Palladin Institute of Biochemistry (IBC), Kyiv

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Palladin Institute of Biochemistry (IBC), Kyiv Technical Area: Biotechnologies, Agricultural Sciences and Medicine; Chemistry Keywords: new methods of production and practical application of

first biochemical Institute in the former Soviet Union, moved to Kyiv in 1931 and became a part of the Ukrainian Academy of Sciences. It was directed by its founder, very prominent scientist, Acad. O.

1 Palladin Institute of Biochemistry (IBC), Kyiv Technical Area: Biotechnologies, Agricultural Sciences and Medicine; Chemistry Keywords: new methods of production and practical application of biologically active substances for medicine and veterinary as well as biosensors for medicine, industry, agriculture and ecology General Information This Institute, founded in 1925 in Kharkiv as the first biochemical Institute in the former Soviet Union, moved to Kyiv in 1931 and became a part of the Ukrainian Academy of Sciences. It was directed by its founder, very prominent scientist, Acad. O.V. Palladin, for almost 45 years. During its existence, a number of important discoveries and inventions took place at the Institute. Haemostatic drugs were developed, capable of accelerating the wound adhesive process, that are widely applied in hospital practice even today. The Palladin Institute of Biochemistry (IBC) of National Academy of Sciences of Ukraine has 9 scientific departments, 5 laboratories, and 3 Research Centers. It now employs about 370 people, with more than a 110 having an equivalent of a PhD or above (Dr.Sc.). Institute s Focus Institute s areas of core competencies include the following: Investigation of the structure, physical and chemical properties and biological functions of complex protein and supramolecular systems. Identifying biochemical mechanisms of metabolism regulation by means of low-molecular substances (peptides, vitamins, coenzymes, metal ions etc.). Studying mechanisms of cell signaling. Among other important areas of research in functional biochemistry are: muscle biochemistry; neurochemistry; biochemistry of nutrition; metabolism regulation; lipid biochemistry; molecular immunology; coenzyme biochemistry; protein structure and functions; enzyme chemistry and biochemistry; molecular biology; medical biochemistry; biochemical kinetics, etc. Valuable Technology Offerings Medical and veterinary diagnostics; Biosensors for medicine, industry, agriculture and ecology; Production and application of biologically active substances; Industrial technology for water soluble preparation of Vitamin D3 complexes for babies and another one for prevention of human osteoporosis; Methods for accessing the status of human hemostasis system; Industrial technologies for virus- and prion-safe proteins made of human blood plasma (clotting factors VIII and IX) for intravascular administration etc. Scientific Cooperation and Technology Transfer IBC collaborates with international laboratories and institutes: Lab. of Phisyology, Liverpool University, UK; National Oncology Center of Japan, Kashiwa, Japan; Center of Immunologic Investigation, Marcel- Lumini, France; Nencki Institute of Experimental Biology, Warsaw, Poland; Tomas Jefferson University, Philadelphia, USA; Pasteur Institute, Paris, France, and others. The Institute has extensive experience in manufacturing technologies of medicinal preparations, including the following: VICASOL a water-soluble analogue of K3 vitamin accelerating blood clotting. MEDICHRONAL effective anti-alcoholic drug. CALMIVID a composition of D3 vitamin with calcium. MEBIPHON - an anti-cancer agent etc. Contact Details Sergiy V. Komisarenko, Director, Dr. Sc., Prof., Academician of National Academy of Sciences of Ukraine and Academy of Medical Sciences of Ukraine 9, Leontovicha str., Kyiv, 01601, Ukraine phone: +38 (044) fax: +38 (044) svk@biochem.kiev.ua web site:

2 O. V. PALLADIN INSTITUTE OF BIOCHEMISTRY The Institute, founded in 1925, currently has 363 staff members, including 117 scientific researchers. There are 9 research departments, a department of Scientific and Technical Information and a Biotechnology division with an Information Center, a Center of Analytical Research of the Hemostasis System and an Experimental-Biological Center. The scientific approach is targeted at the following areas: Investigation of structure, physical-chemical properties and biological functions of complex protein and supra-molecular systems. Mechanisms of metabolic regulation by biologically active substances of low-molecular weight (vitamins, coenzymes, peptides, metal ions etc.). Methods of production and practical application of biologically active preparations; medical and veterinary diagnostics and biosensors for medicine, industry and agriculture. The Institute possesses a unique collection of hybridomas with important medical applications, including the diagnosis of hemostasis system and infectious diseases. It also conducts testing for diagnostics of various diseases, chemo- and immunosensors for the environment monitoring, etc. Over the time of Institute s existence, many of its discoveries/developments were successfully transferred into industry, including the following: VICASOL a water-soluble analogue of K3 vitamin accelerating blood clotting. MEDICHRONAL effective anti-alcoholic drug. CALMIVID a composition of D3 vitamin with calcium. 10

ADDRESS Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine 9 Leontovycha St., Kyiv 01601, Ukraine Tel.: +380 44 234-5974 Fax: +380 44 279-6365 www.biochem.kiev.

