Antonio Del Casale. Microbion srl Verona University Spin-off - Italy
|
|
|
- Justin Owens
- 6 years ago
- Views:
Transcription
1 Antonio Del Casale Microbion srl Verona University Spin-off - Italy Food Matters Live 19 November 2014
2 Microbion Verona University Spin-off Biodiversity services & products Finds the best performing microbes using innovative DNA-fingerprinting
3 Microbion Verona University Spin-off Technology Transfer Established company in 2011 >200 peer-review research publications >50 Successful industrial case-studies >20 Customers >6 Industrial sectors
4 Microbion Verona University Spin-off What we do? Service provider: Analytical services R&D services Bio-bank service Products developer: Molecular diagnostics Pro-tech microbial strains
5 Microbion Verona University Spin-off What customers need? Innovation: Product development Process optimization Quality control: Safety assessments Regulatory compliance
6 Microbes Biodiversity Microbes: Smallest & most abundant living organisms Biodiversity Who is the good? Can the good s win?
7 Microbes Biodiversity Pro-technologic Make products Health improver Pathogenic Harmful Spoiling Unwanted Anti-pro
8 Microbes Biodiversity Natural occurring microbes Pro-technologic Make products Health improver Industrial microbes - Manufactured - Controlled Food Fermented Health Probiotics Agriculture Bio-fertilisers Bio-pesticides Green Chemistry Bio-fuels Bio-plastics Bio-preservatives
9 Food Microbes Industrial microbes Bacteria (Lactic Acid Bacteria) Yeast (Saccharomyces spp.) +Raw ingredients Benefits: Shelf-life Taste/Flavour Digestibility Nutrition
10 Health Microbes Industrial microbes Bacteria (Lactic Acid Bacteria) Yeast (Saccharomyces spp.) Probiotics Benefit: Competition to pathogens Wellness & Nutrition Immuno-regulator Psychotropics Human Microbiome Top 10 emerging technologies The World Economic Forum (1 September 2014)
11 Health Microbes
12 Advantages of the molecular approach DNA patters Molecular markers Signature sequences Genomes sequence Meta-genomic High discrimination High accuracy High reliability...and OVER the species level
13 Advantages of the molecular approach Intra-specie biodiversity: Same specie Different abilities DNA patters Molecular markers Signature sequences Genomes sequence Meta-genomic High discrimination High accuracy High reliability...and OVER the species level
14 Genre Advantages of the molecular approach STRAIN Specie DNA patters Molecular markers Signature sequences Genomes sequence Meta-genomic Saccharomyces cerevisiae (strain?)
15 Case study: Innovation in traditional winemaking Improved quality wines Cost efficiency Local population study (1000+ yeasts) MASI Yeast Bio-Bank (100+ yeasts) Experimental wine production (10+ yeasts) Scale-up winemaking (2 yeasts) Distinctive flavour Cost saving (and C0 2 ) Seasonal consistency Unique on the market!
16 Genere Case study: Microbes manufacturing Improved quality control Regulatory compliance Patent deposit Intra-specie biodiversity study Strain? Species Molecular Fingerprinting Services Manufacturing: Batch validation Regulatory: Genome stability reference Legal: IP right defensibility
17 Advantages of the molecular approach genus strain species Consumer confusion by intra-species diversity: S. cerevisiae pathogenic, when adapted to human niche (temperature) Enterococcus faecium health promoter or marker for water pollution? Feed additive Bacillus cereus Vs. hemotoxic B. cereus Probiotic Escherichia coli (Nissle 1917) Vs. virulent E. coli
18 Genome analysis Random genome sampling Random Amplified Polymorphic DNA (RAPD-PCR) Whole genome profiling Pulsed Field Gel Electrophoresis (PFGE) Rapid Not unambiguous Unambiguous Time consuming
19 Genome analysis Recent advancement of PFGE methodology: Optical Mapping Linearized genome Genome restriction Fragments detection and measuring Strain specific DNA-barcode Strain tracking Detection of genomic rearrangement Genome sequencing scaffolding
20 Genome analysis Strain specific DNA-barcode Genome sequencing scaffolding L. brevis ATCC 367 (NC ) (in-silico WGM) L. brevis KB290 (NC ) (in-silico WGM) L. brevis ATCC 367 (NC ) (in-silico WGM) L. brevis LMG (4 independent replicates)
21 Genome analysis Genomic DNA restriction fragment (PFGE, ribotyping) Profiling PCR-amplified DNA (RAPD-, ERIC-, REP-PCR) PCR-amplification of restriction fragments (AFLP) Restriction analysis of DNA fragments (PCR-RFLP) DNA Multi-Locus Sequence Typing (MLST) House-keeping Multi-Locus Sequence Analysis (MLSA) Amplified Ribosomal DNA Restriction Analysis (ARDRA) rrna gene sequencing analysis (SSU, LSU) Genomic DNA-DNA Hybridisation (DDH) Genomic DNA mol% G+C Whole genome sequencing analysis
