Product Catalogue From cell counting to diagnostic Tool & solution provider

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1 Product Catalogue From cell counting to diagnostic Tool & solution provider

2 NanoEnTek Inc. (HQ) 12F, 5, Digital-ro 26-gil, Guro-gu, Seoul, , Korea Tel : Fax : NanoEnTek USA Inc Stoneridge Drive Suite 304, Pleasanton, CA 94588, USA Tel : , (Toll free) Fax : sales@nanoentek.com

3 Contents About NanoEnTek Company Overview Our History Partnership & Global Networks Life Science Research Cell Counting EVE C-chip ADAM-MC ADAM-SCC Cell Imaging JuLI Br JuLI FL Cell Assay LuBi Others Multi mixer Clinical Diagnostics Residual WBC Counting ADAM-rWBC In Vitro Diagnostics FREND System Sample Banking isbs Product Profile Ordering Information

4 Company Overview NanoEnTek Inc., devoted to R&D for the last 13 years, develops and manufactures automated life science research and on-site diagnostic products utilizing core technology, Lab-on-a-chip. Outstanding experts in the fields of biomedical engineering, bio-mems (Micro-Electro-Mechanical Systems), electronics, chemistry, and optics. NanoEnTek Inc. (KOSDAQ: ) aims to overtake the market leader in biotechnology, nanotechnology, and information technology field. 4

5 Our History -Founding of company research institute as academic venture in Seoul National University -International launch of the disposable hemocrytometer, C-chip and the automatic cell counter, C-Reader -Establishment of NanoEnTek USA Inc (Boston, MA) -Establishment of production factory (Hwasung, Korea) -Strategic alliance with SK Telecom for Global Healthcare Business -Co-operate with SKC Co., Ltd -International launch of the electroporation device, MicroPorator system -Manufacture and supply contract with Life- Technologies -Licensing-out of the gene transfection technologies to Life Technololgies -International launch of the smart fluoresence image viewer, JuLI -FDA 510k clearance of ADAM-rWBC -International launch of the live cell movie analyzer, JuLI Br FDA 510k clearance of PSA diagnostic kits and Frend system -International launch of the automatic cell counter, EVE and the fluorescence live cell movie analyzer, JuLI FL -Relocation of NanoEnTek USA Inc. (Pleasanton, CA) Copyright 2014 NanoEnTek Inc. All rights reserved. 5

Partner Ship & Global Networks Accelerate an effort to secure a global sales network to hold partnership

a global distribution network with 45 nations.

development supply contract Secure sales network through partnership with international global companies

6 Partner Ship & Global Networks Accelerate an effort to secure a global sales network to hold partnership with world s largest biomedical device production and distribution company Life Technologies and to secure a global distribution network with 45 nations : Countess supply contract (5 yr) : Microporator patent sold Global Market : New product development supply contract Secure sales network through partnership with international global companies Hold distribution network with 45+ nations - R&D investment - Co-establish international business within company - Marketing cooperation - ICT technology cooperation 6

7 Life Science Research Outline Cell Counting Cell Imaging Cell Assay Others

Cell Counting Life Science Research EVE Automatic Cell Counter EVE TM uses state-of-the-art optics and image analysis to automate cell counting.

8 Cell Counting Life Science Research EVE Automatic Cell Counter EVE TM uses state-of-the-art optics and image analysis to automate cell counting. The EVE is a benchtop counter, designed to measure cell count and viability (live, dead, and total cells) accurately and precisely, using the standard trypan blue technique. Features - Fine distinction of clumped cell - Cell size gating - Data storage & analysis - No need to maintenance - Bench top size & LCD touch screen Applications - Cell viability (%) - Total cell counting - Cell concentration measurement - Data analysis with graphical reports Specifications Power AC 100 ~ 240 V, 50 ~ 60 Hz Measuring range 1 x 10 4 ~ 1 x 10 7 cells/ml Size 270 (W) 200 (L) 190 (H) mm Optimal measuring range 1 x 10 5 ~ 4 x 10 6 cells/ml Weight 2.1 kg Cell size range 5 ~ 60 µm Display 7 LCD touch screen Analysis time < 20 sec/test Data storage USB drive (4 GB) Loading sample volume 10 µl (EVE TM counting slide) Data format JPEG (image), CSV (raw data) Staining solution Trypan blue stain 8

Cell Counting C-Chip The World s First True Disposable Hemocytometer A precision disposable plastic hemocytomer, developed to solve the problems of conventional glass hemocytomer.

