CLIB NOVEL BIOBASED VALUE CHAINS. The Industrial Biotechnology Cluster Building Sustainability. Edition 2018 / 2019

Transcription

1 CLIB Edition 2018 / 2019 NOVEL BIOBASED VALUE CHAINS The Industrial Biotechnology Cluster Building Sustainability

2 Contents Introduction 3 CLIB The Bioeconomy Network 4 CLIB Strategy 5 10 Years of CLIB 8 Structured Networking Process 10 BioInnovation Growth mega-cluster - BIG-Cluster 15 Technology Transfer - From Invention to Innovation 17 Scale-up and Demonstration 21 Enabling Novel Value Chains 23 Education - Training the Next Generation of Biotech Professionals 27 Project Fact Sheets 28 CLIB Extended Board 31 CLIB Advisory Board 34 CLIB Office 36 CLIB Members 37 Member Profiles 40 Contact / Imprint 67 2

3 Introduction 10 years of CLIB: Review and Outlook Dear members and friends, This year CLIB looks back on a successful decade of open innovation in bioeconomy. Within this timespan, the view on the bioeconomy and how quickly to implement it, has changed dramatically. Whereas in the past dwindling fossil resources were in the foreground, today climate protection is the focus. The Paris Climate Agreement of 2015 increasingly displays its full effect, demanding greenhouse gas (GHG) reductions, the changing of feedstock and the improvement of feedstock efficiency. The agreement also sets a clear time line for reducing GHG emissions by 95 % compared to the level of This ambitious but inevitable target implies a disruptive transformation of carbon processing industries to be implemented by Society, politics and industries have begun to take up the challenge, modifying general frameworks, defining targets, implementing sustainable processing, and adapting business models. As always, early movers will be the winners. What is the role of CLIB in this transformation process? First: All CLIB members are engaged in this transformation process. Academia and industries develop data-sets, knowhow, and technologies each in their own fields of interest. Across CLIB s about 100 members, an enormous knowledge is waiting to be made available and valorised. CLIB functions as a market radar for the early identification of promising feedstock and product opportunities and technology needs. The main tool-set to make the accumulated wisdom of its academic, industrial, and investing community available, are proven communication platforms developed over the last decade. CLIB adds value by connecting the dots along bioeconomy value chains. One example is the CIC, CLIB s international conference, which has evolved to a highly reputed annual partnering event for international bioeconomy stakeholders. Second: The transformation process into the bioeconomy is fundamental. It is too big and too complex to walk it alone. Maintaining and expanding the network of bioeconomy stakeholders is therefore a never-ending task. Partners are needed to provide the necessary capacity in technologies, human resources, know-how, and capital. CLIB helps to form appropriate consortia out of its membership and beyond. Most consortia are targeting on science & technology, and academic education. Meanwhile CLIB is a proven midwife in forming successful R & D & I consortia. Thomas Schwarz Third: Obviously, there is not one global bioeconomy. Regional ecological, economical, political, and societal conditions all need to be considered when defining strategies to shape the feedstock change and the way into the bioeconomy. From the very beginning, CLIB has payed attention to the global dimension of bioeconomy value chains. Universities, multinational companies, and SME participated in several delegation trips to other EU countries, to South- and North-America, Russia, Japan, China, and South-East Asia. Today, 24 % of CLIB s members are located in these regions and enrich CLIB s accumulated wisdom through their specific views, capabilities, and needs. Cross-regional and international partnering is and remains one of CLIB s focus fields. A well-established example is BIG-Cluster, the cross-regional cooperation of North-Rhine Westphalia (Germany), Flanders (Belgium) and The Netherlands. Supported by the regional governments, well integrated in national and EU bioeconomy programs, and with a jointly defined working plan in technical and scientific topics as well as university education, BIG-Cluster has become a model in pushing cross-regional bioeconomy developments. Fourth: The new approaches in feedstock, processing, and business models the bioeconomy needs often emerge in young companies outside of established structures. The transfer of biotech innovations from academia to industrial practice is essential to realise a European bioeconomy strategy. SMEs and start-ups play a vital role in this transfer process. It is they who possess the required dynamics, courage, and entrepreneurial potential, as well as the scientific excellence of their founders, to bring risky, extraordinary, or explorative business ideas and developments into practice and implementation in industry. In doing so, they connect academia and large industry in the innovation process and accelerate the dynamic development of the bioeconomy. CLIB and its members support SMEs and start-ups in this vital role and thus strengthen European leadership and technologic advancements. CLIB members provide commercial services and pro bono, commitment to define the appropriate strategy, raise financing and grow the enterprise. Several companies have evolved from the cluster over the last decade and found their way into bioeconomy markets. With now 10 years of providing services in networking, communication, and partnering we are grateful for the continuous and effective cooperation with our stakeholders and feel well prepared to effectively support our members on the way into Manfred Kircher the bioeconomy. 3

4 CLIB 2021 The Bioeconomy Network CLIB2021 is an international open-innovation cluster of large companies, small- to medium-size enterprises (SMEs), academic institutes and universities, as well as other stakeholders active in biotechnology and the bioeconomy as a whole. We are a non-profit association, with our members shaping the cluster s interests and activities. Our membership of more than 100 organisations comprises an international share of about 25 % (see figure 1). We aim to network our members within and beyond the cluster to initiate new research and business projects. Our goal is to network stakeholders along and across value chains and to identify new opportunities in the circular bioeconomy. As the bioeconomy becomes increasingly diverse, our membership progressively includes diverse industries and branches such as biotechnology, chemistry, food and feed, and pulp and paper. This includes multinationals, large companies, SMEs, and start-ups. At CLIB, we try to link feedstock owners with technology providers, processing industries, and consumer industries, and this also is reflected in our membership structure. Associations & Business Support Academia Investors CLIB Large Industries Medium-scale Enterprises Fig. 1: CLIB members. Categories subdivided in national / international members Enterprises Small-scale But an innovative field like the bioeconomy needs scientific excellence. This is why the universities in our network have strong track records in basic research while also branching out into applied research and start-ups. Some of them have platforms to generate novel technologies and new scientific insights that are crucial for biotechnological processes and products. Others of our research and technology organisations (RTO) have a dedicated applied focus, such as the German Fraunhofer Institutes and several of our international RTOs. CLIB is also active in two European public-private partnerships funded within Horizon2020: BBI and SPIRE. Closer to home, CLIB has worked to form strong trilateral contacts between its German home state of NRW, The Netherlands, and Flanders. This has been recognised by the German Federal Ministry of Education, Science, and Research (BMBF), which has awarded CLIB funding for its BIG-Cluster - BioInnovation Growth Mega- Cluster project as part of the Internationalisation of Leading Edge Clusters funding programme (see page 22). An invention only becomes an innovation if it can be implemented and commercialised, and start-ups and SMEs especially benefit from access to a thriving ecosystem comprising experts and facilities essential for bringing an innovation to market. To this end, CLIB seeks to include within its network competence in intellectual property (IP) and legal issues, techno-economic evaluation, process development, and scale-up. Our members also include investors, consultants, infrastructure providers, pilot plants, and networks. The bioeconomy is of course not a national German business alone. It is a worldwide trend requiring a global approach. Our members and strong partners in Germany, Europe, Russia, North and South America, and Australasia are the cluster s links to global markets. We have CLIB contact points at our partners in Brazil, Canada, China, Malaysia, and Russia. It is in these regions, and Europe, that most of our activities are centred. CLIB2021 e.v. CLIB is a registered association under German law, based in Düsseldorf, NRW. The main bodies of our association are the extended board, the advisory board, and the annual general assembly. Our extended board (see page 31) has 12 seats, with each group of members (industry, SME, academia, and others) represented by three seats. The extended board meets at regular intervals throughout the year to make strategic decisions, and it elects the executive board of four chairpersons. CLIB receives strategic input from an international advisory board made up of seven experts from academia and industry (see page 34). The general assembly comes together to decide about the formal approval of the actions of the executive board and also elects its members every four years. At the CLIB office in Düsseldorf, a staff of eight carries out the cluster work and organisation. 4

5 CLIB Strategy CLIB Strategy At the CLIB retreat in summer 2017, the extended board, together with several other CLIB members, developed a new vision and mission statement. In the light of the Paris Climate Agreement, sustainability was found to be the most important driver for CLIB, with industrial biotechnology being the central means to foster sustainability in all of its dimensions: people, planet and profit. CLIB2021 pushes sustainability through biotechnological solutions from a strong network This vision clearly focuses on the strengths of the cluster - the competency in industrial biotechnology and the network itself. Toward this aim, CLIB has formulated several activities in its mission: We develop cross-sectoral biotechnological solutions for sustainable processes and products, through offering a cross-sectoral, interdisciplinary, and international networking platform applying an industry-driven structured innovation process initiating collaborative R & D & I projects fostering an interdisciplinary and industry-oriented education Several drivers are promoting the use of biotechnology in the bioeconomy and circular economy today. Alternative feedstocks offer diversification of the feedstock base, adding stability to a volatile market. Biotechnological At CLIB, we believe that the bioeconomy and the circular economy are essential for a sustainable, competitive economy in Europe and that biotechnology is a key technology in realising this carbon neutral economy. How can a budding industrial sector succeed against the hurdles just described? New technologies can be enabled through high-value products, which are accessible by these technologies in the short term. High-value products (such as specialties) will allow for faster market access. On this basis, viable business cases of pilot and demonstration actions with smaller feedstock and product volumes can be drafted. They can then serve as reference points to demonstrate bio-based successes. Specialties can also be enabling products for long-term markets by increasing efficiency and capacities in the mid-term and thus allowing the cost-efficient production of bulk chemicals and fuels. This market-focused technology development is what we drive at CLIB. Our activities, actions, and projects are aligned with this strategy, which has been drafted by our office team in close collaboration with the executive and extended board, our advisory board, and input from our members. We have identified five strategic elements that we use to focus our efforts: networking, education, technology transfer, regulatory framework, and scale-up and demonstration. processes can increase efficiency and lower CO 2 emissions, thereby reducing the carbon and environmental footprints. Both together mean more sustainable, more competitive processes for the industry, society and environment. A different driver is the chance to generate molecules with novel functionalities, increasing competitiveness through innovative products. Biotechnology (and, indeed, the bioeconomy) also faces stiff hurdles. The high availability of fossil feedstocks, along with the drop in oil prices over recent years, has meant less incentive to innovate towards bio-based feedstocks and processes. The high efficiency of the established petrochemical processes, which have often been improved over decades, and the lower technology readiness level (TRL) of biotechnological processes compared to existing petrochemical routes also pose a difficult environment for biotechnology to enter industrial practice. 5

6 CLIB Strategy Education Technology Transfer CLIB CLIB2021 pushes sustainability through biotechnological solutions from a strong network Framework Scale-Up Networking Fig. 2: The five elements of the cluster s strategy. Networking is, of course, the core business of any cluster and includes basics such as member services and acquisition. We provide a networking platform for our members, which serves as a central repository for project-related information and acts as a networking tool to prepare our conferences and meetings. Through our networking efforts, we connect our members with one another, along and across value chains, sectors and disciplines. We also open the cluster to input from partners and stakeholders to invite new ideas and impulses, thereby providing our members with new opportunities in business, networking, and partnering. At CLIB, we have designed and implemented a structured networking process (see pages 10 11) to get the right stakeholders in contact with one another and to provide a fruitful, constructive setting in which to exchange ideas and form project consortia. A dedicated education approach is crucial for fields such as biotechnology and the bioeconomy, in which multiple scientific disciplines intersect. Only through specialised initiatives can new professionals be trained who are experts in their own disciplines but are also able to take a holistic approach to a process, product, or value chain. These experts are needed to advance science and applied technologies, and to create new innovations. CLIB especially supports the collaboration of academia and industry in applied research and is working on cross-border concepts of education in key bio-based technologies. We actively support technology transfer from academia to SMEs and industry, for example, through our technology cluster or prototype workshops. Through our structured networking process, we are able to match technology developers with their downstream value chains and can initiate and evaluate consortia. We offer coaching and support to start-ups and give them opportunities to pitch their ideas to relevant stakeholders. A major hurdle for successful technology transfer is scale-up and demonstration. Even after partners have been found and agree on further development of a research result, it can be a challenge to scale-up a process from the lab to an industrially relevant environment or to produce enough sample material for testing a novel molecule or substance. In our strategy, we focus on higher-value products, which are relatively easily accessible and can serve as enablers to establish biotechnology in the industry. But even for these relatively small-scale processes, universities and RTOs do not always have the necessary equipment of the required scale. Here, CLIB is active in SME-support projects such as the BioBase4SME voucher system to support scale-up financially, and we also support enhanced integration with chemical processes and in chemical parks. CLIB actively supports developments to help SMEs and academia to access equipment for testing. 6

7 CLIB Strategy Implementation of the bioeconomy and the circular economy needs a supporting regulatory framework on regional, national, and EU levels. CLIB has for years been active at all of these levels to promote the potential of bio-based and alternative feedstocks as well as to help identify technologies and market requirements. Although it is clear that no new sector can survive while being dependent on subsidies, a positive regulatory framework that includes certification of bio-based products, the use of side streams for the circular bioeconomy, combined chemical-biotechnological approaches, and a focus on cradle-to-cradle product evaluation can speed up the implementation of a sustainable, bio-based economy. Through these five elements and CLIB s mission, we pursue our vision to push sustainability through biotechnological solutions from a strong network. CLIB provides added value to its members by integrating them into an international network of academia, investors, SMEs, and industry, by building knowledge in relevant topics, markets, and technologies as well as trends in biotechnology and clean technologies. The cluster provides access to specialists in the fields of biology, chemistry, and engineering and helps to create novel business models through the formation of networks and value-chain analysis in biotechnology and clean technologies. The formation of tailored consortia, the provision of information on current calls and strategy processes in the field of the bioeconomy and circular economy, and the support of demo and pilot projects of biotech technologies and processes helps members to realise new research, demonstration, and innovation projects either in consortia or in bilateral contacts. That is CLIB - the industrial biotechnology cluster building sustainability. BIG-C Networking BioBase4SME Technology transfer Scale-up Education HiPerIn Framework CLIB RIN Stoffströme INMARE BiOPEN Fig. 3: Classification of projects according to the cluster s strategic elements. Shades of blue indicate the elements mainly pursued within each project. 7

8 10 Years of CLIB 10 Years of CLIB2021 None of the 33 founding members probably envisioned that the regional activity they initiated in NRW, Germany in 2007 would ten years later have grown into a world-wide network of over 100 members. Not only did CLIB continue to exist beyond the initial funding period of the BioIndustry2021 competition from , it actively grew, gained new members and support, and evolved into a trusted partner in European projects CLIB2021 Founding of the association CLIB2021 e.v. CLIB Technology Platforms Four technology platforms PolyOmics, Expression, Biocatalysis, Downstream Processing established at the Universities Bielefeld, Dortmund, Düsseldorf and Forschungszentrum Jülich 2008 First place in the BioIndustrie2021 competition of the BMBF (Federal Ministry of Education and Research) BioBaseNWE Launch of the INTERREG BioBaseNWE project, led by Bio Base Europe Pilot Plant Malaysian Office 4 th international office at Malaysian Biotechnology Corporation, Kuala Lumpur, Malaysia CLIB New Logo & Chinese Office New CLIB logo published th international office at Qingdao Institute of Bioenergy and Bioprocess Technology, Qingdao, China BIG-Cluster & RIN Start of the tri-national BIG-Cluster initiative of Flanders, the Netherlands and NRW 2015 Grant for the RIN Stoffströme, funded by the Ministry of Culture and Science of NRW 8

9 10 Years of CLIB 1 st CIC & Russian Office 1 st CLIB International Conference nd international office at the Research Center of Biotechnology, Moscow, Russia CLIB-GC & Alberta Office Until 2016, over 120 doctoral students took part in the CLIB-Graduate Cluster Opening of the 1 st international office in Drayton Valley, Alberta, Canada German-Russian Cooperation Initiation of the German-Russian Cooperation Network Biotechnology ( ). 3 rd international office in São Paulo, Brazil Spitzencluster & HiPerIn BMBF grant for the BIG-Cluster in the call Internationalisierung von Spitzenclustern Start of the HiPerIn project, funded by the Ministry of Economic Affairs, Innovation, Digitalization and Energy of NRW Québec Office 6 th international office at Saint-Hyacinthe Technopole, Québec, Canada 2017 Today, CLIB helps its members to develop their business ideas and turn scientific results into marketable products. In this regard, we are looking forward to further evolve CLIB together with our members and partners, for the next decade and beyond... 9

10 Networking Process Structured Networking Process Our structured networking process is designed to get the right stakeholders in contact with one another and to provide a fruitful, constructive setting in which to exchange ideas and form project consortia. The CLIB team has developed a series of event formats that span the range from conferences to bilateral talks to narrow down a specific topic and help individual members to find the right partners, build trust, and share information that can lead to new ideas and opportunities. Our CLIB International Conference showcases emerging trends and connects them to markets. Especially relevant topics are taken up and presented in greater detail during forum events, which usually are attended by 40 to 60 people and are also seen as scouting opportunities for larger companies. They also involve non-members as input-givers. Roundtable meetings are held with a smaller group of about 10 to 20 invited experts; these meetings cover specific topics and build consortia or proceed to bilateral talks. The CLIB team also helps members to initiate bilateral meetings and moderates such meetings. The following example shows our workflow in the BIG-Cluster project to illustrate our structured process, which we also optimise and implement in other projects. Here, the different stages of the networking process were the kick-off event, working group meetings, and round-table meetings. The aim was to connect international clusters from NRW, Flanders, and The Netherlands to network stakeholders, competencies, and projects; to generate the critical mass for pilot and demo plants to implement new technologies in the region; and to implement value chains for biobased aromatics. A parallel workflow was carried out for new value chains in C1 utilisation. Working Group Meeting BIG-C Kick-off Similar to the CIC for CLIB, the BIG-Cluster kickoff meeting served as a starting point for the BMBF-funded BIG-Cluster project to identify interested stakeholders in the three regions and to perform an analysis of their interests and expertise. After extensive preparatory work to obtain an overview of relevant stakeholders, to analyse technology approaches in the field of biobased aromatics, and to map running activities and projects in Europe with a focus on the BIG-Cluster region (e. g. Biorizon and the Vanguard Initiative), CLIB organised the kick-off meeting with two parallel sessions. In the biobased aromatics session, presentations given by Ludo Diels (VITO and Biorizon) and Willem Sederel (Biobased Delta) illustrated the diverse projects, initiatives and activities that had already been initiated with a main focus on lignin valorisation. During the C1 session, representatives from thyssenkrupp Steel Europe and Covestro gave an overview of industry s interests in this topic. Rich discussions in both sessions raised several important aspects. CLIB analysed the main topics raised during the meeting and prepared further working group meetings to sharpen the focus of the project. In the following working group meetings on biobased aromatics, a comprehensive expertise mapping was achieved to identify stakeholders covering the whole value chain from lignocellulosic feedstock suppliers via technology providers to chemical process industry and brand owners. The focus was on suitable pretreatment methods to obtain high-quality lignin fractions, on tailormade DSP to fractionate and separate highly functionalised bioaromatic molecules and on industry-relevant applications like coatings and adhesives. The CLIB team researched funding options for trinational R & D projects and the promotion of early-stage researchers in this field. 10

11 Networking Process Round-table Meetings The aim of the roundtable meetings was to build on the outcomes of the working group meetings and derive from them concrete actions to plan projects and draft proposals. The list of available technologies was discussed and potential industry-relevant applications were identified. Several project ideas were defined and funding strategies were analysed. This was finalised in the last round-table meeting, in which the project concepts for e. g. R & D projects or Innovative Training Networks and consortia were defined. Projects & Bilateral Collaborations Delegation Trips Each year, CLIB, together with its members, selects countries or region that offers exciting developments in the bioeconomy. CLIB performs an analysis and establishes the first contact with competent local networks. After checking funding possibilities, CLIB organises a trip for its members to visit the region. Often in combination with a conference in the area, the delegation visits companies and business sites and networks with stakeholders. The aim of the delegation trip is to initiate contacts and identify project opportunities for CLIB members. After the visit, CLIB remains in contact with the network established abroad. Further cooperation, in research or business projects, is pushed directly by the participants. 11

