Overall Architecture and Distributed Analysis Tools
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1 Overall Architecture and Distributed Analysis Tools Daniella Meeker, PhD Department of Preventive Medicine University of Southern California Michael E. Matheny, MD, MS, MPH Tennessee Valley Healthcare System VA Departments of Biomedical Informatics Vanderbilt University Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
2 User Experience Goal The overall goal of the development of the analytic tools and user interfaces in pscanner is to: Conduct analyses in a distributed national network that achieves a user experience comparable to execution on a single local node Provide menu and graphical user interface to» Manage study meta-data and provenance» user role drive permissions at each node» Study design» Analytic cohort development» Support common comparative effectiveness statistical methods» Provide result tables and graphs typically useful for reports and manuscripts Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
3 PCORNet Coverage Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
4 Requirements Privacy Preserving No patient row level data sharing Service Oriented Architecture allows for tools and modules to be stored in a different location from the end user Extensible established guidance and interface to allow anyone to contribute methods / user interfaces within the overall framework Open Source promotes transparency, independent validation of functionality, and larger user community of use Leveraging large initiatives / established user community PopMedNet data mart client (version proximity to Mini-Sentinel) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
5 pscanner Architecture portal aggregator General to Site Specific Translator MSSQL 2016 SITE NODE(S) API Data Mart Client DAN (Site Analytic Coordination) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
6 pscanner Process Model Separation Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
7 Reference -> Local Translation Engine Process we need to represent Data processing rules HQMF Cohort definition rules Data set description Data Analysis Methods Standard Rationale HQMF QRDA PMML PMML CMS, ONC, HL7 endorsed Part of EHR certification process 100 s of established data sets 1000s of cohort criteria QRDA Quality Measurement EHR Certification & CMS PMML Data analysis UCSD Data Mining Group Extensible to support model specifications Data Analysis Results PMML Developed to represent results General to Site Specific Translator Process Workflow BPML? Ad-Hoc at present, in development Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
8 Architecture Drill-Down PopMedNet pscanner API Communication Layer Between:» PopMedNet Client» pscanner Portal PopMedNet DataMart Adapters Site-Specific Analytic Cluster (DAN/OCEANS) Contract with Lincoln Peak to extend existing API / DataMart adapters for use with pscanner API Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
9 PopMedNet à DAN DataMart Client Requests Analysis from Portal Data Mart Client Sends Standardized Analytic Request to DAN via DataAdapter On completion returns result to Portal DataAdapter Pulls standardized requests from PopMedNet Calls DAN (Site specific analytics coordination) with request to queue for processing DAN (Site Analytic Coordination ) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
10 Distributed Analysis Network Three-tier Distributed Network Broker accept External Requests (e.g. DataMartClient) Cluster accepts Broker Requests based on» Analysis Type» Analysis Engine» Availability Processing Node accepts Cluster Requests Design Simple Deployment as resource need increases Fault-Tolerance A node fails, and the analysis continues High-availability Distribution of load via routing algorithm Analysis Engine Agnostic Workflow supports integration into widely used engines (e.g., R, Spark, SAS, OCEANS, etc.) Asynchronous Queues requests for processing as resources become available DAN (Site Analytic Coordination ) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
11 DAN Components DAN (Site Analytic Coordination) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
12 Local Analytic Engines R/RServe (active) Revolution Analytics (in exploration) Potential Analytic Engines Oracle In-Database R Microsoft SQL 2016 In-Database R Apache Spark (future) SAS / SAS Grid (future) MSSQL 2016 SITE NODE(S) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
13 Development Team Bill Clarke (Lincoln Peak) Claudio Farcas (UCSD) Josh Gieringer (VA/VU) Michael Matheny (VA/VU) Daniella Meeker (USC) Laura Perlman (USC) Dax Westerman (VA/VU) Bruce Swan (Lincoln Peak) Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN
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