Results of Applications for the 2013 Integrated Thematic Projects at Academia Sinica Announced

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1 Results of Applications for the 2013 Integrated Thematic Projects at Academia Announced There is a total of 34 applications for the 2013 Thematic Projects (11 from Division of Mathematics and Physical Sciences; 17 from Division of Life Sciences; 6 from Division of Humanities and Social Sciences). The applications require a budget of NT$306,555,000 in total (NT$110,831,000 for Division of Mathematics and Physical Sciences; NT$163,914,000 for Division of Life Sciences; NT$31,810,000 for Division of Humanities and Social Sciences). Of all the applications, 16 were approved in the meetings of the Second-round Review and Budget Review, including 6 from Division of Mathematics and Physical Sciences, 6 from Division of Life Sciences, and 4 from Division of Humanities and Social Sciences. The total approved budget amounts to NT$108,221,000 (NT$38,500,000 for Division of Mathematics and Physical Sciences; NT$52,800,000 for Division of Life Sciences; NT$16,921,000 for Division of Humanities and Social Sciences). Please refer to the following table for detailed information. Type I : The 1st category grants are unsolicited integrated research programs. A. Division of Mathematics and Physical Sciences: (6 projects) Project No. Title of Projects Principal Investigators Institutions AS-102-TP-A01 Advanced Electron and Ion Spectromicroscopy Based on Single-Atom Emitters Ing-Shouh Jason Chia-Seng Chang Physics, Physics, A01-1 Advanced Electron Microscopy Based on Single-Atom Emitters Ing-Shouh Jing-Jong Shyue Fu-Rong Chen Physics, Applied Sciences, Dept. Engineering and System Science, National Tsing Hua A01-2 Advanced Ion Spectromicroscopy Based on Single-Atom Emitters Jason Chia-Seng Chang Jing-Jong Shyue Tsu-Yi Fu Ing-Shouh Physics, Applied Sciences, Physics, National Taiwan Normal Physics, AS-102-TP-A03 Advanced Glyco-Proteomics Tools to Delineate the Sweet Signals of Normal and malignant B Cells Inside-Out Yu-Ju Chen Shang-Ju Wu Chemistry, Internal Medicine, National Taiwan Hospital 1

2 A03-1 Global and Targeted Quantitative Glycoand Phospho- Proteomics by Advanced High Precision Mass Spectrometry Analysis Yu-Ju Chen Kay-Hooi Khoo Chemistry, Biological Chemistry, Academia A03-2 Development of Molecular Probes for Targeting Specific Galectins and Their Counterparts on B-cell Lymphoma Chun-Cheng Lin Chun-Hung Lin Chemistry, National Tsing Hua Biochemistry, A03-3 Illumination of the Biological Effects of Targeted Glycoproteins on B Cell Malignancies Kuo-I Lin Hwei-Fang Tien Genomics Research Center, Academia Internal Medicine, Division of Hematology and Oncology, National Taiwan Hospital AS-102-TP-A06 Mobile Apps Living Lab: Service Platform, Social Data Mining, and Sensing Techniques Yi-Bing Lin Chih-Wei Yi Yu-Chee Tseng Wen-Chih Peng Ling-Jyh Chen Information Science, (joint-appointment) Computer Science, National Chiao Tung Information Technology Innovation, Academia (joint-appointment) Computer Science, National Chiao Tung Information Science, AS-102-TP-A07 Optical Study of Cellular Response to Small Molecule Ta-Chau Chang Atomic and Molecular A07-1 Investigation of Cancer Metastasis and Circulating Tumor Cells by BMVC Derivatives Ta-Chau Chang Atomic and Molecular A07-2 Novel Single-Molecule Optical Methods and Optical Tweezers Platform to Study G-quadruplex Structure and Its Dynamical Properties Hung-Wen Li Chemistry, National Taiwan 2

