Chemistry Notices VISITING SPEAKERS & SEMINARS. Greg M. Swain. For the Week of March 4 to March 8, 2013

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1 Chemistry Notices For the Week of March 4 to March 8, 2013 Submissions: Please send to newsletter@chem.ualberta.ca by Wednesday for the following week s edition VISITING SPEAKERS & SEMINARS Analytical Division Visiting Speaker Dr. Ulrich Krull GRL/Bonnie x3477 Last printed :56 AM Professor, Department of Chemical and Physical Sciences University of Toronto Mississauga will speak on " Quantum Dots as Multiplexed Optical Transducers: From Microfluidic Bioassays and CMOS Sensors to Interrogation of Chemical Dynamics within Cells" There are significant analytical advantages that can be achieved by combining the unique optical properties of quantum dots (QDs) with bioconjugation of oligonucleotide probe molecules to create nano-scale biosensing elements. Of particular relevance are advantages in size scale and in multiplexing using optical technology. We have been exploring QDs that are decorated with oligonucleotides as the basis for bioprobes that operate using fluorescence resonance energy transfer (FRET), where the QD excites a nearby dye that is associated with the formation of double-stranded DNA. By extension, the principles of function have bearing on use of other selective binding agents such as based on proteins and aptamers. Migration from use of optical fiber technology to place solid-phase bioassays into microfluidic channels has allowed for transduction of sub-femtomole levels of target nucleic acid within minutes, rather than hours as typically required in previous assay designs. Moreover, the rate of mass transport of an injection of oligonucleotide targets to the in-channel interface that was coated with immobilized QDs enabled the quantitative transduction of target nucleic acid by measuring the length of the microfluidic channel that exhibited FRET sensitized photoluminescence. This represents a new approach to quantification that is not dependent on the proportionality of fluorescence intensity to concentration, and that allows for accurate quantification without use of fluorescently labeled target. This presentation will explore the design of QD-bioprobes, multiplexing of QD-bioprobes that are immobilized on optical fibers and in microfluidic channels, integration of optical nanoparticle probes on CMOS technology, the use of microfluidics to construct nano-scale biosensing elements for intracellular applications, and some early results of QDbioprobes in intracellular response. DATE: Friday, 8 March 2013 TIME: 1:00 p.m. PLACE: E3-25 DEPARTMENT OF CHEMISTRY, UNIVERSITY OF ALBERTA Analytical Division Visiting Speaker Greg M. Swain NINTSeminar Tuesday,March5,10am TaylorLectureTheatre,NINT Title:"Nanoplasmonics:Reachingoutto thesinglemolecule" ProfessorReuvenGordon Abstract:NanoplasmonicsreferstothenanostructuringofmetalstoachieveenhancedlightF matterinteraction,downtothesinglemoleculelevel.thistalkwillhighlightsomeofour researchadvancestowardssinglefmolecule(andother)technologies.inparticular,iwilldiscuss reliablesinglemoleculeramanbyusingtheantennaconceptofdirectivity.iwillshowhowwe cangrabholdofsingleproteinswithlightandalsodetectsingleproteinbindingwithgreat sensitivity.nanoholearraysurfaceplasmonresonancewith10^f7riusensitivitywillbe discussed.iwillshowhownanoplasmonicscanimprovethzsources,andcanallowfor enhancedsecondharmonicgeneration.finally,iwilltalkaboutlargefieldenhancementsthat canbeachievedbycombiningnanoplasmonicswithpermittivityfnearfzeromaterials. Bio:ReuvenGordon ReuvenGordonreceivedhisPh.D.inPhysicsfromtheUniversityofCambridge.In2002,he joinedtheuniversityofvictoria,wherehecurrentlyholdsacanadaresearchchairin NanoplasmonicsandanAssociateProfessorpositionintheDepartmentofElectricaland ComputerEngineering.In2009,Dr.GordonwasavisitingProfessorattheInstituteforPhotonic Sciences(ICFO,Barcelona,Spain).HehasreceivedaCanadianAdvancedTechnologyAlliance Award(2001),anAccelerateBCIndustryImpactAward(2007),anAGAURVisitingProfessor Fellowship(2009),andtheCraigdarrochSilverMedalforResearchExcellence(2011).Dr. GordonhasauthoredandcoFauthoredover95journalpapers(including6invited contributions),twomagazinecontributionsandhehascofauthoredtwobookchapters.heis cofinventorfortwopatentsandtwopatentapplications(inreview).dr.gordonisasenior MemberoftheIEEEandaProfessionalEngineerofBC. Professor of Chemistry Neuroscience Program Michigan State University will speak on "Tetrahedral Amorphous Carbon New Electrodes for Electroanalytical Measurements" DATE: Friday, 08 March 2013 TIME: 4:00 p.m. PLACE: E Gunning/Lemieux Chemistry Centre RLMc/ldl (ext: ; office: W5-39a) Please turn over for Abstract

