The Benefits of SOLAμ Technology in Sample Preparation. Jon Bardsley and Ken Meadows Thermo Fisher Scientific, Runcorn, UK
|
|
- Leon Heath
- 5 years ago
- Views:
Transcription
1 The Benefits of SOLAμ Technology in Sample Preparation Jon Bardsley and Ken Meadows Thermo Fisher Scientific, Runcorn, UK
2 Introduction The modern bioanalytical and clinical research laboratory must provide high quality analytical results from complex biological samples in a high throughput environment while complying with strict legislation. These demands are compounded by the continued drive to higher efficacy drugs and long acting formulations which continue to push the required quantification limits to lower levels. There is also the desire to take advantage of the replacement, refinement and reduction policy. The growth of bio pharmaceuticals also brings into consideration additional analytical challenges such as solvation and non-specific binding. Thermo Scientific SOLAμ plates are designed for bio-analytical and clinical research analyst s who require cleaner, highly reproducible and robust sample extraction at very low sample and solvent volumes in high throughput workflows. SOLAμ achieves this due to the unique and innovative frit-less SPE technology. SOLAμ meets bioanalyitcal needs by providing: A Robust low sample volume preparation platform Reproducibility at low sample and solvent levels Processing of low volume samples Sample enrichment Mitigates against solvation and non-specific binding issues Speeds up bionalyical work-flows Sensitivity Counts SOLAµ allows users to pre-concentrate the sample up to twenty- times prior to injection, allowing greater limits of sensitivity to be achieved whilst maintaining a high level of analyte recovery, accuracy and precision. FIGURE 1. Loading capacity of 50 µl to 500 µl (top) of human plasma spiked with a polar and a non-polar compound was assessed demonstrating excellent flowthrough characteristics and reproducibly low matrix effects (bottom) 2 The Benefits of SOLAμ Technology in Sample Preparation
3 Users can load high volumes of sample onto the SOLAµ plate and elute in as low as 25 µl of solvent allowing greater levels of sensitivity to be achieved. Even with this low elution volume high levels of accuracy, precision, recovery and sample cleanliness are achieved. FIGURE 2. Comparison of a sample spiked with Niflumic acid before (bottom) and after (top) being taken through the SOLAµ extraction process, demonstrating a twenty-fold linear increase in response Thermo Scientific Poster Note PN20953_HPLC_2014_E_05/14S 3
4 Precision Matters The proprietary Thermo Scientific SOLA manufacturing process generates an SPE micro elution product which eliminates the issues with traditional loose-packed micro elution formats. By combining the support material and active media components into a solid uniform sorbent bed we remove the need for frits. FIGURE 3. SOLAμ SPE design limits issues associated with conventional SPE formats Stable and controllable flow through the SPE micro elution device is another key factor controlling reproducibility of the final analytical method. This is especially important in low bed weight devices where flow control is more difficult due to lower back pressure from the sorbent. The macro-porous structure found within SOLAμ is defined by a well controlled, reproducible manufacturing process which results in uniformity well to well, plate to plate and batch to batch. This provides an added advantage when dealing with viscous biological samples, preventing blocking and enabling high throughput processing of samples. 4 The Benefits of SOLAμ Technology in Sample Preparation
5 processing of samples. FIGURE 4. Recovery data for SOLAμ WAX demonstrating excellent inter and intra plate precision Scale Things Down With Accuracy Ethical, analytical and sample availability considerations are a challenge faced by many bioanalytical laboratories and have resulted in a drive to limit sample volume. SOLAµ allows users to directly scale down the volumes used in their analytical methods, allowing for a reduction in sample usage and eliminating issues caused by evaporation without compromising the sensitivity of their assay. Figure 5 demonstrates a ten-fold reduction in sample usage without compromising assay limits. 250 µl of sample was reduced to 25 µl of sample maintaining the same level of sensitivity. This is due to the reduction of elution volumes required to release the compound of interest from the extraction plate Thermo Scientific Poster Note PN20953_HPLC_2014_E_05/14S 5
