Curriculum Vitae José P. Marques 2017

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1 PERSONAL INFORMATION Family name, First name: Marques, José P. Date of birth: 27/12/1977 Nationality: Portuguese Family: web site and Research ID: SUMMARY Married with 3 daughters (0/3/6 years old) ORCID Scopus I was educated as an experimental physicist at the most prestigious university of Portugal, (Coimbra University). I later received a PhD in Physics from the University of Nottingham, where I worked at the laboratory of Sir Peter Mansfield (Medicine Nobel Laureate in 2003 for his contributions to the field of MRI) under the supervision of Richard Bowtell. During this period, I worked on the topic of long range dipolar fields in NMR and MRI. I subsequently took a postdoctoral position back in my home town University of Coimbra, where I developed new methods to process EEG-fMRI data in epilepsy. I was invited to work at one of the most well equipped high field MRI laboratories (7T human and 14T animal scanners) in Europe at the time, the CIBM (BioMedical Imaging Centre) at the University of Lausanne & EPFL, where I worked for 8 years in the institute of the renowned spectroscopist Prof. Gruetter. I grew from postdoctoral fellow to lecturer and permanent senior scientist, took several PhD supervision duties, established an own group and coordinated the institutes imaging efforts both for functional and quantitative structural imaging on the 7T human scanner. Some of the developed methods are now part of clinical devices thanks to a collaboration with Siemens Healthcare T 1 mapping using the MP2RAGE sequence. I was offered a position as the senior researcher NMR scientist at one of the leading European Centres for Cognitive Neuroimaging (Donders Institute) at Radboud University (>200 researchers). This has allowed me to work closer to neuroscientific and neurological applications, while continuing developing MR imaging methods that, can now find a quicker translations to medical diagnosis and large population studies. EDUCATION 2005 PhD, School of Physics and Astronomy, University of Nottingham, United Kingdom Masters/Doctoral Program in Biophysics, Faculty of Science, University of Lisbon, Portugal Experimental Physics Graduate, University of Coimbra, Portugal (and Universitá degli Studi di Trento, Italy) POSITIONS 2015 Senior MRI Researcher, Donders Centre for Cognitive Neuroimaging (DCCN), Radboud University, The Netherlands Senior Researcher and junior group leader, CIBM, EPFL, Lausanne, Switzerland Invited Lecturer, Faculty of Science and Technology, University of Coimbra, Portugal Lecturer ( Maitre Assistant ), CIBM, University of Lausanne, Switzerland Premier Assistant on High Field MRI, CIBM, University of Lausanne, Switzerland Postdoctoral fellowship, Faculty of Medicine, University of Coimbra, Portugal SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS Postdoc (Lauren Bains), 2 PhD students, 1 Technician, Radboud University Postdoctoral Fellow (João Jorge), EPFL, Switzerland PhD students (Mayur Narsude, Florent Eggenschwiller, Diana Khabipova, Rajika Maddage), EPFL, Switzerland Master Projects (from: University of Coimbra, Portugal; IST, Portugal; Université Pierre & Marrie Curie, France; Imperial College, UK; EPFL, Switzerland, University of Twente, The Netherlands) TEACHING ACTIVITIES Lecturer of the Toolkits (PhD Course) on Advanced MR Physics for Cognitive Neuroscientists and Essentials of Neuroimaging, Radboud University, Nijmegen Lecturer at the Radboud Summer School: Introduction to Cognitive Neuroscience MRI module on Advanced Neuroscience Techniques of the MSc program Cognitive Neuroscience at the Donders Institute Lecturer of the MRI module on Medical Instrumentation MSc on Biomedical Engineering, 1