22 Genome analysis Tremendous advancement of DNA sequencing = Next Generation Sequencing Reduced time and lower cost Improved downstream analysis Regulatory authorities suggest or require state-of-the-art-technology = genome sequencing: FDA Guidance for Industry: Early Clinical Trials with Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information Strain-specific diagnostics and tracking EFSA Guidance on the safety assessment of Enterococcus faecium in animal nutrition Safety assessment
23 Genome analysis All molecular markers become available (also currently unknown) development of specific diagnostic methods Gene copy number and regulators of health claims relevant genes Adaptation to the intestinal niche Genes involved in the interactions with the host Probiotic factors (e.g. serpin) able to suppress inflammatory responses Antimicrobial compounds for pathogen inhibition Assessment of health risks Biogenic amine production Virulence genes Antibiotic-resistance gene
24 Genome analysis Antibiotic-resistant strains Comparative Genomics the study of the relationship of genome structure and function across different biological species or strains (EFSA, 2012)
25 Team Antonio Del Casale CEO MSc Biotechnology Tech Transfer Open Innovation Fabio Fracchetti COO PhD Biotechnology Molecular Microbiology Patents Valter Carturo CFO MEc Business Administration Chattered Accountant Start-up Operations Sandra Torriani Scientific Adv. Full Professor Microbiology Food-tech Innovation 150+ Peer review publications Giovanna Felis Scientific Adv. Associate Professor Microbiology Lactic Acid Bacteria Taxonomy & Genomics
26 The leading microbiology innovation provider (micro-organisms making mega-impact) Antonio Del Casale Meet us at:
27 Milestones & Use of funds Seed 10K Spin-off First 10K customer Veneto Region grant First commercial partner First EU-H2020 project First strain licensed University grants First tech partner First conference invitation Impresa per Impresa ConfindustriaProgramme First patent First patent licensed Spin-out from University facilities Second patent licensed Royalties > Sales Marketing team Second patent SME Instrument EU-H2020 project Third patent Microbion Agro Microbion Health Microbion Food-tech Microbion Energy
28 Golden standards for identification: Multi-locus sequence typing Within a species, ribosomal subunit are not discriminant Actinobacteridae putative proteomes All vs All BLASTp In-silico selection One copy in every genome Dinucleotide frequencies, GC content and codon usage consistent with genome Core genes of Bifidobacteria 18 High resolution between species Discriminate strains of same species 7 Molecular markers typing scheme (Ventura et al. 2006) 9 Candidate markers analysis (partial sequences) Vitafoods Europe 2013
29 ROI Strategy Potential acquisition paths: A Management buy-back B Partial asset sale C Diagnostic brand co-development Lactic Acid Bacteria ID Yeasts ID Acquisition examples benchmark: Lumora Cambridge Spin-off R&D of BART tech raised $2.1M by Tate&Lyle now licensed to 3M
30 ROI Strategy Potential acquisition paths: A Management buy-back B Partial asset sale Diagnostics patents Microbial Strains Acquisition examples benchmark: BioFire sold FilmArray asset to biomérieux s for $450M BioGaia receive 10M/year for L. reuteri from Nestlé infant nutrition
31 Key Advantages Service and Products 20+ Customers success cases 6 Industries Unique advantage: 2013 Sales 50+ collective years of experience Market needs & solutions Unique microbes bio-bank Non-patented trade secrets Open innovation network Consumer products Agri-food Dairy Wine Universities Probiotics
32 Key partners Business Scouting Institutional
33 Genome analysis Definition of Species: Group of strains sharing high level of genomic and phenotypic similarity Foundations for microbial characterization Exchange of information among scientific community Laws regulations and guidelines FDA Generally Regarded As Safe (GRAS) EFSA Qualified presumption of safety (QPS)
Providing clear solutions to microbiological challenges TM. cgmp/iso CLIA. Polyphasic Microbial Identification & DNA Fingerprinting
Providing clear solutions to microbiological challenges TM Cert. No. 2254.01 Polyphasic Microbial Identification & DNA Fingerprinting Microbial Contamination Tracking & Trending cgmp/iso-17025-2005 CLIA
cgmp/iso CLIA Experience Unsurpassed Quality
Cert. No. 2254.01 cgmp/iso-17025-2005 CLIA Experience Unsurpassed Quality Polyphasic Microbial Identification & DNA Fingerprinting Microbial Contamination Tracking & Trending Microbial Identification
Microbial Diversity and Assessment (III) Spring, 2007 Guangyi Wang, Ph.D. POST103B
Microbial Diversity and Assessment (III) Spring, 2007 Guangyi Wang, Ph.D. POST103B guangyi@hawaii.edu http://www.soest.hawaii.edu/marinefungi/ocn403webpage.htm Overview of Last Lecture Taxonomy (three
Contents. 1 Basic Molecular Microbiology of Bacteria... 1 Exp. 1.1 Isolation of Genomic DNA Introduction Principle...
