NOVOZYMES & RENEWABLE CHEMICALS

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1 NOVOZYMES & RENEWABLE CHEMICALS Per Falholt, CSO & EVP, Novozymes Nomura Global Chemical Leaders Conference 2013 Venice, March 21, 2013

2 Safe Harbor Statement This presentation and its related comments contain forward-looking statements, including financial expectations. Forward-looking statements are by their very nature associated with risks and uncertainties that may cause actual results to differ materially from expectations. The uncertainties may include unexpected developments in the international currency exchange and securities markets, marketdriven price decreases for Novozymes products and the introduction of competing products in Novozymes core areas. 2

3 Novozymes The World Leader in Bioinnovation Business consists of two segments: Enzyme Business and BioBusiness 2012 sales: DKK 11,234 million Founded 1925 Listed EBIT margin: 24.4% Ticker NZYM B More than 700 products used in 130 countries in over 40 different industries Exchange Copenhagen Market Cap (MDKK)* ~ 52,000 ~ 7,000 granted and pending patents + 6,000 employees Two share classes; A and B shares A share capital and 11% of B shares (25.5% of O/S; 70.1% of votes) held by Novo A/S, the management company of the Novo Nordisk Foundation Enzyme Business BioBusiness Household Care Food & Beverages Bioenergy Feed & other Tech. Microorganisms Biopharma *A+B shares January,

Delivering Tomorrow s Solutions Today Delivering solutions from nature: food applications, detergents, pharmaceutical products, the energy sector and countless other applications Helping companies

4 Delivering Tomorrow s Solutions Today Delivering solutions from nature: food applications, detergents, pharmaceutical products, the energy sector and countless other applications Helping companies become more efficient: energy efficiency, saving raw materials, reducing waste and replacing chemicals This unique approach leads to: more with less higher quality, lower costs, better yields and a better environment 4

Uniquely Diversified Group Creates Synergies and New Opportunities Unique biotech-focused business

in R&D Global provider of enzymes to all market segments creates global market leader position

creates high barriers to entry Household Care Food & Beverages Bioenergy Feed & other Technical

juice Corn ethanol Cellulosic biofuels Animal feed Textile Leather Pulp & Paper BioAgriculture

5 Uniquely Diversified Group Creates Synergies and New Opportunities Unique biotech-focused business with a strong legacy of delivering growth, earnings, and cash flow ~ 14% of annual sales invested in R&D Global provider of enzymes to all market segments creates global market leader position Leveraging competencies across segments accelerates pace of innovation, reduces competition and creates high barriers to entry Household Care Food & Beverages Bioenergy Feed & other Technical Microorganisms Biopharma Laundry & Dishwasher detergents Baking Brewing Starch to syrups Wine & juice Corn ethanol Cellulosic biofuels Animal feed Textile Leather Pulp & Paper BioAgriculture Wastewater Cleaning Drug delivery & formulation Medical devices 34% 28% 16% 13% 8% 1% Enzyme Business BioBusiness 5

6 Undisputed Market Leader Expanding Enzyme Application Global enzyme market value: 2000: DKK ~ 12bn 2012: DKK ~ 21bn Global enzyme market value 2012: DKK ~ 21bn Rest of market 58% Novozymes 42% Rest of market 53% Novozymes 47% Others and captive 26% Market potential* Current enzyme market DKK ~ 21bn DSM 6% Genencor (DuPont) 21% Novozymes 47% Untapped market Multi-billion (US$) Rules of competition dictated by innovation *Global markets for chemicals, food ingredients, feed additives, etc. 6

Enzymes Allow for the Decoupling of Economic Growth from Resource Consumption Enzymes are efficient biological catalysts, with microbial origin Utilized in production processes they can increase

7 Enzymes Allow for the Decoupling of Economic Growth from Resource Consumption Enzymes are efficient biological catalysts, with microbial origin Utilized in production processes they can increase efficiency, reduce energy consumption, lower raw material input or limit waste streams With bioinnovation we can produce more with less and help decouple economic growth from the consumption of natural resources Economic Growth Resource Consumption Bioinnovation Time 7