9 Cell Counting C-Chip The World s First True Disposable Hemocytometer A precision disposable plastic hemocytomer, developed to solve the problems of conventional glass hemocytomer. Life Science Research Features - No need to coverslips - No need to wash for reuse - No more contact to hazardous materials (e.g., AIDS patient blood, urine) - Accurate and reliable - Quartz grade optical plastic Applications - Blood analysis(hematology): Blood cell counting - Cell culture: Cell concentration measurement, Cell viability test - Microbiology: Bacterial & fungus spores counting - IVF, IUI: Sperm counting Specifications Size 25 (W) x 75 (L) x 1.6 (T) mm Cat. No. Grid Depth Type 5 grid types DHC-N01 Neubauer Improved 100 µm Loading sample volume 10 µl (DHC-N01, B01, B02) 20 µl (DHC-F01, M01) DHC-F01 DHC-B01 Fuchs-Rosenthal Bürker 200 µm 100 µm DHC-B02 Bürker-Türk 100 µm DHC-M01 Malassez 200 µm Copyright 2014 NanoEnTek Inc. All rights reserved. 9

10 Cell Counting Life Science Research ADAM-MC New Standard of Automatic Cell Counter The ADAM-MC automated cell counter performs viability and cell counting measurements using the PI staining method of dead-cell staining combined with advanced image analysis. Features - Automatic image analysis - Accurate result - Sensitive CCD detection - Precise automatic stage - Auto focusing - No need of calibration Applications - Cell viability (%) - Total cell counting - Cell concentration measurement - Data analysis (PC software) Specifications Power AC 100 ~ 240 V, 50 ~ 60 Hz Measuring range 5 x 10 4 ~ 4 x 10 6 cells/ml Size Weight 220 (W) 375 (L) 250 (H) mm 9.0 kg Analysis time 45 sec/test (AccuChip 2X) 2 min/test (AccuChip 4X) Objective lens Light source Camera Filter 4 X Green LED B/W CCD Excitation, Emission, Dichroic filter Loading sample volume Measuring sample volume Staining solution 20 µl/test (AccuChip 2X) 12 µl/test (AccuChip 4X) 8.5 µl/test (AccuChip 2X) 3 µl/test (AccuChip 4X) PI (Propidium Iodide) 10

11 Cell Counting ADAM-SCC Compact Somatic Cell Counter ADAM-SCC counts somatic cell to determine raw milk quality with unique image cytometer technology. ADAM-SCC designed for using in research field, milk manufacturing facility and even dairy farm with it s compact and high stability structure. Life Science Research Features - Easy to use (Loading & counting) - Small & compact design - No need of calibration - Low maintenance cost - High accuracy with unique image cytometer technique Applications - Counting somatic cells - Raw milk quality control Specifications Power AC 100 ~ 240 V, 50 ~ 60 Hz Measuring range 0 ~ 1 x 10 7 cells/ml Size Weight 220 (W) 375 (L) 250 (H) mm 9.0 kg Analysis time 45 sec/test (SomaChip 2X) 2min/test (SomaChip 4X) Objective lens Light source Camera Filter 4 X Green LED B/W CCD Excitation, Emission, Dichroic filter Loading sample volume Measuring sample volume Staining solution 20 µl/test (SomaChip 2X) 12 µl/test (SomaChip 4X) 8.5 µl/test (SomaChip 2X) 3 µl/test (SomaChip 4X) PI (Propidium Iodide) Copyright 2014 NanoEnTek Inc. All rights reserved. 11

Cell Imaging Life Science Research JuLI Br Live Cell Movie Analyzer Increasing number of researchers are using live-cell imaging to study cellular functions.

