Biomedical Optics Instrumentation

Transcription

1 Physical Sciences Inc. VG Biomedical Optics Instrumentation Dan Hammer, Dan Ferguson, Nick Iftimia, Dave Rosen A Case Study for University Industry Collaboration presented by Mark Druy and B. David Green at the Session on SBIR Successes at 2010 National SBIR Beyond Phase II Conference and Technology Showcase 15 September New England Business Center Andover, MA 01810

2 Who we are A growing 37 year-old company of 180 scientists, engineers and administrative professionals Headquartered in Andover, MA; operations in: Pleasanton, CA (PSI) Lanham, MD and Princeton, NJ (RSI) Bedford, MA (Q-Peak) Dayton, OH (Faraday Technology) College Park, MD (Maxion Technologies) Research Support Instruments supports the Naval Research Laboratory and National programs Q-Peak manufactures lasers and optical devices Faraday Technology develops electrochemical processing Maxion Technologies develops long-wavelength (3-12 microns) infrared semiconductor lasers PSI is a technologically diverse research and development organization with revenues of $50+M Owned by the PSI Employee Stock Ownership Trust VG

3 Pleasanton, CA PSI Space Exploration Technologies and Novel Electro-optic Materials Our Locations Andover, MA Corporate Headquarters PSI Main Offices Material Sciences and Technologies, Optics and Laser Technologies, Space and Atmospheric Studies, Energy Technologies Haverhill, MA PSI Advanced Composite Structures Bedford, MA Q-Peak Solid State Lasers Princeton, NJ RSI MEMS and Plasma Technologies Lanham, MD RSI Systems Support and Calibration College Park, MD Maxion Technologies, Inc. Quantum and Interband Cascade Lasers IR EO Materials and Devices VG Clayton, OH Faraday Technology, Inc. Pulsed/Pulse Reverse Electrochemical Engineering for Precise Surface Modification C-7543

4 Creating Value For Our Customers Leading edge technology invention, development, and application VG Custom instrument development Prototype product development, premanufacturing, and technology transfer Production of specialized instruments Technology and product licensing to strategic partners and spin-outs

5 Army, Air Force, and NIH SBIR/STTR Funding has led to Rapid assessment tool for retinal damage from laser illumination Tools for angiography and guided surgery in the eye VG Biomedical optical systems for ophthalmic researchers, clinicians, and other medical personnel Detection of diseases Discovery of novel therapies Understanding of the body from system/organ to sub-cellular and molecular structures PSI (small business) creating improved diagnostic instrumentation Eye diseases, eye health, drug discovery University Teaching hospital Industry collaborative research Publications motivating additional research by many groups around world Sale of advanced instrumentation to leading research labs Licensing of technology to leading established OCT manufacturer Wide spread application in clinics and laboratories Licensing of enabling technology to several focused start up companies Many formed from university labs

6 Ophthalmic Instrumentation Ophthalmic Diagnostics TSO: Tracking, Scanning Ophthalmoscope TOCT: Tracking Optical Coherence Tomography LSO: Line Scanning Ophthalmoscope AOSLO: Adaptive Optics Scanning Laser Ophthalmoscope Applications Laser illumination damage and mechanisms Diagnosis and surgical guidance in the eye Degenerative eye diseases in children and aged Diabetic retinopathy, macular degeneration Research on the cellular basis of eye diseases VG

7 Biomedical Imaging Instruments Line scanning ophthalmoscopy (LSO) Compact retinal imager to augment or guide OCT Autofluorescence, microperimetry Small animal imaging and advanced therapies patents 5 licenses with ophthalmic instrument manufacturers Retinal tracking (TOCT) High-speed, high fidelity stabilization of eye motion Applications: AO, SDOCT, PSOCT, hemodynamics Diagnostic or therapeutic beams > 12 systems sold to researchers patents Adaptive optics (AOSLO) Measurement and correction of ocular aberrations Ultrahigh resolution of retinal structures patent applications Real-time Fourier domain OCT processor VG