12 Networking Process In Dialogue with CLIB CIC2017, January 2017 CLIB2021 launched its year with a highlight: the seventh CLIB International Conference (CIC2017). 170 participants from 14 nations, presentations ranging from the development of biotechnologically and economically feasible processes to biobased applications in home and personal care, and a high-profile panel discussion made this first international conference on bioeconomy in 2017 a good start of the year. The CIC once again emphasised a change in thinking in the bioeconomy. In addition to aspects of sustainability, the individual lectures also highlighted an increasing number of marketdriven aspects, which promote the future implementation of the bioeconomy into processes and products. A first-rate panel discussion concluded the first day of the congress, which was moderated this year by Dr. Ludo Diels (VITO). The panellists were Ms. Andrea Noske (BMBF), Prof. Stefanie Heiden (University of Osnabrück), Dr. Dr. Christian Patermann (former Director, EU Commission) and Dr. Roland Breves (Henkel AG & HiPerIn Forum Events In its different projects, CLIB organises several forum events each year. These serve to focus on topics relevant to bioeconomy and the project at hand, with at each event three to four presentations and a total of participants. The networking during and after the forum events has become a mainstay of CLIB s network activities. Examples are the 2017 forum events on technology transfer and life cycle analyses, which where part of the Biobase4SME project (see p.18). Within the HiPerIn project, four forum events were organised between September 2016 and July 2017, which covered a diverse range of topics: HiPerIn Biotech for high performance ingredients in flavours & fragrances Biotechnology for food and feed High-performance ingredients for cosmetics - new innovations through biotech Biotech innovations for coatings Co. KGaA), who discussed market requirements and the role of brand owners to ease biotech products into the market. Their discussion, but also many of the presentations during the day, emphasised that many wheels in business, science and politics, must be set in motion to bring bio-based products on the market. The CIC not only offers a forum to draw attention to these challenges, but also tries to define approaches to address them, said Dr. Thomas Schwarz, Chairman of the Board of CLIB. Many participants concluded that the CIC offers an exciting congress programme, and a familiar atmosphere where old and new faces of the industrial biotechnology scene meet. Many also appreciated that the CIC again managed to let science and industry meet on an equal footing. All events had a representative from a large industrial company giving some insight into how they view the opportunities biotechnology offers in the production of high performance ingredients for added functionality in novel products. For Dr. Borup from ALTANA/BYK, the expectations were clear: biotech-derived products would not gain by being greener, they would naturally have to be sustainable to be considered by the company. However, the big opportunity would be to offer something new, a special extra to add to a product in order to improve it or make it unique. Cosmetic products at Henkel are very innovative: Dr. Sättler explained that the business unit beauty care has a high innovative value of 45 %, meaning that 45 % of sales are generated by new products launched on the market within the last three years. This requires active R & D to constantly develop novel products which presents a chance for biotechnology-enabled novel ingredients to find their niche. 12

13 Networking Process However, at shelf prices of e. g. 99 cents per 100 ml of shampoo, the financial margin is tight. The big challenge for novozymes, who engineer and produce enzymes for a variety of applications, is to translate consumer demand into industry. For example, to produce enzymes which help create a bread which is soft, moist, tender, and has an appealing texture all characteristics desired by consumers these characteristics first have to be translated into measurable parameters. Then an assay can be developed, and the application (in this case bread-baking) downscaled, which can be tested in the lab. Similar challenges were given by Henkel for testing new ingredients for laundry detergents. Other presentations touched on novel products, for example novel carbohydrates from sugarbeet, bio-based surfactants, self-healing coatings or bio-based pigments for colourful biobased plastics. Making complex natural substances readily accessible through biotechnological production routes makes BIG-Cluster Stakeholders Meeting, June 2017 The BIG-Cluster Stakeholders Meeting, held on 12 June 2017 in Eindhoven, illustrated the vivid knowledge exchange and cross-border collaborations under the umbrella of the BIG- Cluster. Diverse innovation projects bring together high-level experts from BIG-Cluster region in the flagship to product (F2P) value chains Aromatics from woody biomass, C1 gases to chemicals, Aviation fuels from various feedstocks, and the horizontal topic Circular economy education. 100 experts from large companies, SMEs, academic institutes and universities, as well as networks attended the matchmaking event and developed roadmaps on the BIG-Cluster F2P value chains in parallel workshops. The participants agreed that all stakeholders need to work together and build new value chains supported by the government(s) to facilitate large investments. The meeting revealed starting points for new collaboration topics and cross-border research & innovation projects. them also available for new applications what would have been a prized ingredient for fragrances can now be used in larger scales e.g. as insect repellent, or levulinic ketals can now be used in cosmetics. The cross-border activities under the umbrella of the BIG- Cluster will be intensified in the future. The next Stakeholders Meeting in 2018 will further foster bio-based economy in the BIG-Cluster region. In 2018, CLIB staff will organise follow-up events, Round Tables, on topics identified as especially relevant during the forum events. These will serve to connect stakeholders and initiate new projects and business ideas. They will also guide the development of a roadmap towards a HiPerIn Competence Centre. CLIB members and participants of the individual forum events can download the full reports and presentations from the CLIB networking website. The BIG-Cluster initiative has started in Today, we look back on a success story as the 10 project pitches have impressively demonstrated. They build a sustainable base to expand the close collaboration of the three BIG-Cluster regions. Willem Sederel, Biobased Delta 13

14 Networking Process BMBF Delegation Trip on Entrepreneurship to China, June 2017 China is one of the most important research nations in the world and is systematically expanding its innovative capacity. Like Germany, China has placed innovation at the centre of its economic and social developments. It has consequently become an important research and development partner in the search for solutions to global challenges. In June 2017, CLIB participated in a delegation to Jiangsu province organised by the German Federal Ministry of Education and Research, BMBF. With over 200 German companies, the city of Taicang hosts the largest number of German enterprises in China. The aim of the trip was to participate in the Sino-German Youth Innovation Cooperation and Entrepreneurship week. This event intended to promote communications and experience sharing between young entrepreneurs from China and Germany. The more than 30 BMBF delegates visited the Sino- German Dual System Training Centre, which is the first of its New CLIB Canada Representative Office in Quebec, July 2017 To increase the strong collaborations between the Canadian province of Quebec and Germany, an agreement for a CLIB representative office was signed by CLIB and Saint-Hyacinthe Technopole on 24 July 2017 during the BIO World Congress in Montréal. Saint-Hyacinthe will be the second contact point for companies interested to get in touch with cooperation partners in Canada. CLIB opened its first Canadian representative office in Drayton Valley, Alberta, in For more than a year and a half CLIB has been maintaining a close contact with Saint-Hyacinthe Technopole, which was initiated by CLIB s long-term Canada expert Bruno Wiest (Trade Commissioner, Embassy of Canada). During a 2016 delegation visit, CLIB members and partners met with Canadian researchers and entrepreneurs from Saint-Hyacinthe to discuss scientific topics and cooperation opportunities. After the trip, both CLIB and Saint-Hyacinthe Technopole agreed to keep in close contact. kind, located in Taicang. After splitting the delegation into two subgroups focusing on either IT and process manufacturing, or biotechnology and medicine, the delegates visited the Chinese cities of Wuxi and Nanjing. CLIB was part of the biotechnological delegate group and visited the Nanjing Biotech and Pharmaceutical Valley, an accelerator for young biotech companies. Also impressive was the YouthSpace Incubator. This office building for young entrepreneurs provides a supported infrastructure to startups. CLIB had already, at earlier visits, experienced the kind hospitality and the scientific expertise of its Chinese members, the Nanjing Tech University and Qingdao Institute of Bioenergy and Bioprocess Technology. The latter is the official CLIB representative office in Qingdao. CLIB will continue to strengthen the ties to China and its Chinese members, also by organising future visits. This collaboration has now been further deepened, when Manfred Kircher and André Barnabé (General Manager, Saint-Hyacinthe Technopole), finalised the agreement for the new CLIB representative office in Quebec hosted by Saint- Hyacinthe Technopole. They will support CLIB s members to develop business in Canada by offering on-the-ground assistance, helping to reach new export markets in Canada and North America. Further on, the Technopole will help to connect with qualified Canadian contacts for R & D partnering, commercialization or sourcing of technology. CLIB is looking forward to a fruitful cooperation with Saint-Hyacinthe Technopole. Quebec and Germany share the very same bioeconomy vision and provide excellent academic and private facilities willing to cooperate in research, development and commercialization. Therefore I m happy to see CLIB s next anchor in Canada opened 14 Dr. Manfred Kircher, Chairman of the CLIB Advisory Board

15 BIG-Cluster BIG-Cluster The BioInnovation Growth mega-cluster (BIG-Cluster) is a cross-border Smart Specialisation Initiative aiming at making Europe s industrial mega-cluster in the Flanders region of Belgium, The Netherlands, and the German state North Rhine- Westphalia (NRW) a global model in comprehensive bio-based value chains. The region has been a powerhouse of industrial innovation for decades. BIG-Cluster was initiated by the three cluster organisations BE- Basic (The Netherlands), Catalisti (Flanders, Belgium), and CLIB (NRW, Germany). It is backed by Biobased Delta, BIO.NRW, CEF.NRW, Chemelot Brightlands, CleanTechNRW, FlandersBio & Flanders Biobased Valley. BIG-Cluster s purpose is to speed up the transition into the bioeconomy and circular economy in the participating regions, to identify and take advantage of critical mass and synergies in public and private R & D and training and education facilities, and to implement and build capacity in the aforementioned fields and in industries. One of the long-term goals is to enable pilot and demonstration activities for the production of chemical building blocks and fuels based on alternative resources - 2 nd generation biomass and industrial waste gases - in the region. Fuels) and the cross-sectional topic Circular Economy Education (Education). In 2016 and 2017, CLIB initiated three international consortia focused on these topics via the previously described structured networking process. F2P Value Chain C1 Bioconversion Generally, CO- and CO 2 -containing gas streams from diverse industrial sectors (chemical, energy, steel) are abundant in the BIG-Cluster region as Europe s industrial heart. Moreover, syngas from the gasification of organic materials, such as municipal solid waste or industrial solid waste, provides another source. These C1 gases can become valuable feedstock for the production of chemical building blocks that are currently being produced via petrochemical process routes. The capability to produce these building blocks from renewable non-food feedstocks would be an asset for European industries and offers a model of innovative circular integration and explores a new-to-the-market carbon source available in Europe in very big volumes. First C1 bioconversion technology approaches are currently on the brink of commercialisation, but C1 bioconversion still has several hurdles before it can be extensively implemented. The German Federal Ministry for Education and Research (BMBF), as part of its Internationalisation of Leading- Edge Clusters, Forward-Looking Projects, and Comparable Networks Strategy, supports CLIB s internationalisation strategy within the BIG-Cluster initiative with up to 4 M EUR in the period of International partners from industry and academia along specific Flagship-to-Product (F2P) value chains join their high-level, multidisciplinary expertise to set up a project network around various technology fields, spanning the entire BIG-Cluster region and beyond. The project network fosters the systematic development of key technologies crucial for the realisation of novel biobased value chains. Working groups regularly meet to discuss recent progress, define new project ideas, and set up consortia. These meetings act as innovation hubs for the development of new technologies and novel sustainable value chains and, as such, provide a platform for all stakeholders of the whole BIG-Cluster region and beyond. Due to the focus on specific topics and its super regional character, BIG-Cluster offers the possibility for CLIB and its members to actively foster cross-border projects, acquire funding on an international level, and expand their network. Currently, BIG-Cluster focuses on the three F2P value chains Aromatics and Fine Chemicals from Woody Biomass (Biobased Aromatics), Chemicals from CO and CO 2 (C1 Bioconversion), Aviation Fuel from Various Feedstocks (Aviation Internationalisation Circular Economy BIG-Cluster BioInnovation Growth mega-cluster Bioeconomy The major challenges that must be overcome to be competitive with petrochemical routes and processes based on sugar fermentation are a lower TRL compared with chemocatalytic conversion and sugar fermentation, resulting in a lack of know-how and experience; a lower process efficiency; a limited product spectrum; limited genetic toolboxes for efficient strain development; the necessity of alternative reactor design; and, last but not least, the need for proof-of-concept studies at relevant scale to demonstrate technical and economic feasibility. 15

16 BIG-Cluster To tackle this hurdle, the project BioCOnversion will develop a process enabling the biotechnological conversion of CO/ syngas into a high-value plastic precursor (for more detailed information, refer to p. 19). The first BIG-Cluster think tank C1 Bioconversion was set up with more than 20 stakeholders. Its experts are developing integrated process optimisations with hand-in-hand strain development and process engineering. One of the major challenges is the limited product spectrum, since the only intermediates accessible to date are small molecules such as alcohols and organic acids. They are bulk chemicals which suffer from high economic pressure, especially under the current historically low oil price. This restricts the implementation of new processes based on CO or CO 2. The C1 Bioconversion Think Tank aims to develop novel value chains ranging from the primary conversion of these C1 gases via gas fermentation into intermediates, which will in turn be converted to higher-value chemicals using biotechnological and / or (electro)chemical methods. Target products in focus are chemical building blocks with wide-range applications but a higher value than ethanol, such as plastic precursors and further platform chemicals. Therefore, it is highly desirable to develop conversion routes to upgrade renewable biomass to aromatic molecules. Lignin, the second most abundant terrestrial polymer and the only large source for biobased aromatics, is currently used only in limited amounts since conventional lignin extraction processes often suffer from poor quality of the lignin fraction. The biobased aromatics approach is driven by the need for highly functionalised aromatic molecules that can be applied in different application fields. In BIG-Cluster, a main focus is on molecules with new functionalities. Chemical and/or enzymatic upgrading strategies are of particular interest to acquire highly functionalised molecules. Therefore, lignin extraction processes, which maintain the structure and functionality of lignin, in combination with innovative chemical and biotechnological conversion routes are urgently needed to enable the production of functionalised biobased aromatics. Against this background, BIG-Cluster initiates projects such as the ALIGN project (see p. 22) focussing on different extraction technologies, biotechnological and chemical conversion routes, tailor-made downstream processing (DSP), and new applications. The whole value chain from feedstock providers to brand owners will be covered to facilitate entry into markets such as adhesives, coatings, plastics, and food and beverages. Because of the vast diversity of both feedstocks and applications, the F2P value chain Biobased Aromatics involves stakeholders from different disciplines and sectors. F2P Value Chain Biobased Aromatics Aromatics represent a significant share of today s chemical building blocks used for a wide variety of applications across the chemical industry. Their growth rate is expected to be proportional to GDP growth. Currently, virtually all aromatic building blocks are produced from fossil oil. But as the use of crude oil for energy is predicted to decrease, also cracker capacities will go down, leading to a smaller BTX stream (aromatic hydrocarbons benzene, toluene and xylenes) available for chemicals. Furthermore, the shift to use natural gas resources for chemical building blocks, such as ethylene and propylene, will further upset aromatics demand and supply, as the BTX stream available from cracking natural gas is much smaller compared to crude oil. Horizontal Flagship Education The horizontal BIG-Cluster flagship Education will include the aforementioned F2P value chains as well as further important topics of the bio-based economy. This flagship brings together existing excellent education activities to train the next generation of highly skilled scientists and future entrepreneurs. The universities in the BIG-Cluster region already offer a number of high-quality study courses (BSc/MSc/PhD) in disciplines such as biotechnology, chemistry, engineering, and economics, but none of them conveys a holistic approach to the circular economy and bioeconomy in the region. In the long term, BIG-Cluster aims at aligning these courses with a comprehensive concept of the bioeconomy (please see p. 27 for further information). 16

17 Technology Transfer From Invention to Innovation CLIB brings together stakeholders from academia and industry along the whole value chain in its structured network process. This helps academia learn more about market needs, required product specifications, and required process or technology performance. CLIB moderates the related exchange between academic and industrial stakeholders in order to initiate joint R & D projects with defined technology development goals. CLIB also supports market-oriented technology development through a dedicated selection process of target products and appropriate technology approaches based on market needs. The BioCOnversion project, as an example of such a process is showcased on page 19. The exploitation of research results from academic institutions is often limited due to an insufficient technology readiness level (TRL) and a lack of commercialisation strategies. As a result of high technical and financial risks, industry is often hesitant to pick up such ideas for further development. The transfer of research results into commercial applications requires tremendous financial and time efforts as well as diverse scientific and economic expertise. The extraordinary diversity of life science technologies, their areas of application, and the necessary knowledge needed to apply them further complicate technology transfer in this sector. (LCA) or scale-up. The latter is done through the BioBase4SME project. Furthermore, the cluster creates visibility for novel technologies and young companies through presentations at its events and in its publications. For each project involving technology transfer, a dedicated workflow fitted to the demands of the given topic is developed. CLIB performs value-chain analyses in order to identify available technology approaches, relevant stakeholders, and potential markets. Based on this evaluation, a SWOT analysis will elucidate the near-, medium-, and long-term business opportunities of the value chain in focus. To which depth CLIB is able to pursue these analyses depends on the project involvement and funding. As was done in BIG-Cluster, CLIB can help to select one or two technology approaches or concepts of novel value chains with extraordinary potential for commercialisation. For these, tech-transfer strategies are then developed by evaluating the technology readiness as well as potentials and risks. Business models will be prepared, including calculations of production costs, investments, and revenues as well as estimations of volume availabilities and market shares. IP concepts and strategies for further technology developments and strategic partnerships can be designed. To bridge this gap and to trigger industrial interest for further development, CLIB supports technology transfer through a multifaceted approach that also involves its strong network of strategic partners. In this regard, CLIB helps match up needed experts and investors and facilitates access to vouchers for preliminary techno-economic analysis, life-cycle-assessment CLIB is active in promoting technology transfer from academia to industry and also among sectors. We do this through targeted intervention by connecting single members to relevant industrial partners through our work in funded projects or with partners in project consortia. 17

18 Technology Transfer Project Implementation Technology transfer is an important aspect in many of the CLIB s active projects. In the local HiPerIn project, biotechnological concepts for high-performance ingredients will be established by combining different scientific fields on the one hand and market needs on the other hand, which will help to transfer technology from the lab to an industrial scale. By combining different research areas such as biotechnology, structural chemistry, and process engineering, new approaches and workflows for a more targeted screening for novel molecules can be created. High-performance molecules can have desired properties in functionality, colour, taste, solubility, or temperature stability. These might be changed by specific triggers, for example, a shift in temperature change causing a colour change, indicating when a cooling chain has been broken. Within HiPerIn, CLIB aims to draft plans for a Competence Centre to combine the necessary experience and speed up technology transfer. A first step has been the application for funding of a Competence Centre Biotechnology (CKB) within the research infrastructure initiative by the German state of NRW. This virtual centre has been proposed by four academic members of CLIB: Bielefeld University, TU Dortmund University, the University of Düsseldorf and the Forschungszentrum Jülich. The CKB builds on the previously funded separate technology platforms at the institutions, which will now be integrated into a joint centre to develop biotechnological processes in a holistic approach. CLIB will anchor this centre within its network. Technology transfer also means cooperation between different sectors or industries. To improve utilisation of side and waste streams in industry, agriculture, or forestry, the so-called regional innovation network (RIN) model region for innovative and sustainable material flow was set up in The project s goal is to improve exploitation of biomass, wastes, and side streams in the cross-border region of NRW and The Netherlands. The current aim of the RIN is to develop feasible concepts for that task through an interdisciplinary approach that also integrates practitioners and society. That interdisciplinary solutions are required is obvious when considering how many different scientific areas (e.g., agricultural sciences, biology, biotechnology, chemistry, process engineering, logistics, economics, social sciences) are addressed, and such interdisciplinary cooperation is a feature of a multitude of research projects and clusters. Stakeholders such as farmers and representatives from cooperatives, the processing and waste industry, and public administration are currently not often included in such efforts. The experience within the RIN shows that although including such stakeholders increases the complexity of the work, it can lead to new approaches and synergies and can raise new scientific questions. Within the EU-funded project INMARE, CLIB aims to optimise exploitation of the expected scientific results. Researchers are screening libraries generated from extreme marine environments for interesting enzymatic activities and will characterise and produce the relevant ones. In doing so, they will develop novel technologies and processes. CLIB will help to moderate between researchers and industrial partners in the consortium to translate industry needs. CLIB also offers a workflow to help researchers evaluate their results and advises on further work needed or the best approach to take to bring a scientific advancement to commercial use. CLIB s activities in the European public private partnerships (PPPs) Biobased Industries JU and SPIRE also aim toward bringing research results into practice. BioBase4SME Technology transfer is essential to bring innovations into the market: it is needed to support the development of ideas generated in the lab into future processes and products. The BioBase4SME project provides crucial support for SMEs who want to upscale their processes, by providing vouchers for a diverse range of services, but also through information events. One example is the BioBase4SME Forum Event on technology transfer organised in Düsseldorf in March Several speakers presented the different approaches to tech transfer in Germany and the Netherlands. Markus Struppe from UnternehmerTUM, showed how automotive and mechanical engineering is bringing new products from lab to industry by 18

19 Technology Transfer using a comprehensive tool box, comprising prototyping labs, consulting, and access to venture capital. The Unternehmer- TUM Center for Innovation and Business Creation is a privately owned associated institute of the Technical University Munich (TUM), founded in In future, UnternehmerTUM plans to expand its focus to cover also biotechnology. In the Netherlands, the Dutch Topsector Chemistry proposes an innovation ecosystem where ilabs (incubators for start-ups close to knowledge institutes), COCIs (Centres for Open Chemical Innovation) and CoEs (Centres of Expertise, which act as service points for SMEs) work together. The Centre of Expertise in BioBased Economy (CoE BBE) aims to support companies in their biobased ambitions by involving them in modernising professional education and by supporting their applied research with a strong linkage to economic demands. Dr. Douwe-Frits Broens explained that their Biopolymeer Applicatie Centrum (BAC) organises workshops for the development of applications from existing biopolymers. These workshops are organised in cooperation with educational institutes and partner companies. One project example was the construction and building process of a biobased bridge. The forum event focused not only on the transfer of technologies from lab to industry, but also took a broader view on open innovation approaches to create favourable conditions to stimulate collaboration between companies. Dennis van der Pas from REWIN described their clustering process set up to bring companies together. The current seven clusters cover multiple themes such as natural fibres, coatings & colorants, packaging, or pyrolysis. The clusters function on a combination of market pull and technology push by using an open innovation approach and are open to foreign organisations. Concluding the forum, Tobias Wingbermuehle explained the approach of the start-up Clustermarket, which facilitates market -entry and scale-up for start-up companies. Clustermarket aims to establish an online market place for sharing lab equipment and facilities in the region. A first test of this business model has already been successful in the UK, at King s College London. BIG-Cluster Project BioCOnversion The project BioCOnversion will vividly illustrate the successful technology transfer across borders. Within the project, different technologies will be evaluated by an international consortium of industry and academia partners who combine their high-level, multidisciplinary expertise to develop and implement a sustainable process from carbon monoxide (CO)- containing process gases to a defined polymer precursor. CO-containing process gases, abundant in the BIG-Cluster region from e.g. steel mills, are among the most relevant industrial side streams and can be valuable feedstock streams for the biotechnical production of building blocks that are currently produced through petrochemical process routes. Mid-chain carbon compounds with multifunctional groups are of special industrial interest. Since they are conventionally generated from fossil resources, developing new routes using renewable non-food feedstocks to provide such precursors would be a major step to establish a sustainable bioeconomy. The process under investigation in the BioCOnversion project comprises the primary conversion of CO/syngas into an intermediate through gas fermentation and the subsequent enzymatic upgrading conversion into the polymer precursor. BioCOnversion unites several innovative providers of conversion and recovery technologies into a powerful consortium covering the entire value chain making a high-value building block available from a CO-based, renewable process. The project focusses on developing technologies for the individual process steps and on the conceptional design of the overall process using the best-suited technologies for each process step. In a first phase, the individual process steps will be independently developed. Their performance will then be evaluated by techno-economic assessments and life cycle analysis. Based on these results, the overall process will be experimentally validated and further optimised. A final process evaluation will be done from a techno-economic viewpoint along the whole development chain. 19