Contents 1 Basic Molecular Microbiology of Bacteria... 1 Exp. 1.1 Isolation of Genomic DNA... 1 Introduction... 1 Principle... 1 Reagents Required and Their Role... 2 Procedure... 3 Observation... 4 Result
MicroSEQ Rapid Microbial Identification System
MicroSEQ Rapid Microbial Identification System Giving you complete control over microbial identification using the gold-standard genotypic method The MicroSEQ ID microbial identification system, based
CERTIFICATE OF ACCREDITATION
CERTIFICATE OF ACCREDITATION ANSI-ASQ National Accreditation Board/ACLASS 500 Montgomery Street, Suite 625, Alexandria, VA 22314, 877-344-3044 This is to certify that Molecular Epidemiology, Inc. (MEI)
Genetics Lecture 21 Recombinant DNA
Genetics Lecture 21 Recombinant DNA Recombinant DNA In 1971, a paper published by Kathleen Danna and Daniel Nathans marked the beginning of the recombinant DNA era. The paper described the isolation of
Patentability/Literature Research
Patentability/Literature Research The probiotic-based solution to combat cholera as presented here comprises of two major innovative components: (1) the metabolite-dependent pathogen inhibition by a probiotic
What s Spoiling Your Beer?
What s Spoiling Your Beer? the MiL, Inc. MICROBE INOTECH LABORATORIES, INC. The Microbiology of Beer Contamination Microorganisms that contribute to the spoilage of beer, such as bacteria, wild yeasts,
HiPer Random Amplification of Polymorphic DNA (RAPD) Teaching Kit
HiPer Random Amplification of Polymorphic DNA (RAPD) Teaching Kit Product Code: HTBM031 Number of experiments that can be performed: 5 Duration of Experiment: Protocol: 3.5 hours Agarose Gel Electrophoresis:
METAGENOMICS. Aina Maria Mas Calafell Genomics
METAGENOMICS Aina Maria Mas Calafell Genomics Introduction Microbial communities Primary role in biogeochemical systems Study of microbial communities 1.- Culture-based methodologies Only isolated microbes
USP Probiotic Roundtable Summary
USP Probiotic Roundtable Summary USP Stakeholder Forum Buffy Stahl DuPont Nutrition and Health 1 June 2016 Topics discussed 1. Monograph requirements for Dietary Supplements vs. Dietary Ingredients. 2.
The right answer, every time
MICROSEQ MICROBIAL IDENTIFICATION SYSTEM The right answer, every time Definitive identification of bacterial and fungal isolates. Accuracy adds confidence. When microbial contamination poses problems,
What is it? Sherlock knows! Microbial Identification System
What is it? Sherlock knows! Microbial Identification System Sherlock Microbial Identification System Microbial ID 10 Minutes... $2.50 Is it accurate? Established technology with 15 years of clinical and
Multiple choice questions (numbers in brackets indicate the number of correct answers)
1 Multiple choice questions (numbers in brackets indicate the number of correct answers) February 1, 2013 1. Ribose is found in Nucleic acids Proteins Lipids RNA DNA (2) 2. Most RNA in cells is transfer
Compendium. of Methods. for the Microbiological Examination of Foods APHA PRESS. Mary Lou Tortorello. Yvonne Salfinger.