12 Cell Imaging Life Science Research JuLI Br Live Cell Movie Analyzer Increasing number of researchers are using live-cell imaging to study cellular functions. The JuLI TM Br, a smart bright-cell movie analyzer, was developed to enable a variety of biological experiments for live cell imaging. Features - Capturing time-lapse images & making movie - Automated quantitative cell confluence analysis - Real-time cell growth curve color LCD touch screen - Semi-auto focusing using LCD interface - Double scopes available (optional) Applications - Cell confluence analysis - Real time cell growth curve - Cell migration assay - Cell viability & total cell counting (optional) Specifications Power AC 100 ~ 240 V, 50 ~ 60 Hz Display 10.1 LCD touch screen Size Scope 300 (W) 190 (L) 188 (H) mm Station 282 (W) x 285 (L) x 160 (H) mm Data storage Hard drive (320 GB) USB drive (4 GB) Weight Scope 4.0 kg Station 3.2 kg Data format JPEG (image), AVI (movie), CSV (raw data) Objective lens Light source Camera 4 X & digital zoom White LED CMOS (5 M pixels, 2560 x 1920) Operation temperature Maximum relative humidity 5 ~ 40 C 20 ~ 95 % 12

13 Cell Imaging JuLI FL Fluorescence Live Cell Movie Analyzer The JuLI TM FL, the fluorescence live cell movie analyzer, with the states-of-the-art optics enables uers to perform the image capturing and the time-lapse movie making. It also can support cell counting and measuring the level of flourescence expression. Life Science Research Features - Different scopes share one station - Quantitative analysis of GFP/ RFP expression level check - Sensitive image resolution - Capturing bright, fluorescence, and merged image at the same time Applications - Cell growth monitoring - Cell confluence detection - Cell migration assay - Cell culture quality control - Proliferation assay - Cell viability & total cell counting Specifications Power Size AC 100 ~ 240 V, 50 ~ 60 Hz Scope 300 (W) 190 (L) 188 (H) mm Station 282 (W) x 285 (L) x 160 (H) mm Data format Operation temperature JPEG, TIFF, BMP, PNG (image) AVI (movie), CSV (raw data) 5 ~ 40 C Weight Scope 4.5 kg, Station 3.2 kg Maximum relative humidity 20 ~ 95 % Objective lens 4 X & digital zoom Counting time < 10 sec/test Camera CMOS (1.3M pixels, 1280 x 960) Cell measurement range 1 x 10 4 ~ 1 x 10 7 cell/µl Display 10.1 LCD touch screen Optimal measurement range 1 x 10 5 ~ 4 x 10 6 cell/µl Data storage Hard drive (320 GB), USB drive (4 GB) Cell size range 5 ~ 60 µm Sample volume 10 µl Copyright 2014 NanoEnTek Inc. All rights reserved. 13

14 Cell Assay Life Science Research LuBi Microplate Luminometer A luminometer designed to measure luminous cells. The high sensitivity and reproducibility of LuBi allow researchers to get accurate laboratory results in cell related researches. Features - Easy to control hardware & software - Compatible with any type of plate and reagents - Accurate and reliable data - Superior sensitivity & unsurpassed dynamic range - Intuitive & flexible interface - Internal auto-injection system integration Applications - Cell viability, proliferation, cytotoxicity, signaling - Cellular luminescence - DNA/RNA quantitation - Environmental toxicity - Apoptosis, ATP, aequorin-based, report gene assay Specifications Power AC 85 ~ 264 V Limit of detection 3 x moles Size 561 (W) 544 (L) 275 (H) mm Linear dynamic range < 5 x 10 6 Weight 28.6 kg Crosstalk (with white plate) < 3 X 10-5 Detector PMT (Photomultiplier tube) Spectral response range 350 ~ 650 nm Peak wavelength 420 nm Injection volume 25 ~ 300 µl Injector precision CV < 1 % Injection increment 1 µl 14

