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1 Introduction Welcome to The best global medical research and review information with a reputation for clinical excellence. The Lancet has a prestigious heritage as one of the world s leading independent medical journals. It is renowned as a major contributor to health and medical research worldwide. When Thomas Wakley founded The Lancet in 1823, he announced A lancet can be an arched window to let in the light or it can be a sharp surgical instrument to cut out the dross and I intend to use it in both senses. This philosophy remains at the heart of the The Lancet today. Harness the power of our new platform \\ The Lancet has a fantastic new launching off point for a new generation of users, in ways that are completely unprecedented for all of us. - Dr Richard Horton, Editor-in-Chief & Publisher, The Lancet In October 2008 we launched The Lancet.com: leading content for a new generation of users. Applying the same rigour to developing our new website that we apply to publishing our content, we worked with development partners around the globe to create a unique, global platform for medical information with a wealth of commercial channels. Reach our influential, high earning users Advertisers can reach the 1.85 million registered users that engage with and explore a range of opportunities to partner with our influential global brand. Target our users with surgical precision With a vast array of specialist amongst our users, you can tailor campaigns with specialised site wide targeting to get a detailed return on investment. Associate your brand with our trusted service We aim to build the world s leading independent forum for the exchange of information and ideas by the global medical community. You can harness the power of that forum to engage with our influential users.

2 Introduction Fast and engaging Deliver your campaign through our engaging interface and communicate alongside a host of interactive media Feedback from clinicians and researchers has driven everything we have done with the new site. Fewer clicks to get to the content you need. Dynamic tabbing system minimises navigation and provides increase exposure and impact for display adverts. Clean, attractive interface and alerting services Pulls users into the content and encourages registration. Search engine optimised The most relevant and current content appears in the top results on Google and other search engines. Video and audio channels Rich multimedia content to provide new context and greater depth.

3 Planning your campaign Plan your campaign The Lancet.com is a first port of call for cutting-edge medical developments. Expose your brand to a receptive audience in a truly dynamic environment. Precise targeting offers advertisers a fantastic opportunity to reach the right people in the right places. As home to four of the highest ranked clinical journals in the world, is a magnet site for the world s medical community, attracting over 1.8 million individual registered users since launch. Thanks to the information we hold about our users, we can offer advertisers bespoke targeting for each campaign they run with us. \\ You ve got enough stress in your life. So when things are easier, you appreciate the fact that it s quick and simple. - Dr Anne Szarewski, Clinical Consultant, Cancer Research UK, commenting on the all-new Target by content In addition to the weekly general medical journal, The Lancet, is also home to speciality journals in the fields of neurology, oncology and infectious diseases. You can target your campaign to a particular journal. Target by location If your campaign covers just one country, then we can ensure that your ad is only seen by people in that country. Target Article Collections Reach your chosen speciality by targeting adverts around new collections of original research, expert comment, and authoritative review. Target by medical speciality Choose from 45 different medical specialities to ensure that your ad is seen by site users for whom it is guaranteed to be relevant. From Allergists to Urologists, has it covered. Target by work-setting Our users work in a variety of settings, from private practice to research institutes. Pick those of greatest relevance to your campaign. Target by user search results Reach users that are actively engaging in research in your chosen area by targeting to specific search terms.

4 Making an impact High impact display For maximum standout and strong click-through \\ No more fighting over prime advertising positions! Buying print ads means having to fight for impact: will your ad appear in a cover position? or at least in the first quarter or first half? Will you get a right-hand page? But every advertiser on is guaranteed a prime position: There is just 1 Leaderboard and 1 Skyscraper on each page, so your ad is guaranteed to make a strong impact on everyone viewing any page on which it appears. potential. Leaderboard position available across the entire site Skyscraper position available across the journal pages Premium homepage exposure with our Boombox position Perfect for delivering high impact video content in parallel with The Lancet.com s video and audio channels Premier home page Multiple Purpose Unit

5 E-alert Advertising \\ Benefits Advertising on these E-ToCs ensures that your message will reach thousands of respected decision makers. Spaces are available each week on The Lancet E-ToC, or on a monthly basis on The Lancet specialty E-ToCs if you wish to target oncologists, neurologists or infection specialists When you advertise in The Lancet you are associating your brand with our own and with its brand values: medical excellence & clinical relevance Advanced statistics are available to E-ToC advertisers. We can identify who has opened the and who has responded to it; we can even identify which articles have been read It is not just the E-ToCs flexibility that makes them so appealing, it is also their targeting features. Our technology enables you to directly reach your target audience through their in-box and increase response rates Deliver your message to our subscribers in-box There are now even more opportunities for advertisers to target the 83,877 subscribers who have already signed up to our regular alerts. This electronic Table of Contents (E-ToC) enables subscribers to save time by simply clicking straight through to a specific article of interest in the latest edition on Currently there are 83,877 subscribers. An E-ToC is produced for all four of The Lancet journals and advertising space is available on each of them. The E-ToCs mirror the layout of and provide a high-impact environment for your advertising. There are two advertising spaces available. 60 words plus a link 160 x 600 pixel skyscraper banner E-ToC advertising gives your message a high impact and is a great way to reinforce your advertising on www. One commercial advert per E-ToC

6 Advertising Specifications Display Advertising E - Table 0f Contents Banner advertising specification Pixel dimensions Leaderboard 728 x 90 Skyscraper 160 x 600 MPU 336x280 file names dos lowercase graphics format Flash/gif/jpg Maximum File Size 60K For integration with our Ad Server, the ClickTag variable must be inserted within the Flash files action script. E- Table Of Content Specifications 60 words of text and one URL link or animated Gif display advert. No Flash files Pixel dimensions Skyscraper 160 x 600 Maximum file size 50k Animations limited to 3 rotations before resting on a single frame. Contact For further information and bookings Martin Sibson Business Development Executive Tel +44 (0) Fax +44 (0) m.sibson@elsevier.com Sarah Cahill Business Development Executive Tel +44 (0) Fax +44 (0) s.cahill@elsevier.com Expandable banners are availiable subject to Editorial approval. Expandable Rich Media Creatives must be click initiated. Mandatory close button required. Audio and video within adverts must be user initiated and are subject to editorial approval. All bookings are subject to The Lancet conditions of acceptance.

7 Terms & Conditions Advertising orders are subject to written confirmation and will only be accepted on condition that the advertiser warrants that the advertisements supplied do not contravene the Trade Description Act 1968, the Race Relations Act 1968 or the ABPI Code of Practice/ FDA Guidelines. Accounts are strictly net and are subject to satisfactory reference. All invoices must be settled within 30 days of receipt. All copy is subject to the approval of the publishers. The publishers reserve the right to reject any advertisement not of direct interest to the readership or not in keeping with the scientific and ethical standards of the publication. Cancellations must be received in writing no later than six weeks before publication date. Advertisers failing to comply with these requirements will be liable for payment of the full space booked. If the advertiser cancels part of the series booking, all unearned discounts will be surcharged. If the copy instructions have not been received by the stated deadline, existing material may be repeated and the advertisers will be liable for payment of the full space booked. Advertiser s material is held at the owner s risk and should be insured by them against fire, loss or damage. Material will be held for twelve months and then destroyed unless return is requested. The publishers will not be liable for any loss occasioned by the failure of any advertisement to appear, nor do they accept liability for printer s errors, although every care is taken to avoid mistakes. All freight and import charges incurred in sending material for publication and all costs incurred because of failure to comply with mechanical specifications will be charged to the advertiser. The advertiser will indemnify and protect the publishers from any claims or actions against them arising from unauthorised, inaccurate or libellous statements appearing in advertising material.

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