Compendium of Methods for the Microbiological Examination of Foods Editors Yvonne Salfinger Mary Lou Tortorello % A P H L ASSOCIATION OF PUBLIC HEAL1 HEALTH LABORATORIES* APHA PRESS AH IMPRINT OF AMERICAN
BIOTECHNOLOGY. Course Syllabus. Section A: Engineering Mathematics. Subject Code: BT. Course Structure. Engineering Mathematics. General Biotechnology
BIOTECHNOLOGY Subject Code: BT Course Structure Sections/Units Section A Section B Unit 1 Unit 2 Unit 3 Unit 4 Unit 5 Unit 6 Unit 7 Section C Section D Section E Topics Engineering Mathematics General
N.H. Sea Grant Research Project Progress Report
N.H. Sea Grant Research Project Progress Report Today s date: May 17, 2010 Project number: R/CE-137 Project title: Microbial Interactions Influencing the Emergence of Pathogenic Vibrios in Oysters Project
Practical quality control for whole genome sequencing in clinical microbiology
Practical quality control for whole genome sequencing in clinical microbiology John WA Rossen, PhD, MMM Department of Medical Microbiology, University of Groningen, UMCG, Groningen, The Netherlands Disclosure
Preservation and Skin Microflora: A Conflict? Understanding the Role of Skin Microflora in Cosmetic Formulation
Preservation and Skin Microflora: A Conflict? Understanding the Role of Skin Microflora in Cosmetic Formulation Importance of the Skin Microbiome Introduction Skin microbiome discovery is a revolutionary
Chapter 10 Analytical Biotechnology and the Human Genome
Chapter 10 Analytical Biotechnology and the Human Genome Chapter Outline Enzyme tests and biosensors DNA-based tests DNA analysis technologies Human genome and genome-based analytical methods 1 Enzyme-based
THE BENEFITS AND USES OF MICROBES
MODULE 4 MICROBES AND MICROBIAL BIOTECHNOLOGY U N I T 2 THE BENEFITS AND USES OF MICROBES A. MICROBIAL BIOTECHNOLOGY 1 Read What is biotechnology? and decide which of the words below can be used instead
Microbial Biotechnology agustin krisna wardani
Microbial Biotechnology agustin krisna wardani 1. The Structure of Microbes Microbes (microorganisms) are tiny organisms that are too small to be seen individually by the naked eye and must be viewed with
Driving sustainable growth through innovation Rob van Leen, Chief Innovation Officer & Member Executive Committee Delft, September 25, 2017
Driving sustainable growth through innovation Rob van Leen, Chief Innovation Officer & Member Executive Committee Delft, September 25, 2017 ROYAL DSM HEALTH NUTRITION MATERIALS Safe harbor statement This
Genetic Engineering & Recombinant DNA
Genetic Engineering & Recombinant DNA Chapter 10 Copyright The McGraw-Hill Companies, Inc) Permission required for reproduction or display. Applications of Genetic Engineering Basic science vs. Applied
Chapter 9 Genetic Engineering
Chapter 9 Genetic Engineering Biotechnology: use of microbes to make a protein product Recombinant DNA Technology: Insertion or modification of genes to produce desired proteins Genetic engineering: manipulation
Molecular Cell Biology - Problem Drill 11: Recombinant DNA
Molecular Cell Biology - Problem Drill 11: Recombinant DNA Question No. 1 of 10 1. Which of the following statements about the sources of DNA used for molecular cloning is correct? Question #1 (A) cdna
Environmental Genomics and Systems Biology Institute of Natural Resource Sciences Zurich University of Applied Sciences, Wädenswil, Switzerland
Environmental Genomics and Systems Biology Institute of Natural Resource Sciences Zurich University of Applied Sciences, Wädenswil, Switzerland www.zhaw.ch MALDI-TOF MS for microorganism identification:
Chapter 10: Classification of Microorganisms
Chapter 10: Classification of Microorganisms 1. The Taxonomic Hierarchy 2. Methods of Identification 1. The Taxonomic Hierarchy Phylogenetic Tree of the 3 Domains Taxonomic Hierarchy 8 successive taxa
Implementation of the VITEK MS and Its Use in Microbial Identification
Implementation of the VITEK MS and Its Use in Microbial Identification K a t a l i n K i s s, P h. D., P M P M a n a g e r, S c i e n t i s t, L a b o r a t o r y Te s t i n g S e r v i c e s, AT C C O
JEFFERSON COLLEGE GENERAL MICROBIOLOGY
JEFFERSON COLLEGE COURSE SYLLABUS BIO215 GENERAL MICROBIOLOGY 5 Credit Hours Prepared by: Dr. Cecil M. Hampton Revised Date: November 2005 by Dr. Ken Balak Arts & Science Education Dr. Mindy Selsor, Dean
RFLP: Restriction Fragment Length Polymorphism
RFLP: Restriction Fragment Length Polymorphism Various endonucleases: 6 cutters and 4 cutters Enzyme Source Recognition Sequence Cut EcoRI Escherichia coli 5'GAATTC 5'---G/AATTC---3' EcoRII Escherichia
Conflicts of Interest. Rapid Cycle PCR (20 60 second cycles) How long does it take to. 10/16/2014
Extreme PCR Efficient Amplification in Less Than One Minute Carl Wittwer, MD, PhD, Department of Pathology, University of Utah Conflicts of Interest BioFire/Idaho Technology CoFounder and Chairman Royalties,
AM-1 an innovative anti-microbial preserving agent from fungi source. CLIB-Forum Biotechnologie in der Lebensmittelindustrie, July 2013
AM-1 an innovative anti-microbial preserving agent from fungi source CLIB-Forum Biotechnologie in der Lebensmittelindustrie, July 2013 Mission of INS IMD Natural Solutions ( INS ) aims to develop and commercialize
B.Sc. MICROBIOLOGY SYLLABUS DDU GORAKHPUR UNIVERSITY, GORAKHPUR Industrial Microbiology D. D. U. Gorakhpur University, Gorakhpur B.Sc.
