MANGAIYARKARASI R. OSU Post-Doctoral Fellow

Transcription

1 MANGAIYARKARASI R OSU Post-Doctoral Fellow mangaii_r@yahoo.com OBJECTIVE I have interested in working with the challenging research and teaching environment using my analytical, research experience and group activity skills and to be in part of the asset to the human society. LINK TO RESEARCH INTEREST EDUCATION PERIOD July January 2016 Ph.D (Technology) TITLE Study and Characterization of Rare earth doped nanoparticles for Theranostic applications UNIVERSITY Anna University Chennai, Tamil Nadu PERIOD July June 2010 M.Tech (Nanotechnology) UNIVERSITY VIT University Vellore, Tamil Nadu PERIOD July May 2008 B.E (Electronics & Communication Engg) COLLEGE Adhiparasakthi College of Engineering UNIVERSITY Anna University Chennai, Tamil Nadu HONORS & AWARDS Anna Centenuary Research Fellowship (ACRF) during January December 2014 was awarded by Centre for Research, Anna University. TEACHING EXPERIENCE

2 Worked as an Assistant Professor at L.C.R College of Engineering & Technology, Later named as Jaya Institute of Technology, Kanchipadi, Thiruvallur District, from September 2010 to July Had taken classes for the students persuing B.E and M.E degrees (part time) in Tamilnadu Open University during During my Ph.D, I was guided 9 M.Sc/ M.Tech students for their Master s project in the field of Nanoparticles formulated with various anticancer drugs for Targeted drug delivery systems applications. Working as a Resident Counselor for the Non-Residing Indian (NRI) and Foreign Students at Anna University, Chennai-25 from January 2012 to January HANDLING EXPERIENCE Instruments UV-Visible Absorption Spectroscopy Fluorescence Emission Spectroscopy Fluorescence Lifetime Spectroscopy (TCSPC) Cyclic Voltammetry Atomic Force Microscopy (AFM) Scanning Tunneling microscopy (STM) Raman Spectroscopy Softwares Matlab Monte-Carlo Simulations UV-Winlab Fluoromax Origin 9.1 RESEARCH EXPERIENCE The broad area of my research involves in synthesis and characterization of various biocompatible and less toxic nanoparticles for cancer diagnosis and therapeutical applications. I have also been involved in formulation and bioconjugation of nanoparticles with anticancer drugs such as 5-Fluorouracil, Methotrexate, Paclitaxel and thiosemi carbazone derivatives for targeting drug delivery mechanism. The confirmation of drug conjugation with the nanoparticles have been carried out using various physico-chemical techniques such as Transmission electron

3 microscopy, Scanning electron microscopy, Spectrophotometer, Fluorescence spectroscopy, Time-resolved fluorescence spectroscopy and Micro Raman spectroscopy. The percentage yield and encapsulation efficacy of these nanoparticles have also been calculated, in order to know the effective dose. While designing and dealing with the biomedical applications of any nanoparticles, it is important to study the biosafety and effect of these nanoparticles inside our body using carriers albumin (protein) model and DNA. Hence, the studies on the interactions between the protein and DNA models with drug-nanoparticles have also been carried out. Since, my research also deals with the therapeutical applications, i have also been involved in studying the efficacy of nano formulated drugs in breast and lung cancer cell lines for the confirmation of increased cell death using formulated drug conjugated nanoparticles compared with that of drugs (without nanoformulation) using fluorescence inverted microscopy. As we are also focusing on designing a cost effective nano-biosensors for DNA detection applications, at present, I am working with rare earth doped nanoparticles for effective detection of DNA in biological samples. In addition to this, I have also well trained in operating Scanning electron microscopy, Atomic force microscopy, Cyclic Voltammeter, Spectrophotometer, fluorescence spectroscopy, fluorescence lifetime and Raman spectroscopy with imaging system instrumentation. Technical Skills: Handling and well trained in equipment operation such as Scanning electron microscopy, Atomic force microscopy, Cyclic Voltammeter, UV-VIS spectroscopy (Perkin Elmer), Fluoromax, Fluorolog, Micro-Raman Spectroscopy and imaging system (LabRAM HR800 Horiba Jobin Yvon) and TE300 Nikon Inverted Fluorescence Microscope. Softwares: Origin 9.1 and IBM SPSS Operating System: Windows 7, 8 LIST OF PUBLICATIONS (A) Published/Accepted for Publication in Journals

