Abderahim Gaceb. Translational Neurology Group, Department of Clinical Sciences, Division of Neurology, Wallenberg Neurocentrum SE Lund Sweden

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1 Abderahim Gaceb Translational Neurology Group, Department of Clinical Sciences, Division of Neurology, Wallenberg Neurocentrum SE Lund Sweden Place/date of birth: August 03, 1987 Gender: Male Nationality: Algerian 1. Higher education degree(s) Ph.D Ph.D. in Human Physiology and Physiopathology University of Angers, France. Sept 2010 July 2011 Master s 2 degree University of Paris 12, Paris 7 and Paris 5, France. Sept 2009 July 2010 Master s 1 degree University of Paris 12, France. Sept 2004 July 2009 Engineer s degree in bioengineering University of Science and Technology of Algiers, Algeria. 2. Doctoral degree Dec 2014: Project: Modulation of inflammatory responses by microparticles UMR-INSERM-1063, Oxidative Stress and Metabolic Pathology, Health Biology Institute, Medicine School, University of Angers, France. Supervisor: Dr. Ramaroson Andriantsitohaina ( ramaroson.andriantsitohaina@univangers.fr) website 3. Qualification as Associate Professor NA 4. Present position, share of time spent in research Feb 2015 Postdoc Fellow (100% research) Translational Neurology Group, Department of Clinical Sciences, Division of Neurology, Wallenberg Neurocentrum SE Lund Sweden Supervisor: Dr. Gesine Paul ( gesine.paul@med.lu.se) website 5. Previous positions and periods of appointment Sept 2010 July 2011 Master s 2 degree training 1

2 Field: Biology, Physiology and Pharmacology of Circulation and Respiration. Project: Effects of intermittent hypoxia (obstructive sleep apnea) and/or obesity (metabolic syndrome) on vascular function: role of microparticles. UMR-INSERM-1063, Oxidative Stress and Metabolic Pathology, Health Biology Institute, Medicine School, University of Angers, France. Tutor: Prof. Frederic Gagnadoux ( Sept 2009 July 2010 Master s 1 degree training Field: Biology-Health Project: Molecular mechanisms of mast cell degranulation: the role of interaction between SNARE fusion proteins and SNARE fusion regulators Munc18-2. INSERM-699, Medicine School, University of Paris 7, Bichat site, France. Tutor: Ulrich Blank ( ulrich.blank@inserm.fr) Sept 2004 July 2009 Engineer s degree training Field: bioengineering (Msc) Project: Study of the effect of grape seed extract on peripheral blood mononuclear cells induced by protoscolexes of Echinococcus granulosis. Laboratory of Cellular and Molecular Biology, Biology institute, University of Science and Technology of Algiers, Algeria. Tutor: Dalila Mezioug ( mezioug_dalila@yahoo.fr) 6. Fellowships Scholarship, Molecular Targeting and Therapeutic Application, Sept 2011 April 2013, France. Travel and registration fees award, EMBO meeting, Sept 2013, Amsterdam, Netherland. 7. Supervision Sept 2012 Dec 2012 Co-supervisor of Master student 2

3 8. Others Technical knowledge Cell culture (line, primary), western blot, co-immunoprecipitation, ELISA assay, immunohistochemistry (Histological sections of organs (liver, lung, aorta) light microscopy and confocal microscopy), stereotaxic injection in rats, electron paramagnetic resonance (in vitro and in vivo), flow cytometry, myography, magnetic resonance imaging (MRI), chromatography techniques, differential proteomics, mass spectrometry. Software Excellent knowledge of Word, Excel, PowerPoint, GraphPad Prism, Adobe Illustrator and Photoshop, Image J. Languages Arabic: Reading, Writing, Speaking very good. French: Reading, Writing, Speaking very good. English: Reading, Writing, Speaking very good. Expertise and Workshops Diploma level 1 Animal experimentation, Veterinary School of Nantes, Member of the French Society of Pharmacology and Therapeutics. Member of the French Society of cardiology and Reflection Group on Cardiovascular Research. Fall of Reflection Group on Cardiovascular Research (Toll-like receptors and inflammation), Abbaye of Fontevraud, Sensibilisation to the laboratories risk, Nantes, France, Fall School of the Institute of Thorax: Metabolic and cardiovascular risk: new approaches in genetics, Nantes, France, Workshop Tomographie at shared service of imaging and microscopic analysis IFR132, Angers, Neuro-digestive and Metabolic diseases meeting, Nantes,

