Overview of IR-4 Biopesticide Research and Support Program
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1 Overview of IR-4 Biopesticide Research and Support Program Presented to: IR-4/EPA/PMRA/CA-DPR Biopesticide Registration Workshop November 13, 2001 Robert Holm, Ph.D. Executive Director
2 IR-4 Milestones! 1963! 1975! 1976! 1977! 1982! 1989 Initiated by the Directors of State Agricultural Experiment Stations working with the U.S. Department of Agriculture- Cooperative States Research Service. Regional Leader Laboratories- established to provide regional coordination and analytical services. USDA-ARS established minor use program Expanded to cover nursery and floral crops, forest seedlings, turfgrass, Christmas trees, and woody nursery stock Expanded to cover registration of Biological Pest Control Agents Established a GLP program
3 IR-4 Milestones! 1993! 1995! 1997! 2000 Initiated Quality Assurance Unit with SOP s and GLP guidelines and training Updated Strategic Plan to focus on Reduced Risk Products and Biopesticides (dedicated research funds) Food Quality Protection Act (FQPA) Reduced Risk Strategy Promote the registration of Reduced Risk products Expand biopesticide programs Revised Strategic Plan to focus on Accelerate Reduced Risk chemistry registration Gaining access to new chemistries and biopesticides
4 Biopesticide Program IR-4 Strategy! Initiated in 1982! Focused mainly on support for registrants from ! Designated funding for research projects since 1995 ($1,795,000 in total)! Early Stage Projects for $300,000! Early Stage Projects for $194, Advanced Stage Projects for $111,000! Early Stage Projects for $102, Advanced Stage Projects for $201,282
5 Biopesticide Program IR-4 Strategy! 2000 Biopesticide Workshop co-sponsored by IR-4, PMRA and BPPA.! Early Stage Project for $19, Advanced Stage Projects for $254,017-4 Food Use Workshop Biopesticide Projects for $20,183-4 Ornamental Workshop Biopesticide Projects for $6,000! 2001 Biopesticide Registration Workshop planned for November co-sponsored by IR-4, BPPD and PMRA
6 IR-4 Biopesticide Program Success Stories # Food Crop Clearances 1! Product " Bacillus thuringiensis (Bt) " Gibberellic Acid (GA) " Bacillus popilliae " Methyl Eugenol (w/ Malathion) " Grape Berry Moth Pheromone " Codling Moth Granulosis Virus " Pseudomonas fluorescens Strain NCIB " Lagenidium giganteum! Crop(s) All (Label Expansions) Strawberries & Blueberries Pastures All Grape Apple, Pear, Walnut & Plum Mushroom Rice 1 C.L. Hartman & G.L. Markle (1996) IR-4 Program for Minor Crops in Methods in Biotechnology. Vol. 5: Biopesticides Use and Delivery
7 IR-4 Biopesticide Program Registration Success Stories! 1995 " Methyl Anthranilate - bird repellent on blueberries, grapes and cherries " Codling Moth Granulosis Virus - apple, pear, walnut & plum " Cinnamaldehyde - mushrooms (Verticillium spot and dry bubble disease control)! 1996 " Aspergillus flavus AF 36 - cotton-az only (aflatoxin control)-eup " Trichoderma hamatum and Flavobacterium balustinum (TT and EUP) - on vegetable bedding plants (damping-off and root rot control)! 1997 " Beauveria bassiana GSA - in CA greenhouse ornamentals (western flower thrips control) (Efficacy Data)