20 Technology Transfer Start-up Support Inventions from academia present an important innovation pool that encourages the further development of industrial biotechnology. However, experience has shown that many valuable R & D results never move from lab to industrial applications and further on to the market. CLIB aims to foster, together with experienced partners and based on the knowhow of its network, the successful transfer of academic inventions into innovations. As such, the support of start-ups is an essential element of CLIB s cluster strategy. In industrial biotechnology, inventions that come out of the laboratory are usually less mature than those in other scientific areas. Therefore, they are a challenge for the transfer centres located at universities. Here, start-ups come into play because they offer an ecosystem in which the technologies can be developed further by the initial inventors. They are highly qualified, have the required know-how, and are motivated to take the risks of technology development in order to lead the project to economic success. In this way, barriers to market entry are lowered, and the inventions become more attractive to industry and investors. Additionally, this model offers income and reputation for the university as the origin of the invention. Thus, start-ups play a key role in successful technology transfer from university to industry. To convince industry or investors to finance a novel product or process, it is crucial to demonstrate that the invented technology is controllable or that remaining risks are calculable. In many cases, only lab-scale results can be provided by the academic institutes, but those are usually not sufficient to derive aspects such as industrial feasibility, economic efficiency, or scalability to industrial needs. Preparing resilient proof-ofconcept studies, which withstand industrial validation and are geared toward available technology and product benchmarks, is crucial. A structured approach to describing customer benefits and the intrinsic value of the business model is also key. Here, CLIB and its network of experienced entrepreneurs offer valuable assistance. Together with b.experts, our network provides several further support actions, such as identification of implementable inventions and development results by industry experts, generation of a comprehensive patent protection plan, and coaching by business development experts. Matchmaking with investors or partners from industry is another. Furthermore, we help to get access to funds through funding programmes such as GO-Bio and EXIST. Moreover, first-reference projects with partners from industry have significant value. Such collaborations are able to demonstrate the level of industrial maturity of a developed technology. For investors, this is a crucial criterion for evaluating a technology. As a partner in projects that award funds to start-ups and SMEs via vouchers for demonstrating the industrial scalability of novel processes, CLIB can also offer support for such demonstrations. By integrating start-ups in its network and by providing valuable contacts to industry and experts, CLIB will more and more become an ecosystem for the incubation of start-ups in industrial biotechnology in itself. Supported by experienced coaches and seed investors from its membership and network, CLIB will help to close gaps within the innovation process and thus contribute to a start-up culture that is geared toward the market demands of the chemical industry. 20

21 Scale-Up Scale-up and Demonstration Europe needs to turn more of its bio-based research into commercial innovation. Companies need to be able to scale up their innovations from lab scale to an industrially viable process; this is often a challenge because of the cost, capital equipment, and expertise required. Furthermore, they need to find partners, users, and investors; assess their feedstock security; and get legal support to bring their product to the market successfully. A major hurdle for successful technology transfer is scale-up and demonstration. Even after suitable partners have been matched and all parties agree on developing a research result further, it can be a challenge to scale up a process from the lab to an industrially relevant environment or to produce enough sample material for testing a novel molecule or substance. In CLIB s strategy, we focus on higher-value products that are relatively easily accessible and can serve as enablers to establish biotechnology in the industry. But even for these relatively small-scale processes, universities and RTOs do not always have the necessary equipment of the required scale. Here, CLIB is active in SME-support projects such as the BioBase4SME voucher system to support scale-up efforts financially. Additionally, the cluster supports the integration of biotechnological and chemical processes as well as the realisation of processes in chemical parks. CLIB is also pursuing developments to help SMEs and academia to access equipment for testing, for example, in prototyping centres. BioBase4SME BioBase4SME aims to bridge the gap between lab scale and industrial scale and provide further services to bring biobased innovation ideas forward and make them ready for the market. BioBase4SME is the follow-up of the highly successful Bio Base NWE project ( The former project was honoured in October 2017 by the RegioStar Award of the European Commission. This three-year ( ) project mentored 755 companies in total and granted 30 innovation coupons worth 10,000-30,000 EUR for technological assistance to SMEs and start-ups. The work done within the innovation coupon scheme created a substantial leverage effect: up to 71 million EUR of investments and the creation of 320 new jobs in the bio-based economy in the coming years. The BioBase4SME network, representing leading bio-based economy experts, advises SMEs from across North-West Europe on how to develop new ideas into marketable products. The 5.83 million EUR project started in March 2016 and helps start-ups and SMEs to overcome technological and nontechnological barriers on their path to turn bio-based research into commercial innovation. The eight partner organisations from six different countries in the BioBase4SME network offer training, innovation biocamps, workshops, and innovation coupons worth up to 100,000 EUR. These coupons can be used for technological assistance, such as scale-up to pilot scale, lifecycle assessment (LCA), techno-economic evaluation, market research, feedstock analysis, social acceptance, and business planning support, or a combination thereof. Coupon applications can be submitted until summer

22 Scale-Up The project also supports young entrepreneurs by offering week-long biocamps where they get in touch with leading experts from business development and bio-based industry to sharpen their company focus. a scoping phase ( ), within which these two value chains have been investigated more in detail. This included a detailed technology and stakeholder analyses, leading to a prioritisation of best approaches for the region. A new approach for a structured networking process to create new consortia has been developed. A subsequent implementation phase starting in 2018 will see the realisation of the selected projects ALIGN - Bio-based Aromatics from LIGNin and Bioconversion of CO/syngas into a plastic precursor (BioCOnversion, see p. 24). Other projects where scale-up is a focus are BBI and SPIRE, in which increase in technology readiness level (TRL) is one of the main aims of the European Commission. In both funding programmes, industry is challenged and invited to propose projects that scale up bioeconomy processes from lab and demo to flagship scale. The INMARE project aims to create a shortcut between TRLs by using biocatalysts adapted to industrially relevant, extreme environments to skip the often long and laborious process of enzyme optimisation. CLIB helps to identify relevant parameters for the industry, enabling researchers to perform a targeted screening for possible enzyme all-rounders - enzymes that can reliably transform a multitude of substrates in harsh conditions. BIG-Cluster An essential element in the envisioned bioeconomy is the efficient conversion of renewable non-food resources into chemicals in biorefineries, in order to reduce our dependency on fossil resources and to reduce the carbon footprint of many production processes. The BIG-Cluster region of Flanders, The Netherlands and North-Rhine Westphalia is Europe s leading industry region with a notably strong chemical industry. The BIG-Cluster initiative aims to establish novel value chains within the topics Aromatics and Fine Chemicals from Woody Biomass and Chemicals from CO and CO 2. Within the project BIG-Cluster funded by the German Federal Ministry of Education and Research (BMBF), the first two years constitute BIG-Cluster Project ALIGN Aromatics represent a significant share of today s chemical building blocks used for a wide variety of applications in fields such as polymers, adhesives, coatings, resins, surfactants, anti-oxidants and cosmetics. Currently, aromatic building blocks are usually produced from fossil resources. The development of less toxic, natural molecules to replace toxic, synthetic ones is an important industrial driver. Therefore, it is highly desirable to develop conversion routes to upgrade renewable biomass to aromatic platform molecules. Lignin, the second most abundant terrestrial polymer and the only large source for bio-based aromatics, is currently used in limited amounts only. Conventional lignin extraction processes are often optimised towards the fractionation and purification of cellulose for pulp production, with lignin regarded as a byproduct, resulting in a poor lignin quality with an undefined structure and a low degree of functionalisation. The use of lignin extraction processes, which maintain the structure and functionality of lignin, in combination with innovative chemical and biotechnological conversion routes enables the production of functionalised bio-based aromatics. New, hitherto not accessible structures including new functionalities and, thus, new performances, which can be used in a variety of industrial applications can be produced. ALIGN focuses on upscaling three innovative extraction processes that lead to both a high-value lignin fraction and a pure cellulose/sugar fraction. The lignin fractions derived from the three processes differ in their composition with regard to the degree of depolymerisation and functionalisation. Starting with this broad range of different lignin derivatives, combined with tailor-made downstream processing strategies, a wide variety of bio-based aromatics with unique properties can be produced for a wide variety of applications in the aromatics sector from fine chemicals to bulk products. 22

23 Novel Value Chains Novel Value Chains Catalysing the establishment of novel value chains within the bioeconomy is one of the major tasks of CLIB. Such value chains can form within a given industry or sector, but they are more likely to develop at the boundary of different industrial sectors. When as-yet individual branches, such as the chemical sector and the pulp and paper sector, start to converge, new value chains start to form. This might happen because an enterprise seeks to forward integrate its product portfolio to gain access to later stages of the value chain, or to diversify its product portfolio. Examples include agriculture or forestry enterprises starting to develop chemicals in addition to their original products for food and feed, or for construction. This is one of the major opportunities of the bioeconomy: creating new business models for agriculture and forestry. New value chains might also form where previously separate markets start to converge. Examples include the fields of nutraceuticals (convergence of pharmaceutical industry with food industry) and cosmeceuticals (pharmaceutical and cosmetics industry). Here, products with properties from both worlds emerge, for example, skin creams with an anti-wrinkle function. Markets like these usually show higher growth rates compared to their established source industries. The field of cosmeceuticals, like that of consumer dermatologicals, is predicted to rise at a compound annual growth rate (CAGR) of 3 to 4 % in , whereas over-the-counter (OTC) drugs are predicted to grow only 2.7 % in the same period (Catching the Consumer Healthcare Growth Wave, A.T. Kearney, Inc., 2015). These higher growth rates are also associated with higher risks: Newly developing markets are less predictable because consumer demands are often unclear, and competitors may emerge overnight. Another advantage of these emerging markets is their smaller market volume. What sounds like a contradiction in the first instance becomes clearer when visualising the challenges new biotechnological processes are facing. They are usually not able to compete with the highly efficient and well-established processes based on petrochemical feedstocks. And in this case, economy of scale makes the situation even worse. Thus, smaller-scale but high-value products offer the chance to find a niche to be profitable with a new bio-based or biotechnological process, even offering business cases for pilot or demo projects. In this regard, such specialties can be enabling products for long-term markets of bulk chemicals and fuels. Reasons for the aforementioned developments typically emerge from market pull. But, of course, technology push can also create novel value chains. Especially in rather young ecosystems such as the bioeconomy, technological breakthroughs can be the force behind the formation of completely new services and products. For instance, the ability to utilize gaseous substrates on a commercial scale to produce platform chemicals such as ethanol opened up new value chains that integrated biotechnology, chemicals, and the steel industry. In this last example, a special kind of market pull also comes into play. As countries across the globe have agreed that anthropogenic global warming should be kept to less than 1.5 C, carbon capture and utilization technologies get more and more political attention. This results in regulatory frameworks raising the price of carbon emissions but also in dedicated funding mechanisms for technologies offering a CO 2 reduction or reuse application. It is in the fields just described where CLIB aims to offer a radar for new developments and opportunities. In close interaction with our members from industry and academia, we try to depict markets that show interesting developments, inform about political regulations, or identify technologies with a high innovation potential. Currently, CLIB focuses on the following near-term markets because they show dynamic growth rates and offer opportunities where biotechnological processes can provide advantages over chemical routes: Personal & home care Cosmetics Cosmeceuticals Detergents Flavours and fragrances Food, feed & nutrition Crop Protection Flavours Nutraceuticals Plant breeding Supplements High performance materials Adhesives Functionalised surfaces Packaging Textiles (fibres) 23

24 Novel Value Chains In addition, process technology and education are two focus topics at CLIB because they have the potential to create further technology push for the bioeconomy. We consider bulk chemicals and fuels and energy to be long-term markets for biotechnology that we keep an eye on but that are not a priority. It is the near-term markets that will be in focus at the CIC in January 2018 as well as in our forum events throughout Our projects, such as BIG-C, HiPerIn, and RIN Stoffströme, as well as our delegation trips also pay special attention to these markets. Together with Springer International Publishing, CLIB will publish CO 2 and CO sustainable carbon sources for the circular economy in This book will be published in German in it s first edition, and will raise awareness for the utilisation of these gas streams to produce chemical building blocks and energy carriers, providing scientifically sound and reliable information. It will give a comprehensive and comparative overview on the material use of CO 2 - and COcontaining gas streams via chemical and biotechnological processes, as well as on the resulting options for the emitting industries. Besides these technical aspects, it also focuses on the economic, ecologic, as well as social impacts. Core issues addressed are the characterisation of different sources of CO and CO 2 gas streams, an overview of the chemical and biotechnological conversion technologies, as well as the description of chemicals and energy carriers accessible by these technologies. Framework conditions which support the establishment of these novel technologies and value chains, and the potentials for employment, regional development as well as public acceptance will be discussed. While scientific experts are the main target audience, also decision makers from economy, administration, politics, and NGOs will benefit from this publication. For them, the book will provide a comprehensive access to the topic and allow a substantiated assessment about potential opportunities and risks. BIG-Cluster Think Tank C1 Bioconversion The fund by the BMBF has supported CLIB to develop novel value chain concepts for the biotechnological conversion of C1 gas streams into valuable chemicals. For this purpose, CLIB initiated an international working group representing relevant stakeholders from the BIG-Cluster region and beyond in To join their forces, the working group has decided to continue their collaboration beyond the BMBF funding period and has initiated the BIG-Cluster think tank C1 Bioconversion in February The think tank represents more than 20 members from academia, SMEs and big industry in Flanders, The Netherlands, Austria, and Germany and covers the whole value chain. The members unify the vision to establish C1 bioconversion technologies and the respective value chains in the BIG-Cluster region. Therefore, the goals of the think tank are cross-border knowledge transfer, technology scouting and the identification of industrially relevant products for market oriented technology developments to initiate joint collaborative R & D projects. Furthermore, it should create the critical mass to realise pilot and demo actions in future. Joint publications should trigger public awareness as well as to outline the way towards realising the think tank s vision. HiPerIn HiPerIn focuses on novel value chains accessed by novel technology developments. Small-scale, high-performance molecules present an interesting niche for biotechnological processes and applications. These molecules play an important role in the pharmaceutical, food and feed, and chemical industries. Applications in the latter, such as cosmetics, adhesives, and polymer additives, can particularly benefit from the competitive advantage offered by new functionalities accessed by the use of high-performance ingredients. The term high-performance ingredients refers to functional components and compounds that are able to adapt product properties to varying environmental conditions, such as, for example, temperature-dependent colour changes. Biotechnology can, sometimes in combination with chemical conversion steps, provide access to molecules that cannot be produced by catalytic processes or can only be synthesised in complex, multi-step reactions. This is a critical, unique selling proposition of biotechnology. The identification, production and approval of high-performance ingredients demand increased research efforts and 24

25 Novel Value Chains longer development times - with the associated higher risks - compared with drop-in approaches. This is because these molecules are usually new to the market and show special properties and functionalities. Therefore, the necessary development and production, research approaches, biocatalysts, and manufacturing processes also pose special challenges in their development, production, and approval. Against this background, an elaborate collaboration between these technology fields is key to delivering target-oriented results in a timely manner. To support this, CLIB aims to build a competence centre for high-performance ingredients. The drafting of a roadmap toward this HiPerIn centre is being funded by the Ministry of Economic Affairs, Innovation, Digitalization and Energy of NRW and includes different activities. CLIB has organised four dedicated forum events on flavours and fragrances, food and feed, cosmetics, and coatings (see also p ). Further roundtable discussions to support the initiation of R & D consortia in this field are planned for the first half of Another focus is on academia and the strengths present in NRW. CLIB has prepared a mapping of the competences in the state, looking at core fields of biotechnology, biochemical engineering, and structural chemistry. The aim is to engage with stakeholders from academia and industry to prepare a gap analysis. Another activity was the facilitation of a consortium to bid for funding towards a competence centre biotechnology, which has in a first round been recommended for funding by the German state of NRW (as of December 2017, see also p. 18). RIN Stoffströme Within RIN Stoffströme, novel value chains from side streams of agriculture and the pulp and paper industry are being investigated. The findings of an INTERREG study that analysed potential resource streams in the cities of Krefeld and Venlo and their surroundings led to the subsequent project BIVAC (Bio value chains for novel value-added products and compounds) that addresses the implementation of innovative bioeconomy value chains in the region. It achieved a funding within the INTERREG Programme Deutschland-Nederland and has a volume of 2.4 million EUR. It deals with two value chains: (1) utilisation of vegetable wastes from the processing of cabbage and (2) usage of bark from cardboard production (poplar). For both value chains, the occurring waste streams are somewhat problematic. Stalks and bracts of cabbage cannot be fed into biogas plants because they contain high amounts of sulphurous ingredients. Thermal utilisation of the poplar bark results in high ash formation. BIVAC aims to utilise the waste streams in a more optimal way. In VC1, the direct extraction of sulphurous ingredients from the cabbage biomass for food and feed applications or the hydrolysis of the stalks and bracts to access the carbohydrates for fermentative processes (also aiming for high-value ingredients such as carotenoids) will be considered. The approach for the second value chain is similar: High-value compounds such as tannins will either be extracted or the poplar bark will be separated into its lignin, hemicellulose, and cellulose fractions. The latter fraction will be further investigated for its application in plant substrates. BIVAC does not only take the technical aspects of these value chains into account; it also incorporates a logistics and site evaluation for possible production sites, as well as a life-cycle analysis. The project will be accompanied by an advisory board with stakeholders from consumer industries, ensuring close contact with the envisaged target markets. This is an example of how the RIN tries to evaluate concepts to utilise specific biogenic waste streams through dedicated projects. Further ventures following that model are currently in preparation. One of them is the project Business-P, funded by the Ministry of Economic Affairs, Innovation, Digitalisation and Energy of NRW. It deals with the valorisation of phosphates from press cakes of oil crops. It follows an interdisciplinary approach, analysing the technical as well as the economic feasibility of this novel value chain. RIN Stoffströme Regionales Innovationsnetzwerk There are also activities under way to create a border-crossing bioeconomy network of stakeholders from Germany and the Netherlands. It aims to develop new business models for farmers through forward integration into the next processing steps of biomass for applications in food and feed, as well as chemicals. It builds on an innovative approach in trying to combine processes and competences from agriculture, waste management, food and feed, and the chemical industry. All of 25

26 Novel Value Chains these industries deal with the collection, storage, and processing of biomass in some way but from different perspectives and with different goals. Discussing and combining these approaches can lead to new ideas and concepts and can help to leverage untapped potentials. BIOPEN Open innovation across value chains and across geographic locations can be facilitated through dedicated virtual platforms. In the BIOPEN project, the eight project partners aim to set up such a platform, dedicated to the biobased sector. It will serve as an information source on funding, but also enable users to search for information on patents, scientific papers and websites. A taxonomy has been developed which will tag this information and make it available for browsing by keywords. The possibility to create user profiles, add project ideas, and to create dedicated project rooms, will make BIOPEN a powerful platform to initiate new cross-sector value chains. In order to facilitate these value chains, the BIOPEN consortium will also prepare perspective studies, analysing the potentials and challenges of up to five novel value chains. BIOPEN is a coordination and support action funded through the H2020 Biobased Industries Joint Undertaking. Moreover, the visit was a great opportunity to follow up on prior contacts made by or social networks, by having face to face meetings. Especially this last point proved to be of great value: we can see hundreds of social network messages, have dozens of contacts with potential partners around the world, but face to face meetings are almost always needed to enable in depth discussion, the concrete evaluation of a potential collaboration, or the initiation of an investment. Delegation Trips With our delegation trips, we at CLIB aim to identify regions with new market opportunities for our members, and to provide a platform to offer first contacts in a foreign country for research and business cooperation. The following testimonial by Dr. Georg Schaumann from the start-up company SenseUp illustrates how this is put into action. SenseUp joined the first delegation visit to China organized by CLIB in April 2015, starting in Beijing and ending in Shanghai with stops in Nanjing, Qingdao, at the Chinese Academy of Sciences, Vland Biotech Group, Sino German Ecopark, and other organisations. The perfectly organized trip with tightly scheduled opportunities for contacts with local companies and research institutions was a great opportunity to become familiar with actors of the Chinese biotech scene and to make first contacts with potential future partners. This was confirmed when SenseUp returned to China, joining the second delegation visit organised by CLIB in November This trip started in Qingdao, lead us to Nanjing, and ended again in Shanghai. During this trip, the contacts made in 2015 could be maintained and intensified, making both visits together even more productive than two independent ones. SenseUp managed to raise substantial investment capital from a Chinese partner, met during both delegation visits. Additionally, SenseUp established a sustainable contact to a Chinese start-up company, which might result in future cooperation. For us, the delegation visits to China were a door opener to the Chinese biotech scene. They initiated first contacts to important Chinese partners and thereby enabled long-term business activities in China. Author: Dr. Georg Schaumann, SenseUp GmbH 26

