一 得獎與榮譽事蹟 : 斐陶斐榮譽會員 2. Moderator: The 6th Pan Pacific Symposium on Stem Cells and Cancer Research (2013) 二 文獻發表 :

Transcription

1 部門 : 1. 中國醫藥大學北港附設醫院教學研究部助理研究員 2. 台南市立安南醫院 - 委託中國醫藥大學興建經營 個人資料 教學研究部助理研究員 姓名 : 詹子民 性別 : 男 學術專長 : 再生醫學 新藥開發 醫學計劃撰寫與管理 人體臨床試驗計畫 分子生物學 基因調控 系統生物學 發育生物學 聯絡方式 : cell phone: ; T70704@mail.tmanh.org.tw 學歷 學校名稱起訖年月學位科系 清華大學 91/09~97/12 博士生物科技研究所 中興大學 89/09~91/07 碩士生物化學 靜宜大學 84/09~89/07 學士應用化學 經歷 ( 請按服務時間先後順序填寫與現提計書有關之經歷 ) 服務機構及單位職稱起訖年月 現任 : 長弘生物科技曾任 : 國家衛生研究院 研發部主任 101/12~ 至今 博士後研究員 98/08 至 101/11 畫執行中之相關研究計 計畫名稱 Cerebraca Wafer 用於惡性腦瘤治療之臨床前期開發計畫計畫編號 : 102-EC-17-A-19-I1-0051; NT: 55,000,000 以上皮 - 間質轉換之基因為標靶開發抑制肝纖維化之 phthalide 藥物 一 得獎與榮譽事蹟 : 斐陶斐榮譽會員 2. Moderator: The 6th Pan Pacific Symposium on Stem Cells and Cancer Research (2013) 二 文獻發表 : 計畫內擔任工計畫支援機起訖年月作關主持人經濟部 2013/06~ 2014/11 協同主持人 國科會 2013/08~ 2014/07 1

2 1. Hui-Ping Lin, Ru-Huei Fu, Chih-Pin Chuu, Shao-Chih Chiu, Tzu-Min Chan *, Shinn-Zong Lin *. Clinical Applicability of Adipose Derived Stem Cells in Type 1 Diabetes Mellitus. Stem Cells Translational Medicine (SCI) (under review). 本人為通訊作者. 2. Tzu-Min Chan, Hui-Ping Lin, Demeral David Liu, Horng-Jyh Harn, and Shinn-Zong Lin. Transplantation of Olfactory Ensheathing Cells to Relieve the Symptoms of Spinal Cord Injury. Tzu Chi Medical Journal. (under review). 本人為第一作者. 3. Tzu-Min Chan, Hui-Ping Lin and Shinn-Zong Lin. In Situ Altering of the Extracellular Matrix to Direct Endogenous Stem Cells Programming. Stem Cells Mar 2. doi: /stem [Epub ahead of print] 本人為第一作者. (SCI, Impact Factor: 7.701; Ranking: 2012: 8/160 (5%) (Biotechnology & Applied Microbiology)) 4. Mao-Hsuan Huang, Shinn-Zong Lin, Po-Cheng Lin, Tzyy-Wen Chiou, Yeu-Wei Harn, Li-Ing Ho, Tzu-Min Chan, Chih-Wei Chou, Chang-Han Chuang, Hong-Lin Su, Horng-Jyh Harn, Brain tumor senescence might be mediated by downregulation of S-phase kinase-associated protein 2 via butylidenephthalide leading to decreased cell viability. Tumour Biol Jan 26. [Epub ahead of print] (SCI, Impact Factor: 2.56) 5. Tzu-Min Chan, Horng-Jyh Harn, Hui-Ping Lin, Pei-Wen Chou, Julia Yi-Ru Chen, Tsung-Jung Ho, Tzyy-Wen Chiou, Hong-Meng Chuang, Shao-Chih Chiu, Yen-Chung Chen, Ssu-Yin Yen, Mao-Hsuan Huang, Bing-Chiang Liang, Shinn-Zong Lin. Improved Human Mesenchymal Stem Cells Isolation. Cell Transplantation 2014; 23(4): 本人為第一作者. (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 6. I-Chen Li, Yu-Chia Chen, Yi-Yun Wang, Bo-Wei Tzeng, Chun-Wen Ou, Yi-Yan Lau, Kan-Mai Wu, Tzu-Min Chan, Wei-Hsiang Lin, Sheng-Ping L Hwang, Wei-Yuan Chow. Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2α Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells. PLoS ONE 2014; 9(5):e (SCI, Impact Factor: 3.73; Ranking: 7/56=12.5% (multidisciplinary sciences)). 7. Tzu-Min Chan, Horng-Jyh Harn, Hui-Ping Lin, Shao-Chih Chiu, Po-Cheng Lin, Hsin-I Wang, Li-Ing Ho, Chih-Pin Chuu, Tzyy-Wen Chiou, An-Cheng Hsieh, Yu-Wen Chen, Wen-Yu Ho, Shinn-Zong Lin. The Use of ADSCs as a Treatment for Chronic Stroke. Cell Transplantation 2014; 23(4): 本人為第一作者. (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 8. Tsung-Jung Ho, Li-Ing Ho, Kuo-Wei Hsueh, Tzu-Min Chan, Shih-Li Huang, Jaung-Geng Lin, Wen-Miin Liang, Wei-Hung Hsu, Horng-Jyh Harn, Shinn-Zong Lin. Cell Transplantation 2014; 23(4): (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 9. Tsung-Jung Ho, Tzu-Min Chan, Li-Ing Ho, Ching-Yuan Lai, Chia-Hsien Lin, Iona MacDonald, Horng-JyhHarn, Shinn-Zong Lin and Yi-Hung Chen. The Possible Role of Stem Cells in Acupuncture Treatment for Neurodegenerative Diseases: a Literary Review of Basic Studies. Cell Transplantation (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 2

