Developments and Next Steps
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1 Developments and Next Steps CARINA L. REBULANAN Chief, Institution Development Division Philippine Council for Health Research and Development Department of Science and Technology, Taguig City Philippines
2 Why a Network? Communicable diseases remain to be the major cause of deaths throughout the world, and this situation is expected to continue Desire to enhance progress in product discovery and development in developing countries and contribute to the implementation of the Global Strategy and Plan of Action (GSPA) on Public Health, Innovation and Intellectual Property approved through the World Health Resolution (WHA61.21) One ASEAN by 2015 (ASEAN Secretariat, 2009) 2
3 ASEAN-NDI Conceptualization Interest to establish a network for drugs, diagnostics, vaccines and traditional medicines innovation in Asia, was communicated to WHO-TDR Preparation of proposal for Mapping of Product R&D for Infectious Diseases in ASEAN member states by the Philippines Approval of Proposal by WHO-TDR Proposal presentation to the Subcommittee on Biotechnology of the ASEAN Committee on Science and Technology (COST) ASEAN- COST approval of proposal as ASEAN Initiative 5
4 The Objectives of ASEAN-NDI To establish the capabilities of the ASEAN member countries for drugs, diagnostics, vaccines, and traditional medicine innovation in the areas of infectious tropical diseases, non-communicable diseases, and preventable diseases due to accidents/traumas To identify gaps and opportunities in the ASEAN To create a database of institutions, networks, and initiatives with capacities for innovation To provide the template for the establishment/future directions of an Asian regional network for innovation in product R&D 7
5 Phases of the ASEAN NDI Development Phase 1 Mapping of Product R&D Landscape for Infectious Tropical Diseases in ASEAN Member Countries Phase 2 ASEAN-NDI Strategic Business Plan (SBP) Development Phase 3 ASEAN-NDI SBP Advocacy Phase 4 ASEAN-NDI SBP Launch Next Steps
6 PHASE 1: Mapping of Product R&D Landscape for Infectious Tropical Diseases in ASEAN Member Countries
7 1st ASEAN-NDI Organizational Meeting 21 October 2009, Pan Pacific Hotel Manila, Manila City, Philippines From left to right: Cheu Sivuthy (Cambodia), Monta Thammasatta (Thailand), Sayyadeth Chanthavong (Lao PDR), Dwi Susilaningsih (Indonesia; representing Judhi Rachmat), Jaime Montoya (Philippines), Bernadette Ramirez (WHO-TDR), Lisa F.P. Ng (Singapore), Yadanar Win Myint (Myanmar), Siti Hanna Muharram (Brunei Darussalam) and Ta Thi Tinh (Vietnam) 14
8 Mapping Objectives to establish the capabilities of the ASEAN member countries for drugs, diagnostics, traditional medicine, and vaccines innovation in infectious tropical diseases; identify gaps and opportunities in the ASEAN; create a database of institutions, networks, and initiatives with capacities for innovation; and provide the template for the establishment of an Asian regional network for innovation in product R&D.
9 Mapping Activity December 2009 November 2010 Data Collection Surveys and Key Informant Interviews Elsevier, Scopus Analysis of Data Survey Analyses Literature Analyses Country Report and Consolidated Report Writing Database Construction Survey Database Articles Database Website Code Development Continuous Updating and Uploading of Database Constant Update on Website Continuous Collection and Correction of Data 16
10 2nd ASEAN-NDI Organizational Meeting 06 December 2010, Dusit Thani Hotel Manila, Makati City, Philippines Presented mapping results per country, and overall regional assessment of product R&D (Country Coordinators, Representatives from MOH and MOST, and WHO-TDR and WPRO) Reviewed and consolidated the ASEAN R&D landscape mapping results Shared lessons learned from the African Network on Drugs and Diagnostics Innovation (ANDI) and other regional networks Discussed and agreed on plans for ASEAN NDI including proposed activities for and funding opportunities for future activities 17
11 18
12 ASEAN-NDI website Published Tables Blogs
13 ASEAN-NDI website Dowloadable contents Database Table
14 Mapping Results 21
15 Health Research and Social Development Image Source: World Economic Forum. (2010). The Global Competitiveness Report Geneva, Switzerland. Map can be retrieved from 22
16 RESEARCH PRODUCTIVITY AND COLLABORATIONS Research Productivity Source: Elsevier. (2010).Scopus. Retrieved July Accessed at 23
17 NATIONAL R&D SPENDING AND MANPOWER 24
18 CLINICAL TRIALS IN THE REGION Most clinical trials in the ASEAN region are focused on maladies and conditions other than tropical infectious diseases. Only trials which are currently "open" or "recently completed" in the clinicaltrials.gov database (as of July 2010) were counted. *ClinicalTrials.gov. Data on numbers of clinical trials per country. Retrieved from Accessed J l
19 103 Biomedical articles 977 Citations 182 Inter-country collaborations on infectious diseases 12,568 Biomedical articles 61,201 Citations 5,266 Inter-country collaborations on infectious diseases No. of biomedical articles, tations, inter-country ollaborations on infectious seases per country 12,405 Biomedical articles 108, 150 Citations 1,256 Inter-country collaborations on infectious diseases 168 Biomedical articles 1,044 Citations 268 Inter-country collaborations on infectious diseases 318 Biomedical articles 2,762 Citations 630 Inter-country collaborations on infectious diseases 186 Biomedical articles 619 Citations 80 Inter-country collaborations on infectious diseases Publications 163 Biomedical articles 486 Citations 1,256 Inter-country collaborations on infectious diseases 7,071 Biomedical articles 13,143 Citations 890 Inter-country collaborations on infectious diseases 574 Biomedical articles 3,415 Citations 474 Inter-country collaborations on infectious diseases 1,324 Biomedical articles 8014 Citations 953 Inter-country collaborations on infectious diseases 26 26
20 Collaborations among top 50 most productive institutions for Infectious disease research Network in ASEAN countries for infectious disease research Source: Elsevier. (2010).Scopus. Retrieved July Accessed at Notes: Collaborations among top 50 most productive institutions (within and outside ASEAN) based on articles on infectious diseases. Size of nodes indicates relative number of articles. Thicker links indicate more instances of collaboration between the two 27 institutions. Blue nodes are institutions in the ASEAN region, while orange nodes represent institutions outside ASEAN.