Industrial Microbiology D. D. U. Gorakhpur University, Gorakhpur B.Sc. III B.Sc. II: Three papers and a practical examination as follows: Paper I: Food Microbiology Papers II: Fermentation Technology Papers
Investor Presentation November 2017
Investor Presentation November 2017 1 DISCLAIMER The material contained in this document is a presentation of general information about the proposed activities of Microba Pty Ltd as at the date of this
NOTES - CH 15 (and 14.3): DNA Technology ( Biotech )
NOTES - CH 15 (and 14.3): DNA Technology ( Biotech ) Vocabulary Genetic Engineering Gene Recombinant DNA Transgenic Restriction Enzymes Vectors Plasmids Cloning Key Concepts What is genetic engineering?
3. human genomics clone genes associated with genetic disorders. 4. many projects generate ordered clones that cover genome
Lectures 30 and 31 Genome analysis I. Genome analysis A. two general areas 1. structural 2. functional B. genome projects a status report 1. 1 st sequenced: several viral genomes 2. mitochondria and chloroplasts
CONTENT 1. INTRODUCTION 2. METHODS 3. RESULTS Quality assurance system Staff personnel and analytical activities Laboratory methods
Community Reference Laboratory for E.coli Department of Food Safety and Veterinary Public Health Unit of Foodborne Zoonoses and Veterinary Epidemiology Istituto Superiore di Sanità Inventory of expertise,
DNA-Based Methods for Botanical Identification
USP Dietary Supplements Stakeholder Forum Wednesday, June 1, 2016 DNA-Based Methods for Botanical Identification Nandakumara Sarma, PhD, RPh. USP and USDA Workshop on DNA Methods for Quality Control of
Bio 311 Learning Objectives
Bio 311 Learning Objectives This document outlines the learning objectives for Biol 311 (Principles of Genetics). Biol 311 is part of the BioCore within the Department of Biological Sciences; therefore,
MICROSATELLITE MARKER AND ITS UTILITY
Your full article ( between 500 to 5000 words) - - Do check for grammatical errors or spelling mistakes MICROSATELLITE MARKER AND ITS UTILITY 1 Prasenjit, D., 2 Anirudha, S. K. and 3 Mallar, N.K. 1,2 M.Sc.(Agri.),
Course Descriptions. BIOL: Biology. MICB: Microbiology. [1]
![Course Descriptions. BIOL: Biology. MICB: Microbiology. [1]](/thumbs/72/66855241.jpg "Course Descriptions. BIOL: Biology. MICB: Microbiology. [1]")
Course Descriptions BIOL: Biology http://www.calendar.ubc.ca/vancouver/courses.cfm?code=biol [1] BIOL 112 (3) Biology of the Cell The principles of cellular and molecular biology using bacterial and eukaryotic
The Human Microbiome: A New Paradigm? John Huss Department of Philosophy The University of Akron
The Human Microbiome: A New Paradigm? John Huss Department of Philosophy The University of Akron Structure of talk Some thoughts on the HMP and metagenomics Two paradigms of disease/health Old paradigm:
Organic Materials Review Institute
Organic Materials Review Institute Genetic Engineering Considerations in the Evaluation of Inputs for Organic Farming and Food Processing A Policy in Development December 11, 2000 Box 11558 Eugene OR 97440
A higher education training course Introduction to the selected methods of genomics and bioinformatics Bratislava, Slovakia, October 12-15, 2009
Roman Dušinský A higher education training course Introduction to the selected methods of genomics and bioinformatics Bratislava, Slovakia, October 12-15, 2009 Microbial diversity and identification methods
Functional vs Organismal views of Ecology. One organism: Population genetics Many organisms: Ecology No organisms: Ecosystems
Functional vs Organismal views of Ecology One organism: Population genetics Many organisms: Ecology No organisms: Ecosystems The trade-off between precision and relevance Another trade-off exists: resolution
Sequence Analysis Lab Protocol
Sequence Analysis Lab Protocol You will need this handout of instructions The sequence of your plasmid from the ABI The Accession number for Lambda DNA J02459 The Accession number for puc 18 is L09136
Microbial testing. The issue. Why is this important? Things to consider. What to test for
Microbial testing The issue Microbiological testing of melons is a useful tool to check for contamination of fruit and to test the effectiveness of management practices used to prevent, reduce or eliminate
12/06/2012. Background. Taxonomy. Simone M Cacciò. Phylogenetic position of Dientamoeba fragilis
Simone M Cacciò European Union Reference Laboratory for Parasites Department of Infectious, Parasitic and Immunomediated Diseases Istituto Superiore di Sanità 7th Workshop of National Reference Laboratories
Certificate of Analysis
Certificate of Analysis pet6xhn Expression Vector Set Contents Product Information... 1 pet6xhn-n, pet6xhn-c, and pet6xhn-gfpuv Vector Information... 2 Location of Features... 4 Additional Information...
