PRESENTATION DATA. Track: Exhibitor Tutorial Session: Exhibitor Tutorial (12:30 PM 1:45 PM) Monday, February 5, :30 PM 1:45 PM Room: Room 5A

Transcription

1 Session: Exhibitor Tutorial (12:30 PM 1:45 PM) Monday, February 5, :30 PM 1:45 PM Room: Room 5A The New Sound of Sample Management Development of new technologies and software to enable the use of acoustic liquid handling from sample store to screen Clive Green Executive Director and Head of Sample Management, AstraZeneca Robin Grimwood VP & General Manager, Automated Solutions, Brooks Life Science Systems Toby Winchester Automation Product Manager, Titian Software Randy Dyer Director, Product Marketing, To follow the launch of their collaboration at SLAS of 2017, leaders from AstraZeneca,, Brooks Life Sciences, and Titian Software will discuss their collaborative effort to develop liquid handlers, automated storage systems, and integration software required to implement acoustic tubes for sample management. At this event, attendees will hear about AstraZeneca s experience engaging with multiple technology providers to develop new products for transforming their sample management and screening programs. As AstraZeneca increases the diversity of its screening library, the ability to acoustically transfer nanoliter volumes of sample directly from low-volume storage tubes will enable the screening of rare or difficult to synthesize samples and reduce storage costs. Additionally, the rapid cherry-picking and plating of samples will enable a more efficient creation of target-specific libraries for iterative screening programs. Attendees will also hear from leaders at Labcyte, Brooks, and Titian, who will describe how they have collaborated with AstraZeneca to bring to market a revolutionary sample management system capable of producing assay-ready plates for screening and other research applications, relying only on acoustic liquid handling to transfer samples directly from storage tubes. Clive Green Executive Director and Head of Sample Management AstraZeneca clive.green@astrazeneca.com Office Telephone: Clive Green, PhD, is responsible for the small molecule and human biological sample collections at AstraZeneca. Dr. Green has 16 years of experience in medicinal chemistry and drug discovery, focusing on oncology and cardiovascular disease areas. He has served as an Associate Director in medicinal chemistry, became Head of Compound Management in 2010, and assumed responsibility for AstraZeneca s human biological samples, in addition to the company s small molecule collection, in Dr. Green earned his

2 PhD in Organic Chemistry at the University of Nottingham, and spent two years as a Postdoctoral Research Fellow at the University of Pennsylvania. Robin Grimwood VP & General Manager, Automated Solutions Brooks Life Science Systems robin.grimwood@brooks.com Robin Grimwood VP & Global Business Unit Leader, Automated Solutions Brooks Life Science Systems As the Global Business Unit Leader for Automated Solutions, Robin has overall responsibility for Automated Storage systems, Consumables including the FLUIDX and REMP brands and supporting Instrumentation. Functional responsibilities include Product Management, Engineering development and sustaining efforts, Operations & Manufacturing and Service delivery. Robin leads an advisory team within BLSS to devise cross-business unit solutions that drive accelerated innovation, product development and growth. With over 24 years of experience in sample storage & tracking products, cell line and culture products, genetic research instrumentation and laboratory automation, I joined Brooks in 2014 as part of the FluidX acquisition. He was a co-founder and director of the Fluidx business founded in 2006 which became a global leader in innovative sample storage consumables and instrumentation. Prior to joining Brooks, Robin held leadership positions including Director of European Sales for Thermo-Fisher, General Manager and Product Manager for Hollow Fiber Bioreactors and a number of technical and scientific positions with MRC (Cambridge) and AstraZeneca, where he focused on monoclonal antibody and assay development. Toby Winchester Automation Product Manager Titian Software toby.winchester@titian.co.uk Office Telephone: (508) Toby Winchester, Automation Product Manager, Titian Software, 2 Newhams Row, London SE1 #UZ, UK Tel: Process software business application consultant with 23 years of process management within the pharmaceutical, biotechnology and university sectors. A track record of supporting drug discovery via consultation, change management, line management, project management, product management, quote management and training of teams of diverse individuals. Solid delivery of data and reduction of timelines through driving and implementing cutting edge solutions to compound management. With a broad knowledge of the functionality and detailed workings of Titian s Mosaic product suite. I lead an experienced team of business application consultants to ensure they understand the project requirements, document the software configuration, project manage the implementation of that configuration, testing, ensure customer satisfaction, and evolve processes from the lessons learnt. Project portfolio management of new customer projects. Product management of the Mosaic SampleBank suite of software. Product management of automation integration in the Titian Vendor agnostic environment. This includes marketing workshops, literature and web advertising such as vendor specific web pages. Quote manager for new Titian projects Randy Dyer Director, Product Marketing rdyer@labcyte.com Office Telephone: (408)

