Jun Hong Park, D.V.M., Ph.D.

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1 Curriculum Vitae (Last updated: ) Jun Hong Park, D.V.M., Ph.D. Junior Investigator, Center for Genomic Integrity, Institue for Basic Science, Ulsan National Institute of Science and Techology, Building 103, Room 210 Unist-gil 50, Ulsan, , SUMMARY Interested in anti-diabetics drug & biomarker development in vivo Development of Functional Foods and Drugs Mouse genetic engineering & phenomics Animal development study Cancer cell metabolism study Adipocyte differentiation and metabolism Anti-obesity functional gene study Brown adipocyte and Muscle development Areas of expertise include Metabolism, stem cell and Developmental Biology EDUCATION Post-Doc Tulane University, School of Medicine, Department of Pathology & Laboratory Medicine 2013-Present Post-Doc National Institutes of Health (NIH, U.S. Department of Health & Human Services) Post-Doc College of Agriculture, Seoul National University Ph.D. College of Veterinary, Konkuk University M.S. College of Veterinary, Seoul National University B.S. College of Veterinary, Kyungpook National University RESEARCH EXPERIENCE Tulane University School of Medicine Department of Pathology & Laboratory Medicine (headed by Sean Bong Lee) Post-Doc Ewing sarcoma gene (EWS) function White and beige adipocyte biology Mitochondria biogenesis and function Present National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Genetics of Development and Disease Branch (GDDB), (headed by Sean Bong Lee) Post-Doc Ewing sarcoma gene (EWS) function Brown adipocyte development and function Energy metabolism study Seoul National University College of Agriculture and Life Sciences, Department of Food and Animal Biotechnology, Gamete and Stem Cell Biotechnology, (headed by Pro. Jeong Mook Lim Lab)

2 Post-Doc Alternative stem cell methods establishment Induction of Pluripotent stem cells from mouse embryonic and fibroblast Somatic cell nuclear transfer in porcine In vitro pre-antral follicle culture and studying oocyte maturation system TEACHING EXPERICENCE 2008 Gamete and Stem Cell Biotechnology for graduate course. Department of Food and Animal Biotechnology, Seoul National University, Seoul, Korea Advisor: Professor. Jeong Mook Lim MENTORING 2014 Mentor of a Post-bachelor student (Mr. Mukhtar Kullmbet) 2011 Mentor of a Post-bachelor student (Ms. Jamie Hur) AWARDS AND LICENSE 2011 Young scientist Award, National Institute of Health-Korean scientist association (NIH-KSA) 2011 Poster Presentation Award, National Institute of Health-Korean scientist association (NIH-KSA) 2011 Young scientist Award, The Korea Association for Laboratory Animal Science (KALAS) 2009 Postdoctoral Visiting Fellow Award (NIH/NIDDK) 2007 Poster Presentation Award, The Korea Association for Laboratory Animal Science (KALAS) 2006 Poster Presentation Award, The Asian Federation of Laboratory Animal Science (AFLAS) 2000 Licensed Veterinarian (Ministry of Agriculture & Forestry, Korea) PROFESSIONAL AFFILIATIONS Present Korean-American Society in Biotech and Pharmaceuticals (KASBP) Present Korean-American Scientist and Engineers Association (KSEA) 2009-Present NIH (National Institute of Health)-Korea Scientist Association (NIH-KSA) 2006-Present Korean College of Laboratory Animal Medicine (KCLAM) 2002-Present Korea Association for Laboratory Animal Science 2000-Present Korean Veterinary Medical Association POSTER PRESENTATION Jun Hong Park and Sean Bong Lee. Ewing Sarcoma Gene, EWS, Plays Important Roles in Brown Adipocyte Differentiation and Mitochondria Biogenesis American Diabetes Association 74 th Scientific Sessions.2014, San Francisco, USA. (*This poster selected for a Audio Poster Presentation in novel pathways and mechanisms in adipose development and function section). 2014, American Diabetes Association. USA Jun Hong Park and Sean Bong Lee. A Multifunctional Protein EWS is Essential for Early Classical Brown Fat Lineage Determination NIH-NIDDK: Exploring the Role of Brown Fat in Humans. 2014, National Institute of Health. USA