27 Education Education Biotechnology and, indeed, the bioeconomy are widespanning fields, intersecting multiple scientific disciplines. To ensure specialists who are at the same time experts in their own fields, able to advance technology and applied research,and able to take a holistic view with an understanding of the different areas in the bioeconomy, a special education approach is needed. CLIB addresses this issue through several initiatives. Within the trinational BIG-Cluster initiative, we develop new teaching approaches that target master s students and doctoral students but also lifelong learning. CLIB cooperates also with the Bioeconomy Science Center (BioSC) in educational matters by co-organising the NRW-wide PhD student day. The BIG-Cluster Flagship Circular Economy Education In BIG-Cluster s regions of Flanders, The Netherlands, and NRW, various and diverse technical, academic, and post-academic training activities already exist at a regional level. Within the BIG-Cluster initiative, education has been defined as a horizontal flagship. Recognising the importance of education in providing a skilled workforce for the future bioeconomy, CLIB has included the module BIG-Training in its BMBF-funded BIG- Cluster project, which will help implement cross-border training in the circular economy. BIG-Training aims to establish BIG- Cluster-wide coordinated education and training structures. In doing so, it will build on already-existing regional activities and develop new models to fill existing gaps. It will be important to align the region s activities and intensify the exchange of participants, training topics, and education concepts. On several BIG-Cluster Education working group meetings, two tools were identified to be the first cross-border activities. The global Biobased Business Competition - short G-BiB - focuses on the development of a business plan for biorenewable chemicals, materials, and fuels. The aim is to focus on the practical application of entrepreneurship and interdisciplinarity as well as the transfer of learning. The first round was launched in November 2016 in Germany. In 2018, CLIB, in cooperation with BE-Basic Foundation, is going to coordinate the second cross-border education tool, a massive open online course (MOOC) for higher education on the concept of a bio-based economy. I am very impressed by the quality of the business plans. It is great to see the enthusiasm of the teams for entrepreneurship. This shows that the concept of G-BiB really works. Prof. Patricia Osseweijer, TU Delft & BE-Basic G-BiB Competition The kick-off of the first edition of the Global Biobased Business competition (G-BiB) for the German and Dutch teams took place at Wageningen University in January This interesting and instructive, but most of all inspiring, event marked the actual beginning of the G-BiB for the two German and five Dutch teams, after the official launch in November The final challenge for all teams was to write an innovative business plan based on a design for sustainable production of biorenewable products such as biofuels and biomaterials or partial solutions that will support development of those products. The teams followed a master class in April 2017, focussing on developing their business case and learning how to pitch a business idea. By the end of May, the teams had to submit their business plans. A similar process was done for the teams in Brazil. The semi-finals for teams in all three countries took place in June. N-Chroma from Wageningen University, SANergya from the University of Taubaté and Bicomer from Bielefeld University won the national finals of the first edition of the G-BiB competition. They were chosen from a total of 12 teams of Master and doctoral students from the Netherlands, Germany, and Brazil. The three winning teams competed in the final organized during the 3 rd Brazilian BioEnergy Science and Technology (BBEST) in Campos do Jordão, Brazil, in October The first winner of the G-BiB Competition receiving an award of 10,000 EUR to further develop the business plan, sponsored by Corbion, was the Brazilian team SANergya. G BiB competition 27

28 Project Fact Sheets Overview of Current CLIB Projects BIG-Cluster - BioInnovation Growth mega-cluster BioInnovation Growth mega-cluster Funded by: Project term & volume: Project partners: Responsible at CLIB: Project website: German Federal Ministry of Science and Education (BMBF) Scoping phase ( ), 722,000 EUR Implementation phase ( ), up to 3 M EUR 3 dedicated R & D projects with multiple partners CLIB 2021 (Germany), BE-Basic (The Netherlands) and Catalisti (Belgium) (scoping phase) Vera Haye, Cornelia Bähr The BioInnovation Growth Mega-Cluster (BIG-Cluster) is a cross-border Smart Specialization Initiative aiming to transform Europe s industrial mega-cluster in the Flanders region of Belgium, The Netherlands, and the German state of North Rhine-Westphalia (NRW) into the global leader of the bio-based economy. Within the BMBF project, the first two years constitute a scoping phase, within which the two value chains C1 gases to chemicals and Aromatics from lignocellulosic biomass and activities for bio-based education are investigated. This includes detailed technology and stakeholder analyses, leading to a prioritization of best approaches for the region. Further on, a new approach for a structural networking process to create new consortia will be developed. A subsequent implementation phase starting in 2018 will see the realisation of selected projects. BioBase4SME Funded by: Project term & volume: Project partners: Responsible at CLIB: Project website: INTERREG North-West Europe , 5.8 million EUR AC3A (France), Bio Base Europe Pilot Plant (Belgium), CLIB2021 (Germany), Flanders Bio-Economy Valley (Belgium), Materia Nova (Belgium), NNFCC (UK), REWIN (NL), TCBB Resource (Ireland), York University (UK) Dennis Herzberg The BioBase4SME network, representing many leading bio-based economy experts, advises SMEs from across North-West Europe on how to develop new ideas into marketable products. The BioBase4SME project intends to help start-ups and SMEs to overcome technological and non-technological barriers to bring their innovations to market. The eight partner organisations from six different countries in the BioBase4SME network will offer training, innovation biocamps, workshops, and innovation coupons worth up to 100,000 EUR. The project offers professional training, innovation boot camps, and innovation vouchers. The support offered through the voucher system can consist of technical assistance, such as scale-up to pilot scale, life-cycle assessment, techno-economic evaluation, market research, feedstock analysis, and social acceptance, as well as business planning and business plan support. 28

29 Project Fact Sheets BiOPEN - Open-innovation Platform Strengthening Cooperation and Joint Development of Bio-Based Industries and Downstream Sectors Funded by: The Bio Based Industries Joint Undertaking under the European Union s Horizon 2020 research and innovation programme under grant agreement No Project term & volume: , 1.2 M EUR Project partners: 8 international partners, coordinated by Ciaotech (Italy) Responsible at CLIB: Tatjana Schwabe Project website: The BIOPEN project started in May It aims to support collaboration and knowledge sharing in the bio-based industry, stimulating the set-up of co-innovation partnerships for the development of new products and markets in the sector by setting up an open innovation platform capable to involve industries, research centres and universities. The open innovation platform will be available by the end of December 2017 at the link: The project consortium is highly specialized in the bio-based industry as well as networking and open innovation. It is composed of five European bio-based clusters, three open-innovation expert companies, and one research centre. HiPerIn - Biotechnological Concepts for High-Performance Ingredients Funded by: Ministry of Economic Affairs, Innovation, Digitalization and Energy of NRW Project term & volume: , 220,000 EUR Project partners: CLIB2021 (Germany) Responsible at CLIB: Tatjana Schwabe Project website: The identification, production, and approval of high-performance ingredients place high demands on research efforts and development times compared with drop-in approaches, which also means an increase in financial risk. Many of the necessary development and production aspects, research approaches, biocatalysts, and manufacturing processes are also new. An elaborate collaboration between these different technology fields is key to delivering target-oriented results in a timely manner and to managing risk factors. To support this, CLIB aims to develop a road map toward a competence centre for biotechnological concepts for high-performance ingredients. Furthermore, CLIB organises special forum events and subsequent roundtable discussions to support the initiation of R & D consortia in this field. Topics are selected with member input. 29

30 Project Fact Sheets INMARE - Industrial Applications of Marine Enzymes Funded by: Project term & volume: Project partners: Responsible at CLIB: Project website: The European Union s Horizon 2020 research and innovation programme under grant agreement No , project volume 6 M EUR over 20 international partners, coordinated by University of Bangor, Wales. CLIB members in the consortium: evoxx GmbH, HHU Düsseldorf Tatjana Schwabe Streamlining the pathways of discovery and industrial applications of new marine enzymes and bioactives for targeted production of fine chemicals and drugs and use in environmental clean-up is the aim of the EU-funded project INMARE, in which CLIB2021 is actively involved as a partner and responsible for supporting technology transfer. The consortium of over 20 international partners aims to reduce the time for developing an industrial process based on enzymatic transformation from the current 5 to 7 years down to 3 years by tapping into the potential of biocatalysts from extreme marine environments that are functional in harsh, industrially relevant conditions such as high temperature and high or low ph or pressure. INMARE will contribute to a better understanding of the characteristics and occurrence of all-rounders : enzymes with features that can fulfil the demands of real industrial processes. Libraries will be screened against compounds mimicking challenging chemical steps in actual applications. This is expected to lead to much faster and more efficient enzyme development. CLIB s role in INMARE is to optimise the exploitation of the research results. The cluster will assess results, provide feedback regarding optimal technology transfer, provide exploitation strategies, and mediate the contact between academic researchers and interested industrial parties. RIN Stoffströme - model region for innovative and sustainable material flow RIN Stoffströme Regionales Innovationsnetzwerk Funded by: Project term & volume: Project partners: Responsible at CLIB: Project website: Ministry of Culture and Science of NRW , 540,000 EUR (1 st phase) , 450,000 EUR (2 nd phase) CLIB2021, Deutsche Gesellschaft für Abfallwirtschaft, EnergieAgentur.NRW Dennis Herzberg To improve utilisation of side and waste streams in industry, agriculture, or forestry, the regional innovation network (RIN) model region for innovative and sustainable material flow was set up in The project s goal is to improve exploitation of biomass, wastes, and side streams in the region. Using this approach, the RIN addresses the grand societal challenges of resource scarcity and climate change. In order to achieve a better utilisation of biomass as well as side and waste streams, several hurdles must be tackled. Initially, concrete resource potentials in the region have to be defined. In this regard, aspects such as, for example, seasonal availability, energy density, and ownership of the feedstocks must be considered. The RIN Stoffströme also seeks to identify practical hurdles for utilising biomass and waste streams for the production of intermediates for the chemical industry. A close and continuous dialogue with practitioners from waste management companies, farmers, municipalities, and processing industries is necessary to define these hurdles, which can be of a technical, regulatory, or societal nature. 30

31 Extended Board Members of the CLIB Extended Board Dr. Thomas Schwarz - Chairman Since 2015 he is member of the board of b.value AG and since 2013 he is chairman of the CLIB board. From 2007 until 2013 he was member of the executive board of CLIB. From 2009 to 2014 Dr. Schwarz was CEO of instraction GmbH in Mannheim, Germany and from 2014 to 2016 in part-time CSO of the company. From 1993 to 2009 he led the R & D department and later became CEO, respectively Head of the Board, of bitop AG, which he also co-founded. Moreover, he is co-founder of b.experts, b.value AG and SenseUp. After studying biology at RWTH Aachen and Cologne University, he completed his studies in biochemistry at the University of Witten / Herdecke in He obtained his PhD from the University of Witten / Herdecke in 1993 and in the same year founded bitop GmbH. Dr. Schwarz held a position in the board of BioIndustry e.v. and serves as an advisor for several committees (e. g. NRW Bank). Since 2006, he holds a teaching position in chemical engineering (bioprocess engineering) at TU Dortmund University. He is also working in the field of coaching start-ups and in technology transfer. He is currently a reviewer in two BMBF calls. Dr. Roland Breves - Vice Chairman Dr. Roland Breves currently is Head of Corporate Microbiology of Henkel AG & Co KGaA in Duesseldorf, which as a corporate function acts for all business units, as Cosmetics, Laundry and Home care and Adhesives. After studying chemistry and obtaining a PhD in microbiology (on chitinases from Streptomyces) in Hannover he worked as a post-doc at the IPK Gatersleben on plant cell wall degrading enzymes. After joining Henkel in 1997 (initially in COGNIS Biotechnologie GmbH) he was responsible as head of laboratory for the development and expression in Bacillus of detergent enzymes. In 2000 he joined the microbiology department as project leader Smart Hygiene. Topics were non-biocidal mechanisms against microbes and their negative impacts, e.g. malodour and biofilm formation, as well as prebiotic cosmetics. In addition to these explorative and classical microbiological topics, the department develops innovative concepts for biomaterials like adhesive bioconjugates. Roland Breves is active in several national and international expert groups (DIN, CEN, DECHEMA, AISE). Prof. Dr. Karl-Erich Jaeger - Vice Chairman Karl-Erich Jaeger received a Staatsexamen in biology and chemistry and a PhD in microbiology from Ruhr-Universität Bochum in Germany. In 1995, he obtained the venia legendi for microbiology with a habilitation thesis on bacterial lipases. Karl-Erich Jaeger is co-founder and served as chairman of the management board and member of the scientific advisory board of the biotech company evocatal GmbH (now evoxx technologies GmbH). In 2002, Karl-Erich Jaeger was appointed as Professor for Molecular Microbiology at the Department of Biology of Heinrich-Heine-Universität Düsseldorf and director of the Institute of Molecular Enzyme Technology. In 2013, he was additionally appointed as director at the Institute of Bio- and Geosciences IBG-1: Biotechnology of the Helmholtz-Forschungszentrum Jülich. His research interests focus on bacterial enzymes, their folding, secretion and biotechnological applications. Karl-Erich Jaeger has published about 150 peer-reviewed papers and text book chapters, he is co-inventor on 16 patents and member of various scientific organizations, editorial and advisory boards. Hans-Jürgen Mittelstaedt - Treasurer After his studies of law at the Universities of Bonn and Freiburg, Hans-Jürgen Mittelstaedt worked as an attorney in Düsseldorf from 1988 to In 1992 he joined the Association of the Chemical Industry (VCI) at the department of environmental legislation. He held several positions in Frankfurt and Brussels before he became CEO of VCI NRW, the Association of the Chemical Industry in North Rhine-Westphalia. In this position he is also CEO of BPI NRW, the Association of the Pharmaceutical Industry in North Rhine-Westphalia. Hans-Jürgen Mittelstaedt is one of the founding members of CLIB and has been holding a position in the extended board since the foundation of the cluster. 31

32 Extended Board Prof. Dr. Ludo Diels Prof. Ludo Diels, Dr. in chemistry & biotechnology, works at the University of Antwerp and is research manager Sustainable Chemistry for the Flemish Institute for Technological Research (VITO) in Mol, Belgium. For 15 years he managed the Environment and Process Technology Business Unit and is now responsible for the transition toward sustainable chemistry and clean technology. He is responsible for the organisation of collaboration with the academic and industrial world and for co-financing projects. He is strongly involved in the set up of a biobased economy in Flanders. He is also responsible for the collaboration between VITO and India and he is managing the creation of a road map and Strategic Research Agenda for R & D on biomass and biowaste between India and Europe. He is a founding father of the Shared Research Centre on Bio-aromatics (BIORIZON) between the Netherlands and Flanders. He is also founder and Flanders coordinator of the BIG-C trilateral alliance between Flanders, the Netherlands and NRW. He is case leader for bio-aromatics in the Vanguard Initiative, pilot Bio-economy, leading to smart specialisation of interregional collaboration. He is the chairman of the working group FEED in the Energy and Resources PPP SPIRE and he is member of the SPIRE-BBI JU working group. Dr. Thorsten Eggert Dr. Thorsten Eggert is the co-founder and managing director of evoxx technologies GmbH, located in Monheim am Rhein, Germany. This biotechnology company, founded in 2006 as evocatal GmbH, is a provider of enzymes and fine chemicals for industrial use in the chemical and pharmaceutical industries, as well as the food and animal feed sectors. Thorsten Eggert studied biology at the Ruhr University Bochum from 1993 to 1998 and received his PhD at the Institute for Biology of Microorganisms in Subsequently, he established the directed evolution research group at the Institute for Molecular Enzyme Technology at the Research Center Jülich, which he headed until accomplishing his habilitation in molecular microbiology at the Heinrich Heine University Düsseldorf in Dr. Eggert is a member of the board of the Helmholtz Research Network Molecular Interaction Engineering. Dr. Henrike Gebhardt Dr. Henrike Gebhardt advocates the research and innovation interests of Evonik Industries AG in the European policy environment since She maintains the relationships of Evonik with European institutions and international associations such as CEFIC, SusChem, A.SPIRE aisbl and Bio-based Industries Consortium (BIC). Henrike Gebhardt holds a PhD in biochemistry from the University of Cologne, an engineering degree in biotechnology from the Technical University of Berlin and studied at AgroParisTech (then Institut National Agronomique Paris-Grignon), France and Technion, Israel. Henrike Gebhardt began her professional career within the strategic research unit Creavis of Evonik Industries AG (then Degussa AG) in As project manager, she was in charge of the development of biotechnological processes for the production of surfactants and nutraceuticals. In 2012, she moved to the Corporate Innovation Unit of Evonik to bundle strategic and communicative aspects of the Bioeconomy and to advocate for the interests of Evonik in EuropaBio, CEFIC, EU-RRM, DIN and CEN. Dr. Claas Heise Since April 2008, Dr. Claas Heise is responsible for technology and innovations investments at NRW. BANK in Düsseldorf, Germany. He heads the venture capital activities of NRW.BANK, including several venture funds focused on the German state of North Rhine-Westphalia, as well as fund-of-fund activities sponsoring a number of regionally focused seed capital funds. From 2006 to 2010, Claas Heise was a partner at Innovature Capital Partners, an advisory and venture capital, secondary services firm. From 2002 to 2006, he was managing director for T-Venture of America. He joined Deutsche Telekom in 1995 and held a variety of management positions. He helped found the enterprise software start-up TRAIAN and joined TRAIAN in October 2000, where he led the partnership business development efforts. Dr. Heise joined T-Venture in Bonn, Germany in He received his PhD in physics and worked for seven years in science, including a postdoctoral fellowship at Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass., USA. 32

33 Extended Board Dr. Gernot Jäger Dr. Gernot Jäger is responsible for biocatalytic and biobased processes within Covestro. He joined Covestro (formerly Bayer MaterialScience) in 2012 and held different responsibilities in Innovation Management, Process Research, Project Portfolio Management and the Competence Center for Catalysis. Up to now, he has contributed in various public committees including GDCh (sustainable chemistry, board) and VCI (renewable resources). Gernot Jäger studied biotechnology at RWTH Aachen University and received his PhD (summa cum laude) in biochemical engineering from the Aachener Verfahrenstechnik in His research areas include industrial biotechnology, pharmaceutical biotechnology, process development/conceptual design, and bioanalytics. Dr. Georg Oenbrink Prof. Dr. Georg Oenbrink studied chemistry at the University of Bremen and received his PhD in 1987 in the group of Prof. Dr. Detlef Gabel, Between 1987 and 2002 he held different responsibilities in Product Management, Application Technology, R & D and Innovation Management within the Business Line High Performance Polymers at Hüls AG and Degussa AG. From 2002 until March 2010 he was Senior Vice President within the Business Line High Performance Polymers, which became part of Evonik Industries AG in From April 2010 until August 2017, Georg Oenbrink was Senior Vice President Innovation Networks & Communication within Corporate Innovation of Evonik Industries AG. He is founder and Chief Executive Officer of CREAGO Solutions UG, a business strategy, innovation and technology management consultancy and service providing company focussing on small and medium sized enterprizes. Prof Dr. Georg Oenbrink holds a honary professorship at the University of Applied Science in Aachen. Dr. Peter Welters After his studies of biochemistry in Germany and his doctoral thesis at the Max-Planck-Institute for Plant Breeding Research in Cologne, Dr. Peter Welters spent three years at the University of California, San Diego and two years in Rouen, France as a postdoctoral researcher. In 1998, he founded Phytowelt GmbH in Nettetal and in 2002 he was appointed as CEO of GreenTec GmbH, a spin-off company from the Max-Planck-Institute in Cologne. In January 2006, both companies merged to Phytowelt GreenTechnologies GmbH with Peter Welters as CEO. The company offers contract research in agrobiotechnology and industrial biotechnology. Peter Welters is also founding and board member of CLIB, board member of ABIC Foundation Inc., Canada as well as the German Association of Biotechnology Industries (DIB) and CleanTech NRW. Prof. Dr. Volker F. Wendisch Prof. Dr. Volker F. Wendisch holds the Chair of Genetics of Prokaryotes at the Faculty of Biology at Bielefeld University. Since 2010 he is member of the board of the university s Center for Biotechnology CeBiTec and speaker of its research area Metabolic Engineering of Unicellular Systems and Bioproduction. After having served as Senator of Bielefeld University and Vice-Dean of Biology from , he is Dean of Biology since Volker F. Wendisch received his diploma in biology from Cologne University. After having completed his PhD at the Institute of Biotechnology 1 of the Research Center Jülich in 1997, he worked as postdoctoral researcher at the University of California, Berkeley, CA, USA. In 2004 he received the venia legendi in microbiology from Heinrich-Heine- University Düsseldorf. From he was Professor for Metabolic Engineering at the University of Münster. Prof. Wendisch s research interests concern genome-based metabolic engineering of industrially relevant microorganisms, systems and synthetic microbiology. 33