2 University of Coimbra, Portugal Organization of the PhD course Advanced biomedical imaging methods and instrumentation, teaching the modules on Perfusion Imaging, Phase imaging, and Fourier Transform and Imaging Artefacts; st year Experimental Physics Lab Monitor, University of Nottingham, UK; st year Experimental Physics Lab Monitor, University of Coimbra, Portugal; INSTITUTIONAL RESPONSIBILITIES 2017 Consultant/shareholder of MRcode ( a company providing software to facilitate the use of ultra-high field systems Member of the Research Infrastructure Committee, DCCN, Radboud University 2015 Representative of Senior researchers at the Workers Council, DCCN, Radboud University; 2015 Organizer of the Toolkit (PhD Course) on Advanced MR physics for Cognitive Neuroscientists, Radboud University, Nijmegen; 2015 Organizer of the continuous education seminars: Functional Analysis Meeting at the DCCN; 2015 Organizer of the continuous education: Physics Club of the MR techniques team; Coordinator of the 7T Team Meeting, CIBM, EPFL; Ad hoc reviewer for Journals: Neuroimage, Elsevier; Magnetic Resonance in Medicine, Wiley; NMR in Biomedicine, Wiley; Magnetic Resonance Materials in Physics, Biology and Medicine, MAGMA, Springer; Journal of Magnetic Resonance, Elsevier; BMC Medical Imaging, BioMed Central; European Physics Letters; Neuroimage Clinical, Elsevier; Frontiers in Neuroscience; Ad hoc Reviewer for Conferences: Annual Meeting of the International Society for Magnetic Resonance in Medicine; International Workshop in Quant. Susceptibility Mapping; Ad hoc Reviewer for Grant Agencies: Austrian Science Fund (FWF - Biological and Medical Sciences), Austria; German Research Foundation (DFG), Germany; Swiss National Foundation (SNF), Switzerland; Isaac Newton Trust (INT), United Kingdom; MEMBERSHIPS OF SCIENTIFIC SOCIETIES Member, International Society for Magnetic Resonance in Medicine, 2011 Member, European Society of Magnetic Resonance in Medicine and Biology Member, Portuguese Society of Physics MAIN COLLABORATIONS CIBM, Ecole Polytechnique Federale Lausanne, Prof. R. Gruetter, Hig Field MRI; Sir Peter Mansfield MR Centre, Nottingham University, Prof. R. Bowtell, Magnetic Susceptibility ; Langone Medical Centre, New York University, Prof. D. Sodickson - Electrical Property Mapping; Advanced Clinical Imaging Technology, Siemens Healthcare, Dr. T. Kober - Sequence Development for Quantitative Imaging; CUBRIC, Cardiff University, Dr D. Gallichan - Motion correction and Image Reconstruction; Spinoza Centre for Neuroimaging, KNAW, Amsterdam, Dr. W. van der Zwaag Fast fmri ; Martinos General Hospital, Harvard Medical School, Dr B. Bilgic - Coil Compression; Donders Institute, Radboud University, Prof. D. Norris Accelerated Multi-Band Imaging; Donders Institute, Radboud University, Prof. C. Beckman Normative Imaging and Connectivity; Anatomy Department, Radboud University, Dr. A-M van Cappellen van Walsum Ex-vivo Imaging ; PAST GRANTS Anat. and funct. segregation within cortico-basal ganglia circuits; Role: Co-PI, SNF) - 375k CHF Suscept. Map. of the human brain; Role: PI; SNF, Switzerland- 162k CHF Neuroimaging investigation of learning mechanisms in the human brain; Role: co-pi; FCT, Portugal 95k EUR CAREER BREAKS AND OTHER INTERESTS 2005/02-06 Post PhD break, voluntary work in Huancayo, Peru 2014/05-06 One and a half months of paternity leave and a 2 week (2200km) cycling trip from Lausanne (Switzerlnd) to Coimbra (Portugal) 2

3 On-going Grants Project Title Funding source Amount (Euros) Period Role of the PI Relation to current ERC proposal 1 Thinking Inside the Voxel What can Magnetic Fields tell us about White Matter Properties Foundation for Fundamental Research on Matter (FOM) 424k Euros Principal Investigator This is a project fully based on ex-vivo imaging where: (i) methods to correctly calculate susceptibility in white matter will be developed and validated; (ii) dictionary (of MR signal evolution) based fitting will be tested Know-how will be further explored on WP3 Advanced highfield MR imaging and quantitative analysis for segmentation