3 Jun Hong Park and Sean Bong Lee. Ewing Sarcoma Gene, EWS, Plays Important Roles in Brown Adipocyte Differentiation NIH-KSA Annual Bioscience Engineering symposium (ABES). 2011, National Institute of Health. USA. Jun Hong Park, Joohyeong Lee, Jinyoung You, Jinyoung Kim and Enusong Lee. Effect of Follicle Isolation Methods and Culture condition on Preantral Follicle Development in Pigs. The 8 th International symposium on Developmental Biotechnology. 2008, Hankyung University, Korea. Jun Hong Park, So-Yang Park, Jin-Kyung Kim, Jun-gyo suh, Jae Yong Lee, and Yang-Seok Oh. Silk fibroin increased proliferation of HIT-T15 cells in Hyperglycemic Condition. The Korea Association for Laboratory Animal Science Conference. 2007, Chungbuk National University. Korea. Jun Hong Park, So-Yang Park, Jin-Kyung Kim, Jun-gyo suh, Jae Yong Lee, and Yang-Seok Oh. Silk fibroin protecting pancreatic beta cell and promotion neogenesis in the C57BL/Ksj-db/db mice. The Asian Federation of Laboratory Animal Science Conference. 2006, Je-Ju Island. Korea. PUBLICATIONS Jun Hong Park, Kyung In Cho, Hajin Nam, Nong-Hoon Choe, Jun Gyo Suh. Anti-apoptotic effects of Silk fibroin hydrolysate in RIN5F cell on high glucose condition. Animal Cells and Systems. (Accepted) Jun Hong Park, Hong Jun Kang, Yun Kyung Lee, Hyeog Kang, Jay H. Chung, Ji Suk Chang, Alexandra C. McPherron and Sean Bong Lee. Inactivation of EWS Reduces PGCand Mitochondrial Homeostasis. Proceeding of the Natioanl Academy of Sciences of the United States of America (PNAS) (Published ahead of print April 27, 2015) Jun Hong Park*, Sean Bong Lee. An Essential Role for Ewing Sarcoma Gene, EWS, in Early White Adipogenesis. Obesity (2015) 23, (*; correspond author) (*This paper is introduced in the webpage, MDLinx, Post publication of peer view) Hong Jun Kang, Jun Hong Park, Weiping Chen, Soo Im Kang, Krzysztof Moroz, Marc Ladanyi, Sean Bong Lee. EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neuronal differentiation. Cancer Research. (2014) 74, Jun Hong Park, Sean Bong Lee. Ewing Sarcoma Gene, EWS, Play important role in Brown adipocyte differentiation and mitochondria biogenesis. Diabetes. (2014) 63 (Supplement 1) A433 Jun Hong Park*, Harry Jung*, Hajin Nam, Jin-Bong Kim, Nong-Hoon Choe, Jun Gyo Suh. Silk fibroin hydrolysate ameliorates diabetic dyslipidemia in type 2 diabetic model mice. Animal Cells and Systems. (2013) 17 (5) (*; co-1 st author) (Manuscript ID; TACS ) Jun Hong Park, Hong Jun Kang, Soo Im Kang, Ji Eun Lee, Jamie Hur, Kai Ge, Elisabetta Mueller, Hongjie Li, Byeong-Chel Lee, and Sean Bong Lee. A multifunctional protein EWS is essential for early brown fat lineage determination. Developmental Cell. (2013) 26 (4), (*This paper is introduced in the webpage, Faculty of 1000 Prime, Post publication of peer view)

