Chair: Maurizio Brunori (Università di Roma La Sapienza and Accademia dei Lincei, Roma, Italia)
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1 Wednesday, September Opening of the Secretariat & Registration Congress Opening & Welcome E. Antonini Lecture Chair: Maurizio Brunori (Università di Roma La Sapienza and Accademia dei Lincei, Roma, Italia) Kurt Wüthrich, Nobel Prize in Chemistry (The Scripps Research Institute, La Jolla, CA, USA and ETH Zurich, Switzerland) "NMR from Basic Research to Daily Human Life" Protein Structure, Dynamics and Interactions Chairs: Menico Rizzi (Università del Piemonte Orientale Amedeo Avogadro, Novara, Italia), Anna Marabotti (Università di Salerno, Salerno, Italia) Elena Conti, Max Planck Institute of Biochemistry, Munich, Germany The RNA exosome - ribosome connection: coupling the RNA degradation and translation machineries Carlo Camilloni, Università di Milano, Milano, Italia Multi-scale dynamics of molecular recognition and assembly Barbara Campanini, Università di Parma, Parma, Italia Competition between a toxic trnase and the biosynthetic enzyme CysE for binding to O-acetylserine sulfhyrylase Beatrice Cobucci-Ponzano, Istituto di Bioscienze e Biorisorse, CNR, Napoli, Italia 3D structure of human lysosomal acid-α-glucosidase provides molecular bases of pharmacological chaperones interactions for the treatment of Pompe disease Francesca Vallese, Università di Padova, Padova, Italia Crystal structure of lpp20 (HP1456) from Helicobacter pylori suggests it is a human virulence factor Visit to the Royal Palace and Welcome cocktail
2 Thursday, September Signals driving cell proliferation, commitment, and self-renewal (Session I) Chairs: Rosario Ammendola (Università di Napoli Federico II, Napoli, Italia), Adriana Borriello (Università della Campania Luigi Vanvitelli, Napoli, Italia) Evzen Amler, Czech Technical University in Prague, Buštěhrad, Prague Functionalized nanofibers for regenerative medicine Diego Ingrosso, Università della Campania Luigi Vanvitelli, Napoli, Italia One carbon and sulfur amino acid metabolism: two biochemical pathways connected to new signaling molecules of medical relevance Daniele Dell Orco, Università di Verona, Verona, Italia Phototransduction in normal and altered conditions: from molecules to networks Paola Bruni, Università di Firenze, Firenze, Italia Sphingosine 1-phosphate signaling axis as mediator of vital skeletal muscle functions Marzia Perluigi, Università di Roma La Sapienza, Roma, Italia Crosstalk between insulin and mtor signaling in Alzheimer disease Daria M. Monti, Università di Napoli Federico II, Napoli, Italia Natural products as a source of antiaging molecules Coffee Break Signals driving cell proliferation, commitment, and self-renewal (Session II) Chairs: Michele Caraglia (Università della Campania Luigi Vanvitelli, Napoli, Italia), Federica Maria Angela Rizzi (Università di Parma, Parma, Italia) Ferdinando Chiaradonna, Università di Milano-Bicocca, Milano, Italia Targeting cell metabolism for cancer therapy: a novel class of hexosamine Pathway inhibitors with anti-tumor activity in different types of cancer Franca Esposito, Università di Napoli Federico II, Napoli, Italia Impact of cancer cells metabolic reprogramming on tumor progression and drug resistance: potential implications for cancer treatment Francesca Silvagno, Università di Torino, Torino, Italia TGFbeta-induced epithelial-mesenchymal transition: negative feedback regulation by vitamin D
3 Paola Giussani, Università degli Studi di Milano, Milano, Italia Sphingosine-1-P and its plasma membrane receptors in human glioma cells Lunch Parallel Symposia Università degli Studi della Campania Luigi Vanvitelli, Polo di Viale Ellittico 29, Mitochondrial plasticity: from energetic metabolism to ROS signalling Chairs: Paolo Sarti (Università di Roma La Sapienza, Roma, Italia), Giuseppe Fiermonte (Università di Bari Aldo Moro, Bari, Italia) Gerald Shadel, Yale School of Medicine, New Haven CT, USA Mitochondrial stress signaling in disease, aging and immunity Luca Scorrano, Università di Padova, Padova, Italia The cristae modulator optic atrophy 1 requires mitochondrial ATP synthase dimerization to safeguard mitochondrial function Rino Capitanio, Università di Foggia, Foggia, Italia Mitochondria and clock-genes interplay: a dynamic timekeeping of cell metabolism Annamaria Porcelli, Università di Bologna, Bologna, Italia Understanding the signalling between respiratory Complex I and hypoxia-inducible factor-1α in tumorigenesis Università degli Studi della Campania Luigi Vanvitelli, Polo di Viale Ellittico, 29, Enzymes and metabolic pathways: mechanisms and technologies for advancing the frontiers of enzymology Chairs: Simonetta Bartolucci (Università di Napoli Federico II, Napoli, Italia) e Giovanni Musci (Università del Molise, Campobasso, Italia) Gianfranco Gilardi, Università di Torino, Torino, Italia Human aromatase: catalytic mechanism and role on the emerging problem of endocrine disruptors Gianluca Molla, Università dell Insubria, Varese, Italia Amino acid oxidases: metabolic complexity from structural simplicity Chiara Schiraldi, Università della Campania Luigi Vanvitelli, Napoli, Italia Metabolic engineering in E.coli K4 towards chondroitin production: an insight in the biochemical machinery of capsular polysaccharide biosynthesis Alessio Peracchi, Università di Parma, Parma, Italia Enzymes that make and enzymes that fix mistakes: Nit1 is a repair amidase that hydrolyzes deaminated glutathione Coffee Break and Poster session Exposition