15 Others Multi Mixer All-in-One Rotate System One device that functions Mixer, Rotator, Voltex and Bead beator. Life Science Research Features - One touch dial-control - Cold room & incubator compatible - 15 different programs (6 Rotator, 5 Mixer, 2 Vortex, 2 Bead beater) - Inter-changable 4 different racks (Optional racks for 1.5 ml, 15 ml and 50 ml tube) Applications - Low speed hybridization - Nuclear extract preparation - Immunoprecipitation - Slides washing for array Specifications Power Size Weight Variable rotation speed Speed selection step Timer AC 9VFC, 2000 madc 180 (W) 350 (L) 168 (H) mm 1.62 kg 1 ~ 99 RPM 1 RPM 1 ~ 99 min Copyright 2014 NanoEnTek Inc. All rights reserved. 15

16 Clinical Diagnostics Outline Residual WBC Counting In Vitro Diagnostics Sample Banking 16

Residual WBC Counting ADAM-rWBC New Solution for rwbc counting ADAM-rWBC is an analytical device for counting the number of residual white blood cells (rwbcs) in leukoreduced blood products.

17 Residual WBC Counting ADAM-rWBC New Solution for rwbc counting ADAM-rWBC is an analytical device for counting the number of residual white blood cells (rwbcs) in leukoreduced blood products. The device is to ensure the number of rwbcs and the standards to minimize complications associated with the transfusions performed in hospitals. FDA 510k Cleared MFDS Registered Clinical Diagnostic Features - 3 minutes counting - Accurate and reliable result - Low setup and running cost - Easy-To-Use (Just 3 step) - Automatic image analysis - Sensitive CCD detection Applications - Counting blood product (Red blood cell (RBC pack), Platelet (PLT pack)) - Leukoreduced blood quality control Specifications Power AC 100 ~ 240 V, 50 ~ 60 Hz Measuring range 1 ~ 100 cells/µl Size 220 (W) 375 (L) 250 (H) mm Analysis time 3 min/test Weight 9.0 kg Loading sample volume 100 µl/test (r-slide) Objective lens 4 X Measuring sample volume 57 µl/test (r-slide) Light source Green LED Staining solution PI (Propidium Iodide) Camera B/W CCD Filter Excitation, Emission, Dichroic filter Copyright 2014 NanoEnTek Inc. All rights reserved. 17

In Vitro Diagnostics Clinical Diagnostic FREND System Rapid Quantitative Immunoassay Analyzer Quantitative immunoassay analyzing

FDA 510k Cleared MFDS Registered Registered Features - Accurate & compact - Easy-to-use - Rapid and quantitative immunoassay - Small

Specific Antigen) - TSH (Thyroid-Stimulating Hormone ) - Cardiac Triple (Myoglobin, Troponin I, CK-MB) - BNP (B-type Natriuretic Peptide)

Specifications Power Size Weight Display Data storage AC 100 ~ 240 V, 50 ~ 60 Hz 240 (W) 260 (L) 175 (H) mm 3.

18 In Vitro Diagnostics Clinical Diagnostic FREND System Rapid Quantitative Immunoassay Analyzer Quantitative immunoassay analyzing instrument that utilizes disposable cartridges to provide in vitro diagnostics results for PSA, TSH, BNP and Cardiac Triple, etc. FDA 510k Cleared MFDS Registered Registered Features - Accurate & compact - Easy-to-use - Rapid and quantitative immunoassay - Small sample volume analysis - Innovative microchip technology - Flexible platform for multiple tests Applications - PSA (Total Prostate Specific Antigen) - TSH (Thyroid-Stimulating Hormone ) - Cardiac Triple (Myoglobin, Troponin I, CK-MB) - BNP (B-type Natriuretic Peptide) * CFDA is regested for FREND System. Specifications Power Size Weight Display Data storage AC 100 ~ 240 V, 50 ~ 60 Hz 240 (W) 260 (L) 175 (H) mm 3.5 kg 7 LCD touch screen USB drive (4 GB) Item PSA TSH Cardiac Triple AMR (Analytical measurement range) 0.1 ~ 25 ng/ml 0.1 ~ 25 µiu/ml Myoglobin: 5 ~ 500 ng/ml CK-MB: 1 ~ 80 ng/ml Troponin I: 0.05 ~20 ng/ml Certification FDA 510k Cleared CE, MFDS listing Pending FDA, CE & MFDS - BNP 30 ~ 2500 pg/ml - 18