3 10. Shao-Chih Chiu, Hao-Yu Chung, Der-Yang Cho, Tzu-Min Chan, Ming-Chao Liu, Hiang-Ming Huang, Tsyng-You Li, Jian-Yong Lin, Pei-Chang Chou, Ru-Huei Fu, Wen-Kuang Yang, Horng-Jyh Harn, Shinn-Zong Lin. Therapeutic potential of MicroRNA let-7: tumor suppression or impeding normal stemness. Cell Transplantation 2014; 23(4): (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 11. Hueng-Chuen Fan, Li-Ing Ho, Shyi-Jou Chen, Giia-Sheun Peng, Shinn-Zong Lin, Tzu-Min Chan, Chang-Han Chuang and Horng-Jyh, Harn. Polyglutamine (polyq) diseases: genetics to treatments. Cell Transplantation 2014 (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 12. Tzu-Min Chan, Julia Yi-Ru Chen, Li-Ing Ho, Hui-Ping Lin, Kuo-Wei Hsueh, Demeral David Liu, Yi-Hung Chen, An-Cheng Hsieh, Nu-Man Tsai, Dueng-Yuan Hueng, Sheng-Tzeng Tsai, Pei-Wen Chou, Shinn-Zong Lin, Horng-Jyh Harn. Cell transplantation 2014; 23(4): 本人為第一作者. (SCI, Impact Factor: 4.422; Ranking: 2012: 4/26 (15.38%) (Transplantation)) 13. TM Chan, HJ Harn, TW Chiou, SZ Lin (2013, Apr). Developing New Small Molecular Drugs for Prostate Cancer Therapy. Journal of Cancer Therapy, 4, 本人為第一作者. 14. TM Chan, SZ Lin, TW Chiou, HJ Harn (2013, Feb). NR4A1 (nuclear receptor subfamily 4, group A, member 1). Jean-Loup Huret (Editor-in-Chief); INISTCNRS (Publisher). 本人為第一作者. 15. CH Chao, WF Tseng, TM Chan, HL Chen, CB Huang, TH Jang, HY Hsu, HD Wang, CH Yuh. Mesendoderm gene regulatory networks in zebrafish. Global Journal of Biochemistry Dec;2(4): Tzu-Min Chan, Kuo-Chang Chu, Chiaw-Hwee Lim, Yun-Jin Jiang, Udu and its homologs, Udu2 and Gon4l, may have similar functions in DNA replication SPRINGER. 本人為第一作者. 17. Yu-Shan Huang, Tzu-Min Chan, Yun-Jin Jiang, Sih-Hua Pao, Arthur Chiou. IN VIVO THREE-DIMENSIONAL TIME-LAPSED STUDIES OF Udu DEFICIENT ZEBRAFISH EMBRYOGENESIS BY SINGLE PLANE ILLUMINATION MICROSCOPY (SPIM) Tzu-Min Chan, William Longabaugh, Hamid Bolouri, Hua-Ling Chen, Wen-Fang Tseng, Chung-Hao Chao, Te-Hsuan Jang, Yu-I Lin, Shao-Chin Hung, Horng-Dar Wang, Chiou-Hwa Yuh (2009, Apr). Developmental gene regulatory networks in the zebrafish embryo. Biochim Biophys Acta Apr;1789(4): 本人為第一作者. (SCI, Impact Factor: 5.456; Ranking: 17/283 (6%) (Biochemistry)) 19. Tzu-Min Chan, Chung-Hao Chao, Horng-Dar Wang, Yen-Ju Yu, Chiou-Hwa Yuh (2009, Feb). Functional analysis of the evolutionarily conserved cis-regulatory elements on the sox17 gene in zebrafish. Dev Biol Feb 15;326(2): 本人為第一作者. (SCI, Impact Factor: 3.868; Ranking: 8/57 (14%) (Developmental Biology)) 3