4 Sun-Gil Do, Jun Hong Park, Hajin Nam, Jin-Bong Kim, Jae-Yong Lee, Yang-Seok Oh, Jun-Gyo Suh. Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic -cell mess in C57/Ksjdb/db mice. J. Vet. Sci. (2012) 13 (4), Eun Jung Sohn, Jun Hong Park, Soo-im Kang, Yun-Ping Wua. Accumulation of pre-let-7g and down regulation of mature let-7g with the depletion of EWS. Biochem. Biophys. Res. Commun. (2012) 426 (1), Chae Hyun Lee, Jun Hong Park, Jae Hee Lee, Ji-Yeon Ahn, Jong Heum Park, Bo-Ram Lee, Dae Yong Kim and Jeong Mook Lim. Replacement of mouse embryonic fibroblasts with bone marrow stromal cells for use in establishing and maintaining embryonic stem cells in mice. Cell Biol Int. (2012) 36(6), Jun Hong Park*, YoonYi Nam*, So-Young Park, Jin-Kyung Kim, Nong-Hoon Choe, Jae-Young Lee, Yang-Seok Oh and Jun Gyo Suh. Silk Fibroin Has a Protective Effect against High Glucose Induced Apoptosis in HIT-T15 Cells. J. BIOCHEM. MOLECULAR TOXICOLOGY. (2011) 25, (*; co-1 st author) Jin-Kyung Kim, Eun Kyung Shin, Jun Hong Park, Yoon Hee Kim and Jung Han Yoon Park. Antitumor and Anti-metastatic Effects of Licochalcone A in Mouse Models. J. Mol. Med. (2010) 88(8), Ok Kyu Park, Ki-Yeon Yoo, Choong Hyun Lee, Jung Hoon Choi, In Koo hwang, Jun Hong Park, Young-Guen Kwon, Young-Myeong Kim and Moo-Ho Won. Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia. J. Neurol. Sci. (2010) 294 (1-2), 7-17 Jun Hong Park, YoonYi Nam, Jungkee Kwon and Jun-Gyo Suh. New Splicing Variants of the Murine Damaged DNA Binding 2. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE (2010) 26(1), Jin Young You, Joo Hyeong Lee, Jin Young Kim, Jun Hong Park, Eun Song Lee. Post-fusion Treatment with MG132 Increases Transcription Factor Expression in Somatic Cell Nuclear Transfer Embryos in Pigs. Mol. Rep. Del. (2010) 77, Jae Hee Lee, Eun Ju Lee, Chae Hyun Lee, Jun Hong Park, Jae Yong Han and Jeong Mook Lim. Requirement of leukemia inhibitory factor for establishing and maintaining embryonic stem cells in mice. Fertility and Sterility. (2009) 92(3), Hwang IK, Kim DW, Jun Hong Park, Lim SS, Yoo KY, Kwon DY, Kim DW, Moon WK, Won MH. Effects of grape seed extract and its ethylacetate/ethanol fraction on blood glucose levels in a model of type 2 diabetes. Phytother Res. (2009) 23(8), Hyuck-Se Kwon*, Jun Hong Park*, Dae Hwan Kim*, Yoon Hee Kim, Jung Han Yoon Park, Hyun- Kyung Shin and Jin-Kyung Kim. Licochalcone A isolated from licorice suppresses lipopolysaccharidestimulated inflammatory reactions in RAW cells and endotoxin shock in mice. J. Mol. Med. (2008) 86, (*; co-1 st author) In Koo hwang, Ki-Yeon Yoo, Dae Won Kim, So Young Kim, Jun Hong Park, Zae Young Ryoo, Joon Kim, Soo Young Choi and Moo-Ho Won. Ischemai-induced ribosomal protein S3 expressional changes and the neuroprotective effect against experimental cerebral ischemic damage. J. Neurosci. Res (2008) 86(6),

