Leadership Presentation at Joint US & Russian Academies of Science Conference. Coquí Pharma. Vienna, AUSTRIA 17 July, Carmen I.
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1 Leadership Presentation at Joint US & Russian Academies of Science Conference Coquí Pharma Vienna, AUSTRIA 17 July, 2017 Carmen I. Bigles (CEO)
2 Introduction Medicine is a science of uncertainty and an art of probability William Osler The ever changing landscape of medicine cannot thrive without Nuclear Medicine Coquí mission is to create a commercially scalable and reliable supply of medical diagnostic and therapeutic radioisotopes in the USA using proven technology July
3 Nuclear Reactors to Healthcare Mo-99 is an essential part of modern nuclear medicine Mo-99 s (Molybdenum-99) decay product, Technetium-99m (Tc-99m) is utilized in over 80% of all SPECT nuclear medicine procedures, it is the world s most widely used medical radioisotope Annually over 18 million procedures in the United States utilize Mo-99 (most Myocardial perfusion studies) Mostly produced from weapons grade U-235 (i.e., Highly Enriched Uranium or HEU) USA is the largest global Consumer yet no large scale domestic manufacturing capability July
4 Market Environment - I Repeal of Obamacare is not the only threat to Healthcare Doctors are increasingly worried about shortages Source: Scientific American: January 18, 2017 Amanda Montañez rican.com/savisual/visualizing-themedical-isotope-crisis/ July
5 Market Environment - II National Academy of Sciences [NAS] Private, non-profit society of distinguished scholars. Established by an Act of Congress, signed by President Lincoln in 1863, the NAS is charged with providing independent, objective advice to the nation on matters related to science and technology Second Mo-99 Report issued in Sept # Report states.there is a substantial (>50%) likelihood of severe Mo-99/Tc-99m supply shortages after October 2016 Multiple A ratings for Coquí Only company to get A s for proven technology that is compatible with the existing supply chain, using a reactor design that has been licensed Coqui is a clear technology winner # Free download at: 99-for-medical-imaging July
6 Business Model Coquí plans to own and operate a medical isotope production facility that will consist of twin research-level small nuclear reactors & multiple radiochemical processing plants Coquí & the Supply Chain Snapshot Nuclear Reactors: Two LEU 10MW Open Pool OPAL style LEU Mo-99 Capacity: 7,000 6d Ci/wk LEU Mo-99 Process: Similar to previously FDA approved Market: 50% USA Domestic & 50% Export Operational: 2023 Facility Location:??????? July
7 Strategic Site Location - I The Coquí will be strategically located at Oak Ridge, Tennessee July
8 Strategic Site Location - II ETTP & Heritage Centre Oak Ridge (1942) comprised Y-12, S-50, K-25 & X-10 facilities and was known as the Manhattan Project. Used to produce enriched Uranium using the gaseous diffusion method at K-25 Today Oak Ridge hosts the largest National lab for Science & Energy in the USA Original home of medical radioisotopes Nuclear Technology Park Former ETTP Site Heritage Centre Strategic location for Coquí Centre for USA Nuclear Excellence Nuclear collaborative opportunities Understanding nuclear friendly community Strong nuclear talent pool Nuclear waste processing Y-12 for Fuel & Targets Emergency & Hazmat Services Proactive Economic Development community July
9 Strategic Site Location - III Government attracts Coquí to Heritage Centre at Oak Ridge US Department of Energy (DOE) & Community Reuse Organisation of East Tennessee (CROET) Transfer of DUCT ISLAND at the Oak Ridge Heritage Centre 170 acres Geo-technical surveys completed by DOE Only DOE Land Transfer Agreement for Mo-99 Largest single transfer Strong Government Support July
10 Strategic Site Location - IV Coqui s new home at Oak Ridge Duct Island Water security perimeter 170 Acres SMR will be our neighbour Greenfield site Land transfer in Q Road, air & water access July
11 Strategic Site Location - V Proposed Airport at Oak Ridge Minutes from Duct Island 5,000 foot runway $35-40M Suitable for Type A & Type B transport containers Awaiting approval by FAA Operational in late 2021 Heritage Centre Gross Margin advantage due to close proximity Backup: RKW (30 mins) & TYS (42 mins) Duct Island July
12 The Coquí Solution Proven twin 10MW Nuclear Reactors from INVAP Exclusive license for USA from INVAP: the world s leading designer and developer of LEU Mo-99 production facilities OPAL in Australia, Egypt, Argentina & Algeria All Low Enriched Uranium (LEU) Proven FDA approved LEU Mo-99 process Meet >50% of USA Medical Demand 50% domestic and 50% export Coquí incentivized to be at Oak Ridge Federal Incentive via 170 Acre Duct Island from DOE TN State, TVA, City of Oak Ridge, Roane County Incentive Package Future Heritage Center Airport ~$500M CAPEX facility 1,500 construction jobs >200 permanent high-tech jobs & high average base salary Nuclear collaborative opportunities with ORNL U-235 for targets & fuel rods from Y12 July
13 Timeline Milestones moving forward: Engineering ~45% complete Complete Engineering and NRC license application Q3 2018: Submit License application to NRC (Milestone 3 & 12 Mo) Q1 2019: NRC Commences review of Application (12-18 Mo) Q Q2 2020: Receive Approval for Construction (Milestone 4) Q2 2020: Begin Construction (36-48 Mo) Q2 2023: Begin Operations & Generate Revenue July
14 Our Leadership Team Coquí has assembled a world class team with the proven expertise and skill sets required to succeed in this complex and highly regulated environment of Nuclear Medicine July
15 Conclusion World class team Compelling market opportunity Proven technology Government Endorsement July
16 Спасибо Thank you July
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