4 三 研討會報告及論文 : 1. Chan, T.M. and Jiang, Y.J.*, The roles of Udu and its homologs in development, Notch signaling pathway and DNA replication, Taiwan Zebrafish PI meeting, August 24 th, Huang, Y.S., Chan, T.M., Jiang, Y.J., Pao, S.H., and Chiou, A.*, In Vivo Three-Dimensional Time-Laosed Studies of Udu Deficient Zebrafish Embryogenesis By Single Plane Illumination Microscopy (SPIM) Taiwan Zebrafish Developmental Biology Meeting (Oral), Academia Sinica, Taipei, Taiwan, August 17, Chan, T.M., Lai, L.W., Chu, K.C., and Jiang, Y.J.*, The roles of Udu and its homologs in hematopoiesis, DNA replication and Notch Taiwan Zebrafish Developmental Biology Meeting (Oral), Academia Sinica, Taipei, Taiwan, August 17, Yuh, C.H.*, Tseng W.F., Chan T.M., Jang T.H., Huang C.B., Insights into Endoderm Gene Regulatory Networks and evolutionary conservation, 43 rd Annual Meeting for the Japanese Society of Developmental Biologists Jointly Sponsored by the Asia-Pacific Developmental Biology Network (Invited Speaker), Kyoto, Japan June 20-23, Chan T.M., Tseng W.F., Chao C.H., Wang H.D., Yu Y.J., Jang T.H., Huang C.B. and Yuh, C.H.*, Establish the gene regulatory networks for endoderm formation in zebrafish, 4th Asian-Oceanic Zebrafish Meeting (Oral), Jeju, Korea, August 31-September 2, Chan T.M., Tseng W.F., Chao C.H., Wang H.D., Yu Y.J., Jang T.H., Huang, C.B. and Yuh, C.H.*, The Gene Regulatory Subcircuits of sox32 and sox17 and Evolutionary Conserved Kernel of gata5, gata6 and otx2 for Mesendoderm Development in Zebrafish, Taiwan's recent development of biology-the 25 th Biology Summer Camp (Oral), NanTou, Chi-Tou, Taiwan. August 19-21, Chan, T.M., Longabaugh, W., Bolouri, H., Chen, H.L., Tseng, W.F., Chao, C.H., Jang, T.H., Lin, Y.I., Hung, S.C., Wang H.D. and Yuh, C.H.*, Developmental Gene Regulatory Networks in the Zebrafish Embryo, 2008 Women in Marine Science & Biotechnology Academic Conference and Career Development (Invited Speaker), Taipei, Taiwan, October 27-28, Chan, T.M., Wang H.D. and Yuh, C.H.*, The Endoderm Gene Regulatory Networks: Subcircuits of sox32 and sox17 in Zebrafish Development, 9th International Conference on Systems Biology (Poster), Gothenburg, Sweden, August 23-27, Chan, T.M., Longabaugh W., Bolouri H., and Yuh, C.H.*, Developmental gene regulatory networks (GRNs) of the zebrafish embryo, Gene Networks in Animal Development and Evolution Colloquia (Poster), February 14-16, Chan, T. M., Chen, H. L., Tseng, W. F., Chao, C. H., Jang, T. H., Lin, Y. I., Hsu, H. I., Huang, C. B. and Yuh, C.H.*, The Transcriptional Regulatory Networks of the Zebrafish Endoderm, Symposium of Bioinformatics and Systems Biology in Taiwan (invited speaker), September 4~5, Chan, T. M., Chen, H. L., Tseng, W. F., Chao, C. H., Jang, T. H., Lin, Y. I., Hsu, H. I., Huang, C. B. and Yuh, C.H.*, Systematically decipher the genomic 4

5 regulatory networks for early embryogenesis in Zebrafish, The Sixth across the Taiwan Strait Symposium on Cell Biology (invited speaker), May 19~21, Chan, T. M., Jang, T. H., Wang, H. D. and Yuh, C.H.*, Mapping Mesendoderm Gene Regulatory Network in Zebrafish, Keystone Symposia on Systems Biology: Integrating Biology, Technology and Computation (poster), Taos, New Mexico, USA, March 5-10, Chan, T.M., Jang, T.H., Wang, H.D., and Yuh, C.H.*, Mapping Embryonic Gene Regulatory Network in Zebrafish, the 21 st Joint Annual Conference of Biomedical Science. (Oral) Taipei, March 19, Chan, T.M., Jang, T.H., Wang, H.D., and Yuh, C.H.*, Mapping Embryonic Gene Regulatory Network in Zebrafish. The 21 st Joint Annual Conference of Biomedical Science. (Selected oral presentation) Taipei, March 19, Jang, T.H., Lin, Y.I., Chen, H.L., Tseng, W.F., Chan, T.M., Davidson, E.H. and Yuh, C.H.*, Systematic Approach to Transcriptional Regulation: Establish the Gene Regulatory Network for Endoderm Differentiation in Sea Urchin, Zebrafish and Colorectal Cancer, Taiwan-India joint symposium on functional genomics, (invited speaker) India, New Delhi., October 20-21,2005. 四 教學經驗 : 1. Teaching assistant for Workshop #1, 2, 3 and 4 at 3 rd Taiwan Zebrafish Core Facility Workshop, August 4-31, 2012 (In English) 2. Teaching assistant for Workshop #1, 2 and 3 at 2 nd Taiwan Zebrafish Core Facility Workshop, August 12- September 2, 2011 (In English) 3. Teaching assistant for Workshop at 1 st Taiwan Zebrafish Core Facility Workshop, July 19-23, 2010 (In English) 5