21 diagnostics research Network in ASEAN countries for diagnostics research Source: Elsevier. (2010).Scopus. Retrieved July Accessed at Notes: Collaborations among top50 most productive institutions (within and outside ASEAN) based on articles on infectious diseases. Size of nodes indicates relative number of articles. Thicker links indicate more instances of collaboration between the two institutions. Blue nodes are institutions in the ASEAN region, while orange nodes 28 represent institutions outside ASEAN.
22 vaccines research Network in ASEAN countries for vaccines research Source: Elsevier. (2010).Scopus. Retrieved July Accessed at Notes: Collaborations among top50 most productive institutions (within and outside ASEAN) based on articles on infectious diseases. Size of nodes indicates relative number of articles. Thicker links indicate more instances of collaboration between the two institutions. Blue nodes are institutions in the ASEAN region, while orange nodes represent institutions outside ASEAN. 29
23 CONCLUSIONS FROM PRODUCT R&D LANDSCAPE MAPPING Initiatives of most ASEAN Member States are mostly similar, thus, encouraging collaboration among countries, and coordination between the public and private sectors to address common health needs. Though ASEAN member states are in different stages of economic and health development with inadequate investment for product R&D and minimal research output, ASEAN has substantial human resource and institutions that can support the pursuit of R&D products. The ASEAN region holds a lot of potential in terms of resources for drugs, vaccines, diagnostics and traditional medicine research development.
24 Recommendations drawn from Mapping Activity Challenges ASEAN-NDI Potential Actions 1 Diverse spectrum of capacity ASEAN has substantial human resource and institutions that can support the pursuit of R&D on drugs, traditional medicine, diagnostics, and vaccines. 2 Research gap A number of countries can work on the same disease and for the same products (i.e., drugs, vaccines, etc). 3 Reduced coordination among clusters of researchers and innovators 4 Gaps in R&D investment ASEAN member states can facilitate the exchange of expertise, resources and health products as they have been working in other development initiatives. Collaborative arrangements with private institutions such as pharmaceutical companies can be worked out. 4
25 PHASE 2: ASEAN-NDI Strategic Business Plan (SBP) Development
26 1 st ASEAN-NDI Task Force Meeting 20 October 2011 Dusit Thani Hotel, Makati City, Philippines Discussed and agreed on the framework/ initial outline of the draft ASEAN- NDI Strategic Business Plan (SBP) and the timelines for consultations/ discussions by the business development expert with the TF members. Venue for the discussion of the SBP for ASEAN-NDI, and identification of strategies geared towards the future implementation of collaborations and partnerships within ASEAN on innovation. 32
27 ASEAN-NDI Strategic Business Plan Review via Videoconferencing 28 February 2012 Asian Institute of Management (AIM), Makati City Provided the task force members information on the progress of the SBP. Gathered reactions and post clarifications on the questionnaire provided prior to the meeting which made sure that the SBP would address issues applicable to most of the countries. 33
28 2 ND Videoconference with ASEAN-NDI Task Force Members 10 September 2012 at the Asian Institute of Management, Makati City Presented and solicited comments on the draft Strategic Business Plan 34
29 ASEAN-NDI Strategic Business Plan (SBP) Developed to: Assess and recommend how ASEAN member states can come together to establish a center for drugs, diagnostics, vaccines, and traditional medicine innovation to address public health threats in ASEAN. Provide plans for an inter-governmental, collaborative response to the lack of access of poor countries and people to health products. Create public research and development (R&D) capacity while harnessing the strengths and potential contributions (technical and financial) of the stakeholders including the private sector. Note: SBP can be downloaded at
30 ASEAN-NDI Vision and Mission VISION Asia s premier facilitator for innovation in research and development in health products MISSION To address the unmet public health needs of ASEAN nations through the advancement of ASEAN-led health product innovation in the areas of drugs, vaccines, diagnostics and traditional medicine in order to improve health outcomes in the ASEAN region and beyond, and to support sustainable regional economic development.