6 FIGURE 5. Comparison of 250 μl spiked human plasma following a conventional scale SPE extraction (top) and 25 μl spiked human plasma following SOLAμ SPE extraction (bottom) Speed Things Up With Confidence With traditional SPE the eluted sample is typically blown down to increase the concentration of the sample and thus improve the sensitivity. This causes an issue for certain compound types which can be lost during this step resulting in reduced sensitivity. SOLAμ allows the sample to be concentrated during extraction. It is therefore possible to achieve the required limits of quantitation without the need for dry down and reconstitution. Not only does this maximize recovery of the analytes it improves workflow efficiency and increases productivity. 6 The Benefits of SOLAμ Technology in Sample Preparation
7 FIGURE 6. Diagram of a typical work flow required to concentrate samples using conventional scale SPE (top) and modified workflow utilizing SOLAμ (bottom) SOLAμ SPE is available in a wide range of chemistries to increase selectivity; Hydrophobic Reverse Phase (HRP) for non-polar compounds Mixed-mode Strong Cation Exchange (SCX) for basic compounds Mixed-mode Weak Cation Exchange (WCX) for strongly basic compounds Mixed-mode Strong Anion Exchange (SAX) for acidic compounds Mixed-mode Weak Anion Exchange (WAX) for strongly acidic compounds Thermo Fisher Scientific Inc. All rights reserved. ISO is a trademark of the International Standards Organization. All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. This information is presented as an example of the capabilities of Thermo Fisher Scientific Inc. products. It is not intended to encourage use of these products in any manners that might infringe the intellectual property rights of others. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details. Africa Australia Austria Belgium Brazil Canada China (free call domestic) Denmark Europe-Other Finland France Germany India Italy Japan Korea Latin America Middle East Netherlands New Zealand Norway Thermo Fisher Scientific, Sunnyvale, CA USA is ISO 9001:2008 Certified. Russia/CIS Singapore Sweden Switzerland Taiwan UK/Ireland USA PN20953_E 05/14S
Automated Solid-Phase Extraction of Organochlorine Pesticides from Drinking Water
Automated Solid-Phase Extraction of Organochlorine Pesticides from Drinking Water Johannes Ritter 1 and Pranathi R Perati 2 1 Thermo Fisher Scienti ic, Vienna, Austria, 2 Thermo Fisher Scienti ic, Sunnyvale,
More informationAnalysis of Fracking Flowback Water From the Marcellus Shale Using In-line Conductivity, Automated Dilution, and Ion Chromatography
Analysis of Fracking Flowback Water From the Marcellus Shale Using In-line Conductivity, Automated Dilution, and Ion Chromatography Carl Fisher and Linda Lopez Thermo Fisher Scientific, Sunnyvale, California
More informationA Fast and Robust Linear ph Gradient Separation Platform for Monoclonal Antibody (MAb) Charge Variant Analysis
A Fast and Robust Linear ph Gradient Separation Platform for Monoclonal Antibody (MAb) Charge Variant Analysis Shanhua Lin, Julia Baek, and Chris Pohl Thermo Fisher Scientific, Sunnyvale, CA, USA Overview
More informationConcentration of Human Hormones in Drinking Water Using Solid Phase Extraction and Analysis by High Performance Liquid Chromatography
Concentration of Human Hormones in Drinking Water Using Solid Phase Extraction and Analysis by High Performance Liquid Chromatography Carl Fisher, Monika Verma, and Pranathi Perati; Thermo Fisher Scientific,
More informationAutomated Solid-Phase Extraction of Organochlorine Pesticides from Drinking Water. Pranathi R Perati Thermo Fisher Scientific, Sunnyvale, CA, USA
Automated Solid-Phase Extraction of Organochlorine Pesticides from Drinking Water Pranathi R Perati Thermo Fisher Scientific, Sunnyvale, CA, USA Overview A new method was developed to automate the capture
More informationThermo Scientific icap 7000 Plus Series ICP-OES. Gain more power. experience more performance
Thermo Scientific icap 7000 Plus Series ICP-OES Gain more power experience more performance Thermo Scientific icap 7000 Plus Series ICP-OES Powerful, easy-to-use, solution for multi-element analysis Maximize
More informationJonathan R. Beck and Charles T. Yang; Thermo Fisher Scientific, San Jose, CA
EPA Draft Method 543 Quantitation of Organic Pesticides in Drinking Water Using Online Pre-concentration/Solid Phase Extraction and Tandem Mass Spectrometry Jonathan R. Beck and Charles T. Yang; Thermo
More informationNitrogen Determination in Soils and Plants by Flash Combustion using Argon as Carrier Gas
Nitrogen Determination in Soils and Plants by Flash Combustion using Argon as Carrier Gas Liliana Krotz, Walter Galotta and Guido Giazzi Thermo Fisher Scientific, Milan, Italy Overview Purpose: To show