Polymerase Chain Reaction (PCR) and Its Applications
Polymerase Chain Reaction (PCR) and Its Applications What is PCR? PCR is an exponentially progressing synthesis of the defined target DNA sequences in vitro. It was invented in 1983 by Dr. Kary Mullis,
Future Scenarios of Science, Technology and Innovation
Future Scenarios of Science, Technology and Innovation Heribert Watzke, PhD Nestlé Research Vevey, Switzerland Converging Science & Technology for Nutrition, Health and Wellness Global Food Sector in bn
Rapid Bacterial Identification Using a Mass Spectrometry Based Molecular Diagnostics Approach: Evaluation of the Iridica Platform
Rapid Bacterial Identification Using a Mass Spectrometry Based Molecular Diagnostics Approach: Evaluation of the Iridica Platform Alec Saitman, PhD, Jane Y. Yang PhD, Sharon Reed, David Pride, Michele
WHO S THERE ANYWAY? STRAIN LEVEL DIFFERENTIATION OF THE PROBIOTIC BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS
WHO S THERE ANYWAY? STRAIN LEVEL DIFFERENTIATION OF THE PROBIOTIC BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS Dairy Practices Council November 6, 2015 Robert F. Roberts, Ph.D. Professor and Head Department
Hosted by Paul Webber page 1
A Webber Training Teleclass April 8, 24 Bacterial Typing Methods and Their Value in Infection Control Giles Edwards Consultant Microbiologist Stobhill Hospital, Glasgow, UK Scottish MRSA Reference Laboratory
BA, BSc, and MSc Degree Examinations
Examination Candidate Number: Desk Number: BA, BSc, and MSc Degree Examinations 2017-8 Department : BIOLOGY Title of Exam: Bacterial pathogenesis Time Allowed: 2 hours Marking Scheme: Total marks available
World Congress on Industrial Biotechnology May, 2014
World Congress on Industrial Biotechnology May, 2014 1 The Value Proposition Leader in precision gene editing RTDS Non transgenic, non GMO platform RTDS Broadly applicable across many organisms Significant
BIOTECHNOLOGY SYSTEMS CAREER PATHWAY
Plant Systems Te Power, r Structural and T chnical Systems Natural Resource Car Systems eer Pathway A F N R A F N R Agribusiness Systems C A R E E R C O N T E N T C L U S T E R Career Ready Practices Content
3 Designing Primers for Site-Directed Mutagenesis
3 Designing Primers for Site-Directed Mutagenesis 3.1 Learning Objectives During the next two labs you will learn the basics of site-directed mutagenesis: you will design primers for the mutants you designed
Infectious Disease Omics
Infectious Disease Omics Metagenomics Ernest Diez Benavente LSHTM ernest.diezbenavente@lshtm.ac.uk Course outline What is metagenomics? In situ, culture-free genomic characterization of the taxonomic and
Microbial Culture Collection of Cantacuzino Institute
Microbial Culture Collection of Cantacuzino Institute Present and perspectives of development Olguta Dracea, Camelia Babes, Rodica Oancea, Anca Israil, Irina Codita, Adrian Onu, Gabriel Ionescu Cantacuzino
Probiotic for Aquaculture. Inge Knap Director, Research & Development Chr. Hansen, Denmark
Probiotic for Aquaculture Improving Health and Performance Inge Knap Director, Research & Development Chr. Hansen, Denmark The research for probiotic for aquatic animals is increasing The research for
Lactobacillus acidophilus
TM Primerdesign Ltd Lactobacillus acidophilus Recombinase A (reca) gene genesig Advanced Kit 150 tests For general laboratory and research use only 1 Introduction to Lactobacillus acidophilus Lactobacillus
Chapter 7 DNA Fingerprinting By the end of this chapter you will be able to:
Chapter 7 DNA Fingerprinting By the end of this chapter you will be able to: explain how crime scene evidence is collected and processed to obtain DNA describe how radioactive probes are used in DNA fingerprinting
Sept 2. Structure and Organization of Genomes. Today: Genetic and Physical Mapping. Sept 9. Forward and Reverse Genetics. Genetic and Physical Mapping
Sept 2. Structure and Organization of Genomes Today: Genetic and Physical Mapping Assignments: Gibson & Muse, pp.4-10 Brown, pp. 126-160 Olson et al., Science 245: 1434 New homework:due, before class,
Pharma&Biotech. XS Microbial Expression Technologies Optimize Productivity, Speed and Process Robustness
Pharma&Biotech XS Microbial Expression Technologies Optimize Productivity, Speed and Process Robustness Embracing Complexity Based on 30 years of innovation in microbial biotechnology, Lonza offers the