2 VISITING SPEAKERS & SEMINARS, continued Amira El- Yazbi Ph.D Seminar will speak on Novel spectroscopic probes for detecting DNA damage Chemical Biology Division 502 Seminar: Akemi Darlington will speak on Incorporation of non- canonical amino acids in cancer therapeutics on Wednesday, March 6, 2013 at 11:00 am in room CCIS Friday, March 8, :00 p.m. in Room SAB 326 EMPLOYMENT OPPORTUNITIES The Department of Chemistry and Biochemistry at Mount Allison University invites applications for a tenure-track appointment in Biochemistry. Applicants should possess a Ph.D. and have demonstrated strength in undergraduate teaching and research supervision. We seek candidates with research programs on secondary metabolism of algae, cognate to the Tier I CRC Chair in Phytoplankton Ecophysiology. We particularly seek candidates with broad expertise, and who are able to contribute strong undergraduate teaching in Advanced Metabolism, Molecular Biology, Nucleic Acid Biochemistry, Plant Physiology and Signal Transduction. We are well equipped for research and teaching in Biochemistry and Chemistry. New faculty are expected to launch an active, externally funded research programme that integrates undergraduate research students. The appointment will be made at the rank of Lecturer or Assistant Professor and will commence on July 1, 2013, subject to budgetary approval. Applications should include a curriculum vitae, a statement of the candidate s teaching interests and philosophy, and a research proposal in NSERC format. Review of applications will begin on February 28, 2013 and will continue until the position is filled. Applicants should request that three letters of reference be sent electronically to the Chair of the Search Committee. Applications must be posted electronically at Dr. Amanda Cockshutt Chair of the Search Committee Department of Chemistry and Biochemistry Mount Allison University Sackville, NB E4L 1G8 Fax: , acockshutt@mta.ca

3 EMPLOYMENT OPPORTUNITIES, continued Please be advised that the posting for the soon to be vacant Administrative Assistant position is now active. Please share this posting with anyone you feel might be interested in taking on this type of position. The web posting for competition #S D1 is Active Competition Title: Administrative Assistant Department: SC Chemistry Posting Date: ASAP Group: Chemistry To view the Web Posting: Please be advised that the soon to be vacant Senior Financial Administrator position is now posted on the U of A Careers website. We would encourage you to share this posting with anyone you know that may be interested. The web posting for competition #S is Active Competition Title: Senior Financial Administrator Department: SC Chemistry Posting Date: ASAP Group: Chemistry To view the Web Posting:

4 EMPLOYMENT OPPORTUNITIES, continued UNIVERSITY OF YORK Department of Chemistry and Centre for Hyperpolarisation in Magnetic Resonance - Four postdoctoral positions 1. Reaction monitoring on micro-second timescales by nuclear magnetic resonance: Postdoctoral Research Fellow in organometallic photochemistry w/ Professors Simon Duckett, Robin Perutz Applications are invited for a postdoctoral research fellow to work on photochemical studies of organometallic complexes by NMR spectroscopy. This position is for a period of 2 years in the first instance and available from the 15th of April The post holder requires an organometallic or coordination chemistry background with experience of NMR. The PDRA will be located in the York Centre for Hyperpolarisation in Magnetic Resonance and in the Department of Chemistry. Laser irradiation methods have provided the means to study the evolution of many chemical systems. In proof-of-principle experiments, we have shown that it is possible to record NMR spectra on milli and microsecond timescales. We seek to use NMR to follow fast reactions using parahydrogen. The post holder will work alongside a Postdoctoral Research Fellow responsible for theory to achieve this aim. He/she will prepare complexes, examine their role in catalysis and study their photochemical reactivity by NMR in quantitative, data-rich experiments. 2. Reaction monitoring on micro-second timescales by nuclear magnetic resonance: Postdoctoral Research Fellow in theoretical nuclear magnetic resonance w/ Professors Simon Duckett, Robin Perutz Applications are invited for a postdoctoral research fellow to develop the theoretical basis of NMR in order to allow fast reactions to be followed with parahydrogen. The position is tenable for a period of 2 years in the first instance and available from the 15th of April The post holder requires an excellent theoretical appreciation of NMR spectroscopy. He/she will be located in the York Centre for Hyperpolarisation in Magnetic Resonance and in the Department of Chemistry. In chemistry, laser irradiation methods have provided the means to study the evolution of many chemical systems. In proof-of-principle experiments, we have shown that it is possible to record NMR spectra on milli and microsecond timescales. We seek here to develop a method for using NMR to follow fast reactions using parahydrogen. The post holder will develop a theoretical framework to account for the evolution of parahydrogen-derived magnetisation after the photochemical addition of parahydrogen to a metal complex. He/she will then make measurements in conjunction with a second Postdoctoral Research Fellow to test their conclusions, and ultimately seek to produce NMR spectra that encode reaction rate information on timescales down to microseconds. The new methods will be used to study catalysis. 3. Postdoctoral research fellow exploring MRI and SABRE w/ Professors Simon Duckett, Gary Green Applications are invited for a postdoctoral research fellow to work in the York Centre for Hyperpolarisation in Magnetic Resonance on the development of SABRE methods for MRI. The position is tenable for a period of 3 years and available from the 15th of April The successful candidate will be responsible for the development of SABRE based methods to probe blood flow, the blood-brain barrier, cellular function and cellular metabolism in vivo. The post holder requires a good practical knowledge of MRI. 4. Postdoctoral research fellow in the synthesis and MRI detection of labelled materials w/ Professors Simon Duckett, Gary Green Applications are invited for a postdoctoral research fellow to work in the York Centre for Hyperpolarisation in Magnetic Resonance on the synthesis of labelled materials for subsequent use in imaging studies. The position is tenable for a period of 3 years and available from the 15th of April The successful candidate will be responsible for the synthesis of a range of organic and inorganic systems that are enriched in NMR active nuclei. As part of this work they will be involved in aspects of the development of imaging agents for MRI. The post holder requires a good practical knowledge of organic synthesis and a familiarity with NMR. For all four positions: Salary will be within the range: 29,541 to 36,298 per annum and closing date: 11th March For further details see or type&p_class_value=research&p_title=research%20jobs

5 OTHER OPPORTUNITIES Courage Compassion Connection Commitment E4C is a non-profit human service agency whose mission is to limit, alleviate and ultimately end poverty. Our service philosophy and focus are targeted to address fundamental causes of vulnerability for children, youth, families, individuals and communities. We focus our work in four main areas: Food Security, Housing and Shelter, Education and Skill Development, and Community and Connection. Position Available: Board of Directors (Volunteer Community Representative) E4C Board of Directors: Establishes and monitors E4C's values, ethical and moral culture Establishes, approves and monitors E4C's mission, vision and strategy Develops and approves E4C's Board policies that address areas of organizational decision-making Assesses and assures performance of the E4C Chief Executive Officer Monitors E4C management control systems, including financial systems, assuring that assets are protected and potential risks to the E4C organization are identified and managed Promotes and supports the E4C organization and its purpose Assures E4C governance effectiveness and takes actions as necessary to continuously improve its governance. Board Members: Term: Actively support E4C's mission, values and philosophy Understand governance role of Board Participate in decision-making based on a consensus building model Understand large multi-dimensional, charitable organizations Attend and participate in all Board meetings Attend and participate in all Board orientation, training, planning and evaluation sessions Perform work on behalf of the Board in between Board meetings, whether as a participant on a Board sub-committee or independently Prepare in advance of meetings by reviewing materials related to the agenda Act professionally when dealing with one another, with the Chief Executive Officer, staff, volunteers, service users and other stakeholders Have a cooperative and collaborative working style. Board members are elected at the Annual General Meeting to a term of three years with an option for re-election to a maximum of two additional three-year terms.

6 OTHER OPPORTUNITIES, continued Qualifications & Skills of Interested Candidates: Knowledge, insight and interest: o Understand community perspective o Support E4C s mission, values and philosophy o Reflect community interest o Grasp current social issues and trends o Understand large multi-dimensional charitable organizations o Understand governance role of Boards o Understand ambassadorial and advocacy roles of Boards o Have sufficient time available and are willing to commit to Board duties and activities. Knowledge/skills in the following areas would be an asset: o Financial accounting/management o Scientific/technological expertise o Grasp of social justice and legal rights Applications: Individuals interested are invited to submit their resume by 4:30 P. M on March 15, 2013 to: Patricia Bounds, Nominations Chair c/o Jasmine Monaghan, Executive Assistant 9321 Jasper Avenue Edmonton AB T5H 3T7 Phone: ext. 153 Fax: bassistant@e4calberta.org