More informationExtraction of Phthalates from Solid and Liquid Matrices
Extraction of s from Solid and Liquid Matrices David E. Knowles, Brian C. Dorich, Richard E. Carlson, Brett J. Murphy, Eric S. Francis, Jennifer Paterson, and Bruce E. Richter; Thermo Fisher Scientific,
More informationThermo Scientific icap 7000 Series ICP-OES. Low cost ICP-OES analysis high quality data
Low cost ICP-OES analysis high quality data The NEW Thermo Scientific icap 7000 Series ICP-OES provides low cost multi-element analysis for measuring trace elements in a diverse sample range. The instrument
More informationThermo Scientific icap 7000 Series ICP-OES. Low cost ICP-OES analysis high quality data
Thermo Scientific icap 7000 Series ICP-OES Low cost ICP-OES analysis high quality data Thermo Scientific icap 7000 Series ICP-OES The NEW Thermo Scientific icap 7000 Series ICP-OES provides low cost multi-element
More informationThermo Scientific TSQ Endura Triple-Stage Quadrupole Mass Spectrometer. Extreme quantitative value. with unprecedented ease
Thermo Scientific TSQ Endura Triple-Stage Quadrupole Mass Spectrometer Extreme quantitative value with unprecedented ease Unsurpassed value From forensic toxicology to environmental analysis to pharmaceutical
More informationAnalysis of Illegal Dyes in Food Matrices Using Automated Online Sample Preparation with Liquid Chromatography-Mass Spectrometry
Analysis of Illegal Dyes in Food Matrices Using Automated Online Sample Preparation with Liquid Chromatography-Mass Spectrometry Yang Shi, Catherine Lafontaine, and François A. Espourteille Thermo Fisher
More informationMethod Optimisation in Bottom-Up Analysis of Proteins
Method Optimisation in Bottom-Up Analysis of Proteins M. Styles, 1 D. Smith, 2 J. Griffiths, 2 L. Pereira, 3 T. Edge 3 1 University of Manchester, UK; 2 Patterson Institute, Manchester, UK; 3 Thermo Fisher
More informationBIOANALYSIS CONSUMABLE SOLUTIONS. Sample Preparation and Liquid Chromatography Solutions for Quantitative BIOANALYSIS
BIOANALYSIS CONSUMABLE SOLUTIONS Sample Preparation and Liquid Chromatography Solutions for Quantitative BIOANALYSIS At Waters, we understand the unique challenges faced by the bioanalytical community,
More informationImproving Retention Time Precision and Chromatography of Early Eluting Peptides with Acetonitrile/Water Blends as Solvent B
Improving Retention Time Precision and Chromatography of Early Eluting Peptides with Acetonitrile/Water Blends as Solvent B Stephan Meding, Aran Paulus, and Remco Swart ¹Thermo Fisher Scientific, Germering,
More informationThermo Scientific TSQ Endura Triple-Stage Quadrupole Mass Spectrometer. Extreme quantitative value. with unprecedented ease
Thermo Scientific TSQ Endura Triple-Stage Quadrupole Mass Spectrometer Extreme quantitative value with unprecedented ease Unsurpassed value From forensic toxicology to environmental analysis to pharmaceutical
More informationfor water and beverage analysis
Thermo Scientific EQuan MAX Plus Systems Automated, high-throughput LC-MS solutions for water and beverage analysis Pesticides Pharmaceuticals Personal care products Endocrine disruptors Perfluorinated
More informationThermo Scientific TSQ Endura Triple-Stage Quadrupole Mass Spectrometer. Extreme quantitative value. with unprecedented ease
Thermo Scientific TSQ Endura Triple-Stage Quadrupole Mass Spectrometer Extreme quantitative value with unprecedented ease Unsurpassed value From forensic toxicology to environmental analysis to pharmaceutical
More informationQuantitative LC-MS Analysis of 14 Benzodiazepines in Urine Using TraceFinder 1.1 Software and High Resolution Accurate Mass
Application Note: 529 Quantitative LC-MS Analysis of 14 Benzodiazepines in Urine Using TraceFinder 1.1 Software and High Resolution Accurate Mass Xiang He, Marta Kozak; Thermo Fisher Scientific, San Jose,
More informationClaudio De Nardi, 1 Marta Kozak, 2 David Kasper 3 1. Thermo Fisher Scientific, Dreieich, Germany; 2 Thermo Fisher Scientific, San Jose, CA (USA); 3
Open-Tube Flow Injection Liquid Chromatography- Tandem Mass Spectrometry for In-Born Errors of Metabolism Disorder Research Using a Meta Calculation Software Claudio De Nardi, 1 Marta Kozak, 2 David Kasper
More informationANALYTICAL STANDARDS AND REAGENTS
ANALYTICAL STANDARDS AND REAGENTS productivity future growth globalization compliance Waters, the industry leader in liquid chromatography and mass spectrometry, understands that standards and reagents
More information[ product solution ] Waters Oasis µ Elution PlateS. Patented Innovation. Elution volume as low as 25 μl. No evaporation and reconstitution
[ product solution ] Waters µ Elution PlateS Elution volume as low as 25 μl No evaporation and reconstitution Ideal for small sample volumes Up to a 15x increase in concentration Patented Innovation Now
