Global recognition as a high-performance single-source supplier

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1 Press Release Karlsruhe/Germany, 10/10/2017 Romaco at CIPM China in Changsha Global recognition as a high-performance single-source supplier The Romaco Group s latest machinery developments will be on show for the first time in China in the new corporate industrial design. The company presents a very broad portfolio of packaging and processing technologies in the form of its Innojet, Kilian, Promatic and Macofar brands. Romaco Promatic PCI 915 intermittent motion cartoner The Promatic PCI 915 intermittent motion cartoner features Romaco s new corporate industrial design and is particularly suited for secondary packaging of blisters, strips and vials. This compact cartoner only has a very small footprint and achieves a maximum output of 160 cartons a minute. The ergonomic system concept of the PCI 915 simplifies operation and reduces downtime. For the first time, the containers for rejected products, leaflets and cartons are freely accessible and can be removed and emptied without interrupting operation. Product and packaging changes can be completed quickly and easily without tools. Formats are designed according to the poka-yoke principle to prevent parts from being incorrectly assembled. The cartoner s cgmp compliant balcony architecture moreover speeds up line clearance. All in all, the better visibility on the processes improves operating reliability. The highly automated Promatic PCI 915 provides reproducible parameters and high quality end products. Romaco Macofar MicroMaxX 18 microdosing machine The Romaco Macofar MicroMaxX 18 microdosing machine processes pharmaceutical powders with different flow properties as well as freeze-dried products and sterile liquids. The system is equipped with a dual dosing disc which allows multiple dosing into the same vial; alternatively, the product can be filled in two separate process steps. Furthermore, even very small product quantities right down to 25 mg can be dosed precisely. Thanks to an innovative page 1 of 5

2 in-line weighing system, one hundred percent weight control is now possible for the first time. The machine achieves a maximum filling speed of 12,000 vials per hour. Up to 18,000 vials an hour are possible in the version with statistical weight control. The Romaco Macofar MicroMaxX 18 can be supplied in different containment designs. Automated processes ensure reliable operation and meet the high cgmp requirements for dosing sterile powders and liquids. Romaco Innojet VENTILUS V 5 processing machine The VENTILUS V 5 from Romaco Innojet is a compact laboratory machine for a wide range of applications. This processing machine dries, granulates and coats powders, crystals, granules, pellets and micro-tablets of any size from 10 µm to 2.0 mm in batches from 1,500 ml to 5,000 ml. Thanks to the homogeneous flow conditions in the container and the scalable spray nozzle, the VENTILUS V 5 is equally suited for both process development and scale-up tests. The system can be monitored wirelessly and remote controlled using mobile devices at any time. This simplifies daily work in the laboratory because the lab technicians retain full control over the processes even if they are not in the immediate vicinity of the machine. For many years now, pharmaceutical manufacturers all over the world have trusted in VENTILUS technology for laboratory, pilot or production scale solutions. Romaco Kilian KTP 590X rotary press The Kilian KTP 590X rotary press is the newest model in Romaco Kilian s successful KTP series. The if award-winning KTP press design inspired Romaco to develop a corporate industrial design to be applied to further machines. The Kilian KTP 590X, Romaco s first single-sided rotary press specifically for compressing bi-layer and effervescent tablets, was launched just a few months ago. Two large, standard fill shoe modules allow efficient filling of the die with different powders. Tableting takes place in three steps, namely tamping, precompression and main compression. The use of 28/41 tooling moreover extends the dwell time, which means less risk of capping and improved tablet hardness. The new fill shoe generation has an optimized paddle design which ensures homogeneous compression of tablets with a maximum diameter of 33 mm. The Kilian KTP 590X boasts a maximum output of 511,200 tablets per hour, both mono-layer and bi-layer. The new rotary press is absolutely consistent with the Kilian philosophy: cool, fast and clean. Process temperatures of less than 30 C, page 2 of 5

3 fast product changes and very high hygienic standards are also the hallmarks of the new Kilian KTP 590X. Romaco Kilian STYL ONE Evolution tableting robot The Romaco Kilian STYL ONE Evolution single-stroke press is the ideal solution for laboratory applications, whether for developing new formulations or for scaleup tests. It achieves a maximum output of 1,750 tablets per hour in configurations for mono-layer, multilayer or core tablets. The compression cycles have been speeded up by more than 60% and the maximum compression force increased to 50 kn in order to simulate high speed presses. Compression force profiles for all standard rotary presses like the Romaco Kilian KTP 420X can now be determined at full power. ANALIS, the intelligent PAT software, calculates all relevant tableting parameters based on compression force or displacement controlled cycles. The remarkable precision of the test batches means powder properties can be analysed very realistically. The STYL ONE Evolution can thus also be utilised to optimise processes or troubleshoot errors. On show at CIPM in Changsha from November 6 to 8, 2017 (International Convention and Exhibition Center, International Hall E1-20). The Romaco Group Romaco is a leading global supplier of Processing and Packaging equipment, predominantly for the pharmaceutical industry. Divided into three business areas, Processing, Tableting and Packaging, the company develops engineered system solutions for the pharmaceutical market, but also supplies the cosmetics, food and chemical markets. Romaco operates from four European locations with the headquarters in Karlsruhe, Germany. The company serves the multiple industries through a total of seven brands. The packaging product lines Noack, Siebler and Bosspak are manufactured in Karlsruhe, Germany, and the primary and secondary packaging brands Macofar and Promatic in Bologna, Italy. The tableting product line Kilian is produced in Cologne, Germany, while the Innojet product line in Steinen, Germany, is responsible for granulation and coating. Romaco s product portfolio includes primary, secondary and final packaging, aseptic and non-aseptic liquid and powder filling, tablet press technologies, granulation and coating. Over 12,000 Romaco installations are currently in operation in more than 180 countries. The company s worldwide customer base is supplied and supported by over 550 highly skilled and committed employees. page 3 of 5

4 In 2014 the Romaco Group was voted by Wirtschaftswoche, the prestigious German business weekly, as one of Germany s best 50 innovators among small and medium-sized enterprises. In this corporate benchmarking contest, Romaco was named runner-up in the Process and Packaging Machinery category. In the Pharmaceutical Machinery segment, the Group was awarded first prize. For more information about the Romaco Group, visit The following pictures are enclosed with the press release: 1. Romaco Promatic PCI 915 intermittent motion cartoner Romaco_Promatic_PCI-915.jpg 2. Romaco Macofar MicroMaxX microdosing machine Romaco_Macofar_MicroMaxX-18.jpg 3. Romaco Innojet VENTILUS V 5 processing machine Romaco_Innojet_Ventilus_V-5.jpg page 4 of 5

5 4. Romaco Kilian KTP 590X rotary press Romaco_Kilian_KTP-590X.jpg 5. Romaco Kilian STYL ONE Evolution single-stroke press Romaco_Kilian_STYL-ONE-Evo.jpg Company contact Susanne Silva Market Communications The Romaco Group Am Heegwald Karlsruhe Germany T +49 (0) F +49 (0) E susanne.silva@romaco.com Press contact Susanne Pfeiffer AzetPR International Public Relations Wrangelstrasse Hamburg Germany T +49 (0) F +49 (0) E pfeiffer@azetpr.com page 5 of 5