4 Publications Gaceb A, Martinez MC, Andriantsitohaina R. Extracellular vesicles: new players in cardiovascular diseases. Int J Biochem Cell Biol. 2014; 50; Andriantsitohaina R, Gaceb A, Vergori L, Martinez MC. Microparticles as regulators of cardiovascular inflammation. Trends Cardiovasc Med. 2012; 22; (Top 5 of the most popular articles in 2013). Tual-Chalot S, Fatoumata K, Priou P, Trzepizur W, Gaceb A, Contreras C, Prieto D, Martinez MC, Gagnadoux F, Andriantsitohaina R. Circulating microparticles from patients with obstructive sleep apneas enhance vascular contraction: mandatory role of the endothelium. Am J Pathol. 2012; 181; Vergori L, Lauret E, Gaceb A, Andriantsitohaina R, Martinez MC. PPARα regulates endothelial progenitor cell maturation and myeloid lineage differentiation through a NADPH oxidase-dependent mechanism in mice. Accepted on Stem Cells. Gaceb A, Luisa Vergori, Martinez MC, Andriantsitohaina R. Non-muscle myosin light chain kinase is critical for microvesicle-induced inflammation by endotoxin. Submitted on Am J RCCM. Trzepizur W, Gaceb A, Arnaud C, Ribuot C, Levy P, Martinez MC, Gagnadoux F, Andriantsitohaina R. Vascular and hepatic impact of short-term intermittent hypoxia in a mouse model of metabolic syndrome. Revision on PLoS ONE. Communications microparticles in mice. EMBO meeting Amsterdam (Commented poster). microparticles in mice. Arch Cardiovasc Dis Suppl 2013, 5, 1-84, 286, page 4. 4

5 Vergori L, Lauret E, Gaceb A, Soleti R, Andriantsitohaina R, Martinez MC. Modulation of progenitor cell phenotypes in high-fat diet mice: role of PPAR-alpha. Arch Cardiovasc Dis Suppl 2013, 5, 1-84, 0292, page 12. Vergori L, Lauret E, Gaceb A, Soleti R, Andriantsitohaina R, Martinez MC. Role of PPAR-alpha deletion on the differentiation of progenitors from the bone marrow of mice. Arch Cardiovasc Dis Suppl 2013, 5, 1-84, 0289, page 14. microparticles in mice. Fund Clin Pharmacol 2013, 1, 27, page 122. Vergori L, Lauret E, Gaceb A, Andriantsitohaina R, Martinez MC. Role of PPARalpha deletion on the differentiation of progenitors from the bone marrow of mice. Fund Clin Pharmacol 2013, 1, 27, page 81. Vergori L, Lauret E, Gaceb A, Soleti R, Andriantsitohaina R, Martinez MC. Modulation of progenitor cell phenotypes in high-fat diet mice: role of PPAR-alpha. Fund Clin Pharmacol 2013, 1, 27, page 81. Trzepizur W, Gaceb A, Arnaud C, Ribuot C, Levy P, Andriantsitohaina R, Martinez MC, Gagnadoux F. Circulating microparticle levels and vascular function in a mouse model of combined intermittent hypoxia and high-fat diet. Fund Clin Pharmacol 2013, 1, 27, page 5, 78. microparticles in mice. Scientific meeting of doctoral School of Biology Health Nantes Angers, (Commented poster). microparticles in mice. Scientific meeting of IFR 132, Angers, Price of best poster commented. 5

6 Vergori L, Lauret E, Gaceb A, Andriantsitohaina R, Martinez MC. Modulation of endothelial progenitor cells in high-fat diet mice: role of PPAR-alpha. Scientific meeting of IFR 132, Angers Gaceb A, Trzepizur W, Arnaud C, Ribuot C, Levy P, Andriantsitohaina R, Martinez MC, Gagnadoux F. Circulating microparticle levels and vascular function in a mouse model of combined intermittent hypoxia and high-fat diet. Arch Cardiovasc Dis Suppl 2012, 2, 1-84, 0289, page 25. Vergori L, Lauret E, Gaceb A, Andriantsitohaina R, Martinez MC. Modulation of endothelial progenitor cells in high-fat diet mice: role of PPAR-alpha. Arch Cardiovasc Dis Suppl 2012, 2, 1-84, 0281, page 21. Gaceb A, Trzepizur W, Arnaud C, Ribuot C, Levy P, Andriantsitohaina R, Martinez MC, Gagnadoux F. Circulating microparticle levels and vascular function in a mouse model of combined intermittent hypoxia and high-fat diet. Journée Scientifique de l IFR 132, Angers (Oral communication). 6