3 AS-102-TP-A08 MALDI Mechanism, Soft X Ray Photoionization and Photodissociation Dynamics, and the Applications in Mass Spectrometry for Biomolecules Chi-Kung Kenny Ni Wei-Ping Hu Atomic and Molecular Chemistry and Biochemistry, National Chung Cheng A08-1 Mechanisms of Matrix-Assisted Laser Desorption Ionization and the Applications in Carbohydrates Chi-Kung Kenny Ni Atomic and Molecular A08-2 Investigation of Soft X Ray Photoionization and Photodissociation Dynamics Using Coincidence Electron Ion Velocity Map Imaging Chien Ming Tseng Applied Chemistry, National Chiao Tung A08-3 Applications of X Ray Photoionization in Mass Spectrometry for Biomolecules Chen-Lin Liu Scientific Research Division, National Synchrotron Radiation Research Center AS-102-TP-A09 Dynamical Mechanics of Cell-Mimetic Systems Jung-Hsin Lin Yu-Ling Shih Applied Sciences, Biological Chemistry, Academia A09-1 Cell-Mimetic Systems Derived from Bacterial Cell Division Machinery Yu-Ling Shih Biological Chemistry, Academia A09-2 Optical Measurement on Mechanical Properties of Cell-Mimetic Systems Chau- Lee Biophotonics, National Yang-Ming A09-3 Nanoscale Imaging for Cell and Cell-Mimetic Systems Jing-Jong Shyue Ing-Shouh Applied Sciences, Physics, A09-4 Multiscale Molecular Dynamics Simulations of Cell-Mimetic Systems Jung-Hsin Lin Applied Sciences, 3

4 B. Division of Life Sciences:(5 projects) Project No. Title of Projects Principal Investigators Institutions AS-102-TP-B04 A novel granulysin-mediated cytotoxic pathway as therapeutic targets for Stevens-Johnson syndrome and graft-versus host disease Yuan-Tsong Chen Biomedical Sciences, B04-1 Development of humanized granulysin neutralizing antibodies for treatment of Stevens-John syndrome and graft-versus-host disease Jiann-Shiun Lai Protein Drugs, Development Center for Biotechnology B04-2 Preparation and structural characterization of granulysin and HLA-peptide- drug-tcr complex for the study of Stevens-Johnson syndrome (SJS) You-Di Liao Chwan-Deng (David) Hsiao Biomedical Sciences, Molecular B04-4 Generation of humanized immune system mice as a tool to study immunopathogenesis and target-based therapy of Stevens-John syndrome and graft-versus-host disease Jeffery J. Y. Yen Yuan-Tsong Chen Shuen-Iu Hung Biomedical Sciences, Biomedical Sciences, Pharmacology, National Yang-Ming AS-102-TP-B05 Functional and Mechanistic Analyses of Critical Components of the Ubiquitin System in Arabidopsis: The Proteolytic and Epigenetic Components Hongyong Fu Plant and B05-1 Functional and Mechanistic Analyses of Critical Components of Ubiquitin System in Arabidopsis Ubiquitin Receptors and OTU-Containing Deubiquitinase Family Hongyong Fu Plant and B05-2 Functional Significance of Deubitination in Root Hair Development Wolfgang Schmit Plant and B05-3 Functional Analyses of the Chromatin-remodeling Complex and OTU-type Deubiquitinase in Arabidopsis Heat Stress Response and Thermotolerance Yee-Yung Charng Agricultural Biotechnology Research Center, B05-4 Function of OTU Deubiquitinating Keqiang Wu Plant Biology, National 4

5 Enzymes in Plant Abiotic Stress Responses Taiwan AS-102-TP-B09 Olfactory Computation in the Drosophila Brain Cheng-Ting Chien Wen-Liang Molecular Information Science, B09-1 Structural and Functional Network Analysis of Olfactory Circuits in Drosophila Antennal Lobe Ann-Shyn Chiang Chi-Tin Shih National Tsing Hua Biotechnology Physics, Tung Hai B09-2 Impacts of local interneuron variability on individual olfactory behaviors Ya-Hui Chou Cheng-Ting Chien Cellular and Organismic Molecular B09-3 Wiring the food-odor sensing VL2a circuit for sexual dimorphic olfactory behaviors Hung-Hsiang Yu Cheng-Ting Chien Cellular and Organismic Molecular B09-4 Cracking olfactory neural circuits of Drosophila by combining electrophysiology, voltage imaging and optogenetics Cheng-Chang Lien Hung-Hsiang Yu Ya-Hui Chou Cheng-Ting Chien Neuroscience, National Yang-Ming Cellular and Organismic Cellular and Organismic Molecular B09-5 Mathematic modeling for behavior validation of olfactory computation Wen-Liang Yung-Chang Chen Henry Information Science, Computer Science, National Tsin Hua College of Science, 5