8 Sugar is the New Oil Fuel Chemicals Energy 8

Fermentable sugar Production of Biofuels and Beyond Raw material Production process End product Sugarcane Classical corn Extraction Residues

Residues DDGS; Feed Polypropylene Milling Cooking Enzymes Residues DDGS; Feed Acrylic acid Biomass Collection Pretreatment Enzymes Residues

9 Fermentable sugar Production of Biofuels and Beyond Raw material Production process End product Sugarcane Classical corn Extraction Residues Bagasse; Energy Ethanol Milling Cooking Cooking Enzymes Residues DDGS; Feed Butanol Raw starch hydrolysis Biogas Other crops Milling Enzymes Residues DDGS; Feed Polypropylene Milling Cooking Enzymes Residues DDGS; Feed Acrylic acid Biomass Collection Pretreatment Enzymes Residues * Lignin; Energy, biochemical Etc. *In the US Department of Energy Biomass-model the lignin residue is burned to power the production plant 9

10 Developing Enzymes for Advanced Biofuels in Close Co-operation with Global Partners 10

11 Level of optimization Traditional Chemicals come from an Optimized Industry Petroleum-based chemistry Optimization: Scale Energy efficiency Fixed cost reduction Improved maintenance Sourcing/supply chains Value engineering Plant reliability On-stream time Foundation Development Expansion Diversification Maturity Time 11

12 Level of optimization Challenge while Biochemicals are in their Infancy Petroleum-based chemistry Biochemicals have to compete on price and performance No subsidies New infrastructure Biochemicals industry Time 12

13 Level of optimization Biochemistry Allows for a Paradigm Shift Petroleum-based chemistry Through continuous optimization, biochemistry potentially has a much higher S-curve than petroleum chemistry Biochemicals industry Time 13

Ethanol is Just Pioneering Bio-based molecules; The Sugar Platform will be the Basis

Some exists today, others are developing The vast majority of conversion

Biochemicals Example: Polyethylene Heterogeneous catalysis Biochemicals Example:

14 Ethanol is Just Pioneering Bio-based molecules; The Sugar Platform will be the Basis of a Range of Molecules Biochemicals can be made using different pathways. Some exists today, others are developing The vast majority of conversion technologies uses sugar as intermediate platform Fermentation Bioethanol Biochemicals Example: Polyethylene Heterogeneous catalysis Biochemicals Example: Glycol Novel engineered pathway -- Novel bioprocess Biochemicals Novozymes research partners: Acrylic acid Polypropylene 14

Novozymes Biochemicals Business Model Joint Development Programs and Royalties Novozymes will

.. Established players (chemical industrials that have the application knowhow, supply chain, etc.

License approach, asset light Focus on gradual replacement of existing chemicals with large

15 Novozymes Biochemicals Business Model Joint Development Programs and Royalties Novozymes will not become a chemical company, but partner with... Established players (chemical industrials that have the application knowhow, supply chain, etc.) New players in the value chains (grain processors who own the feedstock of the future) License approach, asset light Focus on gradual replacement of existing chemicals with large markets Participation in expected future growth New markets for grain processors Enabler via Biosolutions Sustainable supply for chemical companies 15

16 New Fermentation-Enabled Route to Acrylic Acid Starch, Biomass Glucose 3-Hydroxypropionic acid Bioacrylic acid Enzymatic process Engineered pathway Chemical downstream process 16

17 The Pipeline will be Filled with more Candidates Malic Acid Bio-Polypropylene 3HP/Bio-acrylic acid Biochemicals Platform Glycols Glutamic Acid Meihua Potential molecules under investigation Novozymes is currently exploring other molecules with potential partners. 17

18 Q&A Further investor relations information is available from the company homepage at

Novozymes. Strategy & Growth. Finansforeningens Virksomhedsdag June 4 th Benny D. Loft CFO & Executive Vice President

Novozymes. Strategy & Growth. Finansforeningens Virksomhedsdag June 4 th Benny D. Loft CFO & Executive Vice President Novozymes Strategy & Growth Finansforeningens Virksomhedsdag June 4 th 2015 Benny D. Loft CFO & Executive Vice President Forward-Looking Statements This presentation and its related comments contain forward-looking