7 Gene Isolation and Analysis of Multiple
Genetic Techniques for Biological Research Corinne A. Michels Copyright q 2002 John Wiley & Sons, Ltd ISBNs: 0-471-89921-6 (Hardback); 0-470-84662-3 (Electronic) 7 Gene Isolation and Analysis of Multiple
Cat # Box1 Box2. DH5a Competent E. coli cells CCK-20 (20 rxns) 40 µl 40 µl 50 µl x 20 tubes. Choo-Choo Cloning TM Enzyme Mix
Molecular Cloning Laboratories User Manual Version 3.3 Product name: Choo-Choo Cloning Kits Cat #: CCK-10, CCK-20, CCK-096, CCK-384 Description: Choo-Choo Cloning is a highly efficient directional PCR
LightScanner Hi-Res Melting Comparison of Six Master Mixes for Scanning and Small Amplicon and LunaProbes Genotyping
LightScanner Hi-Res Melting Comparison of Six Master Mixes for Scanning and Small Amplicon and LunaProbes Genotyping Introduction Commercial master mixes are convenient and cost-effective solutions for
Molecular methods in medical microbiology: Current and future trends
Bangladesh Journal of Medical Science Vol.10 No.3 Jul 11 Editorial Introduction Molecular methods in medical microbiology: Current and future trends Microbial diseases are the principal causes of morbidity
SYMBIOTIC HEALTH. Targeted GI Delivery of Orally Administered Cells and Proteins for Microbiome-Based Therapeutics
SYMBIOTIC HEALTH Targeted GI Delivery of Orally Administered Cells and Proteins for Microbiome-Based Therapeutics Contact: Gerard Honig PhD, Director ghonig@symbioticbio.com Overview Biotechnology startup
Diagnosis Sanger. Interpreting and Troubleshooting Chromatograms. Volume 1: Help! No Data! GENEWIZ Technical Support
Diagnosis Sanger Interpreting and Troubleshooting Chromatograms GENEWIZ Technical Support DNAseq@genewiz.com Troubleshooting This troubleshooting guide is based on common issues seen from samples within
Relating mrna and protein biomarker levels in a Dehalococcoides and Methanospirillum containing community
Applied Microbiology and Biotechnology Electronic Supplementary Material for: Relating mrna and protein biomarker levels in a Dehalococcoides and Methanospirillum containing community Annette R. Rowe a#,
RiboPrinter microbial characterization system
DuPont Qualicon RiboPrinter microbial characterization system Staphylococcus epidermidis RiboGroup 102-45-3 DEDICATED TO MICROBIOLOGY OK. You found it. Now what? RiboPrinter microbial characterization
FIGHT FOOD WASTE & FRAUD CRC. To protect and profit Australia s food & wine industry
FIGHT FOOD WASTE & FRAUD CRC To protect and profit Australia s food & wine industry WHY YOU SHOULD INVEST IN THIS CRC? You are an organisation in the food or beverage industry concerned about the 42% of
Reflection paper on co-development of pharmacogenomic biomarkers and Assays in the context of drug development
1 2 3 24 June 2010 EMA/CHMP/641298/2008 Committee for Medicinal Products for Human Use (CHMP) 4 5 6 7 Reflection paper on co-development of pharmacogenomic biomarkers and Assays in the context of drug
Biotechnology and Genomics in Public Health. Sharon S. Krag, PhD Johns Hopkins University
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this
a. Primers were purchased from Display Systems Biotech and are listed numerically to differentiate them
Table 2-1. Random upstream primers used in fluorescence differential display. Upstream primer a Sequence 1 5 GATCATAGCC 2 5 CTGCTTGATG 3 5 GATCCAGTAC 4 5 GATCGCATTG 5 5 AAACTCCGTC 6 5 TGGTAAAGGG 7 5 GATCATGGTC
Existing potato markers and marker conversions. Walter De Jong PAA Workshop August 2009
Existing potato markers and marker conversions Walter De Jong PAA Workshop August 2009 1 What makes for a good marker? diagnostic for trait of interest robust works even with DNA of poor quality or low
PATHOGENS DETECTION VIA PCR WITH AUTOMATED SAMPLE PREPARATION BASED ON IMMUNOMAGNETIC SEPARATION (IMS) mrama Workshop Barcelona 22 November 2017
PATHOGENS DETECTION VIA PCR WITH AUTOMATED SAMPLE PREPARATION BASED ON IMMUNOMAGNETIC SEPARATION (IMS) mrama Workshop Barcelona 22 November 2017 Assurance GDS Genetic Detection System A unique molecular
Recombinant DNA Technology. The Role of Recombinant DNA Technology in Biotechnology. yeast. Biotechnology. Recombinant DNA technology.