More informationThermo Scientific Solutions for Intact-Protein Analysis. Better, Faster Decisions for. Biotherapeutic Development
Thermo Scientific Solutions for Intact-Protein Analysis Better, Faster Decisions for Biotherapeutic Development Quickly and Accurately Assess Product Quality and Safety Therapeutic proteins and monoclonal
More informationDevelopment of Ultra-fast ph-gradient Ion Exchange Chromatography for the Separation of Monoclonal Antibody Charge Variants
Development of Ultra-fast ph-gradient Ion Exchange Chromatography for the Separation of Monoclonal ntibody Charge Variants Ken Cook, Frank Steiner, Mauro De Pra Thermo Fisher Scientific, Hemel Hempstead,
More informationImplementation of a Walk-Up High- Pressure Capillary Ion Chromatograph for the Fast Separation of Pharmaceutical Relevant Inorganic Anions and Cations
Implementation of a Walk-Up High- Pressure Capillary Ion Chromatograph for the Fast Separation of Pharmaceutical Relevant Inorganic Anions and Cations Terri Christison, John E. Madden, Fei Pang, and Khalil
More informationUse of ScreenExpert RoboColumns u
Application Note USD 99 Use of ScreenExpert RoboColumns u for High Throughput Study of Loading Conditions on HyperCel STAR AX and MEP HyperCel Sorbents for MAb Purification in Flow-Through Mode Summary
More informationHighlighted Capillary IC Applications
Highlighted Capillary IC Applications Monika Verma and Mike Doyle Thermo Fisher Scientific, Sunnyvale, CA, USA White Paper 7094 Executive Summary Capillary IC systems provide true on-request 4/7 uptime
More informationIn-Cell and External Hydrolysis of Biomass for Carbohydrate Determinations Using Automated Solvent Extraction
In-Cell and External Hydrolysis of Biomass for Carbohydrate Determinations Using Automated Solvent Extraction Terri Christison, Richard Carlson, Lipika Basumallick, Linda Lopez Thermo Fisher Scientific,
More informationAnalysis of Glyphosate and AMPA in Environmental Water Samples by Ion Chromatography and On-Line Mass Spectrometry with Minimal Sample Preparation
Analysis of Glyphosate and AMPA in Environmental Water Samples by Ion Chromatography and On-Line Mass Spectrometry with Minimal Sample Preparation Cees Bruggink, Frans Schoutsen Thermo Fisher Scientific,
More informationDetermination of 1,4-Dioxane in Drinking Water by Gas Chromatography/Mass Spectrometry (GC/MS) with Selected Ion Monitoring (SIM)
Determination of 1,4-Dioxane in Drinking Water by Gas Chromatography/Mass Spectrometry (GC/MS) with Selected Ion Monitoring (SIM) Mark Belmont, David Steiniger, Eric Phillips, Sergio Guazzotti, Pat O Brien,
More informationAlex J. Zhang, Pranathi Perati, and Monika Verma; Thermo Fisher Scientific, Sunnyvale, CA, USA
Pesticides in My Beverage Screening (and Subsequent Quantification) of Pesticides in Beverages Originating from Leaves, Grapes, Grasses, and the Hydrologic Cycle (Tea, Wine, Milk, and Water) Using Automated
More informationNew Core-Shell Technology
New Core-Shell Technology Fortis Speedcore columns are the very latest in core-shell technology. Incorporating our optimised bonding and packing practices with a core-shell particle provides the analyst
More informationB r i n g i n g e x p e r t s t o g e t h e r TELOS neo Polymeric Solid Phase Extraction Columns Simple and Effective SPE
B r i n g i n g e x p e r t s t o g e t h e r Polymeric Solid Phase Extraction Columns Simple and Effective SPE www.kinesis-usa.com www.kinesis-australia.com.au www.abimed.de 4350 Overview PRP Non-polar
More informationUsing HRAM Survey Analysis Combined with Rapid MS2 Data to Develop a Fragmentation Based Detection Workflow for Structure ID Acquisition
Using HRAM Survey Analysis Combined with Rapid MS Data to Develop a Fragmentation Based Detection Workflow for Structure ID Acquisition Tim Stratton, 1 Caroline Ding, 1 Christoph Henrich, Hans Grensemann,
More informationGlobal Commerce Review EMEA, Q2 2018
Global Commerce Review EMEA, Q2 2018 Mobile Marches On In APAC, Mobile now accounts for the majority of transactions Europe North America Middle East & Africa Asia Pacfic Latin America 2 Source: Criteo,
More informationBio-Rad Laboratories BIOPLEX 2200 SYSTEM. BioPlex 2200 ANA Screen with MDSS. The first and only fully-automated, multiplexed ANA Screen
Bio-Rad Laboratories BIOPLEX 2200 SYSTEM BioPlex 2200 ANA Screen with MDSS The first and only fully-automated, multiplexed ANA Screen Bio-Rad Laboratories BIOPLEX 2200 SYSTEM Like no other The BioPlex
More informationsuperior performance in virtually every application