8 Including: Collaborators Institutions: VG Bruce Stuck Army Medical Research Branch Henry Hacker Air Force Research Lab HPW, Brooks Ben Rockwell Schepens Eye Research Institute David R. Williams Mass Eye and Ear Infirmary Benjamin Bloom MIT T. Milner University of Pittsburgh Robb Webb University of Rochester Ann Elsner University of Texas, Austin Steve Burns Indiana University Johannes F. de Boer Massachusetts General Hospital Joel Schuman Boston Medical Center Brigham and Women s Hospital University of Texas Medical Branch

9 Representative Journal Publications Applied Optics: Compact Scanning Laser Ophthalmoscope with High-Speed Retinal Tracker Optics Express: Image Stabilization for Scanning Laser Ophthalmoscope Journal of Biomedical Optics: An Active Retinal Tracker for Clinical Optical Coherence Tomography Systems Optics Express: Advanced Scanning Methods with Tracking Optical Coherence Tomography Journal of Biomedical Optics:Scanning Laser Opthalmoscope Optics Express: Wide-field hemodynamic imaging with tracking ophthalmoscope Optics Express: Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging Journal of the Optical Society of America: Increased Signal and Resolution with Adaptive Optics Spectral Domain Optical Coherence Tomography VG Optics Express: Hybrid retinal imager using linescanning laser ophthalmoscopy and spectral domain optical coherence tomography Optics Letters: Tracking OCT Optics Express: Dual-beam Fourier domain optical Doppler tomography of zebrafish Circulation Research: Blood flow and cardiac output measurements in zebrafish (Danio rerio) using dual-beam Fourier domain optical Doppler tomography Review Scientific Instruments: Realtime processing for Fourier domain optical coherence tomography using a field programmable gate array Optics Express: Compact adaptive optics line scanning Ophthalmoscope Journal of the Optical Society of America A: Adaptive optics SLO with integrated wide-field retinal imaging and tracking

10 Licenses: Tracking for Ophthalmic Office Market Partner with major instrument company Non exclusive license Transfer technology Work with development team to incorporate in Gen 4 product Benefit Provides high contrast, wide area image of retina Ensures precise registration between OCT scan and fundus image Adds incremental cost to product Significantly greater value Sold 5940 units in 27 months PSI receives modest royalty income VG

11 Custom Instrument Sales to Researchers Licenses to start up companies commercial product creation retinal metabolic analysis perimetry therapeutics (pending) small animal imaging OCT, optical biometer Custom ophthalmic instruments for researchers at: U. Rochester Indiana U. U. Texas Medical Branch U. Texas Austin Harvard MIT U. Pittsburgh Medical Center Mass General Hospital Children s Hospital/Boston U. Michigan U. Waterloo FDA VG

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13 Summary VG Under Air Force, Army, and NIH SBIR /STTR funding PSI staff has: Performed world class research in the understanding and diagnosis of diseases of the eye Collaborated with many researchers in academia Published and presented results to community to spur additional research Obtained six patents Developed several generations of optical diagnostic technology Standardized subassemblies and process in a Prototype Manufacturing Area Offered specialized instruments and sold them to the research community Created further collaborations and advanced research by the community Licensing several generations of the technology to companies for commercial products Established commercial company next product for wide application in clinics Start up companies for autofluorescence, low cost retinal screening, image-guided therapy Many grow and evolve from university laboratories

14 University PSI Partnerships in Last Five Years VG Alfred University Michigan Tech University University of Illinois Boston University MIT University of Michigan Brown University Northeastern University University of Maryland California State University Ohio State University University of New Hampshire Cornell University Pennsylvania State University University of North Carolina Dartmouth College Princeton University University of Notre Dame Duke University State University of New York University of Pittsburg Emory University UMass Lowell University of Rochester Harvard University University of Arizona University of Texas Indiana University University of Connecticut Utah State University Iowa State University of Deleware Western New England College Johns Hopkins University University of Denver West Virginia University Medical College of Wisconsin University of Florida Worcester Polytechnic Institute