34 Advisory Board Members of the CLIB Advisory Board Prof. Dr. Peter Dürre Peter Dürre holds a diploma in biology and a PhD in microbiology (1981) from the University of Göttingen. Since 1995, Peter Dürre is Professor of Microbiology and Head of the Department of Microbiology and Biotechnology at the University of Ulm in Germany. He served as Vice President for Research from 2003 to Since 2015, he is Dean of the Faculty of Natural Sciences of the University. He has more than 30 years experience in the field of clostridial physiology and genetics. Major research projects include regulation of acetone and butanol formation in Clostridium acetobutylicum and metabolic engineering of solvent-producing strains for industrial use as well as the development of autotrophic clostridia as novel microbial production platforms using syngas (CO/ H 2 mixtures) and CO 2 / H 2 mixtures, from waste gas streams or biomass conversion. Peter Dürre has published more than 140 research articles, reviews, books, and patents. He is on the scientific advisory board of several companies. Dr. Manfred Kircher Based on more than 30 years experience in chemical industry and bioeconomy he works on regional as well as international bioeconomy strategies. Manfred Kircher s career milestones are biotechnological research and development (Degussa AG, Germany), production (Fermas s.r.o.; Slovakia), venture capital (Burrill & Company; USA), biotechnology partnering and branding (Evonik Industries AG; Germany) and building the bioeconomy cluster CLIB In 2014 he joined KADIB, a company consulting on important aspects of industrial bioeconomy. Dr. Dr. h.c. Christian Patermann Christian Patermann studied Law, Economics and Languages in Germany, Switzerland and Spain and completed his doctoral thesis in law at the University of Bonn in He entered the German public service in 1971 by joining the Federal Ministry of Science and Education, Bonn. From 1974 to 1978, he was Science Counsellor at the German Embassy in Washington D.C., USA. He then returned to the Ministry of Research and Technology, where he held many positions in Germany and in international organisations, like ESA, ESO and EMBL. In 1996, he joined the European Commission, DG Research and Technology and was appointed Director for Environment and Sustainability. In January 2004, he was named Programme Director for Biotechnology, Agriculture & Food Research. He also served for four years as co-chair in the EC-US Task Force Life Sciences and Biotechnology Research. He retired in August 2007, but remains active in advising public and private institutions and companies on European affairs and the Bioeconomy. He was a member of the 1 st German Bioeconomy Council from Dr. Markus Struppe Dipl.-Kfm. Markus Struppe is a senior leader with more than 15 years of international experience in the field of healthcare, management consulting and cooperation with startups. He has repeatedly undertaken challenging assignments that require innovative solutions to be built from scratch, or to introduce fresh approaches to existing structures. Currently Markus heads UnternehmerTUM Projekt GmbH as a Partner. It supports corporates and SMEs to cooperate with startups or to apply startup methodologies. He also works as a EXIST, Flügge, HTGF, and KFW coach for several start-ups. Previous work experience: Senior Consultant at Siemens AG, Healthcare Consulting; CEO at Augenklinik am Marienplatz Verwaltungs AG; Controlling at FJH AG; Senior Consultant at Roland Berger Strategy Consultants; Junior Researcher, Institute of Health Economics and Management in the Health Care; Freelance work for TNS Infratest Mobility, Founder and Managing Partner CityFloh. 34

35 Advisory Board Prof. Dr. Rolf D. Schmid Rolf Schmid is Founder and Director of Bio4Business, a consulting company in Stuttgart. He has also established a Steinbeis Consulting Center on Asia Technology Consulting at the Stuttgart Engineering Park. Until his retirement in late 2009, he was Professor at Stuttgart University and Director of the Institute for Technical Biochemistry (since 1993) and the Division of Enzyme Technology and Natural Products Chemistry of then GBF in Braunschweig ( ). His career started at Henkel KGaA in Dusseldorf ( , Director Biotechnology R & D). Rolf Schmid studied chemistry at the Universities of Munich (LMU) and Freiburg, where he obtained his doctorate degree in After post-doctoral training in France and the USA, he moved to Henkel, Düsseldorf. In 2007, he obtained an MBA degree from the University of Reutlingen. Throughout his career, he was involved in activities and projects in Japan and China. He is Honorary Professor at Nanjing University of Technology and, since 2009, Coordinator for the Bilateral Cooperations of the state of Baden-Wurttemberg in the field of biotechnology with the state s Asian partners in China and Japan. Prof. Dr. Luuk A.M. van der Wielen Prof.dr.ir. Luuk A.M. van der Wielen holds a MSc degree in Chemical Engineering from Twente University (The Netherlands), and a PhD degree (with honours) from Delft University of Technology (TUD). Since February 2017, he is Director of the Bernal Institute at the University of Limerick, Ireland and Bernal Professor for Biosystems Design and Engineering, while continuing as Distinguished Professor for Biobased Economy of TUD. He is Full Professor at its Dept. of Biotechnology, where he headed the Bioprocess Engineering Section effectively since The activities of the section were ranked as excellent by consecutive national research evaluations and have resulted in several spin-off companies. His research interests include thermodynamics for bioprocesses, bioseparation/-conversion technologies, multifunctional bioreactors, miniaturized ( on-chip ), highthroughput technology for rapid process development, analysis and development of biorenewables production systems, and their societal impacts. Prof. Dr. Kurt Wagemann Prof. Dr. Kurt Wagemann studied chemistry in Munich and received his PhD in 1989 at the Max- Planck-Institute of Quantum Optics. Since 1989 he headed some of the large departments at the DECHEMA, e.g. for research planning, congresses and for research management and administration. Beside this, he held the position of the executive director of fms e.v. in Dresden and of ProcessNet (a joint venture of DECHEMA and VDI The Association of German Engineers) in Frankfurt. In 2010, he took over the position of DECHEMA s executive director. He regulary operates as an expert for the evaluation of research institutions and is currently chairman of the life science jury for the EXIST programme of the BMWi (Federal Ministry of Economics and Energy). He serves as a member of advisory boards of research institutes and networks a.o. as member of the board of directors at The German Federation of Industrial Research Associations AiF and as head of the advisory board of renewable energies at the Karlsruhe Institute of Technology. In February 2011 he was appointed honorary professor at the University of Stuttgart, where he fulfils a teaching assignment on Technical Chemistry and Technical Biochemistry Biorefineries since

36 Office The Team of the CLIB Office Dr. Thomas Schwarz Cluster Manager T: E: Dr. Juri Bach Science Officer Dr. Cornelia Bähr Project Manager Dr. Vera Haye Project Manager Dennis Herzberg Head Office Manager BIO.NRW C1 to Chemicals BIG-Cluster RIN Stoffströme T: T: T: T: E: E: E: E: Sabine Piontek Project Assistant RIN Stoffströme T: E: Dr. Tatjana M.E. Schwabe Project Manager Horizon2020 T: E: Annika Thamm Project Assistant BIG-Cluster & HiPerIn T: E: 36

37 Member Profiles CLIB Member Profiles 37

38 Members Large Industry Altana AG Covestro AG Evonik Industries AG Henkel AG & Co. KGaA LANXESS AG Stora Enso Oyj Medium-scale Enterprises Corbion Mitsui & Co Deutschland GmbH Pfeifer & Langen GmbH & Co. KG Small-scale Enterprises abc GmbH Autodisplay Biotech GmbH Axxence Aromatic GmbH b.experts Bio Base Europe Pilot Plant Biofidus AG Biomillenia SAS Bioprocess Pilot Facility biotechrabbit GmbH bitop AG BUTALCO GmbH c-lecta GmbH Concord Blue Engineering GmbH Corvay GmbH DASGIP AG DIREVO Industrial Biotechnology GmbH Ecotradex GmbH Evolva SA evoxx technologies GmbH Heinrich Frings GmbH & Co. KG IMD Natural Solutions GmbH INOSIM Consulting GmbH Isobionics BV Jäckering Mühlen- und Nährmittelwerke GmbH Jaeger & Doerr GbR Kuhner Shaker GmbH LanzaTech LXP Group GmbH Mial GmbH Phytowelt GreenTechnologies GmbH SenseUp GmbH Senzyme GmbH SeSaM-Biotech GmbH Smart Bioprocess Swissaustral Biotech SA Syngip BV White Dog Labs Investors and Founders NRW.BANK Prof. Dr. Detlev Riesner Seventure Partners Sofinnova Partners 38

39 Members Infrastructure (Business Support & Networks) Arnold & Porter Kaye Scholer BCNP Consultants GmbH Bio4Business BIO-ARCC Drayton Valley Ltd. Bioindustrial Innovation Canada BioIndustry e.v. BioRiver - Life Science im Rheinland e.v. Black IP CIB - Consorzio ltaliano Biogas Creago Solutions Eder Schieschke & Partner mbb i2i: inventions to innovation InfraServ GmbH & Co. Knapsack KG IP Services KADIB - Kircher Advice in Bioeconomy Malaysian Bioeconomy Development Corporation NC Partnering nova-institut GmbH PROvendis GmbH Saint Hyacinthe Technopole Schnee Research Stolmár & Partner Patentanwälte SolarBioproducts Ruhr Verband der Chemischen Industrie (VCI) NRW Academia (Universities & Research Institutions) Bundesanstalt für Materialforschung und -prüfung (BAM) Eindhoven University of Technology Flemish Institute for Technological Research, VITO Forschungszentrum Jülich GmbH Fraunhofer IGB Fraunhofer IME Fraunhofer UMSICHT Fraunhofer WKI Genetika Heinrich Heine University Düsseldorf Hochschule Niederrhein Justus Liebig University Giessen Nanjing University of Technology Phillips-Universität Marburg, LOEWE-Zentrum für SYNMIKRO Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences Research Center of Biotechnology RAS RWTH Aachen SCION - New Zealand Forest Research Institute Limited TH Köln - University of Applied Sciences TU Dortmund University Universität Bielefeld - CeBiTec Wageningen University and Research 39

40 Profiles abc advanced biomass concepts GmbH abc GmbH is a technical project developer for industrial applications and an innovation agency officially authorized by the German Federal Ministry for Economic Affairs and Energy. abc develops technologies and implements projects in the sectors biotechnology, energy efficiency and recycling. The portfolio covers: Weinsbergstr 190, Cologne Phone: Internet: Founding year: 2011 Number of employees: 27 Project development, engineering and operation of innovative decentral technologies and processes Innovation management for product development in the field of environmental systems Investment management for decentral implementation projects in industry Foreign market development for small and medium sized technology ventures ALTANA AG Abelstrasse 43, Wesel Phone: Internet: Founding year: 1977 Number of employees: 6150 ALTANA develops and produces high-quality innovative products in the speciality chemicals business. The ALTANA Group, with headquarters in Wesel/Germany, is a genuine global player with 83 % of international sales. All divisions of ALTANA occupy a leading position in their target markets with respect to quality, product solution expertise, innovation and service. ALTANA offers innovative, environmentally compatible solutions with the matching speciality products for coating manufactures, paint and plastic processors, the printing and cosmetic industries, and the electrical and electronic industry. The product range includes additives, special coatings and adhesives, effect pigments, sealants and compounds, impregnating resins & varnishes, and testing and measuring instruments. Arnold & Porter Kaye Scholer Bockenheimer Landstraße 25, Frankfurt am Main Phone: Internet: Founding year: 1917 Arnold & Porter Kaye Scholer is an international law firm with over 1,000 lawyers in 13 offices around the world. The Frankfurt Biotech/Pharma team has substantial experience relating to partnership alliances, licensing, technology transactions, distribution agreements, strategic partnerships and investments, protection of intellectual property, financing matters, corporate and tax optimized structuring. In our London office, a team of highly reputed attorneys is dedicated to regulatory issues in the chemicals, healthcare and other industries. The firm s clients range from individuals and small/medium sized companies to large international corporations. About 25 highly experienced attorneys in Frankfurt advise on law areas including Corporate, M&A, Finance, Antitrust, Pharma & Biotech, IP/Patent Litigation, Labor/Restructuring & Business Reorganization, Compliance, Tax, Litigation/Dispute Resolution, Restructuring & Insolvency. Autodisplay Biotech GmbH Autodisplay brings proteins and peptides to the surface of gram negative bacteria. The transport of molecules to the bacterial surface avoids protein expression issues such as inclusion bodies and incorrect folding. With our proprietary cell surface display technology, we create custom-tailored solutions for our clients. Services include: c/o Lifescience Center, Merowinger Platz 1a, Düsseldorf Phone: Internet: Founding year: 2008 Number of employees: High-throughput screening of binding interactions and enhanced enzyme activity via FACS 2. Development of whole cell biocatalysts that combine the benefits of soluble enzymes and classic whole cell biocatalysts - no limitations regarding permeability of substrate or product, yet easy recovery of the biocatalyst for re-use. 3. Functionalisation of solid surfaces with the highest levels of control regarding target molecule orientation. Autodisplay helps prevent the activity loss by-effect which occurs during immobilisation. 40

41 Profiles Axxence Aromatic GmbH Axxence Aromatic was founded in 1986 and is a privately held company with head office in Emmerich, Germany. Over the years our focus has been of the dedication to be one of the most reliable and innovative sources within our prime field of expertise: NATURAL AROMA INGREDIENTS for the flavour & fragrance industry worldwide. By strategic investments in R & D of both novel natural ingredients and new manufacturing processes, we constantly strive to expand the use of our products in existing and new applications as well as markets. Axxence has around 100 employees. Sales offices and warehousing are present in Germany, France, USA and Japan. Manufacturing and R & D facilities are located in the Slovak Republic. Tackenweide 28, Emmerich Phone: Internet: Founding year: 1976 Number of employees: 100 BCNP Consultants GmbH BCNP Consultants GmbH is an acknowledged consulting company specialized in the industries biotech, chemistry, nanotech, and pharma (BCNP). BCNP s clients benefit from the very broad basis of natural scientific expertise of its consultants in the disciplines inorganic chemistry, biochemistry, biology, biotechnology, molecular biology, polymer chemistry, and business chemistry. The team is completed by an experienced finance expert and a specialist for international marketing and branding. The three divisions of BCNP Consultants are: BCNP strategy (market and competitor analysis, technology comparisons) BCNP connect (business networking,customer pipeline support) BCNP communication (communication strategy, strategical positioning) Varrentrappstr Frankfurt am Main Phone: Internet: Founding year: February 2018 Frankfurt, Germany, City Centre Chemistry Makes The World Go Around! 2 nd European Chemistry Partnering What is the ECP? Europe s leading Chemistry Industry Partnering event. What s it all about? Innovation. Cooperation. Investment. Customers. What can I get out of it? A great deal of high-caliber business contacts in One Day. Organizer Diamond Sponsor

42 Profiles b.experts GmbH b.experts b.experts GmbH, Zickenbrink 13, Dortmund Phone: Founding year: 2013 b.experts GmbH is a start-up company established by experienced entrepreneurs. It is active in technology transfer and facilitation of spin-offs and start-ups in the fields of industrial biotechnology and chemistry. b.experts is successfully coaching different teams of founders from universities, which have acquired public funds (e.g. through the funding programmes GoBio, EXIST) to develop their technologies and business models. b.experts is interested to identify technologies and teams with high start-up or transfer potential to help them realise market integration. Bielefeld University - Center for Biotechnology (CeBiTec) CeBiTec is one of the largest faculty-spanning central academic institutions at Bielefeld University. Its purpose is to bundle the biotechnological activities and research projects at the university, to foster cross-linking of research approaches and technologies from different research fields, and to develop innovative projects within its two main research areas Large Scale Genomics and Big Data Bioinformatics and Metabolic Engineering of Unicellular Systems and Bioproduction. Universitätsstraße 27, Bielefeld Phone: Internet: Founding year: 1998 Number of employees: 150 The availability of comprehensive technological infrastructure as being provided by CeBiTec s Technology Platforms is crucial for a successful scientific work. The Graduate Center creates an inspiring interdisciplinary environment for high-level academic training of graduates. Furthermore, the CeBiTec considers itself as a central communication platform and a think tank of the university with respect to initiatives and activities with a dedicated biotechnological perspective. Bio Base Europe Pilot Plant Bio Base Europe Pilot Plant is an open innovation pilot and demonstration facility for process development, scale-up and custom manufacturing of biobased products and processes from lab to multi ton scale. A wide and flexible spectrum of modular unit operations combined with a team of highly trained and experienced engineers, process operators and technicians facilitates the translation of biobased laboratory processes into viable industrial processes. Rodenhuizekaai 1, 9042 Gent Belgium Phone: Internet: Founding year: 2008 Number of employees: 70 Bio Base Europe Pilot Plant has successfully performed 200 projects for more than 100 companies and has been involved in over 30 public projects. It currently coordinates SmartPilots (Improve policies in support of shared pilot facilities and their users) and BioBase4SME (Bio-innovation support for entrepreneurs throughout North-West Europe). Bio4Business Jagdweg 3, Stuttgart Phone: Mobile: Internet: Your reliable partner for scouting, bioprojects and consultation. Featuring: Window to China - provides you with competent and up-to-date information on Chinese bio R & D, based on press releases, reports, and professional network information in Chinese language. Overcome the language barrier and stay informed about the growing biocommunity of China! Other features: Window to Japan - newsletter, website and database Profiler - whom are you talking to in China and Japan? Customer search - an evidence-based approach to marketing 42

43 Profiles BIO-ARCC Drayton Valley Ltd. BIO-ARCC Drayton Valley Ltd. is the not-for-profit company administering the Bio-Mile bioindustrial park located in Drayton Valley, Alberta, Canada. The region has abundant forestry and agricultural resources and the goal is to manufacture a vast array of industrial and consumer products which are presently based on fossil fuels. A fibre mat plant has started operation for the manufacture of biocomposites. In addition, there is a co-gen plant using forestry waste for the production of electricity. The goal is to expand into the production of green chemicals. The Clean Energy Technology Centre (CETC) is located in the heart of the Bio-Mile and has three main strategic directions which are helping to build a successful bioindustrial business sector in Drayton Valley: 1. incubation and commercialization 2. training and skills development 3. applied research Street (Box 6837), T7A 1A1 Drayton Valley, Alberta, Canada Phone: Internet: Founding year: 2010 Number of employees: 2 Biofidus AG Biofidus is a bioanalytical company located in Bielefeld, Germany. Our services include a wide variety of bioanalytical methods such as spectroscopic, chromatographic, and mass spectrometric assays focused on characterization of proteins as well as small molecules. We are specialized in the analysis of biopharmaceuticals or biosimilars, including but not limited to monoclonal antibodies, Fc-fusion proteins, erythropoietin, and ADCs. Additionally, we offer spent-media analysis for fermentation and cell culture technology, which includes the analysis of amino acids, metabolites, and vitamins in culture media. Our analytical service also includes the development of custom tailored and novel client-specific assays. Hainteichstr. 78, Bielefeld Phone: Internet: Founding year: 2015 Number of employees: <10 Bioindustrial Innovation Canada As a not-for-profit organization, Bioindustrial Innovation Canada (BIC) supports Ontario and Canada become globally recognized leaders in the field of sustainable technologies. With a vision to create jobs and economic value sustainably for Canada, BIC provides critical strategic investment, advice and services to business developers of clean, green and sustainable technologies. In Sarnia and Lambton County, a true hybrid cluster has developed around sustainable chemistry, based on fostering partnerships and bringing the right individuals together from industry, colleges, universities and governments to support the development of the cluster. In 2016, BIC established the Centre for Commercialization of Sustainable Chemistry Innovation (COMM SCI) initiative program, which acts as a hub for the commercialization of sustainable chemistry and bio-based innovation. BIC s proven expertise in commercialization is the differentiator that will enable us to build a stronger and more sustainable Canada Modeland Road, Sarnia, Ontario, Canada N7S 6L2 Phone: Ext 237 Founding year: 2008 Number of Employees: 8 BioIndustry e.v. BioIndustry e. V. is a registered association whose main purpose is to activate, concentrate and develop biotechnological competences in the Ruhr region. The key aspects of BioIndustry s activity are industrial biotechnology and bioprocessing technologies, microstructure technology, X-omics and bioinformatics. As a networking service cluster of 50 companies, research and training institutes, technology centres, biotechnological service providers and public business development organizations, the associations objective is to generate product- and process-innovations. This objective will be met by supporting the active transfer from ideas to market. BMZ Dortmund, Otto-Hahn-Str Dortmund Branch office: Universitätsstr. 136, Bochum Phone: Internet: Founding year: 2000 Number of employees: 1 43