superior performance in virtually every application decades of experience bring innovation to life Rely on Thermo Scientific Nunc Microplates for consistency through all your processes Therapeutic drugs
More informationGlobal Commerce Review. Americas, Q2 2018
Global Commerce Review Americas, Q2 2018 Mobile Share of Transactions Mobile continues to steal share, driven by an increase in smartphone transactions Sales by Device, Q2 2017 and Q2 2018, United States,
More informationBIOANALYTICAL STRATEGY FOR IN VITRO METABOLITE SCREENING WITH EXACT MASS USING THE Q-Tof micro. Jose M. Castro-Perez 1, Carina Leandersson 2
In metabolism studies, it is vital to understand how a particular drug is absorbed, distributed, metabolised, and eliminated by the body. Metabolite identification is a very important part of the drug
More informationHigh-speed, High-resolution Oligonucleotide Separations Using Small Particle Anion-Exchangers
High-speed, High-resolution Oligonucleotide Separations Using Small Particle Anion-Exchangers Shanhua Lin, 1 J.R. Thayer, 1 Ken Cook 2 and Srinivasa Rao 1 1 Thermo Fisher Scientific, Sunnyvale, CA, USA;
More informationA Novel ph Gradient Separation Platform for Monoclonal Antibody (MAb) Charge-Variant Analysis
A Novel ph Gradient Separation Platform for Monoclonal Antibody (MAb) Charge-Variant Analysis Shanhua Lin, 1 Julia Baek, 1 Wim Decrop, 2 Srinivasa Rao, 1 Yury Agroskin, 1 and Chris Pohl 1 1 Thermo Fisher
More informationThermo Scientific Dionex ICS-900 Ion Chromatography System
CHROMATOGRAPHY Thermo Scientific Dionex ICS-9 Ion Chromatography System Product Specifications The Thermo Scientific Dionex ICS-9 is an integrated, dual piston, isocratic ion chromatography system that
More information[ PURIFICATION SOLUTIONS ] Pure at Heart
[ PURIFICATION SOLUTIONS ] Pure at Heart Purification is at the heart of laboratory analysis. It s the foundation of every lab analysis, whether focused on pharmaceutical/ life science, chemical materials,
More informationA Novel Screening Method for Anthropogenic Sewage Pollutants in Waste Water, Ground Water and Drinking Water Samples by LC HRAM Analysis
A Novel Screening Method for Anthropogenic Sewage Pollutants in Waste Water, Ground Water and Drinking Water Samples by LC HRAM Analysis Sebastian Westrup, Nick Duczak, and Michal Godula Thermo Fisher
More informationPrimePCR Pricing and Bulk Discounts
Assay and Control Bulk Discounts 25% off 5 or more assays Primer Assay Pricing Product Catalog # Description List Price (EUR) Primer Assays (desalted) 10025636 Primer assay desalted, 200 reactions 96 10025637
More informationLebedev A, 1 Damoc E, 2 Makarov A, 2 Samguina T 1 1. Moscow State University, Moscow, Russia; 2 ThermoFisher Scientific, Bremen, Germany
Winning The Last Battle Against Edman Degradation: Reliable Leucine/Iso-leucine Differentiation In Peptide Sequencing Using an Orbitrap Fusion Mass Spectrometer Lebedev A, 1 Damoc E, 2 Makarov A, 2 Samguina
More informationThermo Scientific MAbPac HIC Columns. Novel Hydrophobic Interaction HPLC Columns. Designed for Monoclonal Antibody Analysis
Thermo Scientific MAbPac HIC Columns Novel Hydrophobic Interaction HPLC Columns Designed for Monoclonal Antibody Analysis Introduction The Thermo Scientific MAbPac HIC column family is designed for separations
More informationThermo Scientific EASY-nLC 1200 System. Leading in simplicity. and performance
Thermo Scientific EASY-nLC 1200 System Leading in simplicity and performance Peak performance made EASY Effortless ultra high performance for everybody A straightforward LC-MS solution Optimized and integrated
More informationPrimePCR Pricing and Bulk Discounts
Assay and Control Bulk Discounts 25% off 5 or more assays Primer Assay Pricing Product Catalog # Description List Price (CHF) Primer Assays (desalted) 10025636 Primer assay desalted, 200 reactions CHF
More informationPrimePCR Pricing and Bulk Discounts
Assay and Control Bulk Discounts 25% off 5 or more assays Primer Assay Pricing Product Catalog # Description List Price (DKK) Primer Assays (desalted) 10025636 Primer assay desalted, 200 reactions DKK
More informationSimple, fast and reliable analysis of lead in whole blood using the Thermo Scientific icap Q ICP-MS
Simple, fast and reliable analysis of lead in whole blood using the Thermo Scientific icap Q ICP-MS Kent W. Warnken, Thermo Fisher Scientific, USA Patrick Messina, Quest Diagnostics, USA Application Note
More informationFast mass transfer Fast separations High throughput and improved productivity Long column lifetime Outstanding reproducibility Low carryover
columns ProSwift Reversed-Phase Monolith Columns for Protein Analysis ProSwift reversed-phase columns use a unique monolith technology for fast, high-resolution HPLC and LC/MS separations of proteins.