Sample Banking isbs Innovative Solution to Your Vital Sample Archiving isbs is designed to aliquot and vacuum-seal a sample-filled tube into smaller

saving Applications - Plasma, serum, whole blood cell, buffy coat - Cell suspension, gametes, embryos - Extracted DNA, RNA - Urine, mouth wash -

19 Sample Banking isbs Innovative Solution to Your Vital Sample Archiving isbs is designed to aliquot and vacuum-seal a sample-filled tube into smaller segments by VLS(Vacuum like sealing), and provide clinical/biological information so that they can be pulled and used whenever they are needed for a research or diagnosis. Clinical Diagnostic Features - Freshness and persistency - Systematic collection and simple pulling - Minimum 4 times the usage efficiency - Labor saving Applications - Plasma, serum, whole blood cell, buffy coat - Cell suspension, gametes, embryos - Extracted DNA, RNA - Urine, mouth wash - Bacterical or viral strains Specifications Power Size Weight Throughput VacTube VacTube box AC 220 ~ 90 W (Standby) 300 W (Operation) 300 (W) 400 (L) 450 (H) mm 30.0 kg 100 samples / hour 1 ml / 2 ml toxic free tube 80 ~ 100 VacTubes Copyright 2014 NanoEnTek Inc. All rights reserved. 19

22 Product Profile Clinical Diagnostics Residual WBC Counting In Vitro Diagnostics Sample Banking ADAM-rWBC FREND System isbs ODM & OEM Products Cell Counting Gene Transfaction Cell Assay Countess Neon Tali Automated cell counter Transfection system Image-based cytometer 22

24 Ordering Information Life Science Research EVE Catalog Number Product Name EVE-MC Automatic cell counter, EVE EVS-050 EVE cell counting slide EVS-1000 EVE cell counting slide EVS-5000 EVE cell counting slide C-Chip Specification 50 slides (100 tests) 1,000 slides (2,000 tests) 5,000 slides (10,000 tests) Catalog Number DHC-N01 DHC-F01 DHC-B01 DHC-B02 DHC-M01 ADAM-MC Catalog Number ADAM-MC AD2K-200 AD4K-200 ADR-1000 ADB-50 ADB-500 ADM-001 ADAM-SCC Catalog Number ADAM-SCC CRS-K01 CRS-K02 ADB-50 ADB-500 ADM-001 ADP-001 Product Name Neubauer Improved Fuchs-Rosenthal Bürker Bürker-Türk Malassez Product Name Automatic cell counter, ADAM-MC AccuChip 2X kit (200 slides & sol.) AccuChip 4X kit (200 slides & sol.) Accustain solution ADAM calibration beads ADAM QC kit External video monitor (optional) Product Name Automatic somatic cell counter, ADAM SCC SomaChip 2X kit (50 slides) SomaChip 4X kit (100 slides) ADAM calibration beads ADAM QC kit External video monitor (optional) External printer (optional) Specification 100 µm 200 µm 100 µm 100 µm 200 µm Specification 200 tests 400 tests T sol. x 4 ea, N sol. x 2 ea 1 ml bead x 5 pcs 2 ch x 50 pcs, 1 ml Bead x 1 ea 7 LCD monitor Specification 100 tests 400 tests 1 ml bead x 5 pcs 2 ch x 50 pcs, 1 ml Bead x 1ea 7 LCD monitor Thermal printer 24