44 Profiles Biomillenia 10 Rue Vauquelin, Paris, France Phone: Internet: Founding year: 2014 Number of employees: 1-10 BIOMILLENIA, a France-based privately held company, is a leading technology solution provider for the development of novel green chemistry products. BIOMILLENIA s disruptive BIOMILLENIA DIMENSION 300X platform, based on licensed technology that was developed by Harvard University, the BROAD Institute and ESPCI Paris, uniquely combines advanced genomics and bioinformatics technologies with microfluidics-based ultrahigh-throughput screening. This unique technology platform delivers novel microbes, production strains and enzymes for manufacture of chemicals and natural products at throughputs and speeds several orders of magnitudes higher than with traditional methods. BIOMILLENIA Unlocks Nature s Potential for cost-competitive and sustainably manufactured novel biology-based products for a better life. Bioprocess Pilot Facility B.V. The Bioprocess Pilot Facility B.V. is a unique open access facility, situated at the Biotech Campus Delft, The Netherlands. Companies and knowledge institutions can upscale new sustainable production processes by converting bio-based residues into useful chemicals or fuels and production processes for food and pharma. Alexander Fleminglaan 1, 2613AX Delft the Netherlands Phone: Internet: Founding year: 2012 Number of employees: 30 The facility has been specifically designed to enable the transition from laboratory to industrial scale. Pretreatment of biomass on benchscale and pilot scale. Fermentation from 10 l up to 8 m 3. (ATEX, GMO) Downstream processing, chemical processing (ATEX) Food grade pilot plant. The upscaling of the lab process can be proven on pilot scale with a good prediction of the process on commercial scale. BioRiver - Life Science im Rheinland e.v. BioRiver - Joining forces for Life Sciences & Biotechnology Merowingerplatz 1a, Düsseldorf Phone: Internet: Founding year: 2004 Number of employees: <10 Founded in 2004, BioRiver Life Science im Rheinland e.v. is fully committed to representing the Life Sciences sector in the bioregion Rhineland as an independent industry organization. The essential aims of BioRiver are to build a strong network within the biotech sector, to improve the political and economic conditions as well as to market the bioregion Rhineland and its members. Thanks to the strong profiles of the partners in the network, it has been possible to initiate various collaboration projects and gain direct access to experts in both business and academia. biotechrabbit GmbH Volmerstr 9, Berlin Phone: Internet: Founding year: 2011 Number of employees: 25 biotechrabbit GmbH was founded in 2011 in Henningsdorf; already 4 years later, in 2015, a second research and production site was opened in Berlin/Adlershof. Biotechrabbit is a team of top class scientists, experienced managers and business developers who are determined to offer highest quality products and services for diagnostic companies and life science research. We value the relationships with our partners and customers and are driven to exceed current limitations with flexibility, innovation and highly customized solutions to match specific requirements. Biotechrabbit s offering includes enzymes for molecular diagnostics, antibody generation and production, high-capacity protein fermentation, lyophilization for diagnostic test kits and pharma, highly parallel, cell-free protein synthesis, mrna for therapeutics, site-directed amino acid incorporation for labeling or cancer biotherapeutics and a full molecular biology products catalog. Our way of doing business combines the passion and pure curiosity of excellent researchers with the agile spirit of true entrepreneurs. 44

45 Profiles bitop AG bitop AG is a biotechnology company focused on products based on extremolytes, a group of natural protective molecules responsible for the stress resistance of extremophilic microorganisms. bitop develops and employs fermentative and biocatalytic bioprocesses for extremolyte production. The company offers innovative medical devices based on the extremolyte Ectoin in the areas of allergy, dermatology, respiratory diseases and dry epithelia with scientifically confirmed efficacy and tolerability. Furthermore, bitop offers extremolyte products like Ectoin, Glycoin, and 28Extremoin as cosmetic active ingredients as well as hydroxyectoin as biostabilizer for diagnostics and life sciences. Stockumer Straße 28, Witten Phone: Internet: Founding year: 1993 Number of employees: 37 Black IP GmbH In den Baumäckern 5a, Insheim Phone: Internet: Founding year: 2016 Number of employees: 5 Bundesanstalt für Materialforschung und -prüfung (BAM) The Federal Institute for Materials Research and Testing (BAM) is a research facility under the authority of the Ministry of Economics and Technology. Its competences are to improve safety and reliability in chemical and materials technologies through research, testing, analysis, and information. The division Biodeterioration and Reference Organisms performs research and development in the field of i) materials protection against biological deterioration and ii) biotechnology with bacteria. We are especially interested in biotechnology and molecular biology of bacteria from extreme environments. Our expertise in molecular biology with extremophiles comprises a wide range of technologies to manipulate metabolic pathways with the goal to improve productivity of strains currently used in industry. Unter den Eichen 87, Berlin Phone: Fax: Internet: Number of employees: 1660 Butalco GmbH Butalco s core technology based on generically optimized yeasts (Saccharomyces cerevisiae) enables increased yiels in bioethanol production by using C5 sugars in the fermentation process. Butalco, c/o Christen und Zobrist Treuhand AG Achereggstrasse 10, 6362 Stansstad, Switzerland Phone: Internet: Founding year:

46 Profiles CIB - Consorzio Italiano Biogas e Gasificazione CIB - Consorzio ltaliano Biogas (Italian Biogas Consortium) aggregates and represents the Italian area of biogas in agriculture. CIB is an instrument wanted by the producers for producers. CIB is the first voluntary Italian network that brings together manufacturers of biogas and syngas from renewable sources (mainly agricultural biomass), business or industrial companies which supply equipment and technology, bodies and institutions that contribute in various ways to achieve social purposes. Via A. Einstein snc, Lodi, Italy Phone: Internet: Founding year: 2009 Number of employees: 10 CIB was founded in March 2009, has a national coverage, and is the Italian landmark in the biogas sector which offers real indications to the members in order to improve the production process and to guide the choices on national norms. Today CIB aggregates more than 600 members. c-lecta GmbH c-lecta is a leading industrial biotechnology company, using best-in-class biotechnologies to efficiently provide customized enzymes and microbial strains to industrial applications. Scientific excellence is combined with in-depth commercial and regulatory know-how to bring innovative and competitive bioprocessed products into scale. Besides our in-house project and product pipeline we have a strong focus on strategic cooperation with industrial partners. Perlickstr. 5, Leipzig Phone: Internet: Mail: contact@c-lecta.com Founding year: 2004 Number of employees: 50 Moreover, c-lecta is an established enzyme supplier, manufacturing unique, qualitycontrolled enzyme products on large technical scale. Concord Blue Engineering GmbH Concord Blue is a waste management company that transforms nearly any form of local waste into a variety of clean, renewable fuels. Concord Blue has developed a revolutionary closedloop system that efficiently and cost-effectively produces the highest quality sustainable energy with virtually no pollutants. Unlike other available waste-to-energy processes, Concord Blue s unique technology benefits the environment, fulfilling all international, EPA and European regulations for renewable energy and air emissions. Königsallee 6-8, Düsseldorf Phone: Internet: Founding year: 1997 Number of employees: 160 Corvay GmbH Sophienstraße 6, Hannover Phone: Internet: Founding year: 2002 Number of employees: <10 Since 2002 Corvay provides consulting and project management services. We are proud to look at a successful track record, e.g. BioRegioN, Vakzine Projekt Management, Direvo Industrial Biotechnology. Corvay actively supports Sino-German collaboration in biotechnology. Now Corvay has built a specialty chemicals business, marketing and selling specialties from Chinese and Indian suppliers. Long chain aliphatic diacids are sold under the brandname Himount Europe, long chain diols and diamines complete this portfolio, which also covers specialty enzymes and vitamin D. Our success factors: high performance over many years, broad operational expertise in biotechnology, enzymes, vaccines, pharmaceuticals, and internationality, international management experience plus an efficient business network. 46

47 Profiles Covestro Deutschland AG Covestro is a world-leading supplier of high-tech polymer materials: innovative, sustainable, and diverse. We are serving key industries (such as automotive, construction, and electro/electronics) around the globe with technologically leading processes. Our products and application solutions are used in many areas of modern life. In line with our vision To make the world a brighter place, we work on solutions to the challenges of our time. Alternative raw materials (such as biomass) and alternative production concepts (e.g. via biotechnology) are the basis for various new innovation-driven products and production processes. With approximately 15,800 employees Covestro posted sales of 12.1 billion euros in It has some 30 major production sites worldwide that operate in a safe, efficient and ecofriendly way. The product range includes the high-performance polymer polycarbonate and precursors for polyurethanes that are used to produce foam. Kaiser-Wilhelm-Allee 60, Leverkusen Phone: Internet: Founding year: 2015 Number of employees: 15,800 CREAGO Solutions UG CREAGO Solutions UG offers strategy, innovation management & technology management consultancy and support for small and medium sized companies (SME s). We act as classical consultants as well as interim managers or service providers for our clients. CREAGO Solutions has a strong focus on SME s within the chemical industry, biotechnology,and plastics processing industry. Our service is based on long-lasting practical experience within a multinational specialty chemicals company and we are part of a strong network of well-known and experienced partners and industry experts. Haverlandweg 101a, Dülmen Phone: Internet: Founding year: 2017 Number of employees: 1 DASGIP AG DASGIP has been an industry-leading supplier of benchtop bioreactor solutions for the biotech, pharmaceutical and chemical industries as well as academia and research institutions since Our parallel bioreactor systems for the cultivation of microbial, plant, animal and human cells utilize industry-standard benchtop glass and single-use bioreactors. DASGIP s best-in-class configurable control systems and state-of-the-art bioprocess analyzers deliver unparalleled functionality coupled with user-friendly design for optimal bioprocessing. Our proven solutions for interconnectivity to 3rd party bioprocess analyzers, supervisory control systems and DoE tools, combined with our best-in-class control systems, enable migration strategies for optimization of legacy benchtop bioreactor equipment. The outstanding DASGIP bioprocess solutions support QbD-driven process development. As of January 2012, DASGIP is an Eppendorf company. DASGIP is headquartered in Juelich (Germany) and has operations throughout Europe, North America and Asia. Rudolf-Schulten-Straße 5, Jülich Phone: Internet: Founding year: 1991 Number of employees: about 70 DIREVO Industrial Biotechnology GmbH Direvo is a biotechnology company with a focus on the biomass conversion industry. Direvo applies its profound expertise in bioengineering to provide custom solutions for partners in areas that include: protein & enzyme engineering, application development and process engineering. Direvo identifies bottlenecks and weaknesses in current industrial processes in this sector and develops and implements biology-based solutions together with large and small industrial partners. From the sourcing of biological diversity through our efficient biocatalyst optimization platform to our established process development capabilities, we cover full technology development cycles in all areas of biomass conversion. Our products are newly designed enzymes and microorganisms of the highest quality that provide easyto-implement, cost-effective solutions. Our contribution assures that our partners stay competitive and profitable while we add to their ability to make the future cleaner, greener, and safer. Nattermannallee 1, Cologne Phone: Internet: Founding year: 2008 (spin-off from DIREVO AG) Number of employees: 30 47

48 Profiles Ecotradex GmbH Ecotradex GmbH is focused on facilitating innovations and business development for bio-based, renewable and recyclable materials. This is realized through three fields of activity: offering suitable machine building solutions for mechanical processing of bio-based raw materials, trading in bio-based materials, and innovation consulting in the bio-based field. We offer, for example, packaging materials development based on bio-plastics and cellulosic fiber based solutions to replace plastics based on fossil feedstocks. Sankt-Göres-Straße 34a, Düsseldorf Phone: Internet: Founding year: 2014 Number of employees: 5 Eder Schieschke & Partner mbb Elisabethstr. 34, München Phone: Fax: Internet: The chemical department of the intellectual property law firm Eder Schieschke & Partner mbb has specialized in representing clients in the field of organic chemistry, biochemistry and biotechnology before the European Patent Office, the German Patent and Trademark Office, the German Patent Court and the European Intellectual Property Organization in all areas of intellectual property law. Amongst obtaining patent rights, utility model rights and trademark rights Eder Schieschke & Partner mbb s expertise is also directed to license agreements, preparation of invalidity, infringement and freedom-to-operate studies, as well as German employee law. As a member of CLIB, Eder Schieschke & Partner mbb is supporting the Cluster with the realization of IP coaching seminars for start-ups and SMEs. Eindhoven University of Technology Eindhoven University of Technology (TU/e) is a research university, founded in 1956, specializing in engineering science & technology. The Department of Chemical Engineering and Chemistry aspires to be an academic institution for education and research in chemical science and engineering of the highest international standard. The aim is to generate and to develop technology and scientific knowledge relevant for the long-term needs of society. Groene Loper 5, 5612AE Eindhoven, The Netherlands Phone: Internet: Founding year: 1956 Number of employees: 3239 Scientific curiosity and the use of newly generated knowledge are the main driving forces behind the continuing enhancement of our expertise in (electro-)chemical reactor engineering, multiscale & multiphase modelling, process intensification, membrane processes and heterogeneous catalysis Federal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences» Russian Academy of Sciences was organized through merging the A.N. Bach Institute of Biochemistry RAS (INBI RAS), the S.N. Winogradsky Institute of Microbiology RAS and the Centre «Bioengineering» RAS. Leninsky prospect, 33, Bld. 2, Moscow, , Russian Federation Phone: Internet: Founding year: 2014 Number of employees: 500 The Research Centre of Biotechnology RAS carries out basic and applied research in the fields of biochemistry and biotechnology, microbiology, genomics, bioengineering and genetic engineering, biocatalysis, system and structural biology, biogeotechnologies, bioremediation, agrobiotechnologies, food quality and safety. The Centre is the key member of the Russian Technology Platform «Bioindustry and Bioresources BioTech2030». The Russian National Contact Point on Biotechnology, three core facilities, an accredited testing laboratory, and an experimental greenhouse are functioning at the Centre. 48

49 Profiles Evolva SA Evolva stands for a world where there is less sugar in your food, you and your family are safe from biting ticks, and your cat lives longer - and that s just for starters. We aim to make such things possible by discovering, producing, and supplying innovative, sustainable ingredients. Evolva is a pioneer and global leader in sustainable, fermentation-based approaches to ingredients for health, wellness and nutrition. Our products include stevia, resveratrol, vanillin, nootkatone, valencene, and saffron. As well as developing our own proprietary ingredients, Evolva also deploys its technology for partners, providing them with a competitive edge and sharing in the returns they make. To learn more about us, please watch our YouTube movie Eve explains Evolva s fermentation and on Twitter Duggingerstrasse 23, 4153 Reinach, Switzerland Phone: Internet: Founding year: 2004 Number of employees: 160 Evonik Industries AG Evonik, the creative industrial group from Germany, is one of the world leaders in specialty chemicals, operating in the Nutrition & Care, Resource Efficiency and Performance Materials segments. The company benefits from its innovative prowess and integrated technology platforms. In 2015 more than 33,500 employees generated sales of around 13.5 billion and an operating profit (adjusted EBITDA) of about 2.47 billion. Rellinghauser Str. 1-11, Essen Phone: Internet: Founding year: 2007 Number of employees: approx. 33,500 evoxx technologies GmbH evoxx technologies GmbH, a German industrial biotechnology company, is focusing on the development and production of industrial enzymes. As European subsidiary of the global enzyme manufacturer Advanced Enzymes Technologies Ltd. a comprehensive product portfolio of enzymatic solutions for human nutrition, animal nutrition, bio-processing, and pharma industries is offered. Product development is based on the proprietary technology platform covering the whole value chain from early enzyme and process development to industrial scale production and product deregulation. evoxx industrial partners and customers benefit from the unique metagenomics libraries, the enzyme development skills and tech-transfer and production capabilities. evoxx is located on the Creative Campus in Monheim am Rhein and on the Biotech Campus Hermannswerder in Potsdam. Alfred-Nobel-Str. 10, Monheim am Rhein Phone: Founding year: 2006 Number of employees: 40 Flemish Institute for Technological Research, VITO Within Sustainable Chemistry, VITO focuses on process intensification and replacing fossil with sustainable resources. Key is the integration of conversion with separation processes to improve overall efficiency and sustainability: in situ product recovery within biocatalytic processes, biocatalyst immobilization, and novel separation approaches (membranes are often integrated in these processes) are some of our developments in this field. Using alternative resources (like CO 2, biomass) requests different approaches to deliver high added value products: mild disclosure, (scco 2 ) extraction, fractionation and biocatalytic processes, (bio)electrochemical reactions with CO 2. VITO is one of the partners involved in the inventories and strategic research agenda for Sustainable Chemistry especially in the Flemish (CATALISTI) and European context (BIG-Cluster, SPIRE, BBI, SusChem), but also on a global level (India). VITO is also founding partner of Biorizon, a shared research center for bio-aromatics. Boeretang 200, 2400 Mol, Belgium Internet: sustainablechemistry@vito.be Founding year: 1990 Number of employees:

50 Profiles Forschungszentrum Jülich GmbH - IBG-1: Biotechnology Wilhelm-Johnen-Straße, Jülich Phone: (Prof. Bott) 3118 (Prof. Wiechert) Internet: Founding year: 1977 Number of employees: 120 IBG-1: Biotechnology (formerly Institute of Biotechnology) is one of Germany s leading institutes in the field of microbial biotechnology. IBG-1 develops multipurpose microbial production platforms such as C. glutamicum for the production of industrially or pharmaceutically relevant products from renewable carbon sources (e.g. amino acids, organic acids, proteins). Methods of synthetic biology are used for establishing novel concepts in strain development and implementation of heterologous or artificial metabolic pathways. In parallel, biocatalysis with isolated enzymes or whole cells is developed using a rigorous systems biotechnology approach. IBG-1 runs an extensive omics platform including DNA microarrays, proteomics, metabolomics and fluxomics for strain characterization. Lab investigations are tightly integrated with mathematical modelling for experimental design, parameter estimation and process optimization. Experimental facilities range from parallelized mini bioreactor systems up to pilot plant scale and include tools for single-cell analysis by flow cytometry and microfluidics. Fraunhofer IGB The Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB develops and optimizes processes and products in the fields of health, chemistry and process industry, as well as environment and energy. In the area of industrial biotechnology we focus on establishing, optimizing and scaling up processes that take place with the help of enzymes or microorganisms. For example, hydrolases and oxidoreductases as well as a wide variety of bacteria, fungi and yeasts are used for this purpose. Nobelstraße 12, Stuttgart Phone: Internet: Founding year: 1953 Number of employees: 337 In some cases, the desired conversion also becomes possible through combination with chemical transformation processes. In the development of the conversion processes under laboratory conditions and the optimization of the biocatalysts themselves, the focus is already on scaling up the processes and processing the products. At the Fraunhofer Center for Chemical-Biotechnological Processes CBP, the Leuna branch of the institute, infrastructure and pilot plants are available to scale up processes to production-relevant dimensions. Fraunhofer IME The Fraunhofer Institute for Molecular Biology and Applied Ecology IME conducts research in the field of applied life sciences from a molecular level to entire ecosystems. By strategic orientation along the value chain, the Fraunhofer IME follows the mission to take innovative products closer towards the market, to develop enabling technologies, and provide scientific services to partners from academic institutions and industry. Forckenbeckstraße 6, Aachen Phone: Internet: Founding year: 1959 Number of employees: approx. 600, incl. at international locations In the area of industrial biotechnology, the Fraunhofer IME offers research in the field of directed evolution, classical strain improvement, metabolic pathway engineering, and fermentation. Besides scientific expertise, we possess state-of-the-art facilities for highthroughput screening, enzyme production & purification, fermentation process development and protein crystallization and modelling. Fraunhofer UMSICHT Fraunhofer UMSICHT is a pioneer for sustainable energy and raw materials management. The institute provides scientific results and transfers them to business, society, and politics. The dedicated team researches and develops sustainable products, processes and services. Osterfelder Straße 3, Oberhausen Phone: Internet: Founding year: 1990 Number of employees: 465 (352 in Oberhausen and Willich, 113 in Sulzbach-Rosenberg) We offer process engineering research and development services as well as products and processes incl. industrial property rights. These help to meet the increasing demands for affordable sustainability and innovation in chemistry, petro-chemistry and refinery. Our know-how encompasses the areas of fine and specialty chemicals (organic acids, peptides, sugars, surfactants), polymers (monomer syntheses, polymerization, polycondensation) as well as chemical mass products (alcohols, naphtha) and biofuels (diesel, kerosene). Biomass, synthesis gas and selected residues constitute the portfolio of raw materials from which we suggest process-specific solutions. Know-how regarding the upstream and downstream processing as well as product formulation round out our expertise. 50

51 Profiles Fraunhofer WKI The mission of the Fraunhofer Institut für Holzforschung, Wilhelm-Klauditz-Institut (WKI) is the generation and subsequent application of knowledge in the development of new materials and technologies focused on renewable resources and sustainability, improving the quality and safety of products, and increasing the competitiveness of related industries. WKI has extensive competence in the areas of intermediates preparation from biobased raw materials and polymer synthesis. The main focus was laid on the modification of vegetable oils, saccharides, utilising building blocks generated by industrial biotechnology, and the utilisation of lignin for various applications. WKI is also involved in polymer composite processing as well as mechanical and thermal polymer characterisation, and material testing. Bienroder Weg 54 E, Braunschweig Phone: Internet: Founding year: 1946 Number of employees: 119 FRINGS The company Heinrich Frings GmbH & Co. KG is a worldwide supplier of machines, equipment and components for process technology in the industry sectors food, biotechnology, and the chemical industry as well as environmental technology with special focus on fermenters and bioreactors. FRINGS not only supplies customized systems for each application, but also offers assistance and consulting services. FRINGS has extensive know how and experience concerning process optimization and product development. For downstream processing FRINGS delivers membrane filtration systems (crossflow filtration) for many different industrial sectors. Frings Heinrich Frings GmbH & Co. KG Boschstr. 32, Rheinbach Phone: Internet: Founding year: 1878 Number of employees: 70 State Research Institute for Genetics and Selection of Industrial Microorganisms Genetika Genetika carries out fundamental and applied research in the fields of microbiology, genetic engineering, and biotechnology, with the emphasis on the development of processes based on microorganisms as well as mammalian cells. Genetika is the home of Russian National Collection of Industrial Microorganisms (VKPM) the biggest collection of this type in the country. It boasts ca. 17,000 strains of different bacterial, yeast and fungal species. Principal research areas: microbial strains and cell cultures design; process development and optimization; regulation and evaluation of metabolic processes; biocatalytic processes development. Based at Genetika is the editorial board of the Russian Journal of Biotechnology. Genetika is one of the key members of the Russian Technology Platform Bio-industry and Bio-resources BioTech2030, working in the area of implementation of a number of biotech projects, including the technologies of amino acids, organic acids, enzymes and other value-added products. 1st Dorozny proezd, 1, Moscow, Russian Federation Phone: Internet: Number of employees: 260 Heinrich Heine University Düsseldorf - Institute of Molecular Enzyme Technology (IMET) The Institute of Molecular Enzyme Technology (IMET) of Heinrich Heine University Düsseldorf is located on campus of the Forschungszentrum Jülich, where it is part of the Institute of Bio- and Geosciences IBG-1: Biotechnology, which holds a leading position nationally and internationally in the field of basic research and biotechnological applications of microorganisms. The IMET is directed by Prof. Dr. Karl-Erich Jaeger and currently employs about 40 people. Four different groups cover the scientific topics Bacterial Cell Factories (Dr. Andreas Knapp), Bacterial Enzymology (Dr. Filip Kovacic), Bacterial Photobiotechnology (Dr. Thomas Drepper), and Molecular Biophotonics (Dr. Ulrich Krauß). IMET provides excellent facilities and comprehensive technical support, including state-of-the-art instrumentation to carry out molecular biological, biochemical, and high-throughput screening methods. Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, Jülich Phone: Internet: Founding year: 1986 Number of employees: 40 51