8 IR-4 Biopesticide Program Registration Success Stories! 1998 " Kaolin - insect control on 48 crops " Lysophosphatidylethanolamine (LPE) - EUP - promotion of ripening and extended storage shelf life on 13 fruit crops " Pseudomonas fluorescens PRA 25 - EUP - seed treatment for soil borne diseases on vegetables (peas, snapbeans, & sweet corn)! 1999 " Cinnamaldehyde - for insect and disease control on 53 crops " Formic Acid - for mite control in bee hives " (E)-11-Tetradecen-1-YL-Acetate Mating Disruption Phermone -for sparganothis fruitworm in cranberry (Efficacy Data) " MCH (3-Methyl-2Cyclohex-1-One) Antiaggregation Phermone - for Douglas fir and spruce beetle control (Efficacy Data) " Pseudomonas aureofaciens TX-1 - for pink snow mold control on turf (Efficacy Data) " Gibberellins - for PGR use on minor crops " Surround WP - new weather resistant kaolin formulation on fruit crops
9 IR-4 Biopesticide Program Registration Success Stories! 2000 " LPE - 97 and 98S formulations on 13 fruit crops (EUP) promote ripening and extend storage shelf life. " Cinnamaldehyde for mite/powdery mildew control on 39 crops. " Chitosan (Elexa 4) for powdery mildew control on grapes, roses and strawberries. " Messenger (Harpin Protein) for disease control on apples & grapes. " Milsana for powdery mildew control on ornamentals.! 2001 " Sucrose Fatty Acid Esters - on all commodities for insect and mite control (pending) " Macleaya Extract - for ornamental disease control (pending)
10 IR-4 Biopesticide Program 2001 Funded Projects Advanced Stage Researcher/Organization Approach Target/Crop Adaskaveg/UC-Davis Serenade 1 Biofungicide Botrytis (post-havest)/kiwi Bailey/No. Carolina St. Univ. Benson/No. Carolina St. Univ. Bristow/Washington St. Univ. Brunner/Washington St. Univ. Chase/Chase Gardens Drummond/Univ. of Maine Elkins & Van Steinwyk/UC Lake County Grove/Washington St. Univ. Contans 2 Biofungicide Bl-915 3, Prestop 4, Mycostop 4, & Subtilex 4 Biofungicides Serenade 1 Biofungicide Isomate 5 pheromone Milsana 6 Biofungicide Nature s Glory 9 Bioinsecticide Virosoft 7 Bioinsecticide Milsana 6 & Elexa 8 Biofungicides Sclerotinia Blight/Peanuts Rhizoctonia, Pythium & Thielaviopsis/Flowers Botrytis/Strawberry & Raspberry Leaf Roller spp./apples Foliar Diseases/Ornamentals Insects/Blueberries Codling Moth/Pears Powdery Mildew/Grapes 1 AgraQuest 4 AgBio Development 7 BioTepp 2 Encore Technologies 5 Pacific BioControl 8 Safe Science Inc. 3 AgraSol, Inc. 6 KHH BioSci, Inc. 9 Ecoval, Inc.
11 Gubler/UC-Davis Gubler/UC-Davis IR-4 Biopesticide Program 2001 Funded Projects Advanced Stage Researcher/Organization Approach Target/Crop Gut/Michigan State Univ. Hong & Banko/VPI & SU Milsana 6 Biofungicide Milsana 6 and Elexa 8 Biofungicides Isomate CM/OFM Pheromones AgBio Biofungicide Powdery Mildew/ Cucurbits & Strawberries Powdery Mildew/Grape Codling Moth & Oriental Fruit Moth/Apple Leaf Spot/Photinia Koike/UC-Monterey County Matheron/Univ. of Arizona Matheron/Univ. of Arizona Matheron/Univ. of Arizona Morris & Haust/SuperSweet Farms, CA Serenade 1 Biofungicide Contans 2 & Serenade 1 Biofungicides Milsana 6, Elexa 8 & Serenade 1 Biofungicides Milsana 6, Elexa 8 & Serenade 1 Biofungicides Pelargonic Acid 9 Bioherbicide Botrytis/Chives Sclerotinia/Lettuce Powdery Mildew/Cantaloupe Powdery Mildew/Lettuce Weeds/Stevia 1 AgraQuest 4 AgBio Development 7 Biotepp, Inc. 2 Encore Technologies 5 Pacific BioControl 8 Safe Science Tech. 3 AgraSol, Inc. 6 KHH BioSci, Inc. 9 Dow AgroSciences
