Biomaterials for gene and drug delivery

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Cory Alexina Newton
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1 You are invited by the Montreal student chapter of the CBS to the seminar: Biomaterials for gene and drug delivery Dr. Michael D. Buschmann Department of Chemical Engineering Institute of Biomedical Engineering Director Biomedical Science and Technology Research Group (FRQS) École Polytechnique de Montréal & Dr. Sylvain Martel Department of Computer Engineering École Polytechnique de Montréal November 24th, :00 pm- 7:00 pm Pavillon J- A Bombardier Room 1035 Université de Montréal (UdeM) 5155 Chemin de la rampe Montréal Followed by a networking session with free finger food and drinks.

2 Dr. Michael D. Buschmann Department of Chemical Engineering Institute of Biomedical Engineering Director Biomedical Science and Technology Research Group (FRQS) École Polytechnique de Montréal Montreal, Quebec, Canada Biography Michael Buschmann received a B. Engineering Physics from the University of Saskatchewan in 1984, and a Ph.D. in Medical Engineering and Medical Physics from MIT and Harvard University in Since 1994, Dr. Buschmann is Professor of Biomedical Engineering and Chemical Engineering at Polytechnique de Montréal. His current research program focuses on the use of biomaterials to repair joint tissues and to effectively deliver nucleic acids. He has helped found two previous start- ups and invented 3 technologies that have been commercialized, including a mechanical tester benchtop instrument, a clinical arthroscopic cartilage evaluation device and a therapeutic biomaterial that is approved in 18 countries to repair cartilage. He recently co- founded two additional start- ups based on current research, one in orthopaedic tissue repair and another in RNA therapeutics. He has received the Partnership and Innovator Prize from the Quebec Association for Industrial Research (ADRIQ) and several teaching awards.

3 Abstract RNA Therapeutics Delivery and Biomaterials for Tissue Repair We have developed nanovectors that are electrostatic complexes of the cationic polymer chitosan and its derivatives with nucleic acids (sirna, mrna, mirna, pdna). These polyelectrolyte complexes achieve high levels of gene expression and specific gene silencing in many cell types. A specific intravascular targeting of current systems to proximal tubules in the kidney in mice was found, leading to applications in renal disease. Chemically modified systems are being investigated for cancer applications. The same family of polymers is also used to stabilize platelet rich plasma (PRP) as injectable implants for tissue repair. Specific compositions in a lyophilized form were resuspended in PRP and injected into meniscus tears and rotator cuff tears to biologically stimulate repair at these sites in animal models. The latter technology is now being transferred to a GMP manufacturer and is entering clinical phase testing.

4 Dr. Sylvain Martel Department of Computer Engineering École Polytechnique de Montréal Montreal, Quebec, Canada Biography Prof. Sylvain Martel, Fellow of the Canadian Academy of Engineering as well as IEEE Fellow, is Chair of the IEEE Technical Committee on Micro- Nanorobotics and Automation, and Director of the NanoRobotics Laboratory at Polytechnique Montréal, Campus of the University of Montréal, Canada. He received many awards mostly in interdisciplinary research and he is a recipient of a Tier 1 Canada Research Chair in Medical Nanorobotics. He developed several biomedical technologies including platforms for remote surgeries and cardiac mapping systems when at McGill University, and new types of brain implants for decoding neuronal activities in the motor cortex when at MIT. Among other achievements, Dr. Martel s research group is also credited for the first demonstration of the controlled navigation of an untethered object in the blood vessel of a living animal. Prof. Martel s interdisciplinary team is recognized worldwide as a pioneered and leading authority in the development of navigable therapeutic agents and interventional platforms for cancer therapy.

5 Abstract Canadian nanorobots: an option for fighting cancer? Rapid progress in integrating nanotechnology with robotics has launched nanorobots out of the realm of science- fiction, opening extraordinary new possibilities in medicine and pharmaceutics. Swarms of hundreds of millions of these robots a tiny fraction of the thickness of human hair can now navigate in blood vessels, swim deep inside tumors, then autonomously detect active cancer cells and target precise locations to achieve maximum therapeutic effects. At present, these nanorobots only exist in Canada, putting the country at the forefront of this new field known as medical nanorobotics. The talk will discuss the potentially huge impacts for important industrial and research sectors, as well as the human benefits in terms of more effective treatments with fewer side effects and the expected reduction of costs in health care. The presentation will feature initial results and videos showing the nanorobots in action. At the close of the talk, you will surely agree that the future has arrived!

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