Environmental Sustainability Update Genentech SSF Site February 14, 2013

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1 Environmental Sustainability Update Genentech SSF Site February 14, , Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

2 SSF s Environmental Sustainability Program Our Impact Page 2 Roche Energy Use SSF Key Facts: > 50 buildings > 5.5 million square foot >11,000 employees Almost 20% of Roche total energy use Manufacturing, R&D, administration 2009, Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

3 Remember our Vision Elements Site Services Vision Page , Genentech / Proprietary information Please do not copy, distribute or use without prior written consent 2009, Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

4 SSF s Environmental Sustainability Program Our Reporting Page 4 We ve released 5 sustainability reports now transitioning to online, more dynamic and integrated reporting on gene.com Outlines environmental performance and sustainability strategy and goals 2011 Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

5 SSF s Environmental Sustainability Program Our Issues Page 5 Our program focuses on 5 key issues Energy use down Air travel down Fleet & commute emissions down Waste to landfill down Our focus areas reflect our biggest impacts & support Roche corporate goals

6 SSF s Environmental Sustainability Program Energy Goal: 2011 & 2014 Page 6 SSF Contribution to Group Energy Goal: By the end of 2014, our goal is to reduce absolute energy by 11% compared to SSF on track to meet 2012 site energy goal Goal Achieved Includes SSF, Redwood City, Dixon, and Field Sales 2011 Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

7 SSF s Environmental Sustainability Program Energy Use from Utilities Page 7 Goal: Reduce onsite energy use by 15% by 2014, from 2009 SSF Energy Action Plan includes 300 energy-efficiency projects: o High-tech solar window film o Energy-efficient light bulbs (replaced over 30,000 to date) o Retro-commissioning of buildings to improve HVAC efficiency Over 250 Army of Darkness volunteers - 3% - 3% 2011 Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

8 SSF s Environmental Sustainability Program Air Travel Page 8 TelePresence: SSF air travel down Increased 9% in training 2011 after & access increase bookings 2010 up 78% Video TelePresence: Conference: Increased 95% of training rooms upgraded & access bookings up 78% 17% Biggest Video Conference: increase in virtual 95% meetings of rooms upgraded is with Basel bookings corresponds up 17% to decrease in air travel to Basel Biggest increase in virtual meetings is between SSF and Basel SSF air travel forecast down 9% in 2011 after increase in Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

9 SSF s Environmental Sustainability Program Water Page 9 Goal: Reduce water use by 10% by 2014, from 2009 Water conservation is focus area because biologics manufacturing processes are inherently water intensive. Just completed project with expected savings of ~19 million gallons/yr by using reverse osmosis (RO) reject water to feed cooling towers. - 11% - 5% 2011 Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

10 SSF s Environmental Sustainability Program Waste to Landfill Page 10 Goal: Reduce waste to landfill by 50% through increased recycling, composting, and source reduction by 2014, from Since 2009, landfill wastes are down 22%, while recycling is up 15%. Zero Waste Move Zones donated 750 boxes of office supplies and diverted 4 tons of electronic waste during 2011 campus moves Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

11 USGBC Best Buildings Challenge Page Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

12 USGBC Best Buildings Challenge Page 12 Our commitment is to reduce energy, water, waste to landfill by 20% between 2011 and 2013 in each of 5 buildings. Benefits: Synergistic with SSF and corporate goals Supportive of employee engagement Focuses our efforts Opportunity to pilot initiatives before rolling out across campus Demonstrate leadership in the San Francisco Bay Area 2011 Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

13 USGBC Best Buildings Challenge Targeting Additional Reductions B56 Page 13 B56 includes offices, labs, and cafeteria Energy - Exploring new technologies for energy savings: BuildingIQ smart HVAC controls EnLighted smart lighting controls Joulex smart plug load controls Cogenra solar thermal Water - Monitoring irrigation Waste Expanding collection of compostables and lab plastics 2009, Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

14 USGBC Best Buildings Challenge Targeting Additional Reductions B56 14 Leveraging New Green BioPharma initiative: Green lab assessments provide unique insight into the environmental footprint of a laboratory depending on its functionality. Using the data collected from these assessments, we offer customized suggestions for reducing lab impact based on four major categories. Energy Ventilation equipment (hoods, HVAC), bench-top equipment, instrumentation, computers Waste streams Landfill, recycling, hazardous/biohazardous waste Procurement policy Stocked consumables, lab-specific consumables, green product usage or opportunities Typical chemicals/reagents, media prep orders, etc Cold storage Personal storage, lab-wide storage, ultra-low temp freezers, temp. controlled rooms

15 USGBC Best Buildings Challenge Supported by the SSF Sustainability Council Page 15 Jerry Meek Sam Turney Katie (acting) Dan McCoy Katie Excoffier Marlene Kosinski Tse-Sung Wu Council also includes supporting members from: Procurement (Sharon Anderson) Workplace Planning (Eric Chou) Pharma Informatics (Scott Peterson) Facilities (Keith Sonberg) 2011 Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