5 Jun Hong Park, Sun-mee Oh, Soon Sung Lim, Yeon Sil Lee, Hyun-Kyung Shin, Yang-Seok Oh, Nong-Hoon Choe, Jung Han Yoon Park, and Jin-Kyung Kim. Induction of Heme Oxygenase-1 Mediates the Anti-inflammatory Effect of the Ethanol Extract of Rubus Coreanus in Murin Macrophages. Biochem. Biophys. Res. Commun. (2006) 351, Hyuck-Se Kwon, Jun Hong Park, Yang-Seok Oh, Hyun-Kyung Shin, Sang-Jae Park, Byung-Sik Gang, Jae-Gun Park and Jin-Kyung Kim. Single-Dose and Seven-Day Repeated-Dose Toxicity Tests of the Ethanol from Bark of Pinus Densiflora in Rats. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE. (2006) 22(4), Sung-Hyun Kim, Kil-Soo Kim, Eun-Ju Lee, Myoung-Ok Kim, Jun Hong Park, Kyoung-In Cho, Kazuhiko Imakawa, Byung-Hwa Hyun, Kyu-Tae Chang, Hoon Taek Lee, and Zae-Young Ryoo. Human keratin 14 driven HPV 16 E6/E7 transgenic mice exhibit hyperkeratinosis. Life Science. (2004) 75, Jeong Woong Lee*, Jun Hong Park*, Kil Soo Kim, Eun Ju Lee, Myoung Ok Kim, Sung Hyun Kim, Seong Whan Jeong, Chul Woo Kim, Ho Joon Lee, Kyung Sun Kang, Kyu Tae Chang, Byung Hwa Hyun, and Zae Young Ryoo. Vasopressin-SV40T antigen expression in transgenic mice. Biochem. Biophys. Res. Commun. (2003) 302, (*; co-1 st author) Jung Ok Choi, Jung Woong Lee, Eun Ju Lee, Myoung Ok Kim, Sung Hyun Kim, Jun Hong Park, Kyung In Cho, Boo Kyung Jung,Hi Chol Kim, Sol Ha Hwang, Myung Su Nam. Production of transgenic mice secreting a C. thermocellum Cellulase D in the pancreas. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE. (2003) 19(1), 9-12 Jung Ok Choi, Jung Woong Lee, Eun Ju Lee, Myoung Ok Kim, Sung Hyun Kim, Jun Hong Park, Kyung In Cho, Boo Kyung Jung,Hi Chol Kim, Sol Ha Hwang, Myung Su Nam. Analysis of transgenic mice secreting a C. thermocellum Cellulase D in the pancreas. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE. (2003) 19(1), Eun Ju Lee, Jeong Woong Lee, Jun Hong Park, Joung Ok Choi, Boo Kyung Jung, Kyoung In Cho, and Zae Young Ryoo. The Production of Chimeric Mice by Aggregation Embryonic Stem Cells with 8-Cell Embryo. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE. (2001) 17(3), Eun Ju Lee, Kil Soo Kim, Jeong Woong Lee, Jun Hong Park, Joung Ok Choi, Boo Kyung Jung, Kyoung In Cho, Zae Young Ryoo. Estimation for Enzyme Activity of Energy Metabolism and Subsequent Development of Fresh Bovine Embryos from In Vitro Fertilization. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE. (2001) 17(3), Jong-Sung Kim, Jeong Woong Lee, Eun Ju Lee, Jun Hong Park, Myoung-Ok Kim, Jong-Wan Lee, Byong-Soon Im, Nin-Jae Lee, Zae Young Ryoo. Cryopreservation of Transgenic Mouse Embryos by Using Slow. THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE. (2000) 16(4),

Yuk Pheel Park. (1) Sep Feb. 2007: (Ph.D.) Department of Biology, Chungnam National University, Korea.

Yuk Pheel Park. (1) Sep Feb. 2007: (Ph.D.) Department of Biology, Chungnam National University, Korea. Yuk Pheel Park Personal Information 1) Name: Yuk Pheel Park 3) Gender: Female 4) Marital status: Married 5) Citizenship: Republic of Korea Cellular phone: 301-814-4371 E-mail: Ypark2@dental.ufl.edu, ph7341@hotmail.com