PowerPoint Lecture Presentations prepared by Mindy Miller-Kittrell, North Carolina State University C H A P T E R 8 Recombinant DNA Technology The Role of Recombinant DNA Technology in Biotechnology Biotechnology?
Laboratory Reagents and Raw Materials for Production.
Laboratory Reagents and Raw Materials for Production www.itwreagents.com The Origin of Our Industrial Character ITW Illinois Tool Works Inc. (NYSE: ITW) is a diversified manufacturing company that delivers
Title: Genome sequence of lineage III Listeria monocytogenes strain HCC23
JB Accepts, published online ahead of print on 20 May 2011 J. Bacteriol. doi:10.1128/jb.05236-11 Copyright 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.
New Dairy Products and Value Chains
Whai Hua Primary Growth Partnership (PGP) Programme New Dairy Products and Value Chains Final Summary Report April 2017 1 Executive Summary Investment. The PGP programme New Dairy Products and Value Chains
PCR Bacteria Test Kit
PCR Bacteria Test Kit 2 3 Contents Reagents and Materials 3 Application and Test Principle 4 Precautions 5 Test Protocol 5 Appendix 11 Ordering Information 12 Reagents and Materials Kit Components Bacteria
Supplemental Materials. DNA preparation. Dehalogenimonas lykanthroporepellens strain BL-DC-9 T (=ATCC
Supplemental Materials DNA preparation. Dehalogenimonas lykanthroporepellens strain BL-DC-9 T (=ATCC BAA-1523 = JCM 15061) was grown in defined basal medium amended with 0.5 mm 1,1,2- trichloroethane (1,1,2-TCA)
Chapter 8 Recombinant DNA Technology. 10/1/ MDufilho
Chapter 8 Recombinant DNA Technology 10/1/2017 1 MDufilho The Role of Recombinant DNA Technology in Biotechnology Biotechnology? Recombinant deoxyribonucleic acid (DNA) technology Intentionally modifying
Chapter 15 Gene Technologies and Human Applications
Chapter Outline Chapter 15 Gene Technologies and Human Applications Section 1: The Human Genome KEY IDEAS > Why is the Human Genome Project so important? > How do genomics and gene technologies affect
Using Genetics for Species Identification
Using Genetics for Species Identification John Hyde NOAA Southwest Fisheries Science Center La Jolla, California USA December 6, 2013 2 Important Point to Consider Not all specimens need to be genetically
KOD -Plus- Mutagenesis Kit
Instruction manual KOD -Plus- Mutagenesis Kit 0811 F0936K KOD -Plus- Mutagenesis Kit SMK-101 20 reactions Store at -20 C Contents [1] Introduction [2] Flow chart [3] Components [4] Notes [5] Protocol 1.
Manipulating DNA. Nucleic acids are chemically different from other macromolecules such as proteins and carbohydrates.
Lesson Overview 14.3 Studying the Human Genome Nucleic acids are chemically different from other macromolecules such as proteins and carbohydrates. Nucleic acids are chemically different from other macromolecules
COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS NOTE FOR GUIDANCE 1 : DNA VACCINES NON-AMPLIFIABLE IN EUKARYOTIC CELLS FOR VETERINARY USE
The European Agency for the Evaluation of Medicinal Products Evaluation of Medicines for Veterinary Use CVMP/IWP/07/98-FINAL COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS NOTE FOR GUIDANCE 1 : DNA VACCINES
BSc Minors in English
BSc Minors in English Wageningen University Overview BSc Minors for Exchange Students All minors presented on this information sheet are taught in English. For more information please surf to: www.wageningenuniversity.nl/minors
Application Form for Editorial Board
Application Form for Editorial Board Dr. Mohamed Ahmed El-Esawi Part I: Basic Information Beginning date of editorial work Subject areas I am interested in Starting from NOW Biology, Agricultural and Life