12 Nameth/Ohio State Univ. IR-4 Biopesticide Program 2001 Funded Projects Advanced Stage Researcher/Organization Approach Target/Crop McGrath/Cornell University Mullins/Univ. of Tennessee Milsana 6 Biofungicide Nature s Glory 9 Bioherbicide AgBio Biofungicide Powdery Mildew/Cucumbers Weeds/Snap Beans & Tomatoes Pythium/Geranium Parker, Skinner & Costa/Univ. of Vermont Ragenovich/USDA Forest Service Roberts/Univ. of Florida Ross/Oregon State Univ. Salom/VPI & SU Clark/USDA Forest Service Mycotrol 0 11 Bioinsecticide Douglass-Fir Tussock Moth Pheromone 12 AtEze 14 Biofungicide MCH 12 Antiaggregation Pheromone 13 Verbenone 13 Pheromone Tarnished Plant Bug/Romaine Lettuce Tussock Moth/Conifers Seedling Diseases/ Tomatoes & Bell Peppers Douglas Fir Beetle/ Douglas Fir Southern Pine Beetle/ Southern Pine Stands 4 AgBio Development 11 Emerald BioAg. Corp. 14 EcoSoils 6 KHH Biosciences 12 Hercon Environmental. 10 Ecoval Technologies 13 PheroTech Inc.
13 IR-4 Biopesticide Program 2001 Funded Projects Advanced Stage Researcher/Organization Approach Target/Crop Scherm/Univ. of Georgia Schwartz/Colorado State Univ. Sorenson/No. Carolina State Univ. Serenade 1 Biofungicide AgBio Biofungicide Nature s Glory 10 Insecticide Mummy Berry Disease/ Blueberry Alternaria/Potato Insects/Eggplant Thompson/Utah State Univ. Vargas/Michigan State Univ. Valencia/Univ. of CA-Modesto Williams/Brigham Young Univ. Wilcox/Cornell University IR-4/Food Use Workshop Dyer s Woad Rust Bioherbicide* XPO 14 Bioherbicide Serenade 1 Biofungicide Elexa 8 Biofungicide Milsana 6 & Elexa 8 Biofungicides Retain/AVG 15 Biochemical Dyer s Woad/Range Land & US Forest Service Annual Bluegrass/Turf Alternaria/Basil & Collards Powdery Mildew/ Greenhouse Roses Powdery Mildew/Grapes Postharvest Quality/ Stone Fruit 1 AgraQuest 8 Safe Science 15 Valent Biosciences 4 AgBio Development 10 Ecoval Techonlogies * Early Stage Project- No 6 KHH BioSci, Inc. 14 EcoSoils Commercial Company
14 IR-4 Biopesticide Program 2000/2001 Products in Grants Program Company Ag Bio Development AgraQuest Product Name (Active Ingredient) " Primastop/Prestop (Gliocladium catenulatum J1446) " Subtilex (Bacillus subtilis MBI 600) " Mycostop G (Streptomyces griseoviridis K-61) " AgBio-222 (Dipotassium Phosphate/Phosphonate) "Serenade (Bacillus subtilis QST713)-AS & Organic Formulation Classification 1 Agra Sol, Inc. BioWorks, Inc Biotepp Dow AgroSciences "BL915 (Pseudomonas fluorescens) "Rootshield (Trichoderma harzianum) "Virosoft (codling moth granulosis virus) "Pelargonic Acid BI BH 1 = Biofungicide BH = Bioherbicide B=Biochemical BI = Bioinsecticide P = Pheromone