16 # Green Genes Members Employee Engagement through Green Genes Page 16 Green Genes employee club grew to 1300 members in 2011 Partners with Sustainability Council to promote green practices. Employees engaged through events, online discussions, projects Annual survey shows Green Genes helps make Genentech a great place to work Green Genes Membership Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

17 Employee Engagement through Green Genes Cafeteria compostables Beach cleanup events Annual Eco Fair Earth Week activities Lunchtime speakers Pizza/movie nights Online discussion forums and website Klean Kanteen water bottle project

18 Employee Engagement through Green Genes

19 Employee Engagement through Green Genes Army of Darkness 200 volunteers from Green Genes Surveying buildings and mapping out light switches/controls Identifying opportunities for improved controls Clarifying working hours and needs in local areas Results sent to Energy Group to inform lighting projects Installing stickers in conference rooms Distributing motion detector power strips

20 Employee Engagement through Green Genes GreenGuides Launched Earth Week volunteers trained so far Identified by flags outside offices Peer resource for sharing info on all green practices Our eyes and ears as we roll out new initiatives

21 Employee Engagement through Green Genes Online Training Course Page 21 21

22 Employee Engagement through Green Genes Eco Fair Page , Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

23 Employee Engagement through Green Genes gride Employee Commute Program Page , Genentech / Proprietary information Please do not copy, distribute or use without prior written consent.

24 Expanded Direction and Goals Page Meter and monitor everything 2. Evaluate energy, consumption and water data 3. Annual energy and water reduction target 4. Waste and emission reduction 5. Refrigerant management Passion for Patients A Great Place to Work

25 Energy Focus Areas Page 25 Break down Energy Action Plan into more detail Perform energy audits Modify project delivery process Obtain project funding Create energy and cost reduction schedule Obtain energy rebates

26 Top 10 Energy Efficiency Improvement EAP Types Slide 26 Energy Action Plan Annual GJ Change 1. Retro commissioning HVAC systems - 86, Building Automation control systems - 77, Boiler and chilled water systems - 47, Lab exhaust systems - 41, Utility system efficiencies - 30, Building Shell improvements - 29, HVAC set points - 25, Lighting - 15, Business changes on going 10.K6 Replace chillers and DX air conditioning TBD

27 Project Delivery Process Change Page 27 Existing 5 step project delivery process constraints Support of audits from data collection through report Creation of Quick Strike Team (QST) Project approval process Contractor agreements Speed to implement Cost tracking

28 Implementation Schedule Page ongoing Advanced metering Retro commissioning studies Retro commissioning measures Lighting upgrades & controls HVAC efficiency improvement projects HVAC set point adjustments after hour setbacks Reduce lab & production air exchange rates Travel and sales force fleet efficiency Employee awareness programs are on going

29 Quick Strike Team Focus Areas Page 29 Energy audit and project planning Set priorities Set points Repairs Lighting Solar film Buildings with high energy use factor HVAC air balance Work to be in non FDA validated areas Focus on maintenance not construction

30 The Energy Reduction Project Team Page 30 RCx Consultant Engineering QST Project Team MEP specialist Program Executive Project Engineer Additional Resource Sr Energy Manager Energy Program Manager In House Support Superintendents Estimating Cost / Scheduling Accounting Payroll Value Mgmt. Quality Control Risk Mgmt. Safety Purchasing Equal Opportunity Clerical Project Manager Window Film Project Team Field / Project Engineers Energy Project Team MEP Specialist Project Manager Project Coordinator General Contractor Quick Strike Team Subcontractors Facilitators Engineering Bldg Controls Mechanical Air Water Balance Lighting Electrical FOM input & interface

31 Anemometer Control Schematic Page 31 Anemometer (Wind Speed, Direction) fpm fpm fpm fpm Minimum Fan Speed Calculated Using Empirical Formulas Derived based on Wind Tunnel Model VSD Network Comm Retrofit to Variable Speed Fan Motors Plenum Suction Pressure (Typical of 2) PE PT Plenum Static Pressure Set Point = inh2o PE PT Building Exhaust Sources (Exhaust Valves; Fume Hoods) Caption Here (10pt) EMCS Panel EMCS Terminal /GUI 2012, Genentech

32 Energy & Operational Savings Page 32 Fan power consumption is proportional to fan speed (third power). Any reduction in fan speed yields huge savings in power. Example: A 10% reduction in fan speed equals approximately a 25% reduction in energy consumption. 2012, Genentech Page 32

33 System Implementation kw Energy Reduction Page kw weekend night building demand before implementation 665 kw weekend night building demand after implementation 2012, Genentech

34 B42 monthly gas consumption Page 34

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