6 Horng-Shing Lu Yu-Tai Ching National Chiao Tung Computer Science, National Chiao Tung AS-102-TP-B13 Improving the efficiency and quality of rice transformation Yue-Ie Carol Hsing Gelvin Stanton Plant and Biological Sciences, Purdue B13-1 Using genomics to investigate the variations of transgenic rice plants Yue-Ie Carol Hsing Lin-Yun Kuang Plant and Plant and B13-2 dentification and manipulation of rice genes to improve susceptibility to Agrobacterium-mediated transformation Gelvin Stanton Lan-Ying Lee Lin-Yun Kuang Biological Sciences, Purdue Biological Sciences, Purdue Plant and AS-102-TP-B14 The Assembly of the Death Domain Signaling Complex in Innate Immunity, Apoptosis, and Necrosis Su-Chang Lin Genomics Research Center, Academia B14-1 Death domain signaling complex formation in TLR signaling Yu-Chih Lo Bioinformatics and Biosignal Transduction, National Cheng Kung B14-2 Death domain signaling complex formation in TNFR signaling Su-Chang Lin Genomics Research Center, Academia 6

7 C. Division of Humanities and Social Sciences: (4 projects) Project No. Title of Projects Principal Investigators Institutions AS-102-TP-C01 AS-102-TP-C03 Material Culture of Medicine: Historical Investigations C01-1 Medical Recipes and Discourses for Menopausal Women in Traditional China C01-2 The Material Culture of Early British Parasitology C01-3 Spatial Transformation of Medical Practice: an Observation in Taiwanese History C01-4 A Cultural Diagram of Toxicity in Ming-Qing China C01-5 The Production, Distribution and Consumption of Quinine in Imperial Japan and Colonial Taiwan C01-6 Man as Medicine: A Survey of the Division of Human Body in the Ming Bencao Works C01-7 Mirror and Life from Pre-Chin to Tang C01-8 The Social Life History of Draconis Os The Multiple Faces of Modern Sino-Japanese Relations( ) C03-1 Coexistence and Competition: The Sino-Japan Enterprise Company C03-2 Among Taiwan, china, and Japan: Taiwanese Merchants' Trade, Migration, and Investment in the Asia-Pacific Region, C03-3 Chinese Kuomingtang and Japan, : Focusing on Sun Yet-sen and Chiang Kai-shek C03-4 Chinese Communist Party and Japan before 1949 C03-5 The Interaction of Media Field between Modern Japan and China C03-6 Narrating the Nation: China, Japan and the West in Comparative Historiography Shang-Jen Li Jen-Der Lee Shang-Jen Li Shi-Yung Liu Che-Chia Chang Ya-Wen Ku Hsiu-Fen Chen Shih-ch i Chin Chin Yuan Peng Chen History and Philology, History and Philology, History and Philology, Taiwan Modern Taiwan History, National Chengchi History, National Chengchi Department and History, National Dong Hwa Tzu-Chin Huang Modern Tsu-Yu Chen Man-Houng Lin Modern Modern Tzu-Chin Huang Modern Xinsheng Wang Kwang-Che Pan Qingjia Edward Wang History, Peking Univesity Modern History, Rowan, USA 7

