overview. The process in which the information coded in DNA is used to make proteins
17 CAMPBLL BIOLOGY TNTH DITION Reece Urry Cain Wasserman Minorsky Jackson Gene to Protein Gene xpression The process in which the information coded in is used to make proteins A gene is the part of the
More informationLecture 19A. DNA computing
Lecture 19A. DNA computing What exactly is DNA (deoxyribonucleic acid)? DNA is the material that contains codes for the many physical characteristics of every living creature. Your cells use different
More informationGenes & Inheritance Series: Set 1. Copyright 2005 Version: 2.0
Genes & Inheritance Series: Set 1 Copyright 2005 Version: 2.0 Genes in Eukaryote Cells Eukaryotes have genetic information stored in chromosomes in the nucleus of each cell: Cytoplasm: The nucleus controls
More informationFrom DNA to Protein. Chapter 14
From DNA to Protein Chapter 14 What do genes code for? How does DNA code for cells & bodies? How are cells and bodies made from the instructions in DNA? DNA proteins cells bodies The Central Dogma Flow
More informationMutations. Mutations may be either gene mutations or. These mistakes are called. mutations. Gene mutations produce a change
What is a Mutation? Mutations On occasion cells make mistakes in copying. their DNA An incorrect nitrogen base may be inserted or a base may be skipped altogether. These mistakes are called. mutations
More informationWorksheet: Mutations Practice
Worksheet: Mutations Practice There are three ways that DNA can be altered when a mutation (change in DNA sequence) occurs. 1. Substitution one base-pairs is replaced by another: Example: G to C or A to
More informationIMAGE HIDING IN DNA SEQUENCE USING ARITHMETIC ENCODING Prof. Samir Kumar Bandyopadhyay 1* and Mr. Suman Chakraborty
Volume 2, No. 4, April 2011 Journal of Global Research in Computer Science RESEARCH PAPER Available Online at www.jgrcs.info IMAGE HIDING IN DNA SEQUENCE USING ARITHMETIC ENCODING Prof. Samir Kumar Bandyopadhyay
More informationnumber Done by Corrected by Doctor Hamed Al Zoubi
number 3 Done by Neda a Baniata Corrected by Waseem Abu Obeida Doctor Hamed Al Zoubi Note: it is important to refer to slides. Bacterial genetics *The main concepts we will talk about in this lecture:
More informationStation 1: DNA Structure Use the figure above to answer each of the following questions. 1.This is the subunit that DNA is composed of. 2.
1. Station 1: DNA Structure Use the figure above to answer each of the following questions. 1.This is the subunit that DNA is composed of. 2.This subunit is composed of what 3 parts? 3.What molecules make
More informationThe Molecule of Heredity. Chapter 12 (pg. 342)
The Molecule of Heredity Chapter 12 (pg. 342) What is DNA? DNA contains instructions for assembling proteins. Proteins tell our cells how to function and act. The Roles of DNA DNA has three jobs in heredity:
More informationChapter 13: RNA and Protein Synthesis. Dr. Bertolotti
Chapter 13: RNA and Protein Synthesis Dr. Bertolotti Essential Question How does information flow from DNA to RNA to direct the synthesis of proteins? How does RNA differ from DNA? RNA and protein synthesis
More informationKeywords: DNA methylation, deamination, codon usage, genome, genomics
A PECULIAR CODON USAGE PATTERN REVEALED AFTER REMOVING THE EFFECT OF DNA METHYLATION Xuhua Xia Department of Biology, University of Ottawa E-mail: xxia@uottawa.ca Keywords: DNA methylation, deamination,
More informationChapter 10 Molecular Biology of the Gene
Chapter 10 Molecular Biology of the Gene PowerPoint Lectures Campbell Biology: Concepts & Connections, Eighth Edition REECE TAYLOR SIMON DICKEY HOGAN Lecture by Edward J. Zalisko Introduction The 2009
More informationQ1. Lysozyme is an enzyme consisting of a single polypeptide chain of 129 amino acids.