31 Diseases to be addressed by ASEAN- NDI: Triple Burden of Disease Infectious Tropical Diseases TB, dengue, malaria, Chikingunya, parasitic diseases (Schistosomiasis, Leishmaniasis, etc.) etc. Non-communicable Diseases Cancer, cardiovascular disease, diabetes, etc. Preventable Diseases due to Accidents and Trauma
32 ASEAN-NDI Governance
33 Governing Council The responsibilities of the 14-person Governing Council are as follows: strategy-formulating and policy-making body that ensures the faithful implementation of the vision/mission of ASEAN-NDI define priorities for cooperation within the scope of the ASEAN Socio- Cultural Community Blueprint, the ASEAN Plan of Action on Science and Technology (APAST), the Hanoi Plan of Action to realize ASEAN Vision 2020, and other documents to be endorsed by ASEAN leaders, Ministers of Science and Technology, or other bodies within ASEAN; and sustain the network through an advocacy strategy that will engage all stakeholders in supporting its activities, and to mobilizing financial resources for these purposes.
34 ASEAN-NDI R&D Value Chain
35 ASEAN-NDI R&D Value Chain Inclusion of Knowledge Management The core idea of knowledge management informing, measuring, and accessing are the principles governing the platform and process of cooperation within ASEAN-NDI. Inclusion of Innovation Systems These inputs are concerned with infrastructure, human resources, the knowledge and information systems, and the innovation systems themselves that are at the spirit of innovation communities (IC).
36 PHASE 3: ASEAN-NDI SBP Advocacy
37 Meeting with ASEAN AMBASSADORS 06 September 2012, Asian Institute of Management, Makati City, Philippines In coordination with ASEAN Office of the Philippine Department of Foreign Affairs, meeting was held with Philippine-based ASEAN Ambassadors to brief them about ASEAN-NDI and seek assistance in facilitating exchange of information and resources ASEAN Ambassadors and their representatives committed to coordinate with stakeholders in their home countries 41
38 ASEAN COST Meeting Tagaytay City, Philippines May 2013 Per recommendation of the Sub-Committee on Biotechnology, COST approved the Strategic Business Plan of the ASEAN-NDI. With regard to the request for funding initial ASEAN-NDI activities, the SCB was advised to develop a project proposal that may seek funding support from the ASEAN Science Foundation (ASF), dialogue partners and other sources.
39 PHASE 4: ASEAN-NDI SBP Launch
40 ASEAN-NDI Stakeholders Meeting Dusit Thani Hotel, Makati City, Philippines 5 June 2013
41 ASEAN-NDI Stakeholders Meeting Dusit Thani Hotel, Makati City, Philippines 5 June 2013 OBJECTIVES Present the SBP to various Stakeholders in ASEAN as well as key representatives from other regional health R&D innovation networks in China, India, and Africa and in preparation for its presentation to the ASEAN Ministerial Meeting; Continue advocacy work and ensure buy-in of the SBP among ASEAN stakeholders; Learn from the best practices/experiences of other regional R&D innovation networks in China and Africa; and Lay down plans for ASEAN-NDI, including proposed activities for 2013 and funding opportunities for the network.
42 Timelines ASEAN-NDI operation launch 2014 ASEAN-NDI Strategic Business Plan launch Mapping Activity 2009 ASEAN-NDI Concept Launch 47
43 Next Steps
44 Next Steps.. Seek formal approval of ASEAN for Philippines to host the ASEAN-NDI Secretariat office Set up of the Secretariat office Training of Secretariat and Country Focal Points Seek commitment of Heads of States to the SBP Establishment of ASEAN-NDI Hub and Spoke 51
45 Next Steps.. Negotiate with potential donors, like the ASEAN Science Foundation, ASEAN dialogue partners and other funding sources Organization of the Governing Council Identify Community of Practice (COP) for priority disease burdens Screen initial grants for COPs Mobilize funds for select COPs 51
46 Next Steps.. Conduct of Capacity-building programs a. training of young scientists for leadership roles in R&D in the region b. Involvement of less developed member states in R&D projects Collaboration with similar innovation networks (ANDI, India NDI, China NDI, PAHO Network, WPRO and SEARO Networks, etc.) 51
47 Thank You!
48 Burden of Disease 2007 life expectancy vs GDP per capita With 8.6% of the world s population, ASEAN contributes to the 27% of the global burden of infectious and parasitic diseases (WHO,2007). National Poverty Lines Major factors: lack of market incentives to support health innovations, product R&D, access to essential medicines, fragile health services Data source: Gapminder(2007) 3
49 Committee on Science and Technology 6
50 8
51 Summary Aside from the ASEAN member-states commitment to work together towards a common goal in the spirit of ASEAN help ASEAN, the ASEAN community has been used to several free trade agreements and harmonization initiatives. Hence, establishing a network aimed to strengthen the scientific ties to address neglected diseases will not be a herculean task. ASEAN member states can facilitate the exchange of expertise, resources, and health products as they have been working in other initiatives for the social, political, and economic development of the region. This effort is in line with the ASEAN Harmonization expected to take effect in
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