More informationAnalysis of Monoclonal Antibody and Related Substances using a New Hydrophobic Interaction Chromatography (HIC) Column
Analysis of Monoclonal Antibody and Related Substances using a New Hydrophobic Interaction Chromatography (HIC) Column Julia Baek, 1 Robert van Ling, 2 Xiaodong Liu 1 1 Thermo Fisher Scientific, Sunnyvale,
More informationPESTICIDE SCREENING APPLICATION SOLUTION
PESTICIDE SCREENING APPLICATION SOLUTION The most innovative pesticide screening solution ever built for food, beverage, and water testing. As the global food trade continues to expand, so does the challenge
More informationSimplifying Complex Multi-Residue Pesticide Methodology in GC-MS/MS
Simplifying Complex Multi-Residue Pesticide Methodology in GC-MS/MS David Steiniger, Juan Carmona, Stacy Crain, Paul Silcock, and Jason Cole Thermo Fisher Scientific, Austin, TX, USA Technical Note 10319
More information[ VION IMS QTOF ] BEYOND RESOLUTION
[ VION IMS QTOF ] BEYOND RESOLUTION THE BENEFITS ARE CLEAR and routinely available, Complex samples give complex data with overlapping spectra and background interferences, making compound identification
More informationTargetQuan 3 Software. Leading the way in regulatory. POPs quantification. Bullet Bullet Bullet
TargetQuan 3 Software Leading the way in regulatory POPs quantification Bullet Bullet Bullet Leading the way in regulatory POPs quantification Analyse Samples Open Sequence Process Sequence Analyse Samples
More informationSprint analysis of lubricating oils using the Thermo Scientific icap 7600 ICP-OES
Sprint analysis of lubricating oils using the Thermo Scientific icap 7600 ICP-OES Marine Beauvir, Application Specialist, Thermo Fisher Scientific, Cambridge, UK Application Note 43161 Key Words High throughput,
More informationEDS Phase Mapping of a Contact Metamorphosed Calc-Silicate Rock
EDS Phase Mapping of a Contact Metamorphosed Calc-Silicate Rock Application Note 52452 Key Words COMPASS, Energy Dispersive Spectroscopy (EDS), FESEM, Mineral Phases, Minerals, Multivariate Statistical
More informationBringing custom solutions and contract manufacturing to life
GE Healthcare Bringing custom solutions and contract manufacturing to life Imagined. Delivered. Supported. Custom and bulk solutions Tailored to your precise specifications, our custom products deliver
More informationMultidrop. The most precise and reliable reagent dispensing solution. Analyze Detect Measure Control TM
Multidrop The most precise and reliable reagent dispensing solution Analyze Detect Measure Control TM The Multidrop dispenser family Thermo Electron s Multidrop dispensers provide the most reliable bulk
More informationInstructions for Capillary Electrophoresis Peptide Analysis Kit
Instructions for Capillary Electrophoresis Peptide Analysis Kit Catalog Number 148-4110 For Technical Service Call Your Local Bio-Rad Office or in the U.S. Call 1-800-4BIORAD (1-800-424-6723) Table of
More informationDiscover the Importance of Third Party Quality Control
Bio-Rad Laboratories Q U A L I T Y C O N T R O L Discover the Importance of Third Party Quality Control Introduce Your Laboratory to an Independent Assessment Bio-Rad Laboratories Q U A L I T Y C O N T
More informationBio-Plex suspension array system
Multiplex Assays Bio-Plex suspension array system tech note 6156 Composite Profiling of Angiogenic Factors Using Bio-Plex Pro Human Cancer Biomarker Panel 1 Richard Zimmerman, Tim Hamilton, Li Ma, and
More informationENHANCED MS WITH THE TURN OF A KEY
[ ionkey/ms ] ENHANCED MS WITH THE TURN OF A KEY EXPERIENCE THE FUTURE OF MS, EXPERIENCE ionkey/ms THE LC-MS YOU KNOW, LIKE YOU VE NEVER SEEN BEFORE ionkey/ms Systems integrate the UPLC separation into
More informationImpact of MRCT after ICH E17 fully implement -Industry perspective-
Impact of MRCT after ICH E17 fully implement -Industry perspective- 5th Joint Conference of Taiwan and Japan on Medical Products Regulation December 1st, 2017 Chikara Kikuchi Vice-Chairperson, Drug Evaluation
More information5 REASONS TEKTRONIX OSCILLOSCOPES ARE RELIABLE AND TRUSTED TECHNICAL BRIEF
5 REASONS TEKTRONIX OSCILLOSCOPES ARE RELIABLE AND TRUSTED TECHNICAL BRIEF 5 REASONS TEKTRONIX OSCILLOSCOPES ARE RELIABLE AND TRUSTED TECHNICAL BRIEF The Tektronix TBS1000, TBS2000, and MSO/DPO2000 oscilloscopes,
More information[ MS IMAGING ] FULL SPECTRUM MOLECULAR IMAGING COMPLETE VISUALIZATION OF MOLECULAR DISTRIBUTIONS