Q1. Lysozyme is an enzyme consisting of a single polypeptide chain of 129 amino acids. (a) What is the minimum number of nucleotide bases needed to code for this enzyme? (b) The diagram shows the sequence
More informationGENETICS and the DNA code NOTES
GENETICS and the DNA code NOTES BACKGROUND DNA is the hereditary material of most organisms. It is an organic compound made of two strands, twisted around one another to form a double helix. Each strand
More informationToday in Astronomy 106: the important polymers and from polymers to life
Today in Astronomy 106: the important polymers and from polymers to life Replication or mass production of nucleic acids and proteins Interdependence: which came first, protein mass production or nucleic-acid
More informationReview of Central Dogma; Simple Mendelian Inheritance
Review of Central Dogma; Simple Mendelian Inheritance Problem Set #1 Answers: 1. 5'-ACCGTTATGAC-3' 2. No. You would also need to know if this organism has a double stranded DNA genome. Assuming that it
More informationModule 6 Microbial Genetics. Chapter 8
Module 6 Microbial Genetics Chapter 8 Structure and function of the genetic material Genetics science of o Study of what genes are, how they determine the characteristics of an organism, how they carry
More informationFrom Gene to Protein. How Genes Work (Ch. 17)
From Gene to Protein How Genes Work (Ch. 17) What do genes code for? How does DNA code for cells & bodies? how are cells and bodies made from the instructions in DNA DNA proteins cells bodies The Central
More informationDNA. Empty protein shell Phage. Radioactivity in liquid. Pellet. 3 Centrifuge the mixture so bacteria form a pellet at the bottom of the test tube.
MOLECULAR BIOLOGY: RELICATION, TRANSCITION, AND TRANSLATION Honors Biology 0 IMORTANT EXERIMENTS Frederick Griffith Described a transforming factor that could be transferred into a bacterial cell rocess
More informationChapter 3: Information Storage and Transfer in Life
Chapter 3: Information Storage and Transfer in Life The trapped scientist examples are great for conceptual purposes, but they do not accurately model how information in life changes because they do not
More informationToday in Astronomy 106: polymers to life
Today in Astronomy 106: polymers to life Translation: the current fashion in protein manufacture. The chicken-egg problem Protein-based primitive life? RNA World Emergence of the genetic code. How long
More informationFrom DNA to Protein: Genotype to Phenotype
12 From DNA to Protein: Genotype to Phenotype 12.1 What Is the Evidence that Genes Code for Proteins? The gene-enzyme relationship is one-gene, one-polypeptide relationship. Example: In hemoglobin, each
More informationIf stretched out, the DNA in chromosome 1 is roughly long.
Introduction to Molecular Genetics (http://chemwiki.ucdavis.edu/wikitexts/sacramento_city_college/scc%3a_chem_309_(bennett)/chapters/17% 3A_ucleic_Acids) (http://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660)
More information7.014 Quiz II 3/18/05. Write your name on this page and your initials on all the other pages in the space provided.
7.014 Quiz II 3/18/05 Your Name: TA's Name: Write your name on this page and your initials on all the other pages in the space provided. This exam has 10 pages including this coversheet. heck that you
More informationTRANSCRIPTION. Renáta Schipp
TRANSCRIPTION Renáta Schipp Gene expression Gene expression: - is the process by which information from a gene is used for the synthesis of gene products. These products are proteins, but in the case of
More informationFrom DNA to Protein: Genotype to Phenotype
12 From DNA to Protein: Genotype to Phenotype 12.1 What Is the Evidence that Genes Code for Proteins? The gene-enzyme relationship is one-gene, one-polypeptide relationship. Example: In hemoglobin, each
More informationTranslating the Genetic Code. DANILO V. ROGAYAN JR. Faculty, Department of Natural Sciences
Translating the Genetic Code DANILO V. ROGAYAN JR. Faculty, Department of Natural Sciences An overview of gene expression Figure 13.2 The Idea of A Code 20 amino acids 4 nucleotides How do nucleic acids
More informationKeywords: Staphylococcal phage, Synonymous codon usage, Translational selection, Mutational bias, Phage therapy.
www.bioinformation.net Hypothesis Volume 8(24) Synonymous codon usage in forty staphylococcal phages identifies the factors controlling codon usage variation and the phages suitable for phage therapy Arghya
More informationMOLECULAR EVOLUTION AND PHYLOGENETICS
MOLECULAR EVOLUTION AND PHYLOGENETICS 1 Molecular Basis of Evolution 1.1. Evolutionary Tree of Life From the time of Charles Darwin, it has been a dream for many biologists to reconstruct the evolutionary
More informationBioinformatics 1. Sepp Hochreiter. Biology, Sequences, Phylogenetics Part 1. Bioinformatics 1: Biology, Sequences, Phylogenetics
Bioinformatics 1 Biology, Sequences, Phylogenetics Part 1 Sepp Hochreiter 3 Credits (plus 3 Credits for exercises) Examination at the end of the class Master Bioinformatics and Computer Science Script
More informationGeneral Biology. Structure of Viruses. Viral Genomes
Course No: BNG2003 Credits: 3.00 General Biology 12. Viruses and Bacteria Bacteria, Viruses and Biomedical Engineering: - Medicine ---> Biofilms etc - Energy: Biofuel Cells - Environment/Industries: Bioremediation
More information