of the thalamic nuclei Swiss National Foundation 229k Eu (245k CHF) Co-PI. Since leaving EPFL consultant (and supervisor of one Postdoc) Developed motion and physiology tracking and correction methods based on small off-resonance sensors. Know-how will be further explored in WP2 Publications 41 publications: 13 as first author ( ), 11 and 24 as last author or corresponding author ( ), 4 publications with thesis supervisor ( ) Metrics (google scholar/scopus): h-index 19/16, citations (scholar/scopus) >1600/ co-authors 10 J.P. Marques, D. Khabipova and R. Gruetter, Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R1, R2* and magnetic susceptibility, NeuroImage, vol. 147, pp , Feb J. Jorge, D. Gallichan, F. Gretsch, and J. P. Marques, Tracking Discrete Off-resonance markers with Three Spokes (trackdots) for compensation of head motion and B0 perturbations: accuracy and performance in anatomical imaging, Magn. Reson. Med., doi: /mrm Narsude M, Gallichan D, van der Zwaag W, Gruetter R, Marques J.P. Three-dimensional echo planar imaging with controlled aliasing: A sequence for high temporal resolution functional MRI. Magn. Reson. Med. 2015, doi: /mrm (8 citations) 7 - J.P. Marques, R., Gruetter, New developments and applications of the MP2RAGE sequence - focusing the contrast and high spatial resolution R1 mapping, PLoS ONE 8 (7), art. no. e69294, (30 citations) 6 - J. Jorge, P. Figueiredo, W. van der Zwaag, J.P. Marques, Signal fluctuations in fmri data acquired with single-shot 2D EPI and segmented 3D EVI at 7 Tesla, Magnetic Resonance Imaging, 31 (2), pp , 2013 (23 citations) 5 - G.A. Lodygensky, J. P. Marques, R. Maddage, E. Perroud, S.V. Sizonenko, P. S. Hüppi and R. Gruetter, In vivo assessment of myelination by phase imaging at high magnetic field, Neuroimage, 59 (3), pp , 2012 (51 citations) 4 - F. Eggenschwiler, A. W. Magill, T. Kober, R. Gruetter, and J. P. Marques, Sa2RAGE: a new sequence for fast quantitative B1 mapping, Magnetic Resonance in Medicine, 67(6), , 2012 (24 citations) 3 - J.P. Marques, T. Kober, G. Krueger, W. van der Zwaag, P.-F. Van de Moortele and R. Gruetter, MP2RAGE, a self-bias field corrected sequence for improved segmentation and T1-mapping at high field, Neuroimage, 49 (2), pp , 2010 (227 citations) 2 - J. P. Marques, R. Maddage, V. Mlynarik, R. Gruetter, On the origin of the MR image phase contrast: An in vivo MR microscopy study of the rat brain at 14.1T, Neuroimage, 46(2), , 2009 (87 citations) 1 Describe clearly any scientific overlap between your ERC application and the current research grant or on-going grant application. 3

4 1 - J. P. Marques, R. Bowtell, Application of a Fourier Based Method for Calculating Susceptibility Induced Magnetic Field Perturbations, Conc. Magn. Res. B, 25 (1), 65-78, 2005 (247 citations) Invited reviews 1 J.P. Marques, D. Norris, How to choose the right MR sequence for your research question at 7 Tesla and above?. Neuroimage, in press 2 - Robinson, S.D., Bredies, K., Khabipova, D., Dymerska, B., Marques, J.P., Schweser, F., An illustrated comparison of processing methods for MR phase imaging and QSM: combining array coil signals and phase unwrapping. NMR Biomed. doi: /nbm van der Zwaag, W., Schäfer, A., Marques, J.P., Turner, R., Trampel, R., Recent applications of UHF- MRI in the study of human brain function and structure: a review. NMR Biomed. doi: /nbm Marques, J.P., Gruetter, R., Van Der Zwaag, W., In vivo structural imaging of the cerebellum, the contribution of ultra-high fields. Cerebellum 11, doi: /s Other highly cited papers 1- S. da Costa, W. van der Zwaag, J.P. Marques, R. S.J. Frackowiak, S. Clarke, and M. Saenz, Human primary auditory cortex follows the shape of Heschl s Gyrus, J. Neurosci., vol. 31, no. 40, pp , (117 citations) 2- G. Puy, J.P. Marques, R. Gruetter, J-P Thiran, Y. Wiaux, Spread spectrum magnetic resonance imaging, IEEE Trans. Med. Imaging, vol. 31, no. 3, pp , (53 citations) 3 - J.P. Marques, J. Rebola, P. Figueiredo, A. Pinto, F. Sales, and M. Castelo-Branco, ICA decomposition of EEG signal for fmri processing in epilepsy, Hum. Brain Mapp., vol. 30, no. 9, pp , (38 citations) 4- J.P. Marques, W. Van Der Zwaag, C. Granziera, G. Krueger, and R. Gruetter, Cerebellar cortical layers: In vivo visualization with structural high-field-strength MR imaging, Radiology, vol. 254, no. 3, pp , 2010 (37 citations) 5 - J. P. Marques and R. W. Bowtell, Using forward calculations of the magnetic field perturbation due to a realistic vascular model to explore the BOLD effect, NMR Biomed., vol. 21, no. 6, pp , (34 citations) Other science related publications - G. Morrison, J.P. Marques, A conversation with Sir Peter Mansfield (Nobel Laureate 2013), EuroPhysicsNews, 2006, volume 37(1) - J.P. Marques and G. Morrison, «Há um problem a de falta de confiança na ciência» (There is a problem of lack of trust in science), Gazeta de Física, 2006, 29(4) Invited presentations: Talks at educational sessions at International Conferences: Interaction of magnetic fields with tissue at the Educational Weekend of the 25st Annual Meeting of the ISMRM, Honolulu, Hawaii, 2017 Electrical Property Mapping based on Receiver Coil Sensitivities, 4th International Workshop in Quant. Susceptibility Mapping, Graz, Austria, Sep, 2016 k-space Representation of CAIPI and generalisation to non-cartesian k-space trajectories, ESMRMB Lectures on MR: 2 nd school on Simultaneous Multi-slice/ Multi-band imaging, Nijmegen, Netherlands, 2016 Biophysical mechanisms of phase contrast in the human brain, Annual meeting ESMRMB, Edinburg, Scotland, Oct, 2015 The search of the true inverse problem, MICCAI conference, Intelligent Imaging, Munich, Germany, Oct, 2015 More on Electrical Property Mapping, 2nd International Workshop in Quant. Susceptibility Mapping, Cornell, Ithaka, New York, USA, Jul 2013 Static Magnetic Field: Magnetic Field (in)homogeneity, Effects of Susceptibility, Demagnetizing Field & Lorentz at the Educational Weekend of the 21st Annual Meeting of the ISMRM, Salt Lake City, Utah, 2013 Scanning at High Fields... 7T and Beyond, 1 st International Meeting on Biomedical and Astronomical Signal Processing (BASP) Frontiers, September 2011 Setting up the Inverse Problem From Phase to Magnetic Susceptibility, 1st International Workshop in Quant. Susceptibility Mapping, Dornburg, Germany, 2011 Other Invited Presentations 4

5 Se7en sins & Se7enT images, University College of London, UK, 2016 Imaging with inhomogeneous RF fields: avoiding, fighting and making the most of them, Centre of Biomedical Imaging, Lagone Medical Centre, New York University, US, 2013 In vivo Structural Imaging of the Cerebellum, the Contributions of Ultra-High Fields, University Duisburg, Germany, 2012 Prizes/Awards/Academy memberships Elected for the Board of the ISMRM study group: Electro Magnetic Property Mapping Study Group Currently vice-president, to become president in Distinguished Reviewer of the journal Magnetic Resonance in Medicine (also in 2012 and 2010) Moderator at international conferences (ISMRM, ESMRMB, QSM international Workshop) 2015 Paper in MRM: Single acquisition electrical property mapping based on relative coil sensitivities: a proof of concept demonstration by JP Marques et al, was the editors pick of the month Made Faculty member of 4 international conferences (ISMRM, MICCAI, ESMRMB, QSM international Workshop) 2010 Paper in Radiology Cerebellar Cortical Layers: In Vivo Visualization with Structural High-Field- Strength MR Imaging by JP Marques et al, was selected for journal cover and the Editorial discussion 2006 Travel Award from the organization of Human Brain Mapping Travel Awards from the ISMRM 1999 Premio Dalla Bella awarded to the best graduated student of the Physics degree at the FCTUC; 1998/99 Bolsa de Merito awarded to the ten best students of the Science Faculty, Univ. of Coimbra, Portugal); 5