[ MS IMAGING ] FULL SPECTRUM MOLECULAR IMAGING COMPLETE VISUALIZATION OF MOLECULAR DISTRIBUTIONS THE SPATIAL DISTRIBUTION OF MOLECULES, DETERMINED BY MS IMAGING, CAN PROVIDE A WEALTH OF INFORMATION REGARDING
More informationProduct Quality Control of a HME Co-Extrudate Using a Raman Imaging Microscope
Product Quality Control of a HME Co-Extrudate Using a Raman Imaging Microscope Dirk Leister, 1 Katharina Paulsen, 1 Ines Ruff, 2 Karl C Schwan, 2 Simon Nunn, 3 Martin Long 3 Thermo Scientific, Karlsruhe
More informationno matter the culture we have a solution
Thermo Scientific Nunc Roller Bottles no matter the culture we have a solution Enhanced portfolio, unequaled choice We offer an unmatched portfolio of roller bottles. The choice is yours with options available
More informationENSURING QUALITY THROUGH COMPLIANCE [ COMPLIANCE ]
ENSURING QUALITY THROUGH COMPLIANCE [ COMPLIANCE ] BEING IN COMPLIANCE HAS NEVER BEEN MORE IMPORTANT Quality encompasses more than meeting regulatory requirements. It extends throughout your organization
More informationMAXIMIZE YOUR LABORATORY RESOURCES FOR INCREASED PRODUCTIVITY
[ LABORATORY [ FOLIO ANALYTICS INSIDE SOLUTIONS HEADER ] ] MAXIMIZE YOUR LABORATORY RESOURCES FOR INCREASED PRODUCTIVITY [ LABORATORY ANALYTICS SOLUTIONS ] The proof that you can do more with less, is
More informationAnalytically Monitoring the Effect of Fracturing Activity
Analytically Monitoring the Effect of Fracturing Activity Shona McSheehy Ducos, Rob Henry, Jianfeng Cui, Julian D. Wills, Matthew Cassap Thermo Fisher Scientific, Bremen, Germany Overview Purpose: This
More informationOverview. Tools for Protein Sample Preparation, 2-D Electrophoresis, and Imaging and Analysis
Expression Proteomics // Tools for Protein Separation and Analysis www.expressionproteomics.com 1 2 3 4 Overview Tools for Protein Sample Preparation, 2-D Electrophoresis, and Imaging and Analysis overview
More informationFRACTIONLYNX APPLICATION MANAGER
FRACTIONLYNX APPLICATION MANAGER Sales Offices: Do you need more from your purification system and software? AUSTRIA 43 1 877 18 07 STREAMLINE THE PURIFICATION PROCESS WITH AUTOPURIFY Complete, intelligent
More informationHillary B. Hewitson, Thomas E. Wheat, Diane M. Diehl INTRODUCTION
Enhanc em ent o f t h e U P L C Am ino Ac i d Ana lysis So lu t io n w it h F l e x ibl e Detector Options Hillary B. Hewitson, Thomas E. Wheat, Diane M. Diehl INTRODUCTION The measurement of amino acids
More informationIntroduction. Yan Liu, Victor Barreto, Rosanne Slingsby, Chris Pohl Thermo Fisher Scientific, Sunnyvale, CA, USA
Determination of Trace-Level and in Environmental Samples Using Two-Dimensional Ion Chromatography with Suppressed Conductivity and Mass Spectrometry Detection Yan Liu, Victor Barreto, Rosanne Slingsby,
More informationBio-Plex Pro Mouse Cytokine, Chemokine, and Growth Factor Assays
Acute Phase Response Cancer Cardiovascular Disease Cytokine, Chemokines, Growth Factors Diabetes Gene Expression Genotyping Immunoglobulin Isotyping MicroRNA Expression Signal Transduction Toxicology Bio-Plex
More informationProteoMiner Protein Enrichment Technology
Sample Preparation ProteoMiner Protein Enrichment Technology Digging Deeper in the Proteome Detect More Proteins With ProteoMiner Technology Than With Immunodepletion ProteoMiner Technology vs. an Agilent
More informationInternal Comparative Evaluation Study of Alternative Enrichment Protocols for Detection of Salmonella in Untreated Spices
Internal Comparative Evaluation Study of Alternative Enrichment Protocols for Detection of Salmonella in Untreated Spices Tech Note Introduction Between 1973 and 2010, there were 14 outbreaks of foodborne
More informationBio-Plex suspension array system
Multiplex Assays Bio-Plex suspension array system tech note 6304 Development and Validation of Bio-Plex Pro Human Cancer Biomarker Panel 2 Richard Zimmerman, Tim Hamilton, and Vinita Gupta, Life Science
More informationUser Guide. SMART Digest Kit
User Guide SMART Digest Kit XX21147-EN 0415S Revision A April 2015 SMART Digest Kit Delivering simple, robust, reproducible and fast digestion of proteins SMART Digest kits are designed for biopharmaceutical
More informationNuvia HR-S Strong Cation Exchange Media Instruction Manual