25 Life Science Research JuLIBr Catalog Number Product Name JULI-BR04 Live cell movie analyzer, JuLI Br (Single set) JULI-BRD04 Live cell movie analyzer, JuLI Br (Dual set) JULI-BRSC Scope unit of JuLI Br JULI-BRS50 JuLI Br cell counting slide JULI-BRS1000 JuLI Br cell counting slide JULI-BRS5000 JuLI Br cell counting slide JULI-BRTB JuLI Br XY stage JULI-BRCM JuLI Br counting starter kit JuLIFL Specification 4X objective, Bright 4X objective, Bright 4X objective, Bright 50 slides (100 tests) 1,000 slides (2,000 tests) 5,000 slides (10,000 tests) Ordering Information Catalog Number JULI-FLG04 JULI-FLGD04 JULI-FGSC JULI-FLR04 JULI-FLRD04 JULI-FRSC LuBi Catalog Number HS2129L HS2129L1 HS2129L2 HS2129T Multi Mixer Catalog Number SLRM-3 SLRM-N1.5 SLRM-N15 SLRM-N50 Product Name Fluorescence live cell movie analyzer, JuLI FL (Single set) Fluorescence live cell movie analyzer, JuLI FL (Dual set) Scope unit of live cell movie analyzer Fluorescence live cell movie analyzer, JuLI FL (Single set) Fluorescence live cell movie analyzer, JuLI FL (Dual set) Scope unit of live cell movie analyzer Product Name Microplate luminometer, LuBi Microplate luminometer 1, LuBi Microplate luminometer 2, LuBi LuBi incubator system (Temperature) Product Name Multi Mixer Rack Rack Rack Specification 4X objective, GFP 4X objective, GFP 4X objective, GFP 4X objective, RFP 4X objective, RFP 4X objective, RFP Specification No injector w/ 1 injector w/ 2 injectors 15 ~ 45 C, 4 plates Specification 16 x 1.5 ml, 4 x 15 ml, 2 x 50 ml 30 x 1.5 ml 14 x 15 ml 10 x 50 ml Copyright 2014 NanoEnTek Inc. All rights reserved. 25

26 Ordering Information Clinical Diagnostics ADAM-rWBC Catalog Number Product Name ADAM-rWBC Residual white blood cell counter, ADAM-rWBC AD1K-050 rwbc slide kit (50 slides & sol.) ADM-001 External video monitor (optional) FREND Specification 50 tests, 7 ml Bead x 1ea, r-solution 7 LCD monitor Catalog Number F10 FRPS 025 FRTS 025 FRBN 025 FRCT 025 Product Name FREND System FREND PSA Plus kit FREND TSH kit FREND BNP kit FREND Cardiac Triple kit Specification 25 pcs/kit 25 pcs/kit 25 pcs/kit 25 pcs/kit isbs Catalog Number SBS MD2006B 2-D Barcode sys. SBS MD2006 Vac tube (1 ml) Vac tube (2 ml) Vac tube box Product Name Basic package Bar-code system system & program Full package 1000 vactube/13vac tube box (Urine, Serum, Plasma, etc.) 1000 vactube/13vac tube box (Urine, Serum, Plasma, etc.) Freezer storage box Specification w/ Vac tube x 100 ea N/A W/ Barcode system N/A Consumable N/A Consumable N/A Consumable 26

27 NanoEnTek Inc. (HQ) 12F, 5, Digital-ro 26-gil, Guro-gu, Seoul, , Korea Tel : Fax : NanoEnTek USA Inc Stoneridge Drive Suite 304, Pleasanton, CA 94588, USA Tel : , (Toll free) Fax : sales@nanoentek.com

28 NESCT-ALL-001E (V.0.0)

EVE. Automatic cell counter. Crazy + Tangible play, 2K13.

EVE. Automatic cell counter. Crazy + Tangible play, 2K13. EVE Automatic cell counter Crazy + Tangible play, 2K13 www.nanoentek.com What is a EVE? The EVE Automatic cell counter uses state-of-the-art optics and image analysis to automate cell counting. The EVE