52 Profiles Henkel AG & Co. KGaA Henkel operates globally with a well-balanced and diversified portfolio. The company holds leading positions with its three business units - Laundry & Home Care, Beauty Care and Adhesives - in both industrial and consumer businesses thanks to strong brands, innovations and technologies. Founded in 1876, Henkel looks back on more than 140 years of success. Henkel s preferred shares are listed in the German stock index DAX. The DAX-30 company has its headquarters in Düsseldorf, Germany. Henkelstrasse 67, Duesseldorf Phone: Internet: Founding year: 1876 Number of employees: 50,000 Henkel employs more than 50,000 people worldwide, over 80 percent of whom work outside of Germany. As a recognized leader in sustainability, Henkel holds top positions in many international ratings and rankings. In the fiscal year 2016, the company reported sales of approx billion euros and an operating profit of around 3.2 billion euros (adjusted for one-time gains/charges and restructuring charges). i2i Metzer Strasse 5, Köln Phone: Internet: Number of employees: 1 inventions to innovation i2i is a management consulting platform started by Anindya Mukherjee in 2009 to help entrepreneurs transform their inventive ideas into innovative products. i2i has helped numerous companies and institutions and looks forward to assisting CLIB members. i2i follows a structured yet flexible process (i2i calls it The Growth Initiative Process ) to evaluate new technologies, and product ideas, develop commercialization strategies and actions that allow entrepreneurs commercialize their products. Anindya has over 26 years of experience in industrial biotechnology, plastics and chemicals with 20 years in the corporate world in R & D to executive management, and the last 8 years as a consultant. Talk to Anindya and see what i2i can do for your business! IMD Natural Solutions GmbH Otto-Hahn-Straße 15, Dortmund Phone: Internet: Founding year: 2012 Number of employees: 9 IMD Natural Solutions is a natural product chemistry expert, active in the area of fine chemicals derived from natural sources. We develop and produce innovative natural additives for product preservation in open and closed shelf-life and hygiene applications and deliver services related to natural products: Discovery and qualification of lead candidates and active (pharmaceutical) ingredients Process development and production (fermentation / extraction-based) We operate an integrated technology platform: World largest pure natural product compound collection (15,000 compounds) Screening library (100,000 samples, HTS-ready plated) Bioprofiling database (unparalleled collection of bioactivity data; 12 million entries) Fermentation, purification, analytical lab (uplc-ms/uv/elsd; GC/MS; NMR) InfraServ GmbH & Co. Knapsack KG Chemiepark Knapsack Industriestrasse 300, Huerth (Cologne) Phone: Internet: Founding year: 1997 Number of employees: 850 InfraServ Knapsack places particular emphasis on the engineering of individual plants - from process development and conceptual design to basic and detailed engineering, regardless of whether we just carry out sub-services or take over the general planning for every stage. InfraServ Knapsack does not supply one-size-fits-all solutions. Instead, we adopt a flexible approach and gear ourselves towards the specific requirements of the current project stage - step-by-step. Thanks to a broad range of diverse engineering fields and an extensive selection of methods, we can guarantee the highest degree of flexibility with regard to content. The Chemiepark Knapsack near Cologne in Germany also offers companies a scale-up platform and access to know-how for bio-based production and integration into existing value chains. The innovative capacity of the Chemiepark Knapsack, solid infrastructure, plug&play services, as well as less bureaucracy and red tape all offer huge benefits for your company to commercialize your product. 52

53 Profiles INOSIM Consulting GmbH INOSIM Consulting GmbH is a German company providing sophisticated technological advice and simulation services for process industries and biotechnology. Our engineering and simulative methods for the design and optimization of biotechnological processes allow setting up the mass and energy balances of a process, applying as little experimental and process data as possible. Thereby, alternative process ideas can be evaluated in both process design and scale-up as well as in the optimization of existing processes and plants. Looking at the complete process and plant with all interdependencies in-between helps to develop resource-saving processes and production plants. Besides the resource efficiency, production costs and capacity can, of course, be included in the rating as well. Joseph-von-Fraunhofer-Str. 20, Dortmund Phone: Internet: Founding year: 2010 Number of employees: 5 IP Services The international protection of Intellectual Property (IP) is of great importance for successful collaboration and commercialization. The successful protection of biotechnological inventions e.g. representing one part of a complete value chain requests a sound experimental set-up from the initial idea to patent filing. IP Services assists throughout the process of translating ideas into valuable Intellectual Property Rights. Based on a 17 year experience in a biotech company working as project manager and IP manager in the field of recombinant expression in yeast, I started my own business in The objective is to represent the interface between a company and a law firm and providing any IP service needed by small or mid-sized biotech companies on a cost efficient basis and independent of the company s location. The service comprises assessing the value of a company s technologies, collaboration with R & D, IP searches, definition of patent filing strategy, analysis and maintenance of IP portfolio, patent application processing, cooperation with law firms, preparation for due diligence (M&A processes), IP administration, cost control, and IP training. Unter Linden 35, Köln Phone: Internet: Founding year: 2005 Number of employees: 1 Isobionics BV Isobionics is an ingredients company, producing and selling a range of natural products in the Flavour & Fragrance market using its proprietary platform technology based on fermentative production of terpenes. This technology can produce many compounds that occur as components of plant essential oils, such as Citrus oils (Lemon, Orange, Grapefruit). Current products include Valencene, Nootkatone, Beta-Bisabolene and Beta-Elemene. Sandalwood oil, Patchouli oil, and other building blocks for the Flavour & Fragrance industry are under development. The current supply chain of many natural compounds is unstable and characterized by high volatility regarding availability, quality and pricing. With our proprietary fermentation technology we create stability and a cost price advantage. Urmonderbaan 22, 6167 RD Geleen, The Netherlands Phone: Internet: Founding year: 2008 Number of employees: 10 Jäckering Mühlen- und Nährmittelwerke GmbH The Jäckering group of companies has developed over 100 years (date of foundation 1910) into a group of various activities: wheat starch production (ca tons wheat input per year) machinery production (grinders and dryers on the basis of air turbulence mills under the brand name ULTRA ROTOR) by-product-recycling in the PVC industry logistics and warehousing Most of the activities of Jäckering are located in the harbor of Hamm (the second largest public canal harbor in Germany), with neighboring companies in the businesses of vegetable oil production, animal feed compounding as well as a petrochemical harbour for mineral oil, heating oil, etc. Jäckering plans to move into the biotechnological production of raw materials for the chemical industry on the basis of its by-products, this could be biobased plastics, beta-carotene, or any other glucose-based fermentation product. Research is already carried out together with leading universities, institutes, and a technical application center is under construction. Vorsterhauser Weg 46, Hamm Phone: Internet: Number of employees:

54 Profiles Jaeger & Doerr GbR Thumer Weg 56, Nideggen Phone: Internet: Founding year: 2006 Number of employees: 4 Marketing and consulting for renewable energy, lubrication, tribology, fuel and lubricant market Training programs, management of demo projects and fleet tests B2B Events Justus Liebig University Giessen Giessen University is a modern institution which can take pride in some four centuries of past achievement. The current research activities in biotechnology build bridges from biological and biochemical phenomena to industrial applications. Key aspects comprise the development of novel tools for bio-analytics (e.g. mass spectrometry imaging), protein design (programmable nucleases, photoswitches), and the field of food biotechnology (basidiomycetous enzymes, natural flavors, fermentation). Ludwigstrasse 23, Giessen Phone: Internet: Founding year: 1607 Number of employees: 4,000 The LOEWE focus group Insect Biotechnology ( yellow biotechnology ) is committed to developing innovative, cutting-edge technology at the interfaces between applied entomology and red, green, and white biotechnology. Inter alia, novel concepts for the enzymatic digestion of lignocelluloses are designed. KADIB - Kircher Advice in Bioeconomy Kurhessenstr. 63, Frankfurt am Main Phone: Internet: Founding year: 2014 Number of employees: 1 KADIB offers expertise in the global industrial bioeconomy. We strive to position profitable chemical and energy value chains sustainably in the Political, and Economical, as well as Societal, Technological, Legislative and Ecological (PESTLE) environment and conditions. KADIB provides advice and moderates decision-making: Value Chain Analysis & Bioeconomy Strategies Private & Public Fund Raising Research & Development Marketing & Commercialization International Partnering & Cluster Building Communication & Publishing Material Compliance Service & Process Implementation KADIB works through its unique network of senior experts. We help our clients to specify complex queries and provide analyses and reports through our advisory board and wider network. Kuhner Shaker GmbH Kaiserstr. 100, Herzogenrath Phone: Internet: The Kuhner Shaker GmbH distributes shaking machines and application technologies for shaken bioreactor systems. Moreover, we produce and develop innovative feeding technologies for microtiter plates, shake flasks and spin tube bioreactors. The product portfolio covers bench top shakers, industrial shaking machines for GMP environments as well as the feeding technologies FeedPlate, FeedBead and FeedTube. Kuhner Shaker is driven by a personal and trustful contact to our customers. Based on a long-term experience and our expert knowledge regarding shaken bioreactors we are capable to offer individual and custom-made solutions. As partner of the science, we actively contribute to academic research projects. 54

55 Profiles LANXESS AG LANXESS is a leading specialty chemicals company with sales of EUR 7.7 billion in 2016 and about 19,200 employees in 25 countries. The company is currently represented at 75 production sites worldwide. The core business of LANXESS is the development, manufacturing and marketing of chemical intermediates, additives, specialty chemicals and plastics. Through ARLANXEO, the joint venture with Saudi Aramco, LANXESS is also a leading supplier of synthetic rubber. LANXESS is listed in the leading sustainability indices Dow Jones Sustainability Index (DJSI World) and FTSE4Good. Kennedyplatz 1, Köln Phone: Internet: Founding year: 2005 Number of employees: LanzaTech Founded in 2005, LanzaTech has developed a fully integrated gas to liquid technology platform that produces fuels and chemicals from gas resources. The potential feedstock ranges from industrial waste gases (steel mills, refineries and phosphorous plants) to biomass syngas (MSW, organic industrial waste, and agricultural waste); as well as biogas. LanzaTech employs a strong technical team based in the USA, China and Europe and has a rapidly growing patent portfolio. With agreements now in place across a variety of sectors internationally, including steel, aviation, refining and chemicals, LanzaTech s technology is being scaled to commercial production Lamon Avenue, Skokie, IL USA Phone: nternet: Founding year: 2005 Number of employees: 120 LXP Group GmbH LXP is a tech company, active in the field of industrial biotechnology. The objective of the company is the development, marketing and licensing of technical solutions for the economic and ecological processing of plant residues on the basis of closed carbon and mineral cycles. Our mission is to maximize the ecological and economic efficiency of biotechnological processes. The core technology is based on a patent protected pre-treatment process called LX-Process. This process provides alternative/2g-carbohydrates/-sugars and is easy to integrate into biotechnological processes. It allows the conversion of virtually all carbohydrates of lignocellulosic non-food materials to chemicals or biofuels. Additionally, sulphur free lignin is obtained. Alte Dorfstraße 14a, Marienwerder Phone: +49(0)3337 / Internet: Founding year: 2009 Number of employees: <10 Malaysian Bioeconomy Development Corporation Bioeconomy Corporation is the lead development agency for the bio-based industry in Malaysia, under the purview of Ministry of Science, Technology, and Innovation (MOSTI). Bioeconomy Corporation is: Owned by the Minister of Finance Incorporated & Federal Lands Commissioner Governed by the Biotechnology Implementation Council Advised by the Bioeconomy International Advisory Panel, chaired by the Honorable Prime Minister of Malaysia. Bioeconomy Corporation is responsible for executing the objectives of the National Biotechnology Policy (NBP) and acts to identify value propositions in both R & D and commerce and to support these ventures via financial assistance and developmental services. Level 16th, Menara Atlan,161 B, Jalan Ampang Kuala Lumpur, Malaysia Phone: Internet: Founding year: 2005 Number of employees:

56 Profiles Mial GmbH Mial GmbH is a producer of organic Chlorella at its production facility in Bad Zwischenahn. Using Chlorella and other microalgae as a source for the development and production of new active pharmaceutical ingredients, Mial positions itself as a developer of new nutraceutical formulations. Mial places a special interest in the development and use of novel carbohydrate mixtures, derived from various microorganisms. The complex mixtures may act as ingredients for nutraceutical, cosmetic and veterinary applications. Mittellinie 199, Bad Zwischenahn Phone: Internet: Founding year: 2014 Number of employees: 9 Additional R & D interests are in the discovery and manipulation of new pigment production pathways in selected microalgae. Mitsui & Co. Deutschland GmbH Mitsui & Co. Deutschland GmbH Herzogstrasse 15, Düsseldorf Phone: Internet: Founding year: 1954 Number of employees: 180 Mitsui & Co. Deutschland GmbH is a subsidiary of Mitsui & Co., Ltd., one of the largest general trading companies in Japan with an annual revenue of 39,672 million USD (2016/17). Utilizing our global operating locations, network and information resources, we are multilaterally pursuing business that ranges from product sales, worldwide logistics and financing, through to the development of major international infrastructure and other projects in the following fields: Iron & Steel Products, Mineral & Metal Resources, Infrastructure Projects, Integrated Transportation Systems, Chemicals, Nutrition & Agriculture, Energy, Food, Food & Retail Management, Healthcare & Service, Consumer Business, IT & Communication Business, Corporate Development Business. We combine these functions to create and optimize value chains in a wide range of business fields. Maximizing our value-added content, we strive to meet the diverse needs of our customers around the world. Nanjing Tech University NO.30 Puzhu Road(S), Nanjing China Phone: Internet: Founding year: 1902 Number of employees: 30,000 The NJUT s Faculty of Biotechnology originated from the first discipline in biochemical engineering in China in 1985, which has been leading the way in the higher education and R & D in biotechnology from then on. Prof. OUYANG Pingkai, the founder of the faculty and academician of the Academy of Engineering of China, pioneered biochemical engineering as a mentor and an investigator. Our research and development is focused on the basic, strategic, and perspective aspects of industrial biotechnology directly associated with and serving the sustainability of the country and the welfare of the society. The investigations spanned energy, resources, environment, and health with a broad spectrum, in which the research on bio-energy, bio-polymers, and bio-based fine chemicals are the mainstays. NC Partnering Uusikatu 24 G 70, Oulu, Finland Phone: Internet: We favour renewable over finite-supply, but prefer those technologies that require little or no subsidies to thrive; commercially viable concepts will ultimately stand the test of time. We believe the best long-term effects are achieved when each component in biomass is utilised to its full potential. With respect to wood, this means preferring advanced value chains over simple usages. Our vision calls for a Biofuture that goes beyond traditional solutions. We see danger in oversimplified calls for anything renewable, and prefer an integrated approach to biomass and biotechnology. There are immense opportunities open to those who want to take today s bioeconomy to the next stage - the Biofuture, but only if innovation and commercial sense advance hand in hand! Our newest tool for driving bio-innovation is the BioFutureFactory( ), of which more on our website. 56

57 3,5 actual data 3 2,5 2 1,5 1 0, L-LA Epichlorohydrin Succinic 1,4-BDO acid -Institut.eu 2017 forecast Sebacic MEG Ethylene 1,3-PDO MPG Lactide acid 2,5-FDCA D-LA 11-Aminoundecanoic acid Adipic DDDA acid Full study available at 100% 80% 60% 40% 20% 0% -Institut.eu 2017 PBS(X) APC cyclic PA PET PTT PBAT Starch Blends PHA PLA PE Full study available at PUR PA -Institut.eu 2016 actual data 2% of total polymer capacity, 13 billion turnover Epoxies PET CA PBS PBAT PHA 2017 Starch Blends EPDM 2018 PLA APC PE PEF 2021 PTT Full study available at Bio-based Polymers & Building Blocks The best market reports available Profiles Data for 2016 Commercialisation updates on bio-based building blocks Standards and labels for bio-based products Bio-based polymers, a revolutionary change Bio-based Building Blocks and Polymers Selected bio-based building blocks: Evolution of worldwide production capacities from 2011 to 2021 Comprehensive trend report on PHA, PLA, PUR/TPU, PA and polymers based on FDCA and SA: Latest developments, producers, drivers and lessons learnt Global Capacities and Trends million t/a Bio-based polymers, a revolutionary change million t/a Bio-based polymers: Evolution of worldwide production capacities from 2011 to 2021 Jan Ravenstijn j.ravenstijn@kpnmail.nl Mobile: Picture: Gehr Kunststoffwerk Author: Doris de Guzman, Tecnon OrbiChem, United Kingdom July 2017 This and other reports on the bio-based economy are available at Authors: Lara Dammer, Michael Carus and Dr. Asta Partanen nova-institut GmbH, Germany May 2017 This and other reports on the bio-based economy are available at Author: Jan Ravenstijn, Jan Ravenstijn Consulting, the Netherlands April 2017 This and other reports on the bio-based economy are available at Authors: Florence Aeschelmann (nova-institute), Michael Carus (nova-institute) and ten renowned international experts February 2017 This is the short version of the market study (249 pages, 2,000). Both are available at Policies impacting bio-based plastics market development and plastic bags legislation in Europe Asian markets for bio-based chemical building blocks and polymers Brand Views and Adoption of Bio-based Polymers Market study on the consumption of biodegradable and compostable plastic products in Europe 2015 and 2020 Share of Asian production capacity on global production by polymer in 2016 A comprehensive market research report including consumption figures by polymer and application types as well as by geography, plus analyses of key players, relevant policies and legislation and a special feature on biodegradation and composting standards and labels Bestsellers Disposable tableware Biowaste bags Carrier bags Rigid packaging Flexible packaging Authors: Dirk Carrez, Clever Consult, Belgium Jim Philp, OECD, France Dr. Harald Kaeb, narocon Innovation Consulting, Germany Lara Dammer & Michael Carus, nova-institute, Germany March 2017 This and other reports on the bio-based economy are available at Author: Wolfgang Baltus, Wobalt Expedition Consultancy, Thailand This and other reports on the bio-based economy are available at Author: Dr. Harald Kaeb, narocon Innovation Consulting, Germany January 2016 This and other reports on the bio-based economy are available at Authors: Harald Kaeb (narocon, lead), Florence Aeschelmann, Lara Dammer, Michael Carus (nova-institute) April 2016 The full market study (more than 300 slides, 3,500 ) is available at bio-based.eu/top-downloads. nova-institut GmbH Applied research for your needs As a private and independent institute, nova has over two decades of experience in the bio- and CO 2 -based economy, conducting research projects and consultancy as well as conference management and dissemination. nova experts come from a wide range of backgrounds, including material sciences, economics, chemistry, biology, environmental sciences, biotechnology and physics. This gives nova a unique understanding of the bio-based economy, markets and trends and enables it to support your business. nova surrounds, strengthens and completes scientific and engineering work by linking it to feedstock, markets, ecology, economy and policy. nova offers research and consultancy with a focus on bio- and CO 2 -based economy in the fields of feedstock, techno-economic evaluation, markets, sustainability, dissemination, B2B communication and policy. Industriestraße 300, Hürth Phone: Internet: Founding year: 1994 Number of employees: 27 Institute for Ecology and Innovation Niederrhein University of Applied Sciences Institute for Modeling and High Performance Computing (IMH) More and more companies and research projects analyze and optimize technical systems via computational fluid dynamics (CFD). The IMH applies CFD to very complicated geometries with focus on two-phase flows and program. Furthermore, the IMH programs and parallelizes additional software for commercial software programs. Reinarzstraße 49, 47805, Krefeld Phone: (-4728) Internet: Founding year: 2005 Number of employees: 5 57

58 Profiles Wir fördern das Gute in NRW. Unternehmer wie Dirk Franke setzen für die Digitalisierung auf die Förderprogramme der NRW.BANK 58 Auf immer digitaler werdenden Märkten ist Durchblick der Schlüssel zum Erfolg. Die NRW.BANK finanziert die Realisierung Ihrer Digitalisierungsvorhaben mit attraktiven Förderprogrammen und Beratungskompetenz. Sprechen Sie uns an!