3 Session: Exhibitor Tutorial (12:30 PM 1:45 PM) Tuesday, February 6, :30 PM 1:45 PM Room: Room 3 The New Sound of Sample Management High-Throughput, Fully-Automated, Production of Assay- Ready Plates from Samples Stored in Tubes using Echo Acoustic Liquid Handling on the New Access Dual-Robot System for Acoustic Sample Management. Silvio Di Castro Senior Automation Scientist, AstraZeneca R&D Iain Russell, PhD Senior Product Manager Echo Liquid Handler Product Line, Labcyte, Inc. Justin Jager Product Manager Lab Automation, Hear how AstraZeneca Sample Management is using acoustic tubes to deploy fully acoustic workflows, increasing sample storage density for faster picking throughputs, minimizing sample and solvent consumption, and eliminating the risk of crosscontamination. The deployment of the new technology will provide greater flexibility and better-quality assay data. Working in collaboration with Brooks Life Sciences, Labcyte has launched the next evolution in non-contact acoustic liquid handling with a sample tube compatible with Echo Acoustic Liquid Handling technology. This tutorial will provide an overview of the new liquid handler instrument and data highlighting its performance with the new FluidX Sample Tubes supplied by Brooks. The combination of acoustic tubes and acoustic liquid handling offers a more efficient, streamlined approach to non-contact acoustic transfer of samples and reagents for s management and small molecule screening groups. Building on the success of providing mid-sized automation systems for sample management groups using Echo liquid handlers, Labcyte further expands their automation portfolio with the launch of the Access Dual-Robot Systems (DRS) and Access Single- Robot Systems (SRS). The new systems provide more flexibility and scalability for automating both tube and plate-based acoustic liquid handling workflows. With a compact, modular design and feature set targeting sample management, the new Access systems will allow sample management groups to fully automate assay-ready plate production from samples stored in tubes or plates. Silvio Di Castro Senior Automation Scientist AstraZeneca R&D silvio.dicastro@astrazeneca.com Office Telephone: Silvio joined Sample Management at AstraZeneca in In the current role as senior automation scientist, he is responsible for developing the local sample storage and automation strategy, as well as reach out and implement automated solutions in other areas of the business. Prior to joining AstraZeneca,

4 Silvio gained an MSc in Chemical Engineering at the "Federico II" University, Naples (Italy), under the supervision of Prof. Guido Greco. During his time at AstraZeneca, Silvio has developed knowledge and skills in laboratory automation, from simple benchtop units to large automated systems, and used his experience to improve and streamline workflows and IT systems, addressing the requirements of single users and global community alike. He is currently representing AZ Gothenburg in the delivery of the world s first, next-generation fully acoustic liquid handling platforms, the new global standard for Sample Management in AstraZeneca. Iain Russell, PhD Senior Product Manager Echo Liquid Handler Product Line Labcyte, Inc. irussell@labcyte.com Office Telephone: (408) Cell Phone: (650) Iain Russell has over 15 years of experience in the Life Sciences industry and the genomics field. Iain joined Labcyte in May of this year and currently manages the Echo Liquid Handler product line, a series of instruments that enables the touchless transfer of nanoliter liquid volumes with extreme accuracy and precision. Prior to joining Labcyte, Iain managed a broad variety of novel technologies including microarray and qpcr related instruments and associated consumables. Iain completed his Ph.D. graduate work with a focus on gene expression at the European Molecular Biology Laboratory in Heidelberg, Germany, prior to completing a post-doc at the Massachusetts Institute of Technology in the cell cycle biology field. Justin Jager Product Manager Lab Automation jjager@labcyte.com

5 Session: Exhibitor Tutorial (2:00 PM 2:45 PM) Tuesday, February 6, :00 PM 2:45 PM Room: Room 3 High Precision Liquid Handling - Learn How Acoustic Liquid Handling Can Improve Your Bioassay Workflows Iain Russell Senior Product Manager Echo Liquid Handler Product Line, The Labcyte Echo Acoustic Liquid Handlers have been adopted across pharmaceutical sample management and screening programs for the dispensing of reagents in a wide variety of molecular and cellular assays. The key features of non-contact acoustic liquid handling include lower transfer volumes (as little as 2.5nL) and no sample-tip interactions - eliminating compound lose due to adhesion to or contamination from the tip plastic itself. As a result, use of acoustic liquid handling often leads to improved data quality, higher throughput and lower assay costs. Downstream pharmaceutical groups responsible for bioassay development and testing have expressed interest in using the Echo Liquid Handlers for very similar reasons, however, are often governed by strict regulations designed to maintain full traceability for all aspects of bioassay development and deployment. During this tutorial, we will discuss the benefits to non-contact liquid handling when running bioassays, how Labcyte is supporting customers working within regulated environments and share feedback from our customers on our latest software solution, Echo 21CFR11 Compliance Manager. Iain Russell Senior Product Manager Echo Liquid Handler Product Line Irussell@abcyte.com Office Telephone: Cell Phone: (650) Iain Russell has over 15 years of experience in the Life Sciences industry and the genomics field. Iain joined Labcyte in May of this year and currently manages the Echo Liquid Handler product line, a series of instruments that enables the touchless transfer of nanoliter liquid volumes with extreme accuracy and precision. Prior to joining Labcyte, Iain managed a broad variety of novel technologies including microarray and qpcr related instruments and associated consumables. Iain completed his Ph.D. graduate work with a focus on gene expression at the European Molecular Biology Laboratory in Heidelberg, Germany, prior to completing a post-doc at the Massachusetts Institute of Technology in the cell cycle biology field.