Nuvia HR-S Strong Cation Exchange Media Instruction Manual Catalog numbers 156-0511 156-0513 156-0515 156-0517 Please read these instructions before you use Nuvia HR-S cation exchange media. If you have
More informationBioPlex 2200 Syphilis Total & RPR Assay
BioPlex 2200 System BioPlex 2200 & Assay Simultaneous detection and differentiation of Treponemal and non-treponemal antibodies Redefine your workflow. The BioPlex 2200 & Assay is the only automated dual
More informationBio-Plex Pro Mouse Cytokine, Chemokine, and Growth Factor Assays
Acute Phase Response Cancer Cardiovascular Disease Cytokine, Chemokines, Growth Factors Diabetes Gene Expression Genotyping Immunoglobulin Isotyping MicroRNA Expression Signal Transduction Toxicology Bio-Plex
More informationHow to Create Your Own Affinity Titer Column. Kelly J. Flook*, Yury Agroskin and Chris Pohl Thermo Fisher Scientific, Sunnyvale, CA, USA
How to Create Your Own Affinity Titer Column Kelly J. Flook*, Yury Agroskin and Chris Pohl Thermo Fisher Scientific, Sunnyvale, CA, USA Overview HPLC compatible streptavidin coated monolith column allows
More informationKey Words Q Exactive Focus, SIEVE Software, Biomarker, Discovery, Metabolomics
Metabolomic Profiling in Drug Discovery: Understanding the Factors that Influence a Metabolomics Study and Strategies to Reduce Biochemical and Chemical Noise Mark Sanders 1, Serhiy Hnatyshyn 2, Don Robertson
More informationPassion. Power. Productivity. Corporate Headquarters
Corporate Headquarters Dionex Corporation 1228 Titan Way P.O. Box 3603 Sunnyvale, CA 94088-3603 Tel: (408) 737-0700 Fax: (408) 730-9403 Worldwide Sales and Service North America U.S./Canada (847) 295-7500
More informationChromatography Column Performance and Data Analysis Success Guide. Hints and Tips for Better Purifications
Chromatography Column Performance and Data Analysis Success Guide Hints and Tips for Better Purifications This Chromatography Success Guide provides practical advice on preparative chromatography and protein
More informationAn Automated System for At-Line Process Analysis of Biopharmaceutical Fermentation Reactions
An Automated System for At-Line cess Analysis of Biopharmaceutical Fermentation Reactions Frank Steiner, Susanne Fabel, Fraser McLeod, Dionex Corporation, Germering, Germany Abstract Monitoring amino acid
More informationEVOLUTE ABN FOR EXTRACTION OF DRUGS FROM BIOLOGICAL FLUIDS
Technical ote 3 EVLUTE AB FR EXTRACTI F DRUGS FRM BILGICAL FLUIDS EVLUTE Sample Preparation Products are a new generation of advanced polymeric solid phase extraction sorbents for the high throughput extraction
More informationGet Your Fill. A full line of empty chromatography columns and accessories. Protein Purification
Get Your Fill. A full line of empty chromatography and accessories. Protein Purification Bio-Rad s Empty Line Is Packed With Options From low-pressure chromatography to high-resolution separations, we
More informationThermo Scientific TSQ Quantiva Triple-Stage Quadrupole Mass Spectrometer. Extreme quantitative performance. with unprecedented ease
Thermo Scientific TSQ Quantiva Triple-Stage Quadrupole Mass Spectrometer Extreme quantitative performance with unprecedented ease Unsurpassed quantitation Continual changes in research and regulatory requirements
More informationEU Water Analysis Using the Thermo Scientific icap 7400 ICP-OES Duo
EU Water Analysis Using the Thermo Scientific icap 7400 ICP-OES Duo James Hannan, Applications Chemist, Thermo Fisher Scientific, Cambridge, UK Application Note 43171 Key Words Environmental, EU, waste,
More informationProteOn XPR36 Quantikinetics: Antibody Concentration and Detailed Kinetic Analysis in a Single Experimental Cycle
ProteOn XPR36 Quantikinetics: Antibody Concentration and Detailed Kinetic Analysis in a Single Experimental Cycle Gary Ross, Mingde Zhu, Ruben Luo, Bio-Rad Laboratories, Inc., 2 Alfred Nobel Drive, Hercules,
More informationThermo Scientific EASY-Spray Technology. Plug-and-spray with. State-of-the-art performance
Thermo Scientific EASY-Spray Technology Plug-and-spray with State-of-the-art performance Effortless nano electrospray ionization Integrated design EASY-Spray source Nano-flow LC-MS relies critically on
More informationsingle-use fermentors
Thermo Scientific HyPerforma Single-Use Fermentors Purpose-built single-use fermentors Designed for the unique requirements of microbial fermentation Designed to meet your needs The new Thermo Scientific
More information