Cycle de Séminaires du Quartier de la Création Vivre ou vivre mieux? DHU 2020 Médecine personnalisée des maladies chroniques
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1 Cycle de Séminaires du Quartier de la Création 2014 Vivre ou vivre mieux? Education Human Sciences Arts Quartier HU DHU 2020 Médecine personnalisée des maladies chroniques Un exemple de structuration de la recherche pour la médecine 4P Antoine Magnan, Karine Botturi- Cavaillès
2 Care research interface: a 10 years old Nantese speciality Early 2000» Cohorts of patients Genetics Genomics» Pathophysiology: animal models «Modèle Nantais» inspiring the Marescaux commission on the future of University Hospitals in France: Instituts HU, Pôles HU, Départements HU RHU
3 Care research interface: a 10 years old Nantese speciality Early 2000 Education» Cohorts of patients Genetics Genomics» Pathophysiology: animal models «Modèle Nantais» inspiring the Marescaux commission on the future of University Hospitals in France: Instituts HU, Pôles HU, Départements HU RHU
4 10 years later cohorts, biobanks, models + Education
5 HEALTH CHALLENGES IN THE NEXT DECADES Increase of life length Increase of chronic diseases Increase of health costs Economic crisis
6 HEALTH CHALLENGES IN THE NEXT DECADES Increase of life length Plan the «well ageing» Predict / Prevent chronic diseases Focus on health no more on disease Contain Health costs
7 NEW DRUGS Biotherapies Too expensive to be given to everybody MUST be targeted
8 4P MEDICINE = THE OPPORTUNITY personalized & participative Strategies Predict diseases Predict response Prevent diseases Targeted treatments Possible in XXIth century? - Technology already exists - Will the society be mature enough to accept it?
9 10 years later cohorts, biobanks, models + Education
10 Education UMR CNRS 6297 Droit et Changement Social Equipe Normes, Maladies et Société Human Sciences
11 Translational research strategy of DHU2020 Prevention Prevention Therapeutic targets Education Biomarkers Biocollections Genetics Clinical trials Risk factors Patients Patients Models Cohorts "omics" Personalized medicine Phenotypes Endotypes
12 Prevention Prevention Therapeutic targets Biomarkers Biocollections Genetics Clinical trials Education Risk factors Patients Patients Human Sciences Models Cohorts "omics" Personalized medicine Phenotypes Endotypes Human Sciences
13 PS1 EPIDEMIOLOGY VACARME PS2 BIOCOLLECTIONS healthy people from the Pays de La Loire Region - New biocollections : - GAIA : intra-cranial aneurysm (n=280) - HYPOCHOL : hypobetalipoproteinemia - RAY GENE : Raynaud s phenomenon - Non atopic asthma
14 PS3 GENETICS PS4 PHYSIOPATHOLOGY Differenciation of UhiPS in hepatocytes Modelization of hypercholestérolemia from ipsc Cell Optic System New genes of intra-cranial aneurysm EDUCATION Associate professor of genetics 2015 CALLS: «Animal models» «EMERGENCE»
15 COLT- SysClad COLT : COhort in Lung Transplantation Multicentric Cohort Sep : 12 French and Belgian centers of lung transplantationde TP > Lung transplants, follow-up 5 years Chronic Lung Allograft Dysfunction Biocollection (> samples) Database A Magnan A Haloun C Dromer M Stern S Mussot O Brugière (Bichat), V Boussaud (HEGP) M Dahan JF Mornex C Knoop L Nicod JD Aubert C Pison R Kessler C Benden SysCLAD : Systems prediction of Chronic Lung Allograft Dysfunction CLAD modelization M Reynaud-Gaubert
16 Chronic Lung Allograft Dysfunction Pain M, PhD thesis 2014, in preparation Royer P, in preparation 6 mois 1 an Network N 2: Developmental Disorder, Immunological Disease, Hematological System Development and Function
17 Asthma: from disease to new drug dicovery asthma Biological screening & Hit/lead refinement Patients Resistance (cmh2o.s/ml) *** 1 5 Animal model (SM-Rac1-KO) In silico screening Pharmacophore design Cell & tissue models (human) Molecular mechanisms Target identification Sauzeau V, Loirand G, Magnan A (PCT/EP2014/062402)
18 Education Questioning the transformations of Health care system What does personalized medicine mean for health care providers and researchers? H. Lecompte DCS, DHU 2020 Human Sciences ASHAM project: Sociological analysis of life habits in adults with type 1 myotonyc dystrophy A.C. Hardy, DCS / Y. Pereon, l institut du thorax
19 Education & Dissemination Autumn School: personalized medicine, 9, 10th Education Human Sciences october, 105 participants DHU2020 workshops 4 research calls L intestin au cœur des métabolismes Remodelages ips et médecine personnalisée Allergies System biology MD, PhD cursus Site dhu2020.org Vivre ou vivre mieux
20 UMR CNRS 6297 Droit et Changement Social Equipe Normes, Maladies et Société Education Human Sciences SyMeTRIC : Systems Medicine: Toward a & Innovation Centre (Région Pays de La Loire, Atanpôle biothérapies) Ecosystèmes d Excellences: Plan d investissements d Avenir 2 Initiatives d excellence (IDEX): Université Bretagne Loire Recherche Hospitalo-Universitaire
21 Quartier de la Création Education Human Sciences Arts
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23 Quartier de la Création Education Human Sciences Arts Quartier HU CHU de Nantes 2023
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