59 Profiles NRW.BANK NRW.BANK is the development bank for North Rhine-Westphalia. NRW.BANK essentially gears its equity capital products to companies lifecycles. Using the new programme NRW. SeedCap Digitale Wirtschaft, business angels small-volume early-stage investments in companies of the digital economy can be doubled by the NRW.BANK. The regional seed funds of the NRW.BANK.Seed.Fonds-Initiative and the NRW.BANK.Venture Fonds invigorate the early-phase funding in NRW. For young businesses, the development bank provides contacts to potential private investors within the win NRW.BANK Business Angels Initiative. The NRW.BANK.Venture Center is a specialist advisory unit for business founders from universities and research institutions as well as innovative start-ups. Kavalleriestraße 22, Düsseldorf Phone: Internet: Founding year: 2002 Number of employees: 1,309 Pfeifer & Langen GmbH & Co. KG Pfeifer & Langen operates five sugar factories in Germany. Sugar beets grown by farmers are processed to white sugar and the by-products sugar beet pulp and molasses. These products and intermediate products such as thick juice can be used as carbohydrate sources for biotechnological processes. Pfeifer & Langen supplies sugar and sugar specialities for the food industry and consumers. The production process of Pfeifer & Langen starts when the sugar beet seed is sold to the farmers and ends when the sugar is placed on the shelves of groceries. We are looking for opportunities to use our expertise in the process chain beginning with agriculture and ending in the food retail trade for new processes and products connected with biotechnology. Newly Pfeifer & Langen enters the field of natural functional carbohydrates. Aachenerstr. 1042a, Köln Phone: Research Facility: Dürener Str. 40, Elsdorf Internet: Founding year: 1870 Number of employees: 2,300 Philipps-Universität Marburg LOEWE-Zentrum für Synthetische Mikrobiologie, SYNMIKRO Philipps-Universitat in Marburg is the oldest university in the world that was founded as a Protestant institution. It has been a place of research and teaching for nearly five centuries. Its broad range of arts and humanities, and its experimentally challenging scientific work, constitute an ideal platform for interdisciplinary cooperation. The Philipps-Universitat Marburg and the Max Planck Institute for Terrestrial Microbiology have established a center for Synthetic Microbiology, SYNMIKRO, supported by the state of Hesse within its excellence program LOEWE. In SYNMIKRO, research groups in the areas of microbiology, genetics, medicine, cell biology, chemistry, physics, mathematics, informatics, and bioethics are working together in an interdisciplinary approach focusing on basic research in synthetic biology on all levels of microbial function, ranging from the development of regulatory circuits, genetic codes and metabolic pathways to the synthesis of new minimal cells and microbial communities. Hans-Meerwein-Straße, Marburg Phone: Internet: Founding year: 2010 Number of employees: 120 Phytowelt GreenTechnologies GmbH Phytowelt GreenTechnologies GmbH is a young, innovative company offering contract research and production in plant and industrial biotechnology worldwide. Our tissue culture and genetic engineering know-how assists our clients for the optimization of plants as well as utilization of secondary metabolites and enzymes for industrial use. Phytowelt routinely applies key technologies such as in vitro cultivation of plants, cell fusion, transformation technologies as well as plant analysis and molecular marker assisted breeding. Our approach to link plant and industrial biotechnology is maximizing the synergy from our platform technologies phytodiversity and phytomining to support the aroma and pharmaceutical industry and other users of secondary metabolites and enzymes of plants. Phytowelt GreenTechnologies was created in January 2006 as a merger of Phytowelt GmbH and GreenTec GmbH (created in 1997), a spin-off company from the Max-Planck-Institute for Plant Breeding Research, Cologne. Kölsumer Weg 33, Nettetal Phone: Internet: Founding year: 1998 Number of employees: 25 59

60 Profiles PROvendis GmbH PROvendis acts as a professional service provider in the entire field of IP management for more than 30 universities and extra-university research institutions as well as for companies and start-ups. Schlossstrasse 11-15, Muelheim an der Ruhr Phone: Internet: Founding year: 2001 Number of employees: 33 We provide an exclusive access to licensable inventions of approx. 20,000 scientists from the areas of medicine, natural sciences and engineering. Our Life Sciences Team consists of experienced innovation managers with professional expertise in the fields of biology, chemistry, medicine and pharma. They identify suitable partners, negotiate license agreements and promote long-term research collaborations. Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences No.189 Songling Road, Laoshan District, Qingdao, , P.R.China Phone: Internet: Founding year: 2009 Number of employees: 470 The Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences is one of China s primary national research institutions for renewable energy and green materials, focusing mainly on research and development of the resources, technologies, products and processes for bio-based energy and materials. QIBEBT currently has a staff of 800, 470 of whom are full-time employees and 330 are graduate students. The institute offers PhD, Master and Postdoctoral programs in biology, chemical engineering and technology, and material science and engineering. The institute attaches high importance to promoting international cooperation and has more than 170 global partners including Boeing, Shell, P&G and Total. RWTH Aachen - Lehrstuhl für Biotechnologie Worringer Weg 1, Aachen Phone: Internet: Founding year: 2008 Number of employees: 38 We are experts in biocatalyst engineering with a focus on directed protein evolution. We are developing novel random mutagenesis methods (SeSaM: Sequence Saturation Method), high throughput screening systems and computational programs to manage the complexity of protein sequence space. Based on our core competencies in directed protein evolution we founded a company (SeSaM- Biotech) and collaborate with leading companies in the field of industrial biotechnology. With our expertise we aim to understand structure-function relationships of biocatalysts and functional biomaterials in order to solve significant problems in industrial biocatalysis. Saint-Hyacinthe Technopole 1000 Dessaulles, J2S 8W1 Saint- Hyacinthe, Quebec, Canada Phone: Internet: Founding year: 2003 Number of employees: 14 Saint-Hyacinthe Technopole manages economic development on the city of Saint-Hyacinthe s territory. Its mission is to attract new industrial and commercial businesses, as well as promote and develop tourism. One of the Technopole s main tasks is to attract potential investors to the Maskoutan region. It works closely with investors to help get their projects set up in our area and ensure their success. It also manages and develops the technology park, the City of Agri-Food, Veterinary and Agri-Environmental Biotechnology. The Technopole is in charge of managing and selling lots in the industrial parks. The Technopole also helps established businesses in the city centre with their development projects, namely by securing financing packages and guiding them. 60

61 Profiles Schnee Research Schnee Research sees itself as a mediator between financial markets (e.g. investors) and small to mid-sized companies in different areas (e.g. biotech, chemical industry). Having worked for some years as analyst in the financial industry (independent research house, and rating agency), I now keep strong ties to the chemical industry from by background as a trained chemist (Dipl.-Chem.) and to biotech from my thesis work. My business activities in the area of white biotechnology are focused on evaluation and scouting. I focus on the analysis and evaluation of privately owned as well as listed biotech companies or their development projects. I was contracted as independent specialist by an investment bank to consult and assist a white biotechnology company in obtaining funding. Schnee Research offers two different services directly or via its cooperation partners faireseach (pure-play financial research) and Breslin. As a consequence, Schnee Research can span an investment bank s value chain with its entire network. The services of Schnee Research are closer to the money market than to production. P. O. Box 1104, Maintal Phone: Founding year: 2002 Number of employees: 1 SCION - New Zealand Forest Research Institute Limited Scion is a New Zealand Crown Research Institute that specialises in research, science and technology development for the forestry and wood-derived materials: tree improvement, wood-related bioenergy, industrial biotechnology and high-value manufacturing. Scion is developing biorefinery processes to create new green chemicals and biopolymers from renewable resources, with a focus on lignocellulosic biomass: soft wood. We develop microbial and enzyme-based processes that can be used by industrial partners for the production of valued compounds, enzymes and other biological products. Scion is New Zealand s centre of expertise in bioplastic research and development: production and manufacturing of biopolymers as plastics, adhesives, coatings, foams, pulp/ packaging, and fibre-composites. 49 Sala Street, 3010 Rotorua, New Zealand Phone: Internet: Founding year: 1947 Number of employees: 300 SenseUp GmbH SenseUp develops and optimizes microbial strains for industrial amino acid production. Using its revolutionary metabolite-sensor based screening technology, SenseUp offers strains with superior productivity, massive IP-generation and short development times. The SenseUp-Technology is currently adapted to non-gm compatible natural evolution, enabling unique optimization of probiotic microorganisms in near future. As a spin-off from Forschungszentrum Jülich, SenseUp combines decades of experience in microbial strain-development with novel disruptive technologies. c/o Campus Forschungszentrum, Wilhelm-Johnen-Straße, Jülich Phone: Internet: Founding year: 2015 Number of employees: 10 Senzyme GmbH Senzyme GmbH is innovatively operating in biotechnology and develops and produces technical enzymes and other additives for applications in bioenergy, biorefinement, as well as in the food and feed industries. The company has long and substantial experience in the cultivation of fungi using solid-state fermentation as the preferred method. Senzyme GmbH maintains a quality management system and guarantees the effectiveness and quality of all its processes and products. The company always welcomes cooperations with scientific institutions and other companies. Gierlichsstraße 6, Troisdorf Phone: Internet: Founding year: 2000 Number of employees: 30 61

62 Profiles SeSaM-Biotech GmbH Forckenbeckstraße 50, Aachen Phone: Internet: Founding year: 2008 As an all-in-one protein engineering service provider, SeSaM-Biotech improves industrial enzymes for various industry sectors like the chemical, dish&fabric, feed and food sector. Our expertise covers a range of enzymes including amylases, lipases, esterases, cellulases, glucose oxidases, laccases, monooxygenases, phytases, proteases, pectinases, polymerases and isomerases which we already have improved towards e.g. higher activity, thermal resistance or many other characteristics. With our cutting-edge technologies for mutagenesis (e.g. SeSaM-Technology, OmniChange), computational modelling of enzymes, and individually adapted screening assays we follow our vision: To provide our clients with Quality Enzyme Solutions to make their products eco-friendler, more cost effective and more valuable. Seventure Partners 5-7 Rue de Mouttessuy Paris cedex 07, France Phone: Internet: Founding year: 1997 Number of employees: 25 With over 660m in assets under management as of the end of 2016, Seventure Partners is a leading venture capital firm in Europe. Since 1997, Seventure Partners has invested in innovative businesses with high growth potential in two fields: Digital technologies in France and Germany, and Life sciences across Europe, Israel, Asia and North America. In Life sciences, the four areas of focus include biotechnology and pharmaceuticals, connected/digital health and medtech, industrial biotechnology, and last but not least: the MICROBIOME, nutrition, foodtech and personalized medicine. Investments can range between 500k and 10m per round, or up to 20m per company, from early to late stage. Recently, Seventure Partners successfully launched Health for Life Capital which has attracted strategic investments from prestigious organizations including Danone, Tereos, Tornier, Lesaffre, Bel and Novartis, as well as entrepreneurs and financial institutions. For more details: / Smart Bioprocess Vondelstr. 33, Köln Phone: Internet: Founding year: 2015 Smart Bioprocess consults companies in bioprocess development and innovation management in industrial and pharmaceutical biotechnology. With more than 15 years practice in bioprocess development we consult you in all stages of the development process: screening, media optimization, fermentation optimization, technology selection and scale up. Our special focus is the implementation and application of microbioreactors and automation to accelerate the development process. Through our experience in establishing new technology in international markets we guide start-ups and SMEs through the innovation process from idea to product. In the innovation process we apply Design Thinking and Agile Project Management for the efficient progress of your product and ideas. Our German and international business network will help to enter new markets and establish your business. With Smart Tools to Smart Bioprocess. Sofinnova Partners 17 Rue de Surème, Paris, France Phone: Internet: Founding year: 1972 Number of employees: 22 Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together 12 highly experienced investment professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a founding and lead investor in start-ups and corporate spin-offs, and for more than 40 years has backed nearly 500 companies creating market leaders around the globe. Today, Sofinnova Partners has over 1.3 billion of funds under management 62

63 Profiles SolarBioproducts Ruhr c/o Wirtschaftsförderungsgesellschaft Herne mbh SolarBioproducts Ruhr was founded by the business development agency Herne in cooperation with the Photobiotechnology group (Ruhr-University Bochum). SolarBioproducts Ruhr aims to intensify research projects, develop innovative ideas and bring together different fields of study. We offer outstanding experience in the field of green biotechnology, including in-depth knowledge of biocatalysts from photosynthetic microorganisms. Our team is interested in collaborations across a broad range of fields. Our experience in gene expression and genetic manipulation is applicable in the field of renewable energy, but also for bioeconomical alternatives for industrial applications like the use of microorganisms as chassis for the production of chemical compounds or high-value products. Westring 303, Herne Phone: Internet: Founding year: 1965 Number of employees: 20 Stolmár und Partner Stolmár & Partner is a full service IP law firm with offices in Munich, Düsseldorf and Geneva. A primary focus of S & P s practice is life sciences, Biotech, Pharma, green chemistry, sustainable chemistry, where we provide assistance to our clients in creating, prosecuting and enforcing our clients s valuable IP but we also give advice in complex licensing topics, IP Due Diligence, Freedom-to-Operate scenarios, document protection and arbitration in DIS based proceedings, ICCC and WIPO proceedings. Our technically and legally highly qualified attorneys understand the technology of our clients and that IP does matter and provide with their sound experience also services before various national patent offices, including the European, the German, Swiss, Austrian, Italian and French Patent- and Trademark Offices as a truly European one-stop-shop for IP. S& P clients range from Research institutions, start-up companies to multinational DAX, KOSPI, JPX and Fortune 500 companies. Blumenstraße 17, München Phone: Internet: Founding year: 2004 Number of employees: 40 Stora Enso Oyj Stora Enso is a leading provider of renewable solutions in packaging, biomaterials, wooden constructions and paper on global markets. Our aim is to replace fossil based materials by innovating and developing new products and services based on wood and other renewable materials. We employ some people in more than 35 countries, and our sales in 2016 were almost EUR 10.0 billion. The company is publicly listed in Helsinki (STEAV, STERV) and Stockholm (STE A, STE R). Our business ranges from wood products, pulp and paper to advanced board and packaging solutions and bio-based chemicals and materials. Unlock the power of nature (TM) Kanavaranta 1, FI Helsinki Finland Phone: Internet: Founding year: 1998 (merger of Stora+Enso) Number of employees: 25,000 Swissaustral Biotech SA Swissaustral Biotech SA offers access to unparalleled natural biodiversity through its proprietary collection of unique extremophilic microorganisms isolated from a wide range of extreme environments. Our distinctive proprietary platform for discovery, isolation and characterization of enzymes and/or small molecule secondary metabolites from extremophiles, places us at the front of the field of natural product discovery. Swissaustral core competences in activity assay development ensures the hunt down of the right enzymes for your company with the desired characteristics in terms of stability, activity, ph, and temperature range. Route de l Ile-au-Bois 1A 1870 Monthey, Switzerland Phone Internet: Founding year: 2009 Number of employees: 20 63

64 Profiles Syngip BV Burgemeester Lemmensstraat 360, 6163 JT Geleen, The Netherlands Phone: Internet: Syngip is a next generation carbon capture biotechnology company. Syngip engineers carboxydotrophic bacteria to produce biochemicals and biofuels from syngas and carbon waste gases (gases containing CO and/or CO 2, H 2 ). Currently, the main focus lies on the development of microbial biocatalysts for the production of light olefins. Especially the major target isobutene is an important building block for plastics, rubbers and fuels. Global consumption of isobutene is over 15 million tons per year. Production of isobutene from syngas or industrial waste gases is a very innovative approach to reduce climate destroying greenhouse gases, enable a circular economy and offer an alternative to petrochemical production routes. Syngip has been acquired in 2017 by Global Bioenergies, who already developed an isobutene production process from sugar in E. coli. TU Dortmund University - Department of Biochemical and Chemical Engineering (BCI) Emil Figge Strasse 66, Dortmund Phone: Internet: Founding year: 1969 Number of employees: 200 The Department of Biochemical and Chemical Engineering (BCI) at TU Dortmund University is the largest and one of the most successful engineering departments in Germany. It is active in all areas of biochemical and chemical engineering. The strength of the department is its multidisciplinarity, linking various research areas, such as thermodynamics, fluidics, biomaterials, chemical biotechnology and process engineering, thus covering all stages of (bio)process and (bio)catalyst development. The BCI is the initiator of the SusChemEng research network, bringing together academia and large and medium sized companies for the design and optimization of safe, environmentally friendly and sustainable processes and products for the chemical, pharmaceutical, and related industries. TH Köln - University of Applied Sciences Gustav-Heinemann-Ufer 54, Köln Phone: Internet: Founding year: 1973 Number of employees: 1700 The TH Köln - University of Technology, Arts, Sciences offers students and scientists from Germany and abroad an inspirational study and research environment in the social, cultural, engineering, and natural sciences. Currently there are more than 24,000 students from about 120 countries enrolled in over 90 bachelor s and master s programs of 11 interdisciplinary faculties. Climate change and scarce resources are some of the major challenges mankind will be facing in the coming decades. The faculty of Applied Natural Sciences at Campus Leverkusen engages itself in chemical and biotechnological research projects to address these great challenges and actively contributes to the advancement of science and economy. Völklinger Straße 4, Düsseldorf Phone: Internet: Founding year: 1945 Number of employees: 6 nrw Verband der Chemischen Industrie e.v. - NRW The Verband der Chemischen Industrie e. V. NRW (the Chemical Industry Association in North Rhine-Westphalia) represents the politico-economic interests of more than 500 NRW chemical companies and NRW subsidiaries of foreign enterprises in contacts with politicians, public authorities, other industries, the world of science, and the media. VCI NRW represents about 30 % of the entire German chemical industry, an industry that realised sales of 49.7 billion in 2015 and employed some 100,000 staff. A main focus of the last years was the interlinking of industry and science especially in the area of biotechnology. The association s policies are shaped by a presidential council which works in an honorary capacity and the VCI NRW executive management. 64

65 Profiles Wageningen University and Research To explore the potential of nature to improve the quality of life. Wageningen University and Research is a joint venture between the Wageningen University, which focuses on education and fundamental research, and Wageningen Research which conducts applied research directly for industry. In CLIB2021, the WUR is represented by five academic chair group - Bioprocess Engineering, Microbiology, Systems and Synthetic Biology, Environmental Technology and Biobased Commodity Chemistry and by the applied research centre Food & Biobased Research (WFBR) The groups study microbial processes intra-cellular, cellular, inter-cellular, reactor, and environmental scale with a strong link to the chemical industry. The generated knowledge at the University is translated into application, by WFBR, for production and biorefinery of pharmaceuticals, healthy food ingredients, bulk chemicals, and biofuels. Droevendaalsesteeg 4, 6708 PB Wageningen, The Netherlands Phone: Internet: Number of employees: 8,254 White Dog Labs White Dog labs, Inc. is a biotechnology company. We invented a new class of fermentation technologies that we call MixoFerm combines the conversion of biobased and fossil feedstocks to produce drop-in chemical and fuels at new theoretical yields. MixoFerm is a platform technology that addresses high value, specialty, bulk and commodity chemical markets, which address global sustainability challenges. Additionally, our diverse library of microorganisms produces nutrition and animal feed products that aim to benefit food supply of our growing, global population. Lastly, our technologies are highly scalable, and genetically controllable for short design-build-testlearn cycles, which speeds up product discovery and process development. 239 Lisa Drive, New Castle, DE, USA Phone: Internet: Number of employees: 25 65

66 66 Notes

67 Contact / Imprint Contact Head Office Germany CLIB Cluster industrielle Biotechnologie e.v. Völklinger Straße Düsseldorf T: F: E: info@clib2021.de W: Branch Offices Brazil BE-Basic Brazil Office, BE-Basic Foundation Rua Cora Coralina Campinas - São Paulo Canada Saint-Hyacinthe Technopole 1000, Dessaulles J2S 8W1, Saint-Hyacinthe, Québec Malaysia Malaysian Bioeconomy Development Corporation Sdn Bhd Menara Atlan No 161B, Jalan Ampang Kuala Lumpur Canada Drayton Valley Town Office nd Street, Box 6837 T7A 1A1 Drayton Valley, Alberta China Qingdao Institute of Bioenergy and Bioprocess Technology, CAS No. 189 Songling Road, Laoshan District Qingdao, Russia A.N.Bach Institute of Biochemistry of RAS Leninsky prospekt, 33, build. 3, ap. 3, Moscow Social Media & CLIB Networking Twitter Google+ Xing networking.clib2021.de Imprint Publisher: CLIB Cluster Industrielle Biotechnologie e.v. Völklinger Str. 4, Düsseldorf, Germany P.O. Box , Düsseldorf, Germany T: F: E: info@clib2021.de W: Editorial Staff: Cornelia Bähr, Juri Bach, Vera Haye, Dennis Herzberg, Manfred Kircher, Carolin Lange, Tatjana Schwabe, Thomas Schwarz Design & Production: Juri Bach, Dennis Herzberg Pictures: CLIB 2021 ; Victoria - Fotolia, Login - Fotolia (p.1); Heinz Waldukat - Fotolia (p.2); Trueffelpix - Fotolia (p.5, p.7, p.20); fotoflash - Fotolia (p. 8); V. ZHURAVLEV - Fotolia, Rudolf Balasko - Fotolia (p.9); Sylvia Galaschek (p. 12, p.13); dimakp - Fotolia (p.16); kerdkanno - Fotolia (p.17); freshidea - Fotolia (p.18); Andrei Merkulov - Fotolia (p.19); crazymedia - Fotolia (p.21); Pavel Losevsky - Fotolia (p.22); Svetlana Sayapina - Fotolia, Viktorija - Fotolia, sima - Fotolia, Sinisa Botas - Fotolia, trendobjects - Fotolia (p.23); TSUNG-LIN WU - Fotolia (p.24); Mopic - Fotolia (p.26); pogonici - stock.adobe.com (p.27); Spectral-Design - Fotolia (p.37); PureSolution - Fotolia (p.38 & 39) CLIB 2021 Projects are Promoted by: 67

68