The following technologies/products are offered for commercialization: Methods for accessing the status of the human hemostasis system by means of either quantitative immunochemical determination of

3 ADDRESS Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine 9 Leontovycha St., Kyiv 01601, Ukraine Tel.: Fax: Sergiy Komisarenko, Director secretar@biochem.kiev.ua Tests and instruments for diagnostics of various diseases. The following technologies/products are offered for commercialization: Methods for accessing the status of the human hemostasis system by means of either quantitative immunochemical determination of fibrinogen and D-dimer concentration in blood or by a set of diagnostic methods based on blood coagulation proteins and enzymes of snake venoms; Industrial technologies for virus- and prion-safe proteins extracted from human blood plasma for intravascular administration; A method for isolating highly purified human thrombin; Thrombolytic preparation (on the basis of plasminogen) for treatment of ophthalmic diseases; The anti-tumor medicine created on the basis of certain organophosphorus compounds; Technologies for production of glucosoxidase and catalase from Penicillium vitale and their use in medicine; FILOMEK a drug regenerating cell membranes at different intoxications and disturbances of viscera functions; PANTERON a preparation for treating dysfunctions of male genital system; VITAMIN D3 WATER-SOLUBLE FORM for babies a preparation for prevention of human osteoporosis; NAE (SAVENORIS, CANTIGIL, BERLOXAR, MESTAB) novel c ardioprotective, hepatoprotective, neuroprotective and anti-allergic medical agents; KORECTIN pharmaceutical means of complex action for treating bone damages and hepatites and as a part of complex therapy of oncological diseases, in particular leukaemias; An effective analogue to vitamin E with shortened side chain; A method for cataract treatment on the basis of vitamin E; Fodder admixture kits and premixes increasing the productive capability of cattle, hogs, poultry, fish and bees. 11

Institute of Biochemistry (IBC) CHEM RESEARCH 9 Leontovycha St., Kyiv 01601, Ukraine Tel.: +380 44 234 5974 Fax: +380 44 279 6365 www.biochem.kiev.ua Acad.

4 Institute of Biochemistry (IBC) CHEM RESEARCH 9 Leontovycha St., Kyiv 01601, Ukraine Tel.: Fax: Acad. Sergiy Komisarenko, Director secretar@biochem.kiev.ua The Institute, founded in 1925, currently employs 363 staff members, including 117 researchers. IBC is comprised of 9 research departments, namely the Departments of Molecular Immunology, Lipid Biochemistry, Coenzyme Biochemistry, Muscle Biochemistry, Protein Structure and Function, Enzyme Chemistry and Biochemistry, Molecular Biology, Neurochemistry, and Metabolism Regulation, and several Centers of excellence. Research Focus: Structure, physical-chemical properties and biological function of complex proteins and supramolecular systems; Mechanisms of metabolic regulation by low molecular weight molecules (vitamins, coenzymes, peptides, metal ions etc.); Methods of production and application of biologically active preparations; Medical and veterinary diagnostics; and Biosensors for medicine, industry and agriculture. The Institute possesses a unique collection of hybridomas with important medical applications, including the diagnosis of hemostasis and infectious diseases. It also conducts testing for diagnostics of various diseases, chemoand immuno-sensors for environment monitoring, etc. Products developed at the Institute: VICASOL a water-soluble analogue of Vitamin K3 to accelerate blood clotting; MEDICHRONAL effective anti-alcoholic drug; CALMIVID -Vitamin D3 with calcium; and Tests and instrumentation for diagnostics. 22

CHEM RESEARCH Technologies/Products for Commercialization: Assessment of the human hemostasis system by quantitative immunochemical determination of fibrinogen and D- dimer concentration in blood,

5 CHEM RESEARCH Technologies/Products for Commercialization: Assessment of the human hemostasis system by quantitative immunochemical determination of fibrinogen and D- dimer concentration in blood, and by blood coagulation proteins and enzymes of snake venoms; Industrial technologies for virus- and prion-safe proteins extracted from human blood plasma for intravascular administration; Isolation of highly purified human thrombin; Thrombolytic preparation, based on plasminogen, for treating ophthalmic diseases; Organophosphurus compounds with antitumor activity; Production technology for glucosoxidase and catalase from Penicillium vitale; FILOMEK a drug for regenerating cell membranes in intoxication and disruption of visceral functions; PANTERON for treating dysfunction of the male genital system; VITAMIN D3 water-soluble form for babies and for prevention of human osteoporosis; NAE (SAVENORIS, CANTIGIL, BERLOXAR, MESTAB) novel cardioprotective, hepatoprotective, neuroprotective and anti-allergic agents; KORECTIN pharmaceutical for treating bone damage, hepatitis, and as a part of complex therapy of oncological diseases, in particular leukaemias; Analog of vitamin E with shortened side chain; Vitamin E based treatment for cataract; Fodder admixture kits and premixes for cattle, hogs, poultry, fish and bees. Professor S.Komisarenko, Director of the Institute, with young scientists Scientists in the Laboratory of Biopreparations Technology 23

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