4 Università degli Studi della Campania Luigi Vanvitelli, Biblioteca Polo di Viale Ellittico 29, Poster Discussion Short talks to be selected from submitted abstracts SIB Members Assembly Masseria GiòSole Capua Social Dinner Masseria GiòSole Capua Friday, September Transcriptional regulation, chromatin structure and epigenetic modifications Chairs: Giorgio Dieci (Università di Parma, Parma, Italia) Antonio Simeone, IGB-CNR, Napoli Transcription Factors control of Pluripotency Diego Pasini, IFOM- IEO, Milano, Italia Mechanisms of control of cellular identity by Polycomb chromatin modifiers Italia Di Liegro, Università di Palermo, Palermo, Italia RNA as a carrier of epigenetic information Paola Costanzo, Università di Napoli Federico II, Napoli, Italia Multifunctional role of the ZNF224 transcription factor Paola Loguercio-Polosa, Università di Bari Aldo Moro, Bari, Italia Mitochondrial transcription in animal systems: recent advances and challenges Coffee Break Parallel Symposia Auditorium-Scuola Specialisti dell Aeronautica Militare, Viale Ellittico 33, Proteomics in Cell Biology and Disease Mechanisms Chairs: Margherita Ruoppolo (Università di Napoli Federico II, Napoli, Italia), Andrea Università degli Studi della Campania Luigi Vanvitelli, Polo di Viale Ellittico, 29, Novel Frontiers of Nutritional and Environmental Biochemistry Chairs: Cristina Angeloni (Università di Camerino, Camerino, Italia), Alberto Zullo
5 Urbani (Università Cattolica del Sacro Cuore, Roma, Italia) Robert Russell, Heidelberg University, Heidelberg, Germany Coupling proteomics and genetics to study cilia: a disease relevant organelle Vittorio Bellotti, Università di Pavia, Pavia, Italia Proteolysis and amyloid formation: a new way of reading an old story Maria Monti, Università di Napoli Federico II, Napoli, Italia Not all roads lead GAA to lysosomes Massimo Castagnola, Università Cattolica del Sacro Cuore, Roma, Italia Human saliva: a precious bodily fluid rich of information Angela Chambery, Università della Campania Luigi Vanvitelli,, Italia Deciphering the SECRET language of cellular messengers by OMICS approaches Federica Ciregia, Università di Pisa, Pisa, Italia Proteomic approach to study pancreatic human islets after cytokine exposure Lunch (Università del Sannio, Benevento, Italia) David Vauzour, University of East Anglia, Norwich, UK Neuroprotective effect of flavonoids and their underlying molecular mechanisms Luca Tiano, Università Politecnica della Marche, Ancona, Italia The use of trout erythrocytes as a model for the study of oxidative stress and damage associated to environmental pollutants exposure Gian Luigi Russo, Istituto di Scienze dell'alimentazione, CNR, Avellino, Italia Pros and cons of polyphenols in cancer: the example of quercetin in chronic lymphocytic leukemia Ivana Caputo, Università di Salerno, Salerno, Italia Contribution of type 2 transglutaminase to the celiac cellular phenotype Giuseppe Bruschetta, Università di Messina, Messina, Italia Effect of diet on peripheral tryptophan hydroxylase-1 and plasma tryptophan levels in Goldfish C. Valeria L. Giosafatto, Università di Napoli Federico II, Napoli, Italia Influence on food digestion and glycemic index by enzymatic protein crosslinking Industrial and Molecular Biotechnologies (dedicated to Riccardo Cortese and Anna Tramontano) Session I: Future perspectives in biotechnology research Chairs: Filiberto Cimino (Università di Napoli Federico II, Napoli, Italia), Francesco Salvatore (Università di Napoli Federico II and Ceinge- Biotecnologie Avanzate s.c.ar.l. Napoli, Italia)
6 Gennaro Ciliberto, Istituto Tumori Regina Elena, Roma- Università di Catanzaro, Catanzaro, Italia Personalized medicine in oncology: from target therapies to advanced molecular diagnostics to genome-based clinical trials Roberto Danovaro, President Stazione Zoologica "A. Dohrn", Napoli, Italia Marine biotechnology: new opportunities for italian research and industrial development Session II: Mechanisms, processes and technologies for innovative applications Chairs: Marco Moracci (Università di Napoli Federico II, Napoli, Italia), Carlos Regalado-Gonzales (Universidad Autόnoma de Querètaro, Santiago de Querétaro, Mexico) Marina Lotti, Università di Milano-Bicocca, Milano, Italia Cold Biotechnology : enzymes and antifreeze proteins from Antarctic organisms Eugenio Notomista, Università di Napoli Federico II, Napoli, Italia Cryptic antimicrobial peptides, a still unexploited source of bioactive peptides Mohammed Sabbah, An-Najah National University, Nablus, Palestine Hydrocolloid materials: reinforcement and new plasticizers Riccardo Miggiano, XTAL, Novara, Italia Understanding proteins: tailor-made approaches for biotechnology solutions in industrial processes Session III: Molecular targeting for drug discovery Chairs: Claudia Martini (Università di Pisa, Pisa, Italia), Marzia Bianchi (Università di Urbino, Urbino, Italia) Loredano Pollegioni, Università dell Insubria, Varese, Italia Modulation of NMDA receptor functionality acting on D-serine catabolism: a novel therapeutic approach for various human pathologies Michele Menotta, Università di Urbino, Urbino, Italia Non-conventional splicing modulation by glucocorticoids: the case of ATM Barbara Cellini, Università di Perugia, Perugia, Italia Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase: a protein therapy for primary hyperoxaluria type I Closing remarks
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