8 C03-7 A Chapter of the Modern Sino-Japanese Literary Exchange: The Promoter of Modern Chinese Literature Transformation C03-8 Cultural and Historical Background of Japan's "China Hands" Diplomats and Its Impact on Sino-Japanese Relations C03-9 Modern Sino-Japanese Religious Interactions C03-11 Japan s Academic Investigation in China, Jianhui Liu Jie Liu Jidong Chen Chih-Hung Lin International Japanese Studies, Japan Social Science, Waseda The School of International Politics, Economics and Communication, Aoyama Gakuin Modern C03-12 Japan and the Invention of National Painting in China, Yu-Chih Lai Modern AS-102-TP-C05 AS-102-TP-C06 The Internal Relationships of Tsouic Revisited C05-1 The Position of Tsou within Tsouic Revisited C05-2 The Position of Kanakanavu within Tsouic Revisited C05-3 The Position of Saaroa within Tsouic Revisited Key Determinants of Successful Reading Acquisition: Integrated Research of Behavioral, Developmental, and Neurobiological Approaches Elizabeth Zeitoun Fang-Ching Teng Hsiu-chuan Liao Hsiu-chuan Liao Elizabeth Zeitoun Fang-Ching Teng Fang-Ching Teng Elizabeth Zeitoun Hsiu-chuan Liao Elizabeth Zeitoun Fang-Ching Teng Hsiu-chuan Liao Chia-Ying Lee Maw Kuen Wu Graduate National Tsing Hua Graduate National Tsing Hua Graduate National Tsing Hua Graduate National Tsing Hua Physics, 8

9 C06-1 An Exploration of Predictive Factors of Acquiring Chinese Literacy as First and Second Languages C06-2 How Does Literacy Shape the Directional Mapping between Orthography and Phonology C06-3 The Role of Episodic Memory in Word Learning: Behavioral and Cognitive Electrophysiological Studies C06-4 The Time Course of Orthographic Activation in Chinese Spoken Word Recognition: Evidence from Eye Movements C06-5 Influence of Writing and Typing Experience on the Neural Network for Chinese Character Recognition: fmri Studies Denise Wu I-Hui Hsieh Chia-Ying Lee Chao-Lin Liu Shih-kuen Cheng Chia-Ying Lee Jie-Li Tsai Chia-Ying Lee Wen-Jui Kuo Cognitive Neuroscience, National Central Cognitive Neuroscience, National Central Computer Science, National Chengchi Cognitive Neuroscience, National Central Psychology, National Chengchi Neuroscience, National Yang-Ming 9

10 TYPE II: The 2 nd category grants are solicited research programs related to nation priority research themes, e.g. global changes, biotechnology and drug development, green energy etc. A. Division of Life Sciences: (1 project) Project No. Title of Projects Principal Investigators Institutions AS-102-TP2-B02 How does mucosa glycosylation impact on the therapeutic cost of infectious and inflammatory diseases? Chun-Hung Lin Biochemistry, Academia TP2-B02-1 To decode the interplay between Helicobacter pylori and the gastric host : A model to examine how to interplay glycan Structures Chun-Hung Lin Ming-Shiang Wu Biochemistry, Academia Internal Medicine, College of Medicine, National Taiwan TP2-B02-2 Mapping the glycosylation dynamics of human gastrointestinal mucosal surface and gut associated lymphoid tissue in response to infections and antibiotic treatments Kay-Hooi Khoo Biochemistry, Academia TP2-B02-3 Role of galectin in regulation of mucosal immunity and inflammation Fu-Tong Liu Chen Huan Yuan Daniel Kaiyuan Hsu Biomedical Biomedical Biomedical TP2-B02-4 Role of C-type lectin receptors (CLRs) and dendritic cells (DCs) in controlling mucosal immunity Shau-Ku Huang Deng-Chyang Wu Division of Environmental Health and Occupational Medicine, National Health Research Institutes School of Medicine, Kaohsiung Medical 10

Results of Applications for the 2016 Integrated Thematic Projects at Academia Sinica Announced

Results of Applications for the 2016 Integrated Thematic Projects at Academia Announced There is a total of 23 applications for the 2016 Thematic Projects (7 from Division of Mathematics and Physical Sciences;