4 1. Mangaiyarkarasi, R., Chinnathambi, S., Aruna, P., and Ganesan, S. Synthesis and formulation of methotrexate (MTX) conjugated LaF3:Tb 3+ /chitosan nanoparticles for targeted drug delivery applications, Biomed. Pharma. 69, 170; DOI: /j.biopha Mangaiyarkarasi, R., Chinnathambi, S., Aruna, P., and Ganesan, S. Synthesis of 5- Fluorouracil conjugated LaF3:Tb 3+ /PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach, J. Nanopart Res., 17,136; DOI: /s y. 3. Mangaiyarkarasi, R., Chinnathambi, S., Karthikeyan.S., Aruna, P., and Ganesan, S. Paclitaxel conjugated 3+,Tb 3+ nanoparticles as bifunctional targeting carriers for cancer theranostics application, J. Magnetism and Magnetic Materials, 399, 2016, , DOI: /j.jmmm Mangaiyarkarasi, R., Chinnathambi, S., Karthikeyan.S., Aruna, P., and Ganesan, S. Synthesis, Cytotoxicity, and Antitumor activity of 4-[(1-(2-carbamothioylhydrazinylidene) ethyl] phenyl acetate (Ace semi) Conjugated Chitosan functionalized LaF3:Ce 3+, Tb 3+ Nanoparticles, J. Nanoscience and Nanotechnology (Accepted for publication). 5. Karthikeyan, S., Aruna, P., Mangaiyarkarasi, R., Tamil kumar, P., Rai, R., Velmurugan, D., Ganesan, S., Bharanidharan, G. Insights into the Binding of Cytarabine with Human Serum Albumin: An optical spectroscopy and molecular docking studies, Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (under Review). (B) Papers Presented in Conferences/Symposia/Workshop 1. Mangaiyarkarasi, R., Aruna, P., and Ganesan, S. Paclitaxel conjugated LaF3:Ce 3+, Tb 3+ nanoparticles as a Bifunctional targeting carrier for cancer theranostics application, Indo-Australian Conference on Biomaterials, Tissue Engineering, Drug Delivery system & Regenerative medicine, Anna University, Chennai, India, February 5-7, 2015.

5 2. Mangaiyarkarasi, R., Aruna, P., and Ganesan, S. Spectroscopic Investigation of LaF3/Tb 3+ / Chitosan nanoparticles loaded 5Fluorouracil (5FU)-Synthesis and its formulation, International Conference on nanomaterials: Science, Technology & Applications, B.S.Abdur Rahman University, Chennai, India, December 5-6, Mangaiyarkarasi, R., Aruna, P., and Ganesan, S. Synthesis and formulations of Chitosan functionalized LaF3/Tb 3+ nanoparticles loaded Methotrexate (MTX-spectroscopic approach, National Seminar on recent trends in Nanobiotechnology, Anna University, Chennai, India, September 19-20, Mangaiyarkarasi, R., Aruna, P., and Ganesan, S. Spectroscopic Investigation of Bovine Serum Albumin nanoparticles loaded Methotrexate (MTX)- Synthesis, Formulation and its Sustained release evaluation, International Conference on nanomaterials & nanocomposites- Synthesis, Properties & Applications, Mother Teresa Women s University, Kodaikanal, India, July 12-13, Mangaiyarkarasi, R., Chinnathambi. S., Aruna, P., and Ganesan, S. Drug Delivery using Nanoparticles in the treatment of Breast Cancer, International conference on Nanoscience & Nanotechnology, SRM University, Katankulathur, India, February 24-26, ADDITIONAL INFORMATION Rajendiran