15 IR-4 Biopesticide Program Company Ecogen EcoSoils 2000/2001 Products in Grants Program Ecoval Tech., Inc. Emerald Bioagriculture KHH BioSci, Inc. Product Name (Active Ingredient) " AQ10 (Ampelomyces quisqualis) " Aspire (Candida oleophila I-182) "At-Eze (Pseudomonas chlororaphis) "XPO (Xanthomonas campestris P.V. Poannua) "Nature s Glory Herbicide (Acetic/Ethanolic Acids) "Nature s Glory Insecticide (Citric Acid) "BotaniGard (Beauvaria bassiana GHH) "Mycotrol (Beauvaria bassiana) "Valero (Cinnamite/ Cinnamaldehyde) "Auxigro ( γ Amino Butic Acid) "Milsana (giant knotweed extract) Classification 1 BH BH BI BI BI PGR Lido "eks Purge (Potassium Dihydrogen Phosphate) 1 = Biofungicide BH = Bioherbicide B=Biochemical BI = Bioinsecticide P = Pheromone
16 IR-4 Biopesticide Program 2000/2001 Products in Grants Program Company MycoLogic, Inc. Product Name (Active Ingredient) " Eco-Clear (Chondrostereum purpureum) Classification 1 BH Pacific BioControl PheroTech, Inc. Safe Science Valent Biosciences "Isomate (Mating Disruptant) "Verbonone Pouch "MCH Bubble Capsule "LQ215 (Natural Surfactant Blend) "Elexa 4 Plant Defense Booster (Chitosan) "CIT 30 (Citric Acid, Copper Sulfate & Zinc Citrate) "Dipel (Bacillus thuringiensis kurstaki) "Retain (Aminoethoxyvinylglycine) P BI P BI BI B 1 = Biofungicide BH = Bioherbicide B=Biochemical BI = Bioinsecticide P = Pheromone
17 2001 IR-4 Annual Meeting 2000/2001 Products # Not Commercialized & without Trade Names! Active Ingredient " Trichoderma atroviride " Aspergillus flavus AF 36! Classification 1 " Endochitinase Antifungal Proteins/Transgenic Plants " Collectotrichum gleosporioides " Sclerotinia species " Sucrose Fatty Acid Esters " Puccinia thlaspeos (Dyer s Woad Rust) BH BH BI BH 1 = Biofungicide BH = Bioherbicide B=Biochemical BI = Bioinsecticide P = Pheromone
18 Biopesticide Companies Registrants IR-4 has worked with ! 3M Canada 2! AgBio Development! AgraQuest, Inc. 2! Ag Tech Corporation! AgraSol, Inc.! Apicure! ARCADIS! Arizona Cotton Res. & Protection Council! AVA Chemical Ventures L.L.C.! Becker Underwood! Biologixs! Biotepp, Inc. 2! BioWorks, Inc. 2! Bird Shield Repellent Corporation! CAMAS Technologies! Chemicals Laif! Dow AgroSciences! Ecogen 2! EcoSoils 2! Ecoval, Inc.! Eden Bioscience Corp. 2! Emerald BioAgriculture 2,3 1 Companies involved in the development and registration of biopesticides. Only current name is listed. Names of some biopesticide companies have changed because of mergers and acquisitions. 2 Member of Biopesticide Industry Alliance (BPIA) 3 Formerly Auxein and Mycotech 4 Formerly J.P. Regulators, Inc. 5 Formerly Abbott Laboratories
19 Biopesticide Companies Registrants IR-4 has worked with ! Encore Technologies, LLC 2! Engelhard! Environmentally Safe Systems! Growth Products! Gustafson! Hercon Environmental! KALSEC! KHH BioSci Inc. 2! Lido Chem Inc.! Mann Lake Ltd.! Mycologic Inc.! Nutra-Park, Inc. 2,4! Pacific Biocontrol Limited! PBT International! Pherotech, Inc. 2! Plant Products Co. Ltd.! Proguard Inc.! Safe Science! Sellew & Associates! Taensa, Inc. 2! Thermo Trilogy 2! United Ag Products! Valent BioSciences 2,5 1 Companies involved in the development and registration of biopesticides. Only current name is listed. Names of some biopesticide companies have changed because of mergers and acquisitions. 2 Member of Biopesticide Industry Alliance (BPIA) 3 Formerly Auxein and Mycotech 4 Formerly J.P. Regulators, Inc. 5 Formerly Abbott Laboratories
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