Introduction Hemostasis: Tourniquet Test & Bleeding Time. Hematology-Immunology System Faculty of Medicine Universitas Padjadjaran LOGO
|
|
|
- Basil Carroll
- 6 years ago
- Views:
Transcription
1 Introduction Hemostasis: Tourniquet Test & Bleeding Time Hematology-Immunology System Faculty of Medicine Universitas Padjadjaran LOGO
2 Hemostasis A series of reactions that function to stop bleeding, maintaining blood in a fluid state and confined to the circulatory system During hemostasis, three phases occur in rapid sequence Vascular spasms immediate vasoconstriction in response to injury Platelet plug formation Coagulation (blood clotting)
3 Hemostasis: A delicate balance
4 The function of hemostasis To prevent blood loss from severed vessels To stop bleeding To prevent thrombosis
5 VASCULAR PHASE PLATELET PHASE COAGULATION PHASE These phases are not separated but rather interconnected and related FIBRINOLYTIC PHASE
6 HEMOSTASIS Primary Hemostasis Blood vessel contraction Platelet plug formation Secondary Hemostasis Activation of coagulation cascade Deposition & stabilization of fibrin Tertiary Hemostasis (fibrinolysis) Dissolution of fibrin clot Dependent on plasminogen activation
7 Primary Hemostasis (platelet plug) Secondary Hemostasis (Hemostatic Plug)
8 Primary Hemostasis: Vascular phase When a blood vessel is damaged, vasoconstriction reduces blood flow to injured area Spasm of smooth muscle in blood vessels Vasoconstrictive substances (thromboxane A 2 ) Nervous reflexes
9 Primary hemostasis: Platelet phase Platelets adhere to the damaged surface and form a temporary PLUG
10 Plug Formation
11 SECONDARY HEMOSTASIS: Coagulation Cascade A set of reactions in which blood is transformed from a liquid to a gel (clot) to stabilize and reinforce the weak platelet plug by fibrin Coagulation follows intrinsic and extrinsic pathways 3 main steps (Coagulation Phases): formation of prothrombin activator conversion of prothrombin into thrombin conversion of fibrinogen to fibrin
12 Coagulation Factors
13 Initiated by trauma to the vascular wall Extrinsic Pathway Tissue damage Xa VIIa VII Tissue factor Xa V Ca PF 3 Prothrombin activator Prothrombin Thrombin Fibrinogen Fibrin
14 XII Contact Only uses components found within blood itself or exposure of the blood to collagen Intrinsic Pathway XI IX VIII X Ca PF 3 Xa V Prothrombin activator Prothrombin Thrombin Fibrinogen Fibrin
15 XIIa Intrinsic pathway Extrinsic Pathway XIa TF IXa VIIIa Xa VIIa Ca PF V 3 Prothrombin activator Prothrombin Fibrin Thrombin Fibrinogen
16 Intrinsic pathway XIIa Extrinsic Pathway XIa TF IXa VIIIa Prothrombin Xa Va VIIa Ca, PF3 Fibrinoge n Thrombin Fibrin Soft clot XIIIa Hard clot Fibrin
17 Intrinsic pathway XIIa Thrombin stimulates formation of fibrin stabilizing factor (XIII), factor V and factor VIII VIII XIa IXa VIIIa Prothrombin Xa Va VIIa V Extrinsic Pathway TF Fibrinoge n Thrombin Fibrin Soft clot XIIIa Hard clot Fibrin
18 Screening assays in hemostasis: Hemostasis Tests 1. Patients without any signs/symptoms preoperative 2. Monitoring of anticoagulant therapy 3. Disseminated Intravascular Coagulation 4. Thrombophilia 5. Inhibitor (Lupus Anticoagulant, Anti Phospholipid Antibody)
19 Hemostasis Screening Test 1. Tourniquet Test 2. Bleeding Time 3. Clotting Time 4. Clot Retraction 5. Platelet Count* 6. PT* 7. APTT* 8. TT* 9. Fibrinogen* 10. Euglobulin Clot Lysis Test 11. D-Dimer Thrombelastography
20 20
21 TORNIQUET TEST = RUMPEL LEEDE TEST = HESS TEST Systolic/ diastolic 5 cm 100 mmhg 5 cm 5 min Wait for 5 Menit PETECHIAE : > 10 ABNORMAL Rough capillary fragillity evaluation ABNORMAL : - TROMBOCYTOPENIA - PURPURA - VON WILLEBRAND DISEASE
22 BLEEDING TIME VASKULER PLATELET 1. DUKE METHOD : earlobe - Clean with 70% alcohol - Puncuture with special blood lancet - Touch blood drop with filter every 30 seconds - BT = number of blood drops in filter paper X 30 seconds - If BT > 10 min stop the test Round filter papaer 5 mm N : 1-3 min
23 LOGO
General Principles of. Hemostasis. Kristine Krafts, M.D.
General Principles of Hemostasis Kristine Krafts, M.D. Hemostasis is a balancing act! pro-ting plugs up holes in blood vessels anti-ting keeps ting under control Pro-Clotting Pro-Clotting vessels platelets
Coagulation Mechanisms Dr. Nervana Bayoumy
Coagulation Mechanisms Dr. Nervana Bayoumy Associate Professor Department of Physiology Objectives At the end of this lecture you should be able to: 1. Recognize the different clotting factors 2. Understand
Adv Pathophysiology Unit 4 Page 1 of 10. Learning Objectives for this file:
Adv Pathophysiology Unit 4 Page 1 of 10 Learning Objectives for this file: Topics include structure & function of: 1. Coagulation process platelets, clotting factors 2. Coagulation cascade formation of
Local vasoconstriction. is due to local spasm of the smooth muscle (symp. reflex) can be maintained by platelet vasoconstrictors
Hemostasis Hemostasis ( hemo =blood; sta= remain ) is the stoppage of bleeding, which is vitally important when blood vessels are damaged. Following an injury to blood vessels several actions may help
LABORATORY APPROACH TO BLEEDING DISORDERS DR NISHANTH PG 1 ST YEAR DEPARTMENT OF PATHOLOGY
LABORATORY APPROACH TO BLEEDING DISORDERS DR NISHANTH PG 1 ST YEAR DEPARTMENT OF PATHOLOGY 1 WHEN IS THE LAB REQUIRED TO INVESTIGATE FOR A POSSIBLE BLEEDING DISORDER? Clinically suspected bleeding tendency
Hemostasis. by Mohie-Aldien Elsayed
Hemostasis by Mohie-Aldien Elsayed Hemostasis Hemostasis is defined as the process that maintains the flowing blood in a fluid state and confined to the circulatory system Coagulation prevents excess blood
Sign up to receive ATOTW weekly -
BLOOD PHYSIOLOGY PART 2 ANAESTHESIA TUTORIAL OF THE WEEK 231 11 TH JULY 2011 Dr Karen Hayes Royal Devon & Exeter Correspondence to: kmhayes@hotmail.co.uk QUESTIONS Before continuing, try to answer the
Coagulation in perspective: Blood management. Objectives
Coagulation in perspective: Blood management Julie Wegner, PhD jawrbl@gmail.com Objectives To gain a basic understanding of the following: 1. Coagulation components and processes Why patients bleed. 2.
The Role Of Point of Care Coagulation Testing (POCCT) in Patient Blood Management. Elham Khalaf Adeli
The Role Of Point of Care Coagulation Testing (POCCT) in Patient Blood Management Elham Khalaf Adeli Overview PBM, bleeding management, Coagulation POC Testing Review of laboratory conventional coagulation
Coagulation Cascade. TF-VIIa. Tissue Factor + VII. XIIa. Prothrombin. XIa. IXa. VIIIa. Thrombin. XL- Fibrin. XIII Monomer. Fibrinogen.
Coagulation Cascade Intrinsic Pathway Extrinsic Pathway Contact Activation XIIa XI XIa Prekallikrein HMW Kininogen IX IXa Ca 2+ Anticoagulation proteins: Protein C, Protein S, Antithrombin III, TFPI TF
Using TEG in the ED, OR, and ICU. Don H. Van Boerum, MD, FACS
Using TEG in the ED, OR, and ICU Don H. Van Boerum, MD, FACS Trauma Surgeon, Director of Surgical Critical Care, Co-Director of Shock Trauma ICU, Intermountain Medical Center, Intermountain Healthcare
Evaluation of Complex Coagulation Cases: Case-Based Illustrations of Important Issues
Evaluation of Complex Coagulation Cases: Case-Based Illustrations of Important Issues Kristi J. Smock, MD Associate Professor of Pathology University of Utah Health Sciences Center Medical Director, Hemostasis/Thrombosis
Special Coagulation - APC Resistance. DiaPharma Group, Inc. Customer Service: Technical Support:
Special Coagulation - APC Resistance DiaPharma Group, Inc. Customer Service: 1.800.526.5224 Technical Support:1.800.447.3846 www.diapharma.com 1 Review of Hemostasis Overview Pathways of coagulation, anticoagulation,
Haemostasis. The function of haemostasis is: to prevent blood loss from injured vessels. to stop bleeding. to prevent thrombosis
Haemostasis Haemostasis The function of haemostasis is: to prevent blood loss from injured vessels to stop bleeding to prevent thrombosis Haemostasis blood endothelium basement membrane subendothelium
Primary hemostasis. Vascular endothelium Vasoconstriction : local tissue factor, nervous system
Primary hemostasis Vascular endothelium Vasoconstriction : local tissue factor, nervous system Platelet Plug Platelet Adhesion Platelet Activation Platelet Aggregation Platelet Plug Formation Secondary
These handouts are only meant as a guide while you follow the presentation on the screen. Sometimes the speaker will change some of the slides.
These handouts are only meant as a guide while you follow the presentation on the screen. Sometimes the speaker will change some of the slides. If you would like the 1 slide per page handouts, please ask
Laboratory investigation in the Bleeding Patient. Dr Craig Taylor Consultant Haematologist May 2016
Laboratory investigation in the Bleeding Patient Dr Craig Taylor Consultant Haematologist May 2016 Introduction Bleeding is common May consume significant resources Crossmatched blood Lab results may be
BLOOD COAGULATION. 1. The initial phase of the process is vascular constriction. This limits the flow of blood to the area of injury.
BLOOD COAGULATION The ability of the body to control the flow of blood following vascular injury is paramount to continued survival. The process of blood clotting and then the subsequent dissolution of
*NCCT is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. Program, provider #122.
COURSE DESCRIPTION Have you ever wondered why the blood that a phlebotomist collects in a tube will form a clot unless certain chemicals are added to the tube in advance to prevent it? Have you ever wondered
Rheological and biochemical analyses on blood coagulation ~ Discovery of a new pathway under stagnant flow conditions ~
Rheological and biochemical analyses on blood coagulation ~ Discovery of a new pathway under stagnant flow conditions ~ Computer and Information Division, RIKEN Hiroki Iwata Supramolecular Science Laboratory,
Basic coagulation applications and case studies
Basic coagulation applications and case studies Jing Jin Clinical laboratory Scientist (MLS, ASCP) - Coagulation/Hematology Stanford University Hospital and Clinics 1 Agenda Overview about 3 major phases
Physiology Unit 3 HEMATOLOGY
Physiology Unit 3 HEMATOLOGY In Physiology Today Hematocrit Percentage of blood volume that is erythrocytes 45% in men 42% in women Average blood volume in is 5 L Plasma Large amounts of organic/inorganic
LABORATORY DIAGNOSIS OF BLEEDING DISORDERS
LABORATORY DIAGNOSIS OF BLEEDING DISORDERS Primary & Secondary Hemostasis Disorders http://.columbia.edu/itc/hs/medical/selective/advclinicalpathology/2004/lecture/lab%20diagnosis%20of%20bleeding%20disorders.ppt
Evolution of the Clotting Cascade. Kalyan Banda MD Hematology Fellows Conference 01/13/2017
Evolution of the Clotting Cascade Kalyan Banda MD Hematology Fellows Conference 01/13/2017 Who am I? Born in St. Petersburg, Russia Trivial injuries led to life threatening bleeds all of my life Usually
DEPARTMENT OF CLINICAL LABORATORY SCIENCES SCHOOL OF HEALTH TECHNOLOGY AND MANAGEMENT THE UNIVERSITY AT STONY BROOK STONY BROOK, NEW YORK
DEPARTMENT OF CLINICAL LABORATORY SCIENCES SCHOOL OF HEALTH TECHNOLOGY AND MANAGEMENT THE UNIVERSITY AT STONY BROOK STONY BROOK, NEW YORK 11794-8205 COAGULATION COMPETENCY EVALUATION FORM STUDENT NAME:
Methods of Biomaterials Testing. Special Biology: Blood & Vessel
Methods of Biomaterials Testing Special Biology: Blood & Vessel Blood Compatibility Mainly: Inhibition of blood clot formation Materials in Bloodflow Venous catheter Dialysis filter Dialysis shunt Heart
Transfusion & Non-transfusion Approaches to Bleeding
Transfusion & Non-transfusion Approaches to Bleeding Maureane Hoffman, MD, PhD Professor of Pathology, Duke University and Director, Transfusion Service and Hematology Laboratory Durham Veterans Affairs
Hemostasis and Thrombosis
Hemostasis Hemostasis and Thrombosis Normal hemostasis is a consequence of tightly regulated processes that maintain blood in a fluid state in normal vessels, yet also permit the rapid formation of a hemostatic
Coagulopathy Case-2. Andy Nguyen, M.D. 2009
Coagulopathy Case-2 Andy Nguyen, M.D. 2009 CLINICAL HISTORY A 42 year-old man brought to the emergency room with severe burn. Patient was rescued by firemen in a serious fire. He had been found unconscious
Clumsy Coagulation Communication
Clumsy Coagulation Communication Let s Blame the Lab! Lab Clinician Communication Barriers and opportunities Where are the errors made? How do we enhance patient experience? George A Fritsma MS, MLS, Your
The Coagulation Workup In The Office Setting
CAA Conference alm Springs 2012 The Coagulation Workup In The Office Setting CAA Conference alm Springs, October 2012 Robert Miller, A-C Henoch-Schoenlein urpura 1 CAA Conference alm Springs 2012 2 CAA
Laboratory Investigation of Challenging Cases. Laura A. Worfolk, Ph.D Scientific Director, Coagulation
Laboratory Investigation of Challenging Cases Laura A. Worfolk, Ph.D Scientific Director, Coagulation Coagulation Cascade XII XIIa XI HMWK/Prekallikrein XIa VII Injury IX X IXa VIII Xa X TF TF/VIIa Prothrombin
Linking in silico and in vitro experiments to identify and evaluate a biomarker for enoxaparin activity
Linking in silico and in vitro experiments to identify and evaluate a biomarker for enoxaparin activity Abhishek Gulati What is enoxaparin? Low molecular weight heparin anticoagulant Used to minimise the
Plasma Testing in the Clinical Coagulation Laboratory: New drugs, new problems.
Test Plasma Testing in the Clinical Coagulation Laboratory: New drugs, new problems. Karen A. Moffat BEd, MSc, ART, FCSMLS(D) Technical Specialist, Coagulation, HRLMP Assistant Professor, Department of
Disclosures. I have received research funding from: I have received consulting fees/honoraria from: Novo Nordisk CSL-Behring Boehringer Ingelheim
Test Disclosures I have received research funding from: Novo Nordisk CSL-Behring Boehringer Ingelheim I have received consulting fees/honoraria from: Novo Nordisk CSL-Behring Baxter The Medicines Company
Improving Outcomes of Cardiac Surgery with a Point-of-Care Based Transfusion Algorithm
Improving Outcomes of Cardiac Surgery with a Point-of-Care Based Transfusion Algorithm Summer Syed (local PI) Keyvan Karkouti Deputy Anesthesiologist-in-Chief, Toronto General Hospital, University Health
Coagulation Laboratory: Methods, Standards & Cost Effective Testing Part 1
Coagulation Laboratory: Methods, Standards & Cost Effective Testing Part 1 Donna D. Castellone, MS, MT (ASCP) SH Clinical Project Manager Hematology and Hemostasis Siemens Healthcare Diagnostics Disclosures
Reverse the New Anticoagulants? Mitchell J Daley, PharmD, BCPS
Reverse the New Anticoagulants? Mitchell J Daley, PharmD, BCPS Clinical Pharmacy Specialist, Critical Care University Medical Center Brackenridge / Dell Seton Medical Center at the University of Texas
Coagulation. Coagulation Limited CGL, CGDF Surveys & Anatomic Pathology Education Programs. Coagulation 117
www.cap.org Coagulation Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Serviced (CMS). Coagulation Limited CGL, CGDF Analyte CGL CGDF New
Antifibrinolytic Drugs (Aminocaproic Acid and Tranexamic Acid): Treatment Perspectives for Dental Surgery
Curr Oral Health Rep (2015) 2:143 147 DOI 10.1007/s40496-015-0051-1 ORAL MEDICINE (T SOLLECITO, SECTION EDITOR) Antifibrinolytic Drugs (Aminocaproic Acid and Tranexamic Acid): Treatment Perspectives for
Ch 13: Blood. What does blood do? Transport: Regulation: Protection:
Ch 13: Blood What does blood do? Transport: Regulation: Protection: SLOs Describe the composition of plasma and list the major functions of plasma proteins. Map hematopoiesis, starting from a pluripotent
Case 1. Case 1. Case 2. Case 2. Review of Bleeding Disorders Case 1
Review of Bleeding Disorders Case 1 Robert I. Handin, MD Professor of Medicine, Harvard Medical School Hematology Division Brigham & Women s Hospital 20 year college student is home on spring break and
Hematology Emergencies: Problems with Platelets
Hematology Emergencies: Problems with Platelets Christian Cable, MD, FACP Associate Professor of Medicine Division of Hematology & Oncology Texas A&M HSC College of Medicine Scott & White Healthcare Fundamentals
Laboratory Investigation of Challenging Cases. Laura A. Worfolk, Ph.D Scientific Director, Coagulation
Laboratory Investigation of Challenging Cases Laura A. Worfolk, Ph.D Scientific Director, Coagulation Disclosures Employee of Quest Diagnostics Case focus: Importance of knowing test limitation/interpretations
Dr. Suzana Voiculescu
Dr. Suzana Voiculescu Overview of hemostasis Initiated when trauma, surgery or disease disrupts the vascular endothelium, exposing blood to the subendothelial connective tissue Achieved by: 1)Vasconstriction
Platelet Factor IV- Heparin Antibodies. Presenter: Michael J. Warhol, M.D.
Platelet Factor IV- Heparin Antibodies Presenter: Michael J. Warhol, M.D. Learning Objectives Describe the mechanism of interaction between Heparin and Platelet Factor 4 Review the chemistry of Heparin
Blood 101. Dr. Karen L. Dallas. Medical Director, Hematopathology & Transfusion Medicine Providence Health Care
Blood 101 Dr. Karen L. Dallas Medical Director, Hematopathology & Transfusion Medicine Providence Health Care Alternate Title?: Inside Knowledge About How We re Helping You in the Hematology Laboratory
Lina Al-Lawama. Rama Al-Ashqar. Malik Al-Zohlof
2 Lina Al-Lawama Rama Al-Ashqar Malik Al-Zohlof Anticoagulant drugs Recap Last lecture we were talking about antiplatelet drugs, we mentioned 5 drugs : Aspirin which is used alone with patents that have
Common Inherited Bleeding Disorders
CAA 2015 Annual Conference Common Inherited Bleeding Disorders Bob Miller, A October 8, 2015 VWF has two jobs Loosely bound to protect FVIII and tether to site of injury All other coagulation factors also
Hypercoagulation. CP Conference 11/14/2006
Hypercoagulation CP Conference 11/14/2006 Overview Hypercoagulation: poorly understood phenomena No definite cause is identified in > 40% of cases Three major factors in thrombus formation (Rudolf Virchow,
Evaluation of the Bleeding Patient
Evaluation of the Bleeding Patient Screening Tests Rong He, MD Special Coagulation Laboratory, Division of Hematopathology 2015 MFMER slide-1 DISCLOSURE Relevant Financial Relationship(s) None 2015 MFMER
Why measure thrombin generation? How does measurement of thrombin generation work? Sample material / pre-analytics Test performance Applications
Why measure thrombin generation? How does measurement of thrombin generation work? Sample material / pre-analytics Test performance Applications Revision V02/2009 Theory of coagulation, 1905 thromboplastin
P. W. HOWIE M.D., M.R.C.O.G. first method of activation is the intrinsic system. Hageman factor, which in turn activates a series of
Postgraduate Medical Journal (May 1979) 55, 362-366 Blood clotting and fibrinolysis in pregnancy P. W. HOWIE M.D., M.R.C.O.G. MRC Unit of Reproductive Biology, Edinburgh Summary During normal pregnancy,
Sonoclot Analyzer User Guide
Sonoclot Analyzer User Guide for Cardiopulmonary Bypass Surgery Rev 1. Sienco, Inc. 5721 Arapahoe Ave, Unit A1-A, Boulder, CO 833 USA 33-42-1148 1-8-432-1624 Fax 33-379-443 www.sienco.com e-mail: sienco@sienco.com
Index. Autoimmune thrombocytopenic purpura (AITP), 100, 102, 105, 108, 187 Automated platelet counters, , 108
A Accuracy, 6, 7, 15, 46, 52, 53, 61, 75, 100, 143, 144, 149, 166, 176, 178 Acquired coagulation disorders, 111 115 Acquired platelet disorders, 99 108 ACT. See Activated clotting time (ACT) Activated
Managing the Risks Associated with Anticoagulant Therapy. Steve McGlynn Specialist Principal Pharmacist (Cardiology) NHS Greater Glasgow and Clyde
Managing the Risks Associated with Anticoagulant Therapy Steve McGlynn Specialist Principal Pharmacist (Cardiology) NHS Greater Glasgow and Clyde Background Identified as high risk medicines Wide range
Dr Kate Talks, Consultant Haematologist, Newcastle upon Tyne Hospitals NHS Trust Nov 2012
Dr Kate Talks, Consultant Haematologist, Newcastle upon Tyne Hospitals NHS Trust Nov 2012 What coagulation tests are needed in major haemorrhage What POCT tests are available How do you go about setting
Table of Contents. Introduction. Worldwide Market and Technology Overview
Table of Contents Introduction Worldwide Market and Technology Overview A. Major Routine and Special Coagulation Tests 1. Introduction 2. Activated Partial Thromboplastin Time (APTT) 3. Alpha-2 Antiplasmin
Enzyme Research Laboratories product list 2018
Milan Analytica AG Baslerstrasse 15 4310 Rheinfelden Switzerland www.milananalytica.ch Enzyme Research Laboratories product list 2018 Product # Sizes/quantity Human Proteins Human Prothrombin Prothrombin
Category Storage Shelf Life Additional Criteria
CE Update [blood banking/transfusion medicine] Blood Components for Hemostasis Jun Teruya, MD, DSc, and Glenn Ramsey, MD From the Department of Pathology, Northwestern University Medical School, Chicago.
Haemostasis Reagents product list 2018
Milan Analytica AG Baslerstrasse 15 4310 Rheinfelden www.milananalytica.ch Product # ** = Smaller Kit Format specifically designed for Helena C-1/2/4/AC-4 ^ = For use with Helena C-1/2/4/AC-4 Product name
Sysmex Educational Enhancement and Development No
SEED Haematology Sysmex Educational Enhancement and Development No 3 2014 The Thrombin Time test and Reptilase test what is their role in coagulation testing? The purpose of this newsletter is to provide
HaematologY. Dr Tom Bate Again!
HaematologY Dr Tom Bate Again! THE FRCA What you need to know Blood Groups ~30 blood group systems recognised (ISBT) ABO, Rhesus, Lewis, Kell, Duffy, Kidd MNS system, Kell system The ABO antigens are the
Department of medical physiology 3 rd week
Department of medical physiology 3 rd week Semester: winter Study program: Dental medicine Lecture: RNDr. Soňa Grešová, PhD. Department of medical physiology Faculty of Medicine PJŠU Department of medical
Chapter 19b Blood, cont d
Chapter 19b Blood, cont d White Blood Cells WBCs account for less than 1% of blood volume. There are two major histological categories of WBCs the granulocytes and the agranulocytes. GRANULOCYTES are Basophils,
Session 1 Topics. Vascular Phase of Hemostasis. Coagulation Pathway. Action of Unfractionated Heparin. Laboratory Monitoring of Anticoagulant Therapy
~~Marshfield Labs Presents~~ Laboratory Monitoring of Anticoagulant Therapy Session 1 of 4 Session 1 Topics Review of coagulation and the vascular phase of hemostasis Unfractionated heparin Low molecular
An Analysis of the Robustness and Fragility of the Coagulation System
Complex Adaptive Systems Resilience, Robustness, and Evolvability: Papers from the AAAI Fall Symposium (FS-10-03) An Analysis of the Robustness and Fragility of the Coagulation System Nathan Menke MD PhD
73 Coagulation Laboratory: Methods, Standards and Cost Effective Testing (Part 1) Donna Castellone MS, MT(ASCP)SH
73 Coagulation Laboratory: Methods, Standards and Cost Effective Testing (Part 1) Donna Castellone MS, MT(ASCP)SH 2011 Annual Meeting Las Vegas, NV AMERICAN SOCIETY FOR CLINICAL PATHOLOGY 33 W. Monroe,
Emergency and Perioperative Hemostasis Testing: Which Assays Provide Helpful Information. Wayne Chandler, MD Laboratory Medicine Seattle Children s
Emergency and Perioperative Hemostasis Testing: Which Assays Provide Helpful Information Wayne Chandler, MD Laboratory Medicine Seattle Children s Emergency Hemostasis Testing Patients actively bleeding
TSOAC Case Study 1. Question. TSOAC Case Study 1 Continued
TSOAC Case Study 1 An otherwise healthy 56-year-old man presents to the emergency department with left leg pain and swelling for the last 3 days. Compression ultrasonography confirms left common femoral
LVHN Scholarly Works. Lehigh Valley Health Network. Joseph G. Ottinger RPh, MS, MBA, BCPS Lehigh Valley Health Network,
Lehigh Valley Health Network LVHN Scholarly Works Department of Pharmacy Retrospective Evaluation of Delayed Administration of Fondaparinux in Providing Comparable Safety and Efficacy Outcomes in Patients
Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Department of Haematology Pathology Centre C37 New Cross Hospital Wolverhampton Road Wolverhampton WV10 0QP United Kingdom Contact: Katy New
R.Li, C.Swaelens, F.Vandermijnsbrugge, B.Cantinieaux BSTH Laboratory of haematology, Porte de Hal,
Institut J. Bordet Normal with Actin-FS avoids intrinsic pathway factors assays in the presence of an isolated prolongation of (Platelin-LS) without hemorrhagic history R.Li, C.Swaelens, F.Vandermijnsbrugge,
Management of Bleeding in the Anticoagulated Patient Short Snappers CSIM 2015 Elizabeth Zed, MD, FRCPC October 17, 2015
+ Management of Bleeding in the Anticoagulated Patient Short Snappers CSIM 2015 Elizabeth Zed, MD, FRCPC October 17, 2015 + Disclosures Off label use of PCC and apcc will be discussed My centre participates
Hemostasis practice: state-of-the-art
Perspective Page 1 of 6 Hemostasis practice: state-of-the-art Giuseppe Lippi 1, Emmanuel J. Favaloro 2 1 Section of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences,
COAGULATION: BASIC PRINCIPLES. Peyman Eshghi Prof. of Pediatric Hematology & Oncology
COAGULATION: BASIC PRINCIPLES Peyman Eshghi Prof. of Pediatric Hematology & Oncology 1395 Haemostasis overview: BV Injury Neural Contact/ Tissue Factor Blood Vessel Constriction Reduced Blood flow Platelet
Disseminated Intravascular Coagulopathy
REVIEW ARTICLE Disseminated Intravascular Coagulopathy Lt Col Rajat Kumar Introduction Disseminated Intravascular Coagulopathy (DIC) is an acquired disorder which, in its mildest form is only an aberration
Westmead Hospital XENOTRANSPLANTATION Making Pigs Fly
Westmead Hospital XENOTRANSPLANTATION Making Pigs Fly Philip O Connell Mismatch Between Islet Donors and Recipients 150,000 190 45 There are not enough donors Why Pig as a Donor Few Ethical Problems Potential
Laboratory Monitoring of Anticoagulation
Michael Smith, Pharm. D., BCPS, CACP East Region Pharmacy Clinical Manager Hartford HealthCare Learning Objectives Explain the role of common laboratory tests used in monitoring of anticoagulation therapy.
2 Thomas G. DeLoughery
Tests of Hemostasis and Thrombosis 2 Thomas G. DeLoughery A routine laboratory test once well-established is often slavishly adhered to, with little further thought about how it originated, why it is done
Pharmacology Lecture 5. Anticoagulants
Pharmacology Lecture 5 Anticoagulants General overview Anti-thrombotic Drugs Antiplatlets Anticoagulants Fibrinolytics Anticoagulants Indirect Thrombin Inhibitors Anti-thrombotic effect is exerted by interaction
Immunomodulation at Cardiac Surgery. William T McBride MD
Immunomodulation at Cardiac Surgery William T McBride MD March 2005 Basic Structure of Immune System Immune response Adaptive specific memory Innate non-specific no memory ADAPTIVE (specific) b INNATE
LABORATORY APPROCH TO THE BLEEDING PATIENT
Anne Winkler, MD Emory University School of Medicine, Atlanta Georgia Assistant Professor, Pathology & Laboratory Medicine Medical Director, Transfusion Service, Grady Health System Assistant Director,
Novel Anti-coagulant Agents. David G Hovord BA MB BChir FRCA Clinical Assistant Professor University of Michigan
Novel Anti-coagulant Agents David G Hovord BA MB BChir FRCA Clinical Assistant Professor University of Michigan Objectives Provide an overview of the normal coagulation, including perioperative testing
proteins. The ECs are supported by a collagen-rich
CE Update [coagulation and hematology] An Overview of Hemostasis Henry O. Ogedegbe, PhD, BB(ASCP)SC Department of Environmental Health, Molecular and Clinical Sciences, Florida Gulf Coast University, Fort
Rheological Properties of Fibrin Clots
Rheological Properties of Fibrin Clots A THESIS SUBMITTED TO THE UNIVERSITY OF MANCHESTER FOR THE DEGREE OF MASTER OF PHILOSOPHY IN THE FACULTY OF ENGINEERING AND PHYSICAL SCIENCES Year of submission 2012
Evaluation of Unexplained Prolonged APTT &/or PT Review & Update
Evaluation of Unexplained Prolonged APTT &/or PT Review & Update 12-2016 William L. Nichols, M.D. Special Coagulation Lab, Coagulation Clinic & Hemophilia Center 2016 MFMER slide-1 Prolonged APTT &/or
D-Stat Dry Topical Hemostat Proven to Reduce Time-to-Hemostasis 1,2
D-Stat Dry Topical Hemostat Proven to Reduce Time-to-Hemostasis 1,2 Clinical Data to Support a True Hemostat Results are from a 376-patient, five-center, prospective randomized U.S. clinical study evaluating
Common Inherited Coagulation Disorders. Inherited Coagulation Disorders. All coagulation factors and platelets in circulation (unactivated)
Common Inherited Coagulation Disorders Bob Miller, A 2017 Inherited Coagulation Disorders Brief review of coagulation Disorders related to platelet dysfunction (not the acquired thrombocytopenias) Disorders
CONTRACTING ORGANIZATION: University of Texas Southwestern Medical Center Dallas, TX
AD Award Number: W81XWH-12-1-0152 TITLE: Effects of Thermal Status on Markers of Blood Coagulation During Simulated Hemorrhage PRINCIPAL INVESTIGATOR: Craig G. Crandall, Ph.D. CONTRACTING ORGANIZATION:
REVIEW OF TRANEXAMIC ACID IN TRAUMA
REVIEW OF TRANEXAMIC ACID IN TRAUMA At the bottom of this article are the links to a couple of pretty good recent reviews about the current state of TXA. But first a bit of background. Coagulopathy in
EDUCATIONAL COMMENTARY D-DIMER UPDATE
EDUCATIONAL COMMENTARY D-DIMER UPDATE Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE credits see the Continuing
2013 Health Press Ltd.
Fast Facts Fast Facts: Bleeding Disorders Second edition David Green MD PhD Professor of Medicine Emeritus Feinberg School of Medicine Northwestern University Chicago, Illinois, USA Christopher A Ludlam
OERMATAN SULFATE: A NEW CONCEPT IN ANTITHROMBOTIC THERAPY
OERMATAN SULFATE: A NEW CONCEPT IN ANTITHROMBOTIC THERAPY by JOANNE VAN RYN-McKENNA, B.Sc., M.Sc. A Thesis Submitted to the School of Graduate Studies in Partial Fulfilment of the Requirements for the
Factor Concentrates. More is better? Alexander Duncan MD Emory Medical Labs
Factor Concentrates. More is better? Alexander Duncan MD Emory Medical Labs Call from OR! Scenario -1 Patients is bleeding out! Don t ask why, what rate what s been done! We need blood now! What kind of
2015 Catalogue Coagulation
2015 Catalogue Coagulation 1 CONTENTS Reagents TriniCLOT TM Routine Reagents PT 4 aptt 4 Fibrinogen 5 Thrombin Time 5 Factor Deficient Plasmas 5 Solutions 5 TriniLIA TM D-Dimer TriniLIA TM D-Dimer 6 TriniCLOT
Enzymatic Hydrolysis of Silk Fibroin Peptide for Hemorrhage Control
2015 2 nd International Conference on Material Engineering and Application (ICMEA 2015) ISBN: 978-1-60595-323-6 Enzymatic Hydrolysis of Silk Fibroin Peptide for Hemorrhage Control Jingjing Li 1,2, Hailin
The Cardiovascular System: Blood
The Cardiovascular System: Blood The Functions of Blood General Overview Provides a system for rapid transport within the body Nutrients Hormones Waste products Respiratory gases Cells & Blood Components
New Anticoagulants Linda Liu, M.D.
Difficult Task New Anticoagulants Professor UCSF Dept of Anesthesia 15 minutes! Emphasis on 2 new oral anticoagulants Dabigatran Rivaroxaban Relation to anesthesia Rapid reversal Regional anesthesia UC
Omar A. Elkashef, MD
DVT Prophylaxis in Orthopedic Surgery By Omar A. Elkashef, MD Kasr Al- aini About VTE Venous thromboembolism encompasses deep vein thrombosis (DVT